LOCUS       NM_001304758            1221 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus demethyl-Q 7 (Coq7), transcript variant 2, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001304758 XM_006507296
VERSION     NM_001304758.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1221)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1221)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   3  (bases 1 to 1221)
  AUTHORS   Yan,Q., Han,C., Wang,G., Waddington,J.L., Zheng,L. and Zhen,X.
  TITLE     Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses
            Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death
  JOURNAL   Mol Pharmacol 92 (6), 640-652 (2017)
   PUBMED   29025968
  REMARK    GeneRIF: Clk1 plays a direct role in dopaminergic neuronal survival
            via regulating the autophagy-lysosome pathway that may contribute
            to the pathologic development of Parkinson disease.
REFERENCE   4  (bases 1 to 1221)
  AUTHORS   Stefely,J.A. and Pagliarini,D.J.
  TITLE     Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
  JOURNAL   Trends Biochem Sci 42 (10), 824-843 (2017)
   PUBMED   28927698
  REMARK    Review article
REFERENCE   5  (bases 1 to 1221)
  AUTHORS   Wang,Y., Oxer,D. and Hekimi,S.
  TITLE     Mitochondrial function and lifespan of mice with controlled
            ubiquinone biosynthesis
  JOURNAL   Nat Commun 6, 6393 (2015)
   PUBMED   25744659
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1221)
  AUTHORS   Vajo,Z., King,L.M., Jonassen,T., Wilkin,D.J., Ho,N., Munnich,A.,
            Clarke,C.F. and Francomano,C.A.
  TITLE     Conservation of the Caenorhabditis elegans timing gene clk-1 from
            yeast to human: a gene required for ubiquinone biosynthesis with
            potential implications for aging
  JOURNAL   Mamm Genome 10 (10), 1000-1004 (1999)
   PUBMED   10501970
REFERENCE   7  (bases 1 to 1221)
  AUTHORS   Poon,W.W., Barkovich,R.J., Hsu,A.Y., Frankel,A., Lee,P.T.,
            Shepherd,J.N., Myles,D.C. and Clarke,C.F.
  TITLE     Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze
            both O-methyltransferase steps in coenzyme Q biosynthesis
  JOURNAL   J Biol Chem 274 (31), 21665-21672 (1999)
   PUBMED   10419476
REFERENCE   8  (bases 1 to 1221)
  AUTHORS   Asaumi,S., Kuroyanagi,H., Seki,N. and Shirasawa,T.
  TITLE     Orthologues of the Caenorhabditis elegans longevity gene clk-1 in
            mouse and human
  JOURNAL   Genomics 58 (3), 293-301 (1999)
   PUBMED   10373327
REFERENCE   9  (bases 1 to 1221)
  AUTHORS   Ewbank,J.J., Barnes,T.M., Lakowski,B., Lussier,M., Bussey,H. and
            Hekimi,S.
  TITLE     Structural and functional conservation of the Caenorhabditis
            elegans timing gene clk-1
  JOURNAL   Science 275 (5302), 980-983 (1997)
   PUBMED   9020081
REFERENCE   10 (bases 1 to 1221)
  AUTHORS   Jonassen,T., Marbois,B.N., Kim,L., Chin,A., Xia,Y.R., Lusis,A.J.
            and Clarke,C.F.
  TITLE     Isolation and sequencing of the rat Coq7 gene and the mapping of
            mouse Coq7 to chromosome 7
  JOURNAL   Arch Biochem Biophys 330 (2), 285-289 (1996)
   PUBMED   8660658
  REMARK    Erratum:[Arch Biochem Biophys 1996 Nov 1;335(1):227]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122912.2.
            
            On Sep 27, 2022 this sequence version replaced NM_001304758.1.
            
            Transcript Variant: This variant (2) contains two alternate exons
            including an alternate 3' terminal exon, compared to variant 1. It
            encodes isoform 2 which is longer and has a distinct C-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158380.1, SRR17253011.913254.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC122912.2         216569-216696       c
            129-307             AC122912.2         212949-213127       c
            308-422             AC122912.2         211694-211808       c
            423-562             AC122912.2         210727-210866       c
            563-631             AC122912.2         209214-209282       c
            632-698             AC122912.2         200724-200790       c
            699-1221            AC122912.2         193048-193570       c
FEATURES             Location/Qualifiers
     source          1..1221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.44 cM"
     gene            1..1221
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /note="demethyl-Q 7"
                     /db_xref="GeneID:12850"
                     /db_xref="MGI:MGI:107207"
     exon            1..128
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1069
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /EC_number="1.14.99.60"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquinone biosynthesis protein COQ7 homolog; timing
                     protein clk-1 homolog; coenzyme Q biosynthesis protein 7
                     homolog; DMQ hydroxylase; ubiquinone biosynthesis
                     monooxygenase COQ7; 5-demethoxyubiquinone hydroxylase,
                     mitochondrial"
                     /codon_start=1
                     /product="5-demethoxyubiquinone hydroxylase, mitochondrial
                     isoform 2"
                     /protein_id="NP_001291687.1"
                     /db_xref="CCDS:CCDS80794.1"
                     /db_xref="GeneID:12850"
                     /db_xref="MGI:MGI:107207"
                     /translation="MSAAGAIAAASVGRLRTGVRRPFSEYGRGLIIRCHSSGMTLDNI
                     NRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKNHLKKFNELMI
                     AFRVRPTVLMPLWNVAGFALGAGTALLGKEGAMACTVAVEESIANHYNNQIRMLMEED
                     PEKYEELLQVIKQFRDEELEHHDTGLDHDAELPFQCLNSWKHIPSYMSSPGRDNDHEK
                     KSHQNTKWRTWETAMCRVMREAWVQIPALPLQAIGSQAVNIACLGLSVPTCKVEMKTE
                     AALKIVLHGRDEQAPHREGPRTATEELFWLASISLHNAANRQGRGVLYLACSLCKLCA
                     QWL"
     exon            129..307
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..422
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..562
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..631
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..698
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1221
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /note="hexamer: TATAAA"
     polyA_site      1221
                     /gene="Coq7"
                     /gene_synonym="clk-1"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgagag cacgattggc ggggcgtttg gaccatagct gcattgtccg cagcgatgag
       61 cgccgccgga gccatagcgg ctgcttccgt gggacgcctg cgcactggtg tccggaggcc
      121 cttctcagag tatggaagag gcctcatcat caggtgtcac agttcgggga tgaccttaga
      181 caatattaac cgggcagccg tggatcgaat aattcgggtg gatcacgctg gtgaatatgg
      241 agcaaaccgc atctatgcag ggcaaatggc cgtgctcggt cggaccagtg ttggccctgt
      301 cattcagaaa atgtgggatc aagagaagaa ccatttgaaa aagttcaacg agttgatgat
      361 tgcattcagg gtccgaccta cggttttgat gcccttgtgg aacgtggcag gctttgccct
      421 gggggcagga actgccttgc tggggaagga aggagcaatg gcctgcaccg tggcggtaga
      481 agagtctatc gctaatcact acaacaacca gatccgcatg ctgatggaag aggaccctga
      541 gaagtatgag gagctgctgc aggtcatcaa gcagtttcgc gatgaggagc ttgaacacca
      601 cgatacaggc ctggaccatg acgcagagct gccctttcag tgcctcaaca gctggaaaca
      661 cattccaagc tatatgtctt caccgggcag ggacaatgat catgaaaaaa aaagtcatca
      721 aaacacaaag tggagaacct gggaaacagc aatgtgcagg gtgatgaggg aggcgtgggt
      781 tcaaatccca gctttaccac tgcaggctat aggatcccag gcagtgaaca tagcctgcct
      841 gggcctcagt gttcccacct gcaaagtaga gatgaagaca gaagctgctt tgaagattgt
      901 tctgcatggg agggatgaac aagccccaca tcgtgaggga ccgaggactg ccactgaaga
      961 actgttctgg ctggcttcca tctctctcca caatgctgcc aacagacagg gaagaggggt
     1021 cttatatctg gcatgctcgc tttgcaaact ttgtgcacaa tggctttgag gttctcagtc
     1081 ccactgcctt ctgagtttct ttggctctgt tggacttcgg gccagaaatg taatggctgt
     1141 caggattctc accatgacat cacccgacaa tgtcagtggg aactcggtgt ctataaaatg
     1201 attcaaagtc gatgagatgg a
//
