LOCUS       NM_172974               2819 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus COP9 signalosome subunit 7B (Cops7b), transcript
            variant 1, mRNA.
ACCESSION   NM_172974 NM_012004 XM_006529623
VERSION     NM_172974.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   2  (bases 1 to 2819)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   3  (bases 1 to 2819)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   4  (bases 1 to 2819)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI121193.1, CN721267.1, AK081309.1 and AC158132.6.
            
            On or before Feb 16, 2018 this sequence version replaced
            XM_006529623.3, NM_172974.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1490505.1,
                                           SRR7652917.403135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AI121193.1         13-40
            29-260              CN721267.1         12-243
            261-1258            AK081309.1         1-998
            1259-2819           AC158132.6         152287-153847
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.97 cM"
     gene            1..2819
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /note="COP9 signalosome subunit 7B"
                     /db_xref="GeneID:26895"
                     /db_xref="MGI:MGI:1349388"
     exon            1..176
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     exon            177..396
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     exon            397..574
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1207
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /note="isoform a is encoded by transcript variant 1; COP9
                     signalosome complex subunit 7b; SGN7b; signalosome subunit
                     7b; JAB1-containing signalosome subunit 7b; COP9 complex
                     S7b; COP9 (constitutive photomorphogenic) homolog, subunit
                     7b"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 7b isoform a"
                     /protein_id="NP_766562.1"
                     /db_xref="CCDS:CCDS15122.1"
                     /db_xref="GeneID:26895"
                     /db_xref="MGI:MGI:1349388"
                     /translation="MAGEQKPSSNLLEQFILLAKGTSGSALTTLISQVLEAPGVYVFG
                     ELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSVAQQNKLKHLTIV
                     SLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGR
                     DIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKK
                     TLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH"
     exon            575..650
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     exon            651..739
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     exon            740..942
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1048
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..2819
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /note="hexamer: AATACA"
     polyA_site      2255
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /note="major polyA site"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /note="hexamer: AATAAA"
     polyA_site      2815
                     /gene="Cops7b"
                     /gene_synonym="D1Wsu66e; E130114M23"
                     /note="major polyA site"
ORIGIN      
        1 aacttgggtt ccagtgtgcc gagcagtgtg cacatatttg aaatcctcct atggggttgg
       61 tttctgaatc ctgttacttg aaacccagca ggaaggtctt cttttacccc ggagacgtga
      121 caacccaccg acagttaact tctgtttaca tggaactcag gagtctgcaa accatgcctc
      181 aatctaggtg ggaggtggcg aaagcagagc gggaacattg tgtaggcgga actcgagtgc
      241 agcagtggga ggcttccggg ggaacagcac cggtgacggg tcggcggaga cagaaaagtg
      301 ctggacgccg ggccgatcat ggaagcttga caacctgcag gcaggctctg ggaggccgag
      361 acatcggcga agagaacaga gagtcggcgg ggacagatct caagaccaga gaatggcagg
      421 tgaacagaaa ccctcaagta acctcttgga gcagttcatt ttattagcca aaggtaccag
      481 tggctcagcc ctcaccactc tcataagcca ggtgctagag gctcctggag tttatgtttt
      541 tggagaactg ctggagttgg ccaatgttca ggagcttgca gaaggagcta atgctgcgta
      601 tttgcagttg ctgaacctgt ttgcctatgg tacatacccg gattacatag ccaacaagga
      661 gagcctgcca gaactgagtg tggctcagca gaacaagctg aagcatctta ccatcgtgag
      721 cttggcatca agaatgaagt gtatccccta ctctgtgctg ctgaaagacc tggagatgag
      781 gaatctcagg gaactagaag accttatcat tgaggctgtc tacactgaca tcatccaggg
      841 caaactggac cagcgaaatc agctcctgga agtggatttc tgcattggcc gtgacatccg
      901 gaagaaagat atcaataaca ttgtcaagac cttgcatgag tggtgtgacg gctgtgaggc
      961 agttctcttg ggcattgagc agcaggttct gagagccaac cagtacaaag agaaccacca
     1021 ccggactcag cagcaggtgg aagccgaggt tagcaacatt aagaagacac tcaaagcaac
     1081 agcatcctcc tcagctcagg aaatggagca gcagctggct gaacgggagt gtccccccca
     1141 tactgagcag aggcaaccca ctaagaagat gtccaaagtg aaaggtctgg tctccagccg
     1201 ccactagggc cggctggggc agctggcact cagcaggcct gggtcaggtc gggaggggac
     1261 acccagggcc tatttccgtc cctctctaac tgcagtgagt tccagatctg cccacccctc
     1321 accagtacct ccccatccat tggtaccatt gcggaaaatg attgctcctc ccttgcctcc
     1381 ttccctagtt gttcccttca gactcagggg ctcaatggat gccatcgtaa cagggtccag
     1441 cactgcccgg cttccctgca ggggtccttg tctctgtgat gggctacctc cctcccagtt
     1501 gttctttgct ctctgtcatt ttgtcaggct ggtcctaagc tggaggcagt ttacccagcc
     1561 ccaagggatg actgtggagg tggctcctct ctgagtgaag agggggcctt gcttctccag
     1621 ccccatgtac cacagtatcc acaatggtgc aagtgtctct agccaggtag ccacatgtcc
     1681 cctctcctgc cttacccctg ttggcagtgc cagttgaggc catggaggga tgtggtgctg
     1741 ggctatgttt actaaacctt tgggttttca gcctcttaag cccagccagg atctctcatc
     1801 aagttggggc actgggctga ctaacccctg gtgtctgaca ccagtggagg gtgcttgggt
     1861 ctgggggcag cagaaggtgt ttctcctagc ttggtgtcct ctgctggcta ctcttgctgc
     1921 tgtctctgac tgcacagcct tgatttggca tttcgaccca gctacccact gggattgtct
     1981 gccaacaatt gctctcccaa gatctttcat gcctcctggc tgcccctggg gtaggagtgg
     2041 tggtgcccaa gcccctcaga ctggtgaagg accattgctg cttctttctc cctccttgtc
     2101 tggcgaccca gagccctctg atgacatcat actccactcc tggccagaga aaaggacttg
     2161 actagacttt ctgaacttga acagtttcag gttatatttt aatttttttt ttttgtacag
     2221 gttgattcta atacatttca acatgctttt ttctcctttt gtgtcaatat ttgttatagt
     2281 ccaatcgccg gggatgtctc acttggttgg agggtgtgtg tgtaggtgtg gaggattata
     2341 tgggggtggg atagggtatg tgtatgtgtg gagggcttgg gggtatggag gggtgtgtgt
     2401 gtgtatgtgt gtgtgtattt tgtttcctaa ggggagatgg agaccctgta ctgatttaaa
     2461 cctaattaag ttttaaaaag tacattttag gaaaaaaaaa aaaagaaaaa agaaaagtgt
     2521 agatttgaca tatgcgactg tggagtatgg ggttgtacag ctggtgggtt tggagggcag
     2581 taatttgggt tgttcagaga aatgtgatgc tattttagtg gcatggttaa aaagtgggtt
     2641 gatccagtgt taaagtattc ctgtgttcct tatttgctgg tccatatgcc cagatagcac
     2701 tatacctaac tgtaggttaa gtttgattcc caaaatgtgt ttgatcactc cctaatcaca
     2761 tgctctgtgg aagaggggct ctgttattaa ataaatgtgg cactccctcc ctgcattcc
//
