LOCUS       NM_013715               1731 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus COP9 signalosome subunit 5 (Cops5), transcript variant
            1, mRNA.
ACCESSION   NM_013715
VERSION     NM_013715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Huang,Q., Man,Y., Li,W., Zhou,Q., Yuan,S., Yap,Y.T., Nayak,N.,
            Zhang,L., Song,S., Dunbar,J., Leff,T., Yang,X. and Zhang,Z.
  TITLE     Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal
            Reproductive Hormone Homeostasis and Development in Mice
  JOURNAL   Endocrinology 164 (6) (2023)
   PUBMED   37067025
  REMARK    GeneRIF: Inactivation of Cops5 in Smooth Muscle Cells Causes
            Abnormal Reproductive Hormone Homeostasis and Development in Mice.
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Maeoka,Y., Ferdaus,M.Z., Cornelius,R.J., Sharma,A., Su,X.T.,
            Miller,L.N., Robertson,J.A., Gurley,S.B., Yang,C.L., Ellison,D.H.
            and McCormick,J.A.
  TITLE     Combined Kelch-like 3 and Cullin 3 Degradation is a Central
            Mechanism in Familial Hyperkalemic Hypertension in Mice
  JOURNAL   J Am Soc Nephrol 33 (3), 584-600 (2022)
   PUBMED   35064051
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Rivellini,C., Porrello,E., Dina,G., Mrakic-Sposta,S., Vezzoli,A.,
            Bacigaluppi,M., Gullotta,G.S., Chaabane,L., Leocani,L., Marenna,S.,
            Colombo,E., Farina,C., Newcombe,J., Nave,K.A., Pardi,R.,
            Quattrini,A. and Previtali,S.C.
  TITLE     JAB1 deletion in oligodendrocytes causes senescence-induced
            inflammation and neurodegeneration in mice
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34874913
  REMARK    GeneRIF: JAB1 deletion in oligodendrocytes causes
            senescence-induced inflammation and neurodegeneration in mice.
REFERENCE   4  (bases 1 to 1731)
  AUTHORS   Mamidi,M.K., Samsa,W.E., Bashur,L.A., Chen,Y., Chan,R., Lee,B. and
            Zhou,G.
  TITLE     The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated
            mouse chondrocyte differentiation by repressing p53 activity
  JOURNAL   J Cell Physiol 236 (8), 5686-5697 (2021)
   PUBMED   33393086
  REMARK    GeneRIF: The transcriptional cofactor Jab1/Cops5 is crucial for
            BMP-mediated mouse chondrocyte differentiation by repressing p53
            activity.
REFERENCE   5  (bases 1 to 1731)
  AUTHORS   Samsa,W.E., Mamidi,M.K., Hausman,B.S., Bashur,L.A., Greenfield,E.M.
            and Zhou,G.
  TITLE     The master developmental regulator Jab1/Cops5/Csn5 is essential for
            proper bone growth and survival in mice
  JOURNAL   Bone 143, 115733 (2021)
   PUBMED   33157284
REFERENCE   6  (bases 1 to 1731)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   7  (bases 1 to 1731)
  AUTHORS   Bounpheng,M.A., Melnikova,I.N., Dodds,S.G., Chen,H., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Christy,B.A.
  TITLE     Characterization of the mouse JAB1 cDNA and protein
  JOURNAL   Gene 242 (1-2), 41-50 (2000)
   PUBMED   10721695
REFERENCE   8  (bases 1 to 1731)
  AUTHORS   Tomoda,K., Kubota,Y. and Kato,J.
  TITLE     Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is
            instigated by Jab1
  JOURNAL   Nature 398 (6723), 160-165 (1999)
   PUBMED   10086358
REFERENCE   9  (bases 1 to 1731)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1731)
  AUTHORS   Asano,K., Vornlocher,H.P., Richter-Cook,N.J., Merrick,W.C.,
            Hinnebusch,A.G. and Hershey,J.W.
  TITLE     Structure of cDNAs encoding human eukaryotic initiation factor 3
            subunits. Possible roles in RNA binding and macromolecular assembly
  JOURNAL   J Biol Chem 272 (43), 27042-27052 (1997)
   PUBMED   9341143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102570.8, CX240457.1, AK012499.1, AK005728.1 and BY393956.1.
            
            On Mar 7, 2013 this sequence version replaced NM_013715.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005728.1, BC046753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC102570.8         57609-57640
            33-719              CX240457.1         1-687
            720-1497            AK012499.1         507-1284
            1498-1729           AK005728.1         1284-1515
            1730-1731           BY393956.1         409-410
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.29 cM"
     gene            1..1731
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /note="COP9 signalosome subunit 5"
                     /db_xref="GeneID:26754"
                     /db_xref="MGI:MGI:1349415"
     exon            1..490
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1352
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /note="isoform 1 is encoded by transcript variant 1; Jun
                     coactivator; COP9 signalosome complex subunit 5; COP9
                     complex S5; Kip1 C-terminus-interacting protein 2; Jun
                     activation domain-binding protein 1; COP9 (constitutive
                     photomorphogenic) homolog, subunit 5"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 5 isoform 1"
                     /protein_id="NP_038743.1"
                     /db_xref="CCDS:CCDS14818.1"
                     /db_xref="GeneID:26754"
                     /db_xref="MGI:MGI:1349415"
                     /translation="MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKP
                     WTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEG
                     TETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQ
                     FQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHC
                     KQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQS
                     EAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA
                     "
     exon            491..725
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     exon            726..854
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     exon            855..920
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1006
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1118
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1267
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1731
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /note="hexamer: AATAAA"
     polyA_site      1501
                     /gene="Cops5"
                     /gene_synonym="CSN5; Jab1; Mov34; Sgn5"
                     /note="major polyA site"
ORIGIN      
        1 cggcgcgaaa ggctgtacca ttcccacacc gaggctttgc gtccctcgca gttcacacga
       61 acggatttcc gagccagcat gttctcgttt caccggcaag actgatctta gccgagccga
      121 gccgagccaa ccctaaggaa gtgttttcta tgtcgctgcg ccgccgccgc gccccagcgc
      181 gcgaatggtc tggaccaacg tcacctccgg tctcaagtgt catggctgcc ttgagagtct
      241 agtgagtgtg caccctggtg gggaaggtcc aaagcccgca cgctgaggcc cagtagaaga
      301 aagttgcatc ttgattgtgg agcgacagct tctccggtgc ctcggccatg gcagcttccg
      361 ggagtggtat ggcccagaaa acctgggaat tggccaacaa catgcaggaa gcgcagagta
      421 tcgatgaaat ctacaaatat gacaaaaaac aacaacaaga aatcctggcg gcgaaaccct
      481 ggactaagga tcaccactac tttaaatact gcaaaatctc agcattggct ctactgaaaa
      541 tggtgatgca tgccaggtca ggaggcaact tggaagtgat gggtttgatg ctcgggaaag
      601 tcgacggcga gaccatgatc atcatggaca gtttcgcttt gcctgtagag ggcacagaaa
      661 ctcgagtaaa tgctcaagct gctgcgtatg agtatatggc tgcatacata gaaaatgcca
      721 aacaggttgg ccgccttgag aatgcaatcg gttggtatca tagccaccct ggttatggct
      781 gctggctctc cgggattgat gttagtacac agatgctgaa ccagcagttt caagaaccat
      841 ttgtagcagt ggtgattgat ccaaccagaa caatctctgc aggaaaagtg aatcttggcg
      901 cctttaggac atatccaaag ggctacaaac ctcctgatga aggaccttct gagtaccaga
      961 ctatcccact taataaaata gaagattttg gcgtgcactg caaacaatat tatgccttag
     1021 aagtctcata tttcaaatca tctttggatc gtaaactact tgagcttttg tggaataaat
     1081 actgggtgaa taccctgagt tcctctagct tgcttactaa tgcagactac accacaggcc
     1141 aggtgtttga tttgtctgag aagttagagc agtcggaagc ccaactggga cgtggcagtt
     1201 tcatgttggg cttagaaaca catgaccgca agtcggaaga caaacttgcc aaagctacta
     1261 gagacagctg taaaaccacc atagaagcca tccatggact gatgtctcag gttattaagg
     1321 ataaactgtt taatcagatt aacgttgctt agttaccacc aagtacttct caaagctggt
     1381 gtgtggaagg aaaagaagct caagtaacac ttttaaccca gttaccaaaa ctcagattag
     1441 aagactaagg tgctgtgtgg tgtcctgagt attagcactg taataaaact atcacgtgaa
     1501 attgtccttc tgtggttttg tagttggggt tgcttttggt gctcttgttt atgggaggaa
     1561 aaagactcac tagatctatt gtgttcaaat cctgcctatc aaagtaatca aaggatctta
     1621 gcatttaatc acaccatggt cacaaacttg tcagtttttc ttgtgccttc tcttgacagt
     1681 ctattagtaa aaatgtaatt caacttcaaa taaaatagca tctgacttca g
//
