LOCUS       NM_172687               2679 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus coenzyme Q3 methyltransferase (Coq3), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_172687
VERSION     NM_172687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Stefely,J.A. and Pagliarini,D.J.
  TITLE     Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
  JOURNAL   Trends Biochem Sci 42 (10), 824-843 (2017)
   PUBMED   28927698
  REMARK    Review article
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Lapointe,J., Wang,Y., Bigras,E. and Hekimi,S.
  TITLE     The submitochondrial distribution of ubiquinone affects respiration
            in long-lived Mclk1+/- mice
  JOURNAL   J Cell Biol 199 (2), 215-224 (2012)
   PUBMED   23045551
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Parrado-Fernandez,C., Lopez-Lluch,G., Rodriguez-Bies,E.,
            Santa-Cruz,S., Navas,P., Ramsey,J.J. and Villalba,J.M.
  TITLE     Calorie restriction modifies ubiquinone and COQ transcript levels
            in mouse tissues
  JOURNAL   Free Radic Biol Med 50 (12), 1728-1736 (2011)
   PUBMED   21447381
  REMARK    GeneRIF: Calorie restriction modifies ubiquinone and COQ transcript
            levels in mouse tissues
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Bentinger,M., Turunen,M., Zhang,X.X., Wan,Y.J. and Dallner,G.
  TITLE     Involvement of retinoid X receptor alpha in coenzyme Q metabolism
  JOURNAL   J Mol Biol 326 (3), 795-803 (2003)
   PUBMED   12581641
REFERENCE   7  (bases 1 to 2679)
  AUTHORS   Machleder,D., Ivandic,B., Welch,C., Castellani,L., Reue,K. and
            Lusis,A.J.
  TITLE     Complex genetic control of HDL levels in mice in response to an
            atherogenic diet. Coordinate regulation of HDL levels and bile acid
            metabolism
  JOURNAL   J Clin Invest 99 (6), 1406-1419 (1997)
   PUBMED   9077551
REFERENCE   8  (bases 1 to 2679)
  AUTHORS   Welch,C.L., Xia,Y.R., Billheimer,J.T., Strauss 3rd,J.F. and
            Lusis,A.J.
  TITLE     Assignment of the mouse sterol carrier protein gene (Scp2) to
            chromosome 4
  JOURNAL   Mamm Genome 7 (8), 624-625 (1996)
   PUBMED   8678992
REFERENCE   9  (bases 1 to 2679)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 2679)
  AUTHORS   Marbois,B.N., Xia,Y.R., Lusis,A.J. and Clarke,C.F.
  TITLE     Ubiquinone biosynthesis in eukaryotic cells: tissue distribution of
            mRNA encoding 3,4-dihydroxy-5-polyprenylbenzoate methyltransferase
            in the rat and mapping of the COQ3 gene to mouse chromosome 4
  JOURNAL   Arch Biochem Biophys 313 (1), 83-88 (1994)
   PUBMED   8053692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772187.6, CJ077260.1 and AK028680.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_172687.3.
            
            On Sep 29, 2017 this sequence version replaced NM_172687.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028680.1, AK035318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL772187.6         162715-162719
            6-29                CJ077260.1         7-30
            30-2642             AK028680.1         1-2613
            2643-2679           AL772187.6         195196-195232
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 9.11 cM"
     gene            1..2679
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /note="coenzyme Q3 methyltransferase"
                     /db_xref="GeneID:230027"
                     /db_xref="MGI:MGI:101813"
     exon            1..151
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1155
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /EC_number="2.1.1.114"
                     /EC_number="2.1.1.64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hexaprenyldihydroxybenzoate methyltransferase,
                     mitochondrial; DHHB-MT; DHHB-MTase; DHHB
                     methyltransferase; dihydroxyhexaprenylbenzoate
                     methyltransferase; 3,4-dihydroxy-5-hexaprenylbenzoate
                     methyltransferase; 3-demethylubiquinone-9
                     3-methyltransferase; Coenzyme Q (ubiquinone);
                     2-polyprenyl-6-hydroxyphenyl methylase;
                     2-polyprenyl-6-hydroxyphenol methylase; coenzyme Q3
                     homolog, methyltransferase; 3-demethylubiquinol
                     3-O-methyltransferase; polyprenyldihydroxybenzoate
                     methyltransferase; ubiquinone biosynthesis
                     O-methyltransferase, mitochondrial"
                     /codon_start=1
                     /product="ubiquinone biosynthesis O-methyltransferase,
                     mitochondrial isoform 1"
                     /protein_id="NP_766275.1"
                     /db_xref="CCDS:CCDS18003.1"
                     /db_xref="GeneID:230027"
                     /db_xref="MGI:MGI:101813"
                     /translation="MWRGGRLGSRGVRLLETLGFGCPSAVAQPPRLTSRSAYSGTQLT
                     RNLQIKPWELGEHGTMCFRSYRMALSCLSRVKTYRTPWKRLYSTSQTTVDSREVKNFQ
                     ALAHTWWDEYGKFAPLHSMNDLRVPFIRDNLLKTSASHHPGKPLSGMKILDVGCGGGL
                     LTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKRIQYKVCSLEEAVDESAECFD
                     AVVASEVVEHVSHLEMFIQCCYQVLKPGGSLFITTVNKTQLSYALGIVFAEQIAGIVP
                     KGTHTWEKFVSPEKLESILEPNGLSVETVAGLVYNPFSGYWHWSENTSLNYAAHAVRS
                     RAQEHQEPAESALKGETGALHANTSGSPSVREEQRT"
     exon            152..278
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
     exon            279..431
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
     exon            432..531
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
     exon            532..774
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
     exon            775..934
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
     exon            935..2679
                     /gene="Coq3"
                     /gene_synonym="4732433J24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtgagga gggaccggaa aaggagtagg attctagtcg cgatgtggag aggtggaagg
       61 ctgggctctc gtggggttcg tctcctggaa acgctagggt ttgggtgccc cagcgcggtc
      121 gcccagcctc ctcgcctaac ttcacggtcg gcttactcag ggacgcagct cactaggaat
      181 ctacagatta agccgtggga actcggtgaa cacgggacca tgtgctttag atcctacagg
      241 atggctctct cctgtttgag cagagtaaaa acttacagga ccccttggaa gagattgtac
      301 agtacttcac aaacaacagt tgacagcagg gaggtcaaaa acttccaggc cctggctcac
      361 acgtggtggg atgagtacgg aaagtttgcg cctcttcatt ctatgaatga cctacgggtg
      421 ccattcatta gagacaatct tttgaaaaca agtgctagtc accatccagg aaagccttta
      481 tctgggatga agattcttga cgttggctgt ggcggtgggt tattaactga acctctaggg
      541 agactgggag cttcagttgt tggaattgat cccgtggctg aaaacattaa gatagcacag
      601 caccataagt cctttgatcc agtcctggat aagaggatac agtacaaagt gtgttccctg
      661 gaggaggccg tggatgagag cgcagagtgt tttgatgctg tcgtggcttc tgaagttgtg
      721 gagcatgtga gccacctgga aatgttcatc cagtgctgct atcaagtgct gaaacccggt
      781 ggctctttat tcattactac agtgaacaaa acacagctgt cctatgcctt gggaattgtt
      841 ttcgcagagc aaattgcagg cattgttcca aaaggcactc atacgtggga aaagtttgtt
      901 tcacctgaaa agctagagag tatcttggaa ccaaatggtc tgtcagttga aactgtggca
      961 ggattggtct ataatccttt ctcaggttac tggcattgga gtgaaaatac cagccttaac
     1021 tatgcagccc atgctgtgag atccagggct caggagcacc aggagcctgc tgagtctgct
     1081 ttaaaggggg aaacaggagc actccatgct aacacctccg gtagccccag tgtacgggag
     1141 gagcagagga catgaggtgc ctccaaggac agcagtaaat atacttgaaa ttgtgttgtt
     1201 tacaaagtca aaaatcttac tccatttcgg gagagatttt gaagaacaaa aggtcaataa
     1261 aaatatctaa atcaatggag aaaaatttct gtgtcaccta agagacactt tgaagaattt
     1321 tctggtgagg ttttgtcacg tgtgcttaag gtctctatgc ttttactgta gaaaagtgtg
     1381 tgttcatttc atttacatgt taggcatttc tcacatgtgt aaacagaaac atatgctgat
     1441 atttattgat ttcaactgga atctctgttg tctatggtat tcctttattt tagttaaaga
     1501 tacaatgccc ttgactgata aaaaaaaacc caaaaaacaa aaaacaaaaa ccagctctag
     1561 tttttaatca ctgatatttg ggagtacaaa atatatttta aacctagggt agtgagcata
     1621 cgtgtacctc cctctctcct tccgtctctt ctcccctccc tcccttaatt gagttcagtt
     1681 tgtgtgtttc ttttttaaat atttatttgt tatatgtaag tacagtatca ctatcttcag
     1741 atacaccaga agaggttgtc agatctcacg tggatgctgg ggtttgaact caggacccct
     1801 ggaagagcag cagtcagtga tcttaaccac tgagccatct ctttagctga gttcagtttg
     1861 tgttgaccat cttctcttga gtatagggcc taccttggag tgtggttgat acaccagaga
     1921 tcacagcatt aaaggaagtt gccttttacc agcagctatc aaatgccagt agtgcctcgg
     1981 ctagcgagga gctactttct ccgctatata aataaaatac actttatcct acagaaaaat
     2041 gggattctgg aaataaatga gttattaaat acatggtaga tttgaattca aacattaaaa
     2101 gaagttcagg taatgtttca tgtataggac ttagttccgt atgctgttct ttgaaaatgt
     2161 tatgtccagg aacaggagag atagttcagc agttaagagc gctggttgct ccagcaaagg
     2221 acctgagttt tatccccagc accccatgat gggccacagc tatctacaac tgcagttgtc
     2281 agggatcaga ctccatggct ttggcaggca ctcgtgtgat atacatacat ataggcaaaa
     2341 taaccataca tataaattaa taaaaataac tggtggtggt ttcaatgaga atgttccccg
     2401 taggcttgta tgtttaaatt cttgatcttc atttggtgaa actgggaaca attgggagat
     2461 atgatcttgg tggatgtgtg tcactggtgg tgggatctga ggtttcaaaa gacttctgtc
     2521 attccaagta tgatgtctgc ttcctgctta tggcttgggt gtgagctctc agcagctgct
     2581 cctgcgccat gcctgcctgt gccatgctcc ctgccatgat ggtgacggac tcccacacat
     2641 ctgtaactgt cagcctcaaa taaacccttc cttctatga
//
