LOCUS       NM_133805               1843 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus COP9 signalosome subunit 8 (Cops8), mRNA.
ACCESSION   NM_133805
VERSION     NM_133805.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Abdullah,A., Eyster,K.M., Bjordahl,T., Xiao,P., Zeng,E. and Wang,X.
  TITLE     Murine Myocardial Transcriptome Analysis Reveals a Critical Role of
            COPS8 in the Gene Expression of Cullin-RING Ligase Substrate
            Receptors and Redox and Vesicle Trafficking Pathways
  JOURNAL   Front Physiol 8, 594 (2017)
   PUBMED   28861005
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Su,H., Li,J., Zhang,H., Ma,W., Wei,N., Liu,J. and Wang,X.
  TITLE     COP9 signalosome controls the degradation of cytosolic misfolded
            proteins and protects against cardiac proteotoxicity
  JOURNAL   Circ Res 117 (11), 956-966 (2015)
   PUBMED   26383969
  REMARK    GeneRIF: CSN8/CSN promotes the ubiquitination and degradation of
            misfolded proteins and protects against cardiac proteotoxicity, and
            cullin-RING ligases participate in degradation of cytosolic
            misfolded proteins.
REFERENCE   3  (bases 1 to 1843)
  AUTHORS   Bashur,L.A., Chen,D., Chen,Z., Liang,B., Pardi,R., Murakami,S. and
            Zhou,G.
  TITLE     Loss of jab1 in osteochondral progenitor cells severely impairs
            embryonic limb development in mice
  JOURNAL   J Cell Physiol 229 (11), 1607-1617 (2014)
   PUBMED   24604556
REFERENCE   4  (bases 1 to 1843)
  AUTHORS   Su,H., Li,J., Osinska,H., Li,F., Robbins,J., Liu,J., Wei,N. and
            Wang,X.
  TITLE     The COP9 signalosome is required for autophagy, proteasome-mediated
            proteolysis, and cardiomyocyte survival in adult mice
  JOURNAL   Circ Heart Fail 6 (5), 1049-1057 (2013)
   PUBMED   23873473
  REMARK    GeneRIF: CSN8/COP9 signalosome regulates both proteasome-mediated
            proteolysis and the autophagic-lysosomal pathway, critical to the
            removal of oxidized proteins in the heart.
REFERENCE   5  (bases 1 to 1843)
  AUTHORS   Lei,D., Li,F., Su,H., Liu,J., Wei,N. and Wang,X.
  TITLE     Hepatic deficiency of COP9 signalosome subunit 8 induces
            ubiquitin-proteasome system impairment and Bim-mediated apoptosis
            in murine livers
  JOURNAL   PLoS One 8 (7), e67793 (2013)
   PUBMED   23840878
  REMARK    GeneRIF: Csn8 exerts profound impacts on hepatic
            ubiquitin-proteasome system function and is critical to the
            stability of the pro-apoptotic protein Bim.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1843)
  AUTHORS   Yan,J., Walz,K., Nakamura,H., Carattini-Rivera,S., Zhao,Q.,
            Vogel,H., Wei,N., Justice,M.J., Bradley,A. and Lupski,J.R.
  TITLE     COP9 signalosome subunit 3 is essential for maintenance of cell
            proliferation in the mouse embryonic epiblast
  JOURNAL   Mol Cell Biol 23 (19), 6798-6808 (2003)
   PUBMED   12972600
REFERENCE   7  (bases 1 to 1843)
  AUTHORS   Lykke-Andersen,K., Schaefer,L., Menon,S., Deng,X.W., Miller,J.B.
            and Wei,N.
  TITLE     Disruption of the COP9 signalosome Csn2 subunit in mice causes
            deficient cell proliferation, accumulation of p53 and cyclin E, and
            early embryonic death
  JOURNAL   Mol Cell Biol 23 (19), 6790-6797 (2003)
   PUBMED   12972599
REFERENCE   8  (bases 1 to 1843)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1843)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   10 (bases 1 to 1843)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110895.14, AK079111.1 and DV645014.1.
            
            On Sep 8, 2006 this sequence version replaced NM_133805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021488.1, AK088323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC110895.14        172867-172933       c
            68-1808             AK079111.1         2-1742
            1809-1843           DV645014.1         71-105
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.53 cM"
     gene            1..1843
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /note="COP9 signalosome subunit 8"
                     /db_xref="GeneID:108679"
                     /db_xref="MGI:MGI:1915363"
     exon            1..203
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..755
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /note="COP9 homolog; signalosome subunit 8;
                     JAB1-containing signalosome subunit 8; COP9 (constitutive
                     photomorphogenic) homolog, subunit 8"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 8"
                     /protein_id="NP_598566.3"
                     /db_xref="CCDS:CCDS15153.1"
                     /db_xref="GeneID:108679"
                     /db_xref="MGI:MGI:1915363"
                     /translation="MPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALY
                     LLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETV
                     QPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTR
                     MVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN"
     exon            204..274
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     exon            275..323
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     exon            324..456
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     exon            457..564
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     exon            565..627
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     exon            628..675
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1843
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1592..1597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /note="hexamer: AATAAA"
     polyA_site      1629
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /note="major polyA site"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
                     /note="hexamer: ATTAAA"
     polyA_site      1843
                     /gene="Cops8"
                     /gene_synonym="9430009J09Rik; Csn8; Sgn8"
ORIGIN      
        1 gtgacgacac gctcgcccat gcgtactgag aggcagctcc tttacctcat cgcgggcgcg
       61 acgccccgag ggccagcttg tgctttggtc tggcagaggt ggtggcggcg agagcggccg
      121 ggaagatgcc agtggcggtg atggcggaca acgccttcag tttcagaaag ctgttggatc
      181 agtgcgagaa ccaggaactc gaggctcctg gaggaattgc cacaccgcca gtgtacggtc
      241 agcttctagc tttgtacttg ctccagaacg acatgaataa tgcaagatat ctgtggaaga
      301 ggataccacc tgctataaag tctgcaaatt ctgaacttgg gggaatttgg tcagttggac
      361 agcgaatctg gcaaagagat ttccctggga tctatacaac catcaacgcc caccagtggt
      421 cagagactgt gcagccaatc atggaagccc ttagagatgc aacaaggaga cgcgcctttg
      481 ccctggtctc tcaagcttat acctccatca tcgcagatga ttttgcagcg tttgttggac
      541 ttcctgtgga agaggctgtg aaaggcgtgt tggaacaagg atggcaggcc gactccacca
      601 caagaatggt tcttcccagg aagccagcct caggaaccct ggatgtctcc ttgaacaggt
      661 ttatcccctt atcagagcct gccccagttc cgccaatccc caatgagcag cagctcgccc
      721 ggctcaccga ttatgtggct ttcctggaaa actgattgac cactctgagt tcaagatcca
      781 ccttcagtcc ctgtcactgg caaacagaca tggagtttta ttctgagttc agaacagggt
      841 gagcacctct gtgtcctttg ggtgtgataa aatgcacata gaagatgaag cgcattgtac
      901 agttttctcc tcaggcactt ttgaatgtcc ttggagcagt tttcatttgt attgatcact
      961 ttggttagag ccatcagtat tacacatcga gtttctgtca aggactggac tccgaacaca
     1021 agctgtcctg cttcaagtag cagagggtgc tgtagcatac accacgctcc tgtgtgccgc
     1081 tggcctctag ctgaaatgat gtgcttggga tttgaggagg actgtcccag gtggtgccct
     1141 ccccacattg tcactcacgc tctggagagt gtgctcttcc tcctatccca gaacaaggaa
     1201 gcagtgatgt agcatcagaa agctgcgtgg tggcggaccc tggaggggag cttgtcaatg
     1261 ctccatttgt tttcccagtg tgtgcaagca tccattgcgt gagacagaca gtctgcagtg
     1321 agaactcaac ttaggtgttc tcggggaaac tccaagttct gatgcctcct tagagaagaa
     1381 gggagggagc agagtgcagt gtgtgctgtg ctgaaggagc tcctgacctg agagatggac
     1441 tgcagccctc ctgcctgctg cgcatccaga tcctgaggag aaatgccgaa tgcatctatt
     1501 tttgttcttg tatggcagcc cttgaagatt tgaggtggtt aatgtatctt caggttaaaa
     1561 cggccctagt tcatttattc tgcatttgtt caataaatat ttaattgaat tcgtaaactt
     1621 tcatctaaag ctggctctag aaatttcata tcttggtctt aactgtgggc acattataag
     1681 tttgtccttt tctcaaaaaa tacttaaagt ttaaaaactt ttctcctttt tattttttgg
     1741 gaattttata cacgcttata acctgtttag atcaaattca ctctcctttt cctctgaccc
     1801 cctcccctag aatttaatta aaaagaaact gtcttacctc tga
//
