LOCUS       NM_026504               2008 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus coenzyme Q5 methyltransferase (Coq5), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026504
VERSION     NM_026504.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2008)
  AUTHORS   Nicoll,C.R., Alvigini,L., Gottinger,A., Cecchini,D., Mannucci,B.,
            Corana,F., Mascotti,M.L. and Mattevi,A.
  TITLE     In vitro construction of the COQ metabolon unveils the molecular
            determinants of coenzyme Q biosynthesis
  JOURNAL   Nat Catal 7 (2), 148-160 (2024)
   PUBMED   38425362
REFERENCE   2  (bases 1 to 2008)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   3  (bases 1 to 2008)
  AUTHORS   Yen,H.C., Yeh,W.Y., Lee,S.H., Feng,Y.H. and Yang,S.L.
  TITLE     Characterization of human mitochondrial PDSS and COQ proteins and
            their roles in maintaining coenzyme Q10 levels and each other's
            stability
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (7), 148192 (2020)
   PUBMED   32194061
REFERENCE   4  (bases 1 to 2008)
  AUTHORS   Stefely,J.A. and Pagliarini,D.J.
  TITLE     Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
  JOURNAL   Trends Biochem Sci 42 (10), 824-843 (2017)
   PUBMED   28927698
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145070.10.
            
            On Mar 7, 2023 this sequence version replaced NM_026504.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052345.1, AK050334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC145070.10        41674-41895         c
            223-372             AC145070.10        37873-38022         c
            373-594             AC145070.10        36976-37197         c
            595-701             AC145070.10        30548-30654         c
            702-790             AC145070.10        26673-26761         c
            791-902             AC145070.10        25811-25922         c
            903-2008            AC145070.10        24618-25723         c
FEATURES             Location/Qualifiers
     source          1..2008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.03 cM"
     gene            1..2008
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /note="coenzyme Q5 methyltransferase"
                     /db_xref="GeneID:52064"
                     /db_xref="MGI:MGI:1098643"
     exon            1..222
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1004
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /EC_number="2.1.1.201"
                     /note="ubiquinone biosynthesis methyltransferase COQ5,
                     mitochondrial; 2-methoxy-6-polyprenyl-1,4-benzoquinol
                     methylase, mitochondrial; coenzyme Q5 homolog,
                     methyltransferase"
                     /codon_start=1
                     /product="2-methoxy-6-polyprenyl-1,4-benzoquinol
                     methylase, mitochondrial precursor"
                     /protein_id="NP_080780.1"
                     /db_xref="CCDS:CCDS19585.1"
                     /db_xref="GeneID:52064"
                     /db_xref="MGI:MGI:1098643"
                     /translation="MAAPRCCVLWRVCGRGWWRATGHCRLPGCHRSWPWATLGTRSLS
                     QEKRAAETHFGFETVSEGEKGSKVYQVFENVAKKYDLMNDMMSLGIHRAWKDLLIRKM
                     HPLPGTQLLDMAGGTGDIAFRFLSYVQAQHQRRQRRQLRTQQNLSWEEIAKKYQNEED
                     SLGGSLATVCDINREMLKVGKQKALDQGHTAGLAWVLGDAEELPFDDDSFDVYTIAFG
                     IRNVTHIDQALQEAHRVLKPGGRFLCLEFGQVNDPLISRLYDLYSFQVIPVIGEVIAG
                     DWKSYQYLVESIRKFPNQEDFKDMIEDAGFQRVTYENLTTGIVAIHSGFKL"
     exon            223..372
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     exon            373..594
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     exon            595..701
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     exon            702..790
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     exon            791..902
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     exon            903..2008
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1261
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /note="major polyA site"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
                     /note="hexamer: AATAAA"
     polyA_site      2008
                     /gene="Coq5"
                     /gene_synonym="1810014G04Rik; D5Ertd33e"
ORIGIN      
        1 gcggtcgccg gggtgtcacg atggcggcgc ccaggtgctg cgttctatgg cgcgtctgcg
       61 gccgcgggtg gtggcgagcc acgggacact gcaggctccc cgggtgtcat agatcctggc
      121 catgggccac gctgggaacg cggtccttgt cccaggagaa gcgagccgcg gaaacgcact
      181 tcgggtttga gaccgtgtcg gaaggggaga aaggaagcaa agtctaccag gtgtttgaga
      241 acgtggccaa gaagtacgat ctgatgaatg acatgatgag tctcggcatc catcgagctt
      301 ggaaggattt gcttatcagg aagatgcacc cgctgcccgg gacccagctg ctcgacatgg
      361 ctggaggcac aggtgacatt gcgttccggt tccttagtta cgttcaggca caacatcaga
      421 ggagacagag gagacagcta aggactcagc aaaacctatc ctgggaagaa attgccaaaa
      481 agtaccagaa tgaagaggat tccttgggag gttcacttgc cacggtctgt gacatcaaca
      541 gggagatgct aaaggttggg aagcagaagg ccttggacca aggacacaca gctggactgg
      601 cgtgggtgct gggagacgct gaagaactgc ccttcgatga cgacagcttt gatgtttaca
      661 ccattgcatt tgggatccgg aatgtcacac acattgacca ggctctccag gaagcccatc
      721 gggtcctaaa gccaggaggc cggtttctct gtctggaatt tggccaagtg aatgaccctc
      781 tcatatccag gctttatgat ctgtacagct tccaggtcat ccctgtcatt ggtgaggtca
      841 ttgcaggaga ctggaagtcc taccaatacc ttgtggaaag tattcggaag ttcccaaatc
      901 aggaggactt caaggacatg attgaagacg caggctttca gagggtgacg tacgagaacc
      961 tgactacagg gattgtggcc attcactctg gcttcaaact ctagctcctt ttctactgtg
     1021 gcacacaggc cagtcatttc tactgaaccc cggggccaga tcatctccct gatgagacag
     1081 tagctgacca ttcgtctcct cttacggccg ttaagacttt ggattagctc tcattagtag
     1141 ctgcccaggc tgctgaggcc ttctcccaga aatgtctggc ctggtttctg ctggactcca
     1201 gctagaggct tagccgtgca gtgtgggagt caggtaaaac cagcacgatt gcaattctca
     1261 agtttgttca tagtttcttc catgacagat gttttctaga ggggtaatgg gtcactggaa
     1321 cccaaggaga atctgaacca gctcttcaga ccagattgga atctaaggtg gtccacatca
     1381 gaacgctgac aatgtgggca cccagcggtg agcacctctg agatctgggg ctaggggtac
     1441 agctcagtgg agcacatgcc tggcccgtgg aggccctggg tttggtgctc cgcagaagca
     1501 aacagaagta ggaacctgtg aagcagtgaa gtttacaatt tgggtgtggt tgttactctt
     1561 tcctggaaga ggtgacacag atatacgcca ccctcggctc ctggcactta cacggtgtct
     1621 tacaactctc tgtaactctt actagggaac ccaatgcccc cacacaaaca cacacacaca
     1681 aacacacgcg ttgacataca taaaaagtta aataagaatc acaaaagtgc catctcagca
     1741 ctgccactgc tgagccaagc ccgcagagcg agttccaggc caggcgggac tgcatgttga
     1801 gctcatactt ctctagagaa gcttaaaaga aaaaaaaaat aagactatgc atatagccca
     1861 gttcctccag ttccaagacc agccagagcc tgatctcatt gccctccatt gtgatgttaa
     1921 gggattttct gtgtatcttg aacctgacac taggctttat acaaacattt gtttaaaaaa
     1981 atatataata aagtagggtt atctgaaa
//
