LOCUS       NM_023341               4026 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus coenzyme Q8A (Coq8a), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_023341
VERSION     NM_023341.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4026)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   2  (bases 1 to 4026)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   3  (bases 1 to 4026)
  AUTHORS   Stefely,J.A., Licitra,F., Laredj,L., Reidenbach,A.G.,
            Kemmerer,Z.A., Grangeray,A., Jaeg-Ehret,T., Minogue,C.E.,
            Ulbrich,A., Hutchins,P.D., Wilkerson,E.M., Ruan,Z., Aydin,D.,
            Hebert,A.S., Guo,X., Freiberger,E.C., Reutenauer,L., Jochem,A.,
            Chergova,M., Johnson,I.E., Lohman,D.C., Rush,M.J.P., Kwiecien,N.W.,
            Singh,P.K., Schlagowski,A.I., Floyd,B.J., Forsman,U.,
            Sindelar,P.J., Westphall,M.S., Pierrel,F., Zoll,J., Dal Peraro,M.,
            Kannan,N., Bingman,C.A., Coon,J.J., Isope,P., Puccio,H. and
            Pagliarini,D.J.
  TITLE     Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of
            Unorthodox Kinase Activity
  JOURNAL   Mol Cell 63 (4), 608-620 (2016)
   PUBMED   27499294
  REMARK    GeneRIF: Loss of COQ8a results in cerebellar ataxia and coenzyme Q
            deficiency.
REFERENCE   4  (bases 1 to 4026)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY261815.1, AC132436.3, AK004791.1 and AK014605.2.
            
            On Jul 16, 2009 this sequence version replaced NM_023341.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014605.2, BC030937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY261815.1         1-49
            50-59               AC132436.3         151683-151692       c
            60-2649             AK004791.1         2-2591
            2650-3531           AK014605.2         2592-3473
            3532-4026           AC132436.3         120959-121453       c
FEATURES             Location/Qualifiers
     source          1..4026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.15 cM"
     gene            1..4026
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /note="coenzyme Q8A"
                     /db_xref="GeneID:67426"
                     /db_xref="MGI:MGI:1914676"
     exon            1..148
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            149..334
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2095
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chaperone activity of bc1 complex-like, mitochondrial;
                     aarF domain-containing protein kinase 3; chaperone, ABC1
                     activity of bc1 complex like; atypical kinase ADCK3,
                     mitochondrial; aarF domain containing kinase 3; coenzyme Q
                     protein 8A; atypical kinase COQ8A, mitochondrial"
                     /codon_start=1
                     /product="atypical kinase COQ8A, mitochondrial isoform 1"
                     /protein_id="NP_075830.2"
                     /db_xref="CCDS:CCDS15566.1"
                     /db_xref="GeneID:67426"
                     /db_xref="MGI:MGI:1914676"
                     /translation="MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELLLAARALQ
                     STAVEQFSMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGTSLDFSAASSLDQ
                     SLSPSHSQGPAPAYASSGPFREAGLPGQATSPMGRVNGRLFVDHRDLFLANGIQRRSF
                     HQDQSSVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLA
                     VGLGIGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQ
                     MLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNSDLGPHWRDKLEYFEERPFA
                     AASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLI
                     DVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELISGFPL
                     DQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGAT
                     REYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEA
                     FASEEPFDFGTQSTTEKIHNLIPVMLKHRLIPPPEETYSLHRKMGGSFLICSKLKARF
                     PCKAMFEEAYSNYCRMKSGLQ"
     exon            335..736
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            737..803
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            804..878
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1001
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1087
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1228
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1310
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1404
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1546
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1654
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1720
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1807
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..4026
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /note="hexamer: AATAAA"
     polyA_site      2650
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
                     /note="major polyA site"
     polyA_site      2705
                     /gene="Coq8a"
                     /gene_synonym="4632432J16Rik; Adck3; Cabc1; mKIAA0451"
ORIGIN      
        1 gagggctcgg aggcggggca agcggagcgc ggcgtgcgca cccgggctag aaggtaaaca
       61 gaagcggaga gtgtgcggag cgctcgcagc ggggcgagcg cgcggaggcg ttgcgttgcg
      121 gacggaggag ctaccttcct gcagcccgct ctgaaggatg gctgctatgt tgggggatgc
      181 catcatggtg gccaaaggcc ttgccaagct gacccaagca gcggtggaaa cccacttgca
      241 gaacctgggc cttggtgggg agctcctcct ggcggccagg gccctgcagt ctacagctgt
      301 ggagcagttc agcatggtct tcgggaaggt gcagggtcag gataagcatg aagattcata
      361 tgccactgag aactttgaag atctggaagc cgaagttcag ttctcaacac cacaggcagc
      421 tggaacctcc ctggacttct ctgcggcctc ttccctggac cagtcactgt ctccatccca
      481 cagtcaggga ccggcccctg cctatgcttc cagtgggcct ttcagggaag ctgggctccc
      541 tggacaggcc acctctccta tgggcagagt caatggaagg ctctttgtag atcacagaga
      601 cttgttcttg gccaacggca tccagcgaag atccttccac caggaccagt cctccgtggg
      661 aggcctcacg gctgaagaca ttgaaaaggc ccggcaggcc aaggctcgcc ctgagagcaa
      721 gccacacaag cagatgctca gtgagcgggc tcgggagcgg aaggtgccag ttacccggat
      781 tgggcggttg gccaactttg gaggtctggc tgtaggtctg ggaattgggg cgttggctga
      841 agttgccaag aagagtctgc gttctgagaa ctccacagga aaaaaagccg tgctggattc
      901 tagccccttc ctgtcagagg caaatgcaga gcgcattgtg agtacactgt gcaaggtgcg
      961 tggggccgca ctgaagctgg gccagatgct gagcatccag gatgatgcct tcatcaaccc
     1021 tcacctggcc aagatctttg agcgggtgag gcagagtgct gacttcatgc cactgaaaca
     1081 gatgacgaaa accctcaaca gcgacctggg cccccactgg agggacaagc tggagtactt
     1141 tgaagagcgg ccctttgcag cggcctccat agggcaggtg cacctggccc gcatgaaggg
     1201 tggccgtgag gtggccatga agatccagta ccctggtgtg gcccagagca ttaacagtga
     1261 cgtcaacaac ctcatggctg tgctgaacat gagtaacatg cttccagaag gcctgttccc
     1321 tgagcacctg attgatgtgc tgagacggga gcttaccctt gagtgtgact accagcggga
     1381 ggctgcctat gccaagaagt tcagggaact gctgaaggac catcccttct tctatgtgcc
     1441 tgagattgtg gatgagttgt gcagtcccca tgtgctgacc acagagctca tatcaggctt
     1501 ccccttggac caggcagaag ggctgagcca ggaagtgagg aatgagatct gctacaacat
     1561 tttggtgctg tgcctgagag agctgtttga gttccatgtc atgcagactg accccaactg
     1621 gtccaatttc ttttatgacc ctcagcagca caaggtggct ctcctggact tcggcgcaac
     1681 tagagaatat gacagatcct ttactgacct ctacattcag gtcatccggg ccgctgctga
     1741 ccaggacagg gaggcagtgc taaagaaatc catagagatg aagttcctta ccggttatga
     1801 ggtcaaggcc atggaggatg ctcacctgga tgctattctc atcctggggg aggcctttgc
     1861 ctccgaagag cccttcgact tcggtaccca gagcactact gagaagatcc acaacctgat
     1921 tcccgtcatg ctgaagcacc gcctcatccc acccccagag gagacctact ctctgcaccg
     1981 caagatgggt ggctctttcc tcatctgctc taagctgaag gcccgcttcc cctgtaaggc
     2041 catgttcgag gaagcgtaca gtaactactg caggatgaag tctgggctgc agtaggtgag
     2101 gtgtggtcca ggctaactag gggccatgcc ctccttcagg ctcagtcaag cagagggagg
     2161 acgttgaaag ggagccacgg cctctatgaa taggaagaga gcgttgcgta gaccctccta
     2221 ttgcttctgt actgtccaga caaaaaggca ggcttctttt gccatctcct ccctgctgtg
     2281 gatgtacaac caggaacagg agcaatgcag tactaaactc aacacagcca cctttggggt
     2341 ctagttggcc atgggaatga attgtgtgtt tctgggtgag cttatgtccc tgccctttgc
     2401 caccccagcc tgtggcctgg agctagaagc tcaggacagc agggtagcca ccctagctca
     2461 gtctcagcat ggacaacaga cccttttaaa agcagggctg acattggatg agcagcaggg
     2521 ctccagcatg ccccaggaga gggagctatc accccacccc aggggagcga cacaggctct
     2581 ttgtttgtat gtcttgtaat tacacattca tacctttgcg ttcaataaag aagtgcgttg
     2641 gggactgcca tttcctatgc gttccgtgaa tcctgggaag gaggtggccc cacttatgac
     2701 ctggatgtgt ggtctttgtc tgtctcttgc tcttgatggg gacagaacat ggcaacatag
     2761 gcagatatta agcatttcca tgtatgtgtg tctctgactc aggactttaa tggcactgga
     2821 gattaagcct aatgccttgc agagtgactt gagtgctcta ccaccggttg gttgtaccct
     2881 gagccctttt acttttggga tgggatctca tcaagttgct caggcaagcc ttgaacttgt
     2941 aatcctcctg cttaactccc cctcacccca agtaattagg atcacaagtt taagccacca
     3001 agcttcttag gcatttagag aaaacagctt gtggggttca gtggctacag aacagacact
     3061 gagatctgga tctgggacag gaacagtgtg cccatacaac ccatgcatgc tgtctgtcct
     3121 ggctaggggc ctgggtcact gccacccctg caccacacta ggctcaccga gcttaagttt
     3181 tactgcgtgg tgttcttgtc catttctttg tggaattttt gccaagtctt ggtcttcaca
     3241 gatgctgcct tggaggccca gtgcgacttg aaagatctga aagagtctca atggctaaga
     3301 gggtgatgat ttcagttgca ggtttggggt ctctgataag gtcacccaac cttgcctgtg
     3361 tgtcagctgc accattctaa cagaacagat ccaactccta cgttaatgct gcagacagac
     3421 aaccccgagt ctcaagcgcc agtggagtgt gccctggggg cctaaagcag tgcccgggga
     3481 gttcttatca gagaaaggga gttgagcact tccatggatt tgaatgttat tcttacctga
     3541 gctccaggac ccgatcaaac cgacctgtgt cctctgggat agagaagagg tccagaggga
     3601 gatcagcgag ccaagaatgc ctcacactct ccacacggga agaaatagaa tactcaatgc
     3661 tgacagttcc ttattttatt gcagaacatc aaagtctggt taattaggtg ataccaacat
     3721 aaaatattgg tgagaaatcc tttgttacat ttttgaccac cccaccttaa atagttctgt
     3781 gcaaaagaat ccatgttata gtttggtagc agatactgtc aggaaattcc ctaggacatc
     3841 tagggacaaa accaaaccaa atgagtgcta agaggccaaa gcagtatctt cccttccaca
     3901 cacacacaca caggtcataa ttttctgaac aaaaatgatt acactgaggc catgcaaaac
     3961 tgtacaataa tattacaatg agaaaaaaat cctaaaaatt tataaaataa atgctgttat
     4021 tctatc
//
