LOCUS       NP_598531                533 aa            linear   ROD 28-JAN-2025
DEFINITION  atypical kinase COQ8B, mitochondrial [Mus musculus].
ACCESSION   NP_598531
VERSION     NP_598531.2
DBSOURCE    REFSEQ: accession NM_133770.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 533)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 533)
  AUTHORS   Nicoll,C.R., Alvigini,L., Gottinger,A., Cecchini,D., Mannucci,B.,
            Corana,F., Mascotti,M.L. and Mattevi,A.
  TITLE     In vitro construction of the COQ metabolon unveils the molecular
            determinants of coenzyme Q biosynthesis
  JOURNAL   Nat Catal 7 (2), 148-160 (2024)
   PUBMED   38425362
REFERENCE   3  (residues 1 to 533)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 533)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   5  (residues 1 to 533)
  AUTHORS   Widmeier,E., Yu,S., Nag,A., Chung,Y.W., Nakayama,M.,
            Fernandez-Del-Rio,L., Hugo,H., Schapiro,D., Buerger,F., Choi,W.I.,
            Helmstadter,M., Kim,J.W., Ryu,J.H., Lee,M.G., Clarke,C.F.,
            Hildebrandt,F. and Gee,H.Y.
  TITLE     ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is
            Rescued by 2,4-Dihydroxybenzoic Acid Treatment
  JOURNAL   J Am Soc Nephrol 31 (6), 1191-1211 (2020)
   PUBMED   32381600
REFERENCE   6  (residues 1 to 533)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (residues 1 to 533)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   8  (residues 1 to 533)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202506.1, AK002619.1, AK137168.1, AK079366.1 and BB770607.1.
            
            On Jan 26, 2007 this sequence version replaced NP_598531.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002619.1, SRR1660813.4072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.85 cM"
     Protein         1..533
                     /product="atypical kinase COQ8B, mitochondrial"
                     /note="aarF domain-containing protein kinase 4; aarF
                     domain containing kinase 4; coenzyme Q protein 8B"
                     /calculated_mol_wt=59048
     Site            93..109
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q566J8.1)"
     Region          156..159
                     /region_name="KxGQ motif.
                     /evidence=ECO:0000250|UniProtKB:Q8NI60"
                     /note="propagated from UniProtKB/Swiss-Prot (Q566J8.1)"
     Region          176..425
                     /region_name="ABC1_ADCK3"
                     /note="Activator of bc1 complex (ABC1) kinases, also
                     called aarF domain containing kinase 3; cd13970"
                     /db_xref="CDD:270872"
     Region          217..220
                     /region_name="AAAS motif.
                     /evidence=ECO:0000250|UniProtKB:Q8NI60"
                     /note="propagated from UniProtKB/Swiss-Prot (Q566J8.1)"
     Site            order(229..233,235,245,247,306,325..328,368,372..373,375,
                     386..387)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:270872"
     CDS             1..533
                     /gene="Coq8b"
                     /gene_synonym="0610012P18Rik; Adck4"
                     /coded_by="NM_133770.2:165..1766"
                     /db_xref="CCDS:CCDS39847.1"
                     /db_xref="GeneID:76889"
                     /db_xref="MGI:MGI:1924139"
ORIGIN      
        1 mwlelgamlr rtcgplgrav rlpcggalgp rphwwgpcrs claqsvhqdq pgrglseddi
       61 rrarearlrk aprpqlsdrs rerkvpasri srlasfggla vglglgalae vtkkslpggs
      121 lqhegvsglg sspflseana erivqtlctv rgaalkigqm lsiqdnsfis pqlqriferv
      181 rqsadfmprw qmmrvleeel gkdwqdkvas leevpfaaas igqvhqgllk dgtevavkiq
      241 ypgvaqsiqs dvenllallk msvglpeglf aeqslqtlqq elawecdycr eaacaqtfrk
      301 lladdpffrv pavvqelctt rvlgmelagg ipldqcqgls qdirnqicfq llrlclrelf
      361 efrfmqtdpn wanflydass hqvtlldfga srafgteftd hyievvkaaa dgdrdrvlqk
      421 sqdlkfltgf etkafsdahv eavmilgepf aasgpydfga getarriqgl ipvllrhrlr
      481 pppeetyalh rklagaflac arlhahiacr dlfqdtyhry wasrqtlplp aas
//
