LOCUS       NM_027978               1712 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
            (Coq2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_027978 XM_132218
VERSION     NM_027978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Corral-Sarasa,J., Martinez-Galvez,J.M., Gonzalez-Garcia,P.,
            Wendling,O., Jimenez-Sanchez,L., Lopez-Herrador,S., Quinzii,C.M.,
            Diaz-Casado,M.E. and Lopez,L.C.
  TITLE     4-Hydroxybenzoic acid rescues multisystemic disease and perinatal
            lethality in a mouse model of mitochondrial disease
  JOURNAL   Cell Rep 43 (5), 114148 (2024)
   PUBMED   38697100
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Vargas-Perez,M.L.A., Devos,D.P. and Lopez-Lluch,G.
  TITLE     An AlphaFold Structure Analysis of COQ2 as Key a Component of the
            Coenzyme Q Synthesis Complex
  JOURNAL   Antioxidants (Basel) 13 (4), 496 (2024)
   PUBMED   38671943
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1712)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1712)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   5  (bases 1 to 1712)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1712)
  AUTHORS   Mourier,A., Motori,E., Brandt,T., Lagouge,M., Atanassov,I.,
            Galinier,A., Rappl,G., Brodesser,S., Hultenby,K., Dieterich,C. and
            Larsson,N.G.
  TITLE     Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels
  JOURNAL   J Cell Biol 208 (4), 429-442 (2015)
   PUBMED   25688136
REFERENCE   7  (bases 1 to 1712)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1712)
  AUTHORS   Parrado-Fernandez,C., Lopez-Lluch,G., Rodriguez-Bies,E.,
            Santa-Cruz,S., Navas,P., Ramsey,J.J. and Villalba,J.M.
  TITLE     Calorie restriction modifies ubiquinone and COQ transcript levels
            in mouse tissues
  JOURNAL   Free Radic Biol Med 50 (12), 1728-1736 (2011)
   PUBMED   21447381
  REMARK    GeneRIF: Calorie restriction modifies ubiquinone and COQ transcript
            levels in mouse tissues
REFERENCE   9  (bases 1 to 1712)
  AUTHORS   O'Leary,J. and Osborne,L.R.
  TITLE     Global analysis of gene expression in the developing brain of
            Gtf2ird1 knockout mice
  JOURNAL   PLoS One 6 (8), e23868 (2011)
   PUBMED   21909369
REFERENCE   10 (bases 1 to 1712)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009092.1 and CK626929.1.
            
            On Feb 6, 2008 this sequence version replaced NM_027978.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009092.1, BC080773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-923               AK009092.1         3-925
            924-1357            CK626929.1         196-629
            1358-1712           AK009092.1         1360-1714
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.5 cM"
     gene            1..1712
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /note="coenzyme Q2 4-hydroxybenzoate
                     polyprenyltransferase"
                     /db_xref="GeneID:71883"
                     /db_xref="MGI:MGI:1919133"
     exon            1..268
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1140
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /EC_number="2.5.1.39"
                     /note="para-hydroxybenzoate--polyprenyltransferase,
                     mitochondrial; 4-hydroxybenzoate polyprenyltransferase,
                     mitochondrial; PHB:polyprenyltransferase; 4-HB
                     polyprenyltransferase; coenzyme Q2 homolog,
                     prenyltransferase"
                     /codon_start=1
                     /product="4-hydroxybenzoate polyprenyltransferase,
                     mitochondrial precursor"
                     /protein_id="NP_082254.2"
                     /db_xref="CCDS:CCDS19465.1"
                     /db_xref="GeneID:71883"
                     /db_xref="MGI:MGI:1919133"
                     /translation="MLRWGGAGLARGLRAVRSAWLRGPRGLPLALVRSAGVPGARDRR
                     APAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAD
                     PGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVTRTANRPIAAGDISTFQSF
                     VFLGGQLTLALGVLLCLNYYSIAMGAASLLLVVTYPLVKRITFWPQLALGLTFNWGAL
                     LGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFQENTR
                     QWLSGFGVAMVAALSLAGANNGQTVPYYAAVAAVGAHLAHQIYTVDIHRAEDCWDKFT
                     SNRTVGMLLFLGIVLGNLCKEKTEEAKDAEAVRVGSEQTS"
     exon            269..435
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            436..557
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            558..643
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            644..777
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            778..966
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1712
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1691..1696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /note="putative"
     polyA_site      1712
                     /gene="Coq2"
                     /gene_synonym="2310002F18Rik; PHB:PPT"
                     /note="putative"
ORIGIN      
        1 gtccagcctg gcgccatgct gcgctgggga ggcgcggggc tcgcgcgggg cctgcgggcc
       61 gttcggtccg catggctgcg aggtccgcgc gggctcccat tggccctggt gcgcagcgca
      121 ggggttccgg gcgcgcggga tcggcgagcc ccggcccccg ggacgcagcg gggccgagct
      181 ctcagcctgt cggccgcggc cgtggtgaac tcggcgcccc gcccgctgca gccctacctg
      241 cgcctcatgc gcctggacaa gcccatagga acctggctgc tgtatttgcc atgcacttgg
      301 agcattggtc tggccgctga cccaggttgt tttccagact ggtacatgtt atcacttttt
      361 ggcactggag ctattctgat gcgtggagca ggctgtacta ttaatgacat gtgggaccgt
      421 gacttcgata aaaaggttac aaggacagca aaccgcccaa tcgctgctgg agacatttcg
      481 accttccagt ccttcgtctt ccttggggga cagctgacct tggcactggg cgttctcctg
      541 tgtttaaact actacagtat agcaatggga gcagcgtcct tacttcttgt cgtcacctac
      601 ccactagtga aaagaatcac gttttggcct cagttggctt tgggattgac ttttaattgg
      661 ggtgcgttac tcggatggtc tgctgtcaag ggctcctgtg atccggctgt atgcctgcct
      721 ctgtattttt ctggagttat gtggacactg atatatgata ctatctatgc ccaccaggac
      781 aagaaagacg atgctctgat cggcctgaag tccacagcac tgctgttcca ggagaacaca
      841 aggcagtggc ttagtggctt tggggtcgcc atggtggcag cgctgagcct ggcgggagcc
      901 aacaatggtc agactgtccc ctactacgct gctgtggctg cggtgggagc ccacctggct
      961 caccagattt acactgtaga catccacaga gccgaggact gctgggacaa gttcacctcc
     1021 aaccgcacag taggaatgct cctgttctta gggattgtcc ttggaaacct gtgcaaagaa
     1081 aagacggaag aagcaaaaga tgctgaagct gttagagtgg gaagtgagca gacgagctga
     1141 gcttggcccc tcaggaagca gaggcaggaa aactgtgagg tcaaggcatc gagcggcata
     1201 gtaggatcct gtctcaagca caccggctag agtggtagct catgggaagt gtgggcacca
     1261 tgcagtgtgc ccaaggctct aggttctctc ctagcaaata aactcatttg tacaactttc
     1321 agggcttaag actacattgt taggcttgga tgagcaatct gttaaagaag taagaagcac
     1381 tcgggcagcg tgtactggac tttactgcag ctgctttcaa ccagctccct gtcacagcac
     1441 ctgtcccagg gacctggggt tgggtaggcc cctgtgttag cattctgcaa ccttctgtcc
     1501 ttgttccttc tcatccaaag tttcaggagc ttcaggaaac aacttgcata actcatctaa
     1561 tggcttttat gacatggccg tgtgctttat tttattcctc actaagaatc tccttgtgat
     1621 ctgtactcac tgccaaagct gtaattcaag aagccattct gattctagat gttttagaag
     1681 gatgttggca aataaagttg ttatttatat cc
//
