LOCUS       NM_012001               1771 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus COP9 signalosome subunit 4 (Cops4), transcript variant
            1, mRNA.
ACCESSION   NM_012001
VERSION     NM_012001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1771)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1771)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   3  (bases 1 to 1771)
  AUTHORS   Papin J and Subramaniam S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   4  (bases 1 to 1771)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   5  (bases 1 to 1771)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   6  (bases 1 to 1771)
  AUTHORS   Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M and Deng XW.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX203220.1, BC116800.1 and CD774670.1.
            
            [WARNING] On Nov 18, 2023 this sequence was replaced by
            NM_012001.3.
            
            On Aug 12, 2009 this sequence version replaced NM_012001.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167833.1, AK009955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               CX203220.1         1-150
            151-1437            BC116800.1         5-1291
            1438-1689           CD774670.1         84-335              c
            1690-1771           CD774670.1         1-82                c
FEATURES             Location/Qualifiers
     source          1..1771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.49 cM"
     gene            1..1771
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /note="COP9 signalosome subunit 4"
                     /db_xref="GeneID:26891"
                     /db_xref="MGI:MGI:1349414"
     exon            1..242
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1389
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /note="isoform a is encoded by transcript variant 1; COP9
                     signalosome complex subunit 4; signalosome subunit 4;
                     JAB1-containing signalosome subunit 4; COP9 complex S4;
                     COP9 (constitutive photomorphogenic), subunit 4; COP9
                     (constitutive photomorphogenic) homolog, subunit 4"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 4 isoform a"
                     /protein_id="NP_036131.1"
                     /db_xref="CCDS:CCDS19463.1"
                     /db_xref="GeneID:26891"
                     /db_xref="MGI:MGI:1349414"
                     /translation="MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEA
                     LKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKIQPRVISFEEQ
                     VASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDD
                     PVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVH
                     ESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGN
                     QLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAK
                     AEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTA
                     PEWTAQAMEAQMAQ"
     exon            243..322
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            323..474
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            475..578
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            579..732
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            733..883
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1054
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1170
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1255
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1754
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaactcgg agggcggagc taattcctgc tcccctatcc ggcgctctgg cccacagaga
       61 cgctgctcta tggcacctcg cgtcccctct gcccgcctcc tggaggacca cgctcgtttt
      121 cttcttggca gcgagaggtc ccgcagccgt ggctgagctg gaggaaagat ggcggctgcc
      181 gtgcgacagg atttggccca gctcatgaat tcaagcggct ctcataaaga tctggcgggc
      241 aaatatcgtc agattctgga aaaagccatt cagttatctg ggacagaaca actagaagca
      301 ttgaaagctt ttgtggaagc gatggtgaat gagaatgtca gcctcgtgat ctcacggcaa
      361 ctgctaacag atttctgcac acacctccct aacctgccag acagcacagc caaggaggtc
      421 taccatttca ccttggagaa gatccagcct cgggtcattt cctttgaaga gcaggttgct
      481 tccataagac agcatctggc atctatttat gagaaggagg aagactggag aaatgcagcc
      541 caagtgttgg tggggattcc tctggaaaca ggacaaaaac agtacaacgt agattataag
      601 ctggagactt acctgaagat tgcaaggcta tacctggagg atgacgatcc cgtccaggcc
      661 gaggcttaca taaaccgagc gtccttactt cagaacgaat ccacaaatga acagttacag
      721 atacactata aggtttgcta tgcgcgtgtc cttgattaca gaaggaaatt cattgaggcc
      781 gcccagaggt acaatgagct ctcttacaag acaatagtcc atgaaagtga gagactagag
      841 gccttaaagc atgcactgca ctgcaccatc ttagcatcgg caggacagca gcgctctcgg
      901 atgctggcta ctctttttaa ggatgaaagg tgccagcaac tagctgcata tgggatccta
      961 gagaagatgt acctagacag aatcatcaga gggaaccagc ttcaagaatt tgctgctatg
     1021 ctgatgccac accaaaaagc aacgacagct gatggttcca gcatcttgga cagagctgtt
     1081 attgagcata atttgttgtc agcaagcaaa ttatataaca atatcacctt tgaagaactt
     1141 ggagctcttt tagagatccc tgcagctaag gcagaaaaga tagcatctca gatgataacg
     1201 gaaggacgca tgaatgggtt tattgaccag atcgatggaa tagttcattt tgaaacacga
     1261 gaagccctgc caacatggga caagcagatc cagtcacttt gtttccaagt aaacaacctc
     1321 ctggagaaaa ttagtcagac ggccccggag tggacagcac aagccatgga agcgcagatg
     1381 gcccagtgag ccctcagcgc tgtgcgcact gcatctttgc cacttcgtgc agattgattc
     1441 actgcccctc aaagcatttg catcatgacc ttagacatct cagcctcctt tgctggatcc
     1501 cacttgaaga agatgctaga gcaagaagtg catcgtttaa acataatagc tcccgtgaga
     1561 tctgggtctg tgtattgaac taactcagac gctttgaaaa cttgttcttt aagtggaagt
     1621 gaaagacctg aagtttggga tttgtgatca ctttgtagtc atgtaaaact taagtgcttt
     1681 gtgcctctcc acatgtggtt actctaataa acggagcggt gagccaaata aaggcagtac
     1741 ttggttttta attaaaaaaa aaaaaaaaaa a
//
