LOCUS       NM_172582               1602 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus coenzyme Q6 monooxygenase (Coq6), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_172582
VERSION     NM_172582.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Walker,E.C., Javati,S., Todd,E.M., Matlam,J.P., Lin,X., Bryant,M.,
            Krone,E., Ramani,R., Chandra,P., Green,T.P., Anaya,E.P., Zhou,J.Y.,
            Alexander,K.A., Tong,R.S., Yuasi,L., Boluarte,S., Yang,F.,
            Greenberg,L., Nerbonne,J.M., Greenberg,M.J., Clemens,R.A.,
            Philips,J.A., Wilson,L.D., Halabi,C.M., DeBosch,B.J., Blyth,C.C.,
            Druley,T.E., Kazura,J.W., Pomat,W.S. and Morley,S.C.
  TITLE     Novel coenzyme Q6 genetic variant increases susceptibility to
            pneumococcal disease
  JOURNAL   Nat Immunol 25 (12), 2247-2258 (2024)
   PUBMED   39496954
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Widmeier,E., Airik,M., Hugo,H., Schapiro,D., Wedel,J., Ghosh,C.C.,
            Nakayama,M., Schneider,R., Awad,A.M., Nag,A., Cho,J., Schueler,M.,
            Clarke,C.F., Airik,R. and Hildebrandt,F.
  TITLE     Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression
            and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice
  JOURNAL   J Am Soc Nephrol 30 (3), 393-405 (2019)
   PUBMED   30737270
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Stefely,J.A. and Pagliarini,D.J.
  TITLE     Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
  JOURNAL   Trends Biochem Sci 42 (10), 824-843 (2017)
   PUBMED   28927698
  REMARK    Review article
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Garcia-Corzo,L., Luna-Sanchez,M., Doerrier,C., Garcia,J.A.,
            Guaras,A., Acin-Perez,R., Bullejos-Peregrin,J., Lopez,A.,
            Escames,G., Enriquez,J.A., Acuna-Castroviejo,D. and Lopez,L.C.
  TITLE     Dysfunctional Coq9 protein causes predominant encephalomyopathy
            associated with CoQ deficiency
  JOURNAL   Hum Mol Genet 22 (6), 1233-1248 (2013)
   PUBMED   23255162
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Kohr,M.J., Aponte,A.M., Sun,J., Wang,G., Murphy,E., Gucek,M. and
            Steenbergen,C.
  TITLE     Characterization of potential S-nitrosylation sites in the
            myocardium
  JOURNAL   Am J Physiol Heart Circ Physiol 300 (4), H1327-H1335 (2011)
   PUBMED   21278135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132170.1 and AC120402.10.
            
            On Jan 6, 2010 this sequence version replaced NM_172582.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132168.1, AK131889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1564              BC132170.1         1-1564
            1565-1602           AC120402.10        44248-44285
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.18 cM"
     gene            1..1602
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /note="coenzyme Q6 monooxygenase"
                     /db_xref="GeneID:217707"
                     /db_xref="MGI:MGI:1924408"
     exon            1..270
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1514
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /note="coenzyme Q10 monooxygenase 6; ubiquinone
                     biosynthesis monooxygenase COQ6, mitochondrial; coenzyme
                     Q6 homolog"
                     /codon_start=1
                     /product="ubiquinone biosynthesis monooxygenase COQ6,
                     mitochondrial precursor"
                     /protein_id="NP_766170.2"
                     /db_xref="CCDS:CCDS26044.1"
                     /db_xref="GeneID:217707"
                     /db_xref="MGI:MGI:1924408"
                     /translation="MAARIGSMAGLLCVRWWSSAQLAARGGPLVASQRWAGSSADTVY
                     DVVVSGGGLVGSAMACALGHDIHFHDKKILLLEAGPKKALEKLSETYSNRVSSISPGS
                     TTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNLDDMGYIVENDVIMYAL
                     TKQLEAVADRVKVLYESKAVGYSWPGAFSMADSSPWVHITLGDGSTLQTKLLIGADGH
                     KSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSS
                     LVWSTSHEHAAELVSMDEEEFVDAINSAFWSDVHHTDFVDSASAMVRHAVALLKPTKV
                     SARQLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFG
                     DISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLV
                     LLRTWGLQATNAVSPLKEQIMAFASK"
     exon            271..405
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            406..464
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..588
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..719
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..827
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..890
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            891..998
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1201
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1317
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1484
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1602
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1595
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /note="major polyA site"
     polyA_site      1598
                     /gene="Coq6"
                     /gene_synonym="5930427M12Rik"
                     /note="major polyA site"
ORIGIN      
        1 cacaaggttg acgactgccc cggaagcact ttccaggacc tatcagggag aagtcccggg
       61 cgcgggcgca ggcaggagtc attatggcgg cccgcattgg ctccatggca ggcttgctct
      121 gcgttcgctg gtggagttcc gcgcagctcg cagccagagg aggcccgcta gttgccagcc
      181 agcgatgggc gggctcctcg gcagacaccg tgtacgacgt ggtggtgtca ggaggaggcc
      241 tagtgggctc tgccatggct tgtgccttag gacatgatat tcactttcat gacaagaaaa
      301 tcctgttgct ggaggcgggt ccaaagaaag ccctggagaa actgtcagag acttacagca
      361 acagagtcag ctccatatcc cctggctcca caaccctgct cagcagtttt ggtgcatggg
      421 accacatctg caatatgcgc tgcaaagcct tccggaggat gcaggtgtgg gactcctgct
      481 cagaggcctt gataatgttc gacagggaca acctggatga catgggctat atagtggaaa
      541 atgacgtcat catgtatgcc ctcaccaaac agctggaggc tgtggcagat cgagtgaagg
      601 ttctctatga gagcaaagct gttggctatt cctggcctgg tgcattttcc atggcagact
      661 ccagcccttg ggtccatatt accctaggtg atggcagtac cctccagacc aaactgttga
      721 ttggtgctga tgggcacaag tcaggagtga ggcaagctgc tgggatccag aatgtcagct
      781 ggaagtacga ccagtctgct gtggtggcca ctctccactt atcagaggcc acagaaaaca
      841 atgtagcctg gcagagattt cttccctctg ggcctattgc tctgctcccg ctctcggata
      901 ccttgagctc cttggtctgg tccacatcac acgagcatgc agcagagctg gtcagcatgg
      961 atgaggaaga attcgtggat gccatcaact ctgccttttg gagtgatgtt caccacacag
     1021 acttcgtcga ctctgccagc gccatggtgc gccatgctgt cgcccttctg aagcccacta
     1081 aggtctcagc ccgtcagctg cccccaagta tagccaaggt ggatgctaaa agcagagccc
     1141 tctttcctct ggggctggga catgctgctg agtacgtccg gcctcgggtg gccctcattg
     1201 gtgatgcagc ccacagaatc catccactcg cgggacaagg tgtcaacatg ggcttcgggg
     1261 atatttccag cttggttcat catctcagta cagcagcctt caatgggaag gacttaggct
     1321 ccatgagcca cctcacaggt tatgagacag acagacagcg tcataacact gctctcctgg
     1381 ctgctactga cctgttgaaa aggctctact ctaccagtgc cactcccctc gtgctgctca
     1441 ggacctgggg cttgcaggcc acgaacgcag tgtctcctct caaagaacag attatggcct
     1501 ttgcgagcaa atgagtgctt ctcttctgga gaccgtgatg acaaagaaca cctagccctg
     1561 gggccttccc aatgtggttt aataaattta cactagaact tg
//
