LOCUS       NM_133770               2190 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus coenzyme Q8B (Coq8b), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_133770
VERSION     NM_133770.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Nicoll,C.R., Alvigini,L., Gottinger,A., Cecchini,D., Mannucci,B.,
            Corana,F., Mascotti,M.L. and Mattevi,A.
  TITLE     In vitro construction of the COQ metabolon unveils the molecular
            determinants of coenzyme Q biosynthesis
  JOURNAL   Nat Catal 7 (2), 148-160 (2024)
   PUBMED   38425362
REFERENCE   3  (bases 1 to 2190)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2190)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   5  (bases 1 to 2190)
  AUTHORS   Widmeier,E., Yu,S., Nag,A., Chung,Y.W., Nakayama,M.,
            Fernandez-Del-Rio,L., Hugo,H., Schapiro,D., Buerger,F., Choi,W.I.,
            Helmstadter,M., Kim,J.W., Ryu,J.H., Lee,M.G., Clarke,C.F.,
            Hildebrandt,F. and Gee,H.Y.
  TITLE     ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is
            Rescued by 2,4-Dihydroxybenzoic Acid Treatment
  JOURNAL   J Am Soc Nephrol 31 (6), 1191-1211 (2020)
   PUBMED   32381600
REFERENCE   6  (bases 1 to 2190)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2190)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   8  (bases 1 to 2190)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202506.1, AK002619.1, AK137168.1, AK079366.1 and BB770607.1.
            
            On Jan 26, 2007 this sequence version replaced NM_133770.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002619.1, SRR1660813.4072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY202506.1         1-10
            11-854              AK002619.1         2-845
            855-884             AK137168.1         1777-1806
            885-1172            AK002619.1         876-1163
            1173-2184           AK079366.1         217-1228
            2185-2186           AK002619.1         2175-2176
            2187-2190           BB770607.1         527-530
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.85 cM"
     gene            1..2190
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /note="coenzyme Q8B"
                     /db_xref="GeneID:76889"
                     /db_xref="MGI:MGI:1924139"
     exon            1..161
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            162..269
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1766
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /note="aarF domain-containing protein kinase 4; aarF
                     domain containing kinase 4; coenzyme Q protein 8B"
                     /codon_start=1
                     /product="atypical kinase COQ8B, mitochondrial"
                     /protein_id="NP_598531.2"
                     /db_xref="CCDS:CCDS39847.1"
                     /db_xref="GeneID:76889"
                     /db_xref="MGI:MGI:1924139"
                     /translation="MWLELGAMLRRTCGPLGRAVRLPCGGALGPRPHWWGPCRSCLAQ
                     SVHQDQPGRGLSEDDIRRAREARLRKAPRPQLSDRSRERKVPASRISRLASFGGLAVG
                     LGLGALAEVTKKSLPGGSLQHEGVSGLGSSPFLSEANAERIVQTLCTVRGAALKIGQM
                     LSIQDNSFISPQLQRIFERVRQSADFMPRWQMMRVLEEELGKDWQDKVASLEEVPFAA
                     ASIGQVHQGLLKDGTEVAVKIQYPGVAQSIQSDVENLLALLKMSVGLPEGLFAEQSLQ
                     TLQQELAWECDYCREAACAQTFRKLLADDPFFRVPAVVQELCTTRVLGMELAGGIPLD
                     QCQGLSQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASR
                     AFGTEFTDHYIEVVKAAADGDRDRVLQKSQDLKFLTGFETKAFSDAHVEAVMILGEPF
                     AASGPYDFGAGETARRIQGLIPVLLRHRLRPPPEETYALHRKLAGAFLACARLHAHIA
                     CRDLFQDTYHRYWASRQTLPLPAAS"
     exon            270..389
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            390..456
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            457..534
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..657
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            658..743
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..884
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            885..966
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1060
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1202
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1310
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1376
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1463
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..2190
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /note="major polyA site"
ORIGIN      
        1 ggacgttccc ggaagcttaa gaggcccagc gggtgctaga cctggagcct aaacctggtg
       61 gactgggtgc ttagcaacgg gggaggtgcc ccgtaacggg gtcgtaacgg ggtgtctagg
      121 cagggggcag cacaggaatt gtgaatgctt aacagcccag ggcaatgtgg ctggagctag
      181 gtgccatgct gcgcaggacc tgtggaccgc tgggcagggc tgttcgtctg ccctgtgggg
      241 gggccctagg acctaggccc cactggtggg ggccatgtag gagttgcttg gcccaaagtg
      301 ttcatcaaga ccagcctgga agaggcctca gtgaagatga cattcgcagg gcacgggagg
      361 cccggctcag gaaggcaccc cggccccagc tgagtgatcg ctctcgtgaa cgcaaggtgc
      421 ctgcctcccg catcagtcgc ttggccagct ttggggggct ggctgtgggc ttgggcctgg
      481 gagcgctggc tgaggtgact aagaagtcct tgccaggtgg aagtctgcag catgagggcg
      541 tctctggatt gggctccagt cctttcctct ccgaggccaa tgctgagagg atcgtgcaga
      601 ccttatgtac agtccggggg gctgccctca agatcggcca aatgctcagt atccaggaca
      661 acagctttat cagcccccag cttcagcgaa tctttgagag ggtccgacag agtgccgact
      721 ttatgccccg ctggcaaatg atgagagttc tagaagagga gctaggcaag gactggcaag
      781 acaaggtggc ctccctcgag gaagtgccct ttgctgctgc ctccattggg caggtacacc
      841 aaggcttgct aaaggatggg actgaggtgg ctgtgaagat ccagtaccca ggtgttgccc
      901 agagcatcca gagtgacgtg gagaacctgc tggccctgct caagatgagt gtgggcctgc
      961 cagagggcct gtttgctgag cagagcctgc agaccttgca gcaggagctg gcttgggaat
     1021 gtgactactg cagagaagcg gcctgtgccc agaccttcag gaagctctta gctgacgacc
     1081 ccttcttccg agtgccagct gtggtgcagg agctatgcac tacacgggtg ctgggcatgg
     1141 agctggctgg gggaatccct ctagaccagt gccagggcct gagccaagac atccggaatc
     1201 agatctgctt tcagctcctg aggttgtgtc tgcgggaact gtttgagttc agattcatgc
     1261 agactgatcc caactgggcc aacttcctgt atgatgcctc cagccaccag gtgactctac
     1321 tggattttgg tgcaagccgg gcgtttggga cagagttcac ggaccattac attgaggtgg
     1381 tgaaggctgc agcagatgga gacagagatc gagttctaca gaaatcccag gacctcaagt
     1441 tccttacagg ctttgaaacc aaggcattct ctgacgccca cgtcgaggca gtgatgatcc
     1501 tgggggagcc ctttgctgcc tcaggcccct acgactttgg ggctggagag actgctcgcc
     1561 gaatacaggg cctcatcccg gtattgcttc ggcaccggct gcgcccaccg cctgaggaga
     1621 cctatgctct acaccgcaag ctagctgggg ctttcttagc ctgtgcccgt ctccacgccc
     1681 acatcgcctg ccgggacctc ttccaagata cctaccaccg ctactgggcc agtcgccaga
     1741 cactgccgct gccagcagcc tcctgactag ggacctccct gccgacccca ccatgacaga
     1801 ttccatccag ggataccagc tccacagcag gcagtcccct cctcctcttt cttggtctcc
     1861 agaacctagt ttcttgcctt ggatctttgg gcccctggag ttagctccct gatcctaagt
     1921 gagcaacctt gaattctgag gctaggagcc agcagaatcc tgccaccatc taagtgagcc
     1981 ttgggtccac tctcatgtga aggagacgcc cctcggcccc aggtcttcca ggatctgcag
     2041 gggagatggt ggctgttggg ggcggtcctc acctttgcct cccttgctcc tctaccagct
     2101 gccttcttcc cgggttccag cctgtgtatt ggagggtggg ggtgggtgct gatcctttcc
     2161 tccgaataaa ggcacccttt ccctgccccc
//
