LOCUS       NM_178693               2949 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus coenzyme Q4 (Coq4), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_178693
VERSION     NM_178693.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2949)
  AUTHORS   Pelosi,L., Morbiato,L., Burgardt,A., Tonello,F., Bartlett,A.K.,
            Guerra,R.M., Ferizhendi,K.K., Desbats,M.A., Rascalou,B., Marchi,M.,
            Vazquez-Fonseca,L., Agosto,C., Zanotti,G., Roger-Margueritat,M.,
            Alcazar-Fabra,M., Garcia-Corzo,L., Sanchez-Cuesta,A., Navas,P.,
            Brea-Calvo,G., Trevisson,E., Wendisch,V.F., Pagliarini,D.J.,
            Salviati,L. and Pierrel,F.
  TITLE     COQ4 is required for the oxidative decarboxylation of the C1 carbon
            of coenzyme Q in eukaryotic cells
  JOURNAL   Mol Cell 84 (5), 981-989 (2024)
   PUBMED   38295803
REFERENCE   2  (bases 1 to 2949)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2949)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   4  (bases 1 to 2949)
  AUTHORS   Yen,H.C., Yeh,W.Y., Lee,S.H., Feng,Y.H. and Yang,S.L.
  TITLE     Characterization of human mitochondrial PDSS and COQ proteins and
            their roles in maintaining coenzyme Q10 levels and each other's
            stability
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (7), 148192 (2020)
   PUBMED   32194061
REFERENCE   5  (bases 1 to 2949)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2949)
  AUTHORS   Stefely,J.A. and Pagliarini,D.J.
  TITLE     Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
  JOURNAL   Trends Biochem Sci 42 (10), 824-843 (2017)
   PUBMED   28927698
  REMARK    Review article
REFERENCE   7  (bases 1 to 2949)
  AUTHORS   Salviati,L., Trevisson,E., Rodriguez Hernandez,M.A., Casarin,A.,
            Pertegato,V., Doimo,M., Cassina,M., Agosto,C., Desbats,M.A.,
            Sartori,G., Sacconi,S., Memo,L., Zuffardi,O., Artuch,R.,
            Quinzii,C., Dimauro,S., Hirano,M., Santos-Ocana,C. and Navas,P.
  TITLE     Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency
  JOURNAL   J Med Genet 49 (3), 187-191 (2012)
   PUBMED   22368301
REFERENCE   8  (bases 1 to 2949)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 2949)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   10 (bases 1 to 2949)
  AUTHORS   Belogrudov,G.I., Lee,P.T., Jonassen,T., Hsu,A.Y., Gin,P. and
            Clarke,C.F.
  TITLE     Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q
            synthesis
  JOURNAL   Arch Biochem Biophys 392 (1), 48-58 (2001)
   PUBMED   11469793
  REMARK    GeneRIF: Homologous to the COQ4p in S. cerevisiae, a possible
            component of the biosynthetic complex for production of CoenzymeQ,
            or ubiquinone
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163270.1, AL845323.18 and AK050459.1.
            
            On Feb 8, 2017 this sequence version replaced NM_178693.4.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039422.1, AK050459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AK163270.1         1-655
            656-656             AL845323.18        201270-201270
            657-761             AK163270.1         656-760
            762-2018            AK050459.1         2-1258
            2019-2949           AK163270.1         2095-3025
FEATURES             Location/Qualifiers
     source          1..2949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.62 cM"
     gene            1..2949
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /note="coenzyme Q4"
                     /db_xref="GeneID:227683"
                     /db_xref="MGI:MGI:1098826"
     exon            1..865
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     CDS             793..1593
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /note="coenzyme Q biosynthesis protein 4 homolog"
                     /codon_start=1
                     /product="ubiquinone biosynthesis protein COQ4 homolog,
                     mitochondrial"
                     /protein_id="NP_848808.1"
                     /db_xref="CCDS:CCDS15857.1"
                     /db_xref="GeneID:227683"
                     /db_xref="MGI:MGI:1098826"
                     /translation="MATLLLLRSLRLHRSLRPRTRPAVDVPLRAGSHGARLLYPDHIP
                     TTPLQKMLLAAGAAGMALYNPYRHDMVAVLGETTGCHTLKFLRDQMKKDPEGAQILQE
                     RPRISLSTLDLSKLQSLPEGSLGREYLRFLDVNKVSPDTRAPTRFVDDEELAYVIQRY
                     REVHDMLHTLLGMPTNMLGEVVVKWFEAVQTGLPMCILGALFGPIRLRTQSLQVLFSE
                     LIPWAIQNGRRAPCVLNIYYEQRWEQPLTALREELGISPPPKHIQGLA"
     exon            866..997
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1094
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1197
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1327
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1421
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..2949
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /note="hexamer: AATAAA"
     polyA_site      2021
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /note="major polyA site"
     regulatory      2537..2542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
     regulatory      2924..2929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
                     /note="hexamer: ATTAAA"
     polyA_site      2944
                     /gene="Coq4"
                     /gene_synonym="D2Ertd97e"
ORIGIN      
        1 gagttctcac ctttaagcag ttgcaactcc acggtctcac gcaagtgcag ccacttcagc
       61 cccggaggtt tatagacagc gaagagcccc tgcagccgag ctaggccaga agaacccatg
      121 gctggaactc agcggttcaa catcatccag aagcggggat gcgggcggaa gtgctgcgtg
      181 gtcctttccc aaatgtggtc cctactgtag gtagccgcct tgtttccttg gcaggaagag
      241 gttcttttct tattgccctc cgggggggaa ataagagatg gagaagaaaa tagggccgga
      301 tatcgagcaa ccgaattctc ggttatgtta tttttgaatt cttttcagga gttttttgtt
      361 tgtttgtttc tcatatatcc caggctgccc tcaaacttgc taagttgccg agaattcatt
      421 acttttctgt ctccactttt ccaagatctg gagtgacgag taattcacat caggcttggt
      481 ttttgagaca aggtctctag tactgccttc gtacttaaga aatagccaag aaggatctcg
      541 aactgatcct acggcctcca ggtttcaaat gctgggttga caggcctacg ttataaataa
      601 cgcctggctc acagcagttg ttttacttca gtggcaaaca gatcttgtgg ctttccttct
      661 catgctcctg tccatattac aacatctccg atcaaaaagc cacagtgagt gcagtgtccc
      721 aggagtcttt tgacttctcg ggcctccgta gtacctgcgg agccccgcct aaccacgcgg
      781 acgtccgctg ccatggcgac cctgctgctg cttcgctccc tgcgcctcca ccgcagtctt
      841 cggccccgta cgcggccagc tgtagatgta cccctcaggg ccgggagcca tggcgcccgc
      901 ctgctgtacc cggaccacat cccaaccacc ccgctgcaaa agatgctgct ggctgcgggc
      961 gcggcgggaa tggctctcta caacccctat cgccacgaca tggttgcagt tctaggggag
     1021 accacaggat gccacaccct gaaattcctc agggaccaga tgaagaagga tccagagggt
     1081 gcccagattc tacaagagcg tcccaggatc tccctgtcta ccctcgacct gagcaagctt
     1141 cagagcctgc ctgaaggctc actgggccgt gagtatcttc gcttcctgga tgtgaataag
     1201 gtctctccag acacacgagc acctacacgc tttgtggacg atgaagagct agcctatgtg
     1261 atccagaggt accgtgaagt gcacgacatg ctccacaccc tgctgggcat gcccaccaac
     1321 atgctcggag aggttgtggt aaagtggttt gaggctgtgc agaccggcct accaatgtgc
     1381 atcctgggag cactcttcgg acccatccgc ctccgtactc agagcctcca agtgctgttc
     1441 tcggagctga tcccttgggc gattcagaac gggcgcaggg ccccatgtgt cctcaacatc
     1501 tactatgagc agcgttggga gcagcccctg acagccctgc gggaggagct gggcatcagt
     1561 cctcccccaa aacatatcca gggcctggcc tagcttgagc tgccacacag ggagaattaa
     1621 gcctttctct ccacacactg ccttcctcgg gacaaaagag cctctcagct gcttttgttt
     1681 cttctctttg aaccttgaac tcagagtgtc acttgctgcc ttgtaccttc agggccagcc
     1741 caggagagag aggcagagca atggagcccc aggctgctgt gagccatccg gagagagcag
     1801 tatgtatgcc tcgaacagcc atattggatc atactgatca ttgcagtctg aggctcctct
     1861 tctggacagt gactctgaca gggcgttttg tcaagctgtc ttcgaaagct tgactactac
     1921 atcatgttac caagccctga gcagactggt ggggaggaga aggcgtctct ggtgtctgaa
     1981 taaagctccc atcaggccta gagtctgctg gttgtcctag acttagctcc ctttgcctga
     2041 ggtattggtg aggggaattc cgtcccagtt ggactccagt tgatgttgct gtcattgggt
     2101 cttaaggcaa gcagtctagg aatcaagtcc ccaaccatca gaaaactaac aagtcccttg
     2161 tatttgtaag ccagactttt gacatcagct gaggaacagc agcaatccct atgggtcagt
     2221 ggtaaaggca cctccatcaa gtctgcagac atgattccaa tcccagcacc cacagactag
     2281 aaagataacg gtttctcaca agttgtctgc acgtgtccac acacataaac acacaaaatg
     2341 aaacttcaga gctggaacaa aacaaataaa acagggctta ttggatgact tacaaatgtg
     2401 aaagcacatg tcaccaaacc tgaagacctg acttccgtcc ccaagaccca caaagtggaa
     2461 ggtgaaaaac aacatctgca agttgtcatg accagcacaa acatgccatg gtgtgcatgc
     2521 actcacacct gtgcaaaata aagtgtgaaa actaaagtga tggtttgggg agatgtctca
     2581 gcagctaagc actggaaaac aggacccggt ttaattccca gcacccatgt ggtgattcat
     2641 aactaccctt aactccagtt ctaggaccta atgctgtctt ctgatttcag gatcccaggc
     2701 actctggtgg tgcatataaa tacatgccca caaaatgttc atctacataa atcttttaaa
     2761 aactaaaatg aagccgggcg tggtggcgca cgcctttaat cccaacactc gggaggcaga
     2821 ggcaggcgga tttctgagtt cgaggccagc ctggtctaca aagtgagctc caggacagcc
     2881 agggctatac agagaaaccc tgtctcgaaa aaccaaaaaa aaaattaaaa aataaaaact
     2941 aaaatgaac
//
