LOCUS       NM_012002               1094 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus COP9 signalosome subunit 6 (Cops6), mRNA.
ACCESSION   NM_012002
VERSION     NM_012002.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1094)
  AUTHORS   Liang,Y., Lyon,R.C., Pellman,J., Bradford,W.H., Lange,S.,
            Bogomolovas,J., Dalton,N.D., Gu,Y., Bobar,M., Lee,M.H., Iwakuma,T.,
            Nigam,V., Asimaki,A., Scheinman,M., Peterson,K.L. and Sheikh,F.
  TITLE     Desmosomal COP9 regulates proteome degradation in arrhythmogenic
            right ventricular dysplasia/cardiomyopathy
  JOURNAL   J Clin Invest 131 (11) (2021)
   PUBMED   33857019
REFERENCE   2  (bases 1 to 1094)
  AUTHORS   Mei,Z.L., Wang,H.B., Hu,Y.H. and Xiong,L.
  TITLE     CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via
            inhibiting SIRT2
  JOURNAL   Exp Cell Res 396 (1), 112245 (2020)
   PUBMED   32882218
  REMARK    GeneRIF: CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy
            via inhibiting SIRT2.
REFERENCE   3  (bases 1 to 1094)
  AUTHORS   Deng,Q., He,C., Wu,Y., Zhang,J., Zhang,Y., Wang,Z., Liang,H. and
            Yang,F.
  TITLE     CSN6 and Rab34 Are Involved in Androgen Receptor Trafficking in
            Mouse Testicular Sertoli Cells
  JOURNAL   Cell Physiol Biochem 47 (6), 2360-2368 (2018)
   PUBMED   29991022
  REMARK    GeneRIF: CSN6 and Rab34 are involved in AR trafficking by
            regulating the phosphorylation signaling pathway. These findings
            provide new insights into the testosterone signaling pathway in
            Sertoli cells that mediates spermatogenesis.
REFERENCE   4  (bases 1 to 1094)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   5  (bases 1 to 1094)
  AUTHORS   Chen,J., Shin,J.H., Zhao,R., Phan,L., Wang,H., Xue,Y., Post,S.M.,
            Ho Choi,H., Chen,J.S., Wang,E., Zhou,Z., Tseng,C., Gully,C.,
            Velazquez-Torres,G., Fuentes-Mattei,E., Yeung,G., Qiao,Y.,
            Chou,P.C., Su,C.H., Hsieh,Y.C., Hsu,S.L., Ohshiro,K., Shaikenov,T.,
            Wang,H., Yeung,S.C. and Lee,M.H.
  TITLE     CSN6 drives carcinogenesis by positively regulating Myc stability
  JOURNAL   Nat Commun 5, 5384 (2014)
   PUBMED   25395170
  REMARK    GeneRIF: results define a mechanism for the regulation of Myc
            stability through the CSN-Cullin-Fbxw7 axis and provide insights
            into the correlation of CSN6 overexpression with Myc
            stabilization/activation during tumorigenesis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1094)
  AUTHORS   Zhao,R., Yeung,S.C., Chen,J., Iwakuma,T., Su,C.H., Chen,B., Qu,C.,
            Zhang,F., Chen,Y.T., Lin,Y.L., Lee,D.F., Jin,F., Zhu,R.,
            Shaikenov,T., Sarbassov,D., Sahin,A., Wang,H., Wang,H., Lai,C.C.,
            Tsai,F.J., Lozano,G. and Lee,M.H.
  TITLE     Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice
            through stabilization of MDM2 and is upregulated in human cancers
  JOURNAL   J Clin Invest 121 (3), 851-865 (2011)
   PUBMED   21317535
  REMARK    GeneRIF: loss of CSN6 enhances p53-mediated tumor suppression in
            vivo and CSN6 plays an important role in regulating DNA
            damage-associated apoptosis and tumorigenesis through control of
            the MDM2-p53 signaling pathway
REFERENCE   7  (bases 1 to 1094)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 1094)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1094)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   10 (bases 1 to 1094)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC151719.3.
            
            On Apr 28, 2007 this sequence version replaced NM_012002.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004664.1, AF071315.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC151719.3         191274-191354
            82-204              AC151719.3         191547-191669
            205-336             AC151719.3         191846-191977
            337-425             AC151719.3         192309-192397
            426-488             AC151719.3         192494-192556
            489-536             AC151719.3         192907-192954
            537-651             AC151719.3         193302-193416
            652-744             AC151719.3         193499-193591
            745-845             AC151719.3         193681-193781
            846-1094            AC151719.3         193908-194156
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.97 cM"
     gene            1..1094
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /note="COP9 signalosome subunit 6"
                     /db_xref="GeneID:26893"
                     /db_xref="MGI:MGI:1349439"
     exon            1..81
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..986
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /note="SGN6; signalosome subunit 6; JAB1-containing
                     signalosome subunit 6; COP9 complex S6; COP9 (constitutive
                     photomorphogenic), subunit 6; COP9 (constitutive
                     photomorphogenic) homolog, subunit 6"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 6"
                     /protein_id="NP_036132.1"
                     /db_xref="CCDS:CCDS19792.1"
                     /db_xref="GeneID:26893"
                     /db_xref="MGI:MGI:1349439"
                     /translation="MAAAAAAGANGSGGSSGMEVDAAVPSVMASGVTGSVSVALHPLV
                     ILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYY
                     YTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDL
                     PVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHL
                     IAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDF
                     YDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF"
     exon            82..204
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            205..336
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            337..425
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            426..488
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            489..536
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            537..651
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            652..744
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            745..845
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1094
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1072..1077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /note="hexamer: AATAAA"
     polyA_site      1091
                     /gene="Cops6"
                     /gene_synonym="Sgn3; VIP/MOV34"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggggaa aatggcggcg gcagctgcgg cgggggcgaa tgggagcgga ggcagcagcg
       61 gcatggaagt ggatgcagca gtccccagcg tgatggcctc cggagtgact gggagtgttt
      121 ccgtcgctct tcatcccctt gtcatcctta acatctcaga ccattggatc cgcatgcgct
      181 cccaggaggg gcggcctatg caggtgattg gggctctgat cgggaagcag gaggggcgaa
      241 atatcgaagt gatgaactcc tttgagctgc tgtcccacac cgtggaagag aagattatca
      301 ttgacaaaga atattattac accaaggagg agcagtttaa acaggttttc aaggagctgg
      361 agtttctggg ttggtatacc acaggggggc cacctgaccc ctcagacatc cacgtccata
      421 agcaggtgtg tgagataatt gagagtccgc tctttctgaa gttgaaccct atgaccaagc
      481 acacagatct tcctgtcagc gtttttgagt ctgtcatcga tataatcaat ggagaggcca
      541 caatgctgtt tgctgagctc acttacactc tggccactga ggaagctgaa cggatcggtg
      601 tagaccacgt ggcccggatg acagcaacag gcagtgggga gaactccact gtggctgaac
      661 acctgatagc tcagcatagt gccatcaaga tgctgcacag ccgtgtgaag ctcattttag
      721 aatatgtcaa ggcctctgaa gcaggagagg ttcccttcaa ccatgagatc ctgcgggagg
      781 cctatgccct atgtcactgt cttccagttc tcagcactga caagttcaag acagactttt
      841 atgatcaatg caatgacgtg gggctcatgg cctacctcgg caccatcacc aaaacgtgca
      901 acacaatgaa ccagtttgtg aacaagttca acgtcctcta cgaccgacaa ggcattggcc
      961 ggcgaatgcg gggactgttt ttctgatgat ggttctggaa gggatggtgt gtggggctca
     1021 gacagctgtt ccatggacct gagtaccaca ttccctttag agaaactcat taataaaaga
     1081 gcagcccctt agca
//
