LOCUS       NP_036131                406 aa            linear   ROD 02-MAY-2024
DEFINITION  COP9 signalosome complex subunit 4 isoform a [Mus musculus].
ACCESSION   NP_036131
VERSION     NP_036131.1
DBSOURCE    REFSEQ: accession NM_012001.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   6  (residues 1 to 406)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (residues 1 to 406)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109196.12.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167833.1, SRR7345562.4853569.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.49 cM"
     Protein         1..406
                     /product="COP9 signalosome complex subunit 4 isoform a"
                     /note="COP9 signalosome complex subunit 4; signalosome
                     subunit 4; JAB1-containing signalosome subunit 4; COP9
                     complex S4; COP9 (constitutive photomorphogenic), subunit
                     4; COP9 (constitutive photomorphogenic) homolog, subunit
                     4"
                     /calculated_mol_wt=46154
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9BT78; propagated from
                     UniProtKB/Swiss-Prot (O88544.1)"
     Site            25
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9BT78; propagated from
                     UniProtKB/Swiss-Prot (O88544.1)"
     Region          <71..377
                     /region_name="RPN5"
                     /note="26S proteasome regulatory complex component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5071"
                     /db_xref="CDD:227403"
     Region          264..362
                     /region_name="PCI"
                     /note="PCI domain; pfam01399"
                     /db_xref="CDD:460195"
     Region          365..406
                     /region_name="CSN4_RPN5_eIF3a"
                     /note="CSN4/RPN5/eIF3a helix turn helix domain; pfam18420"
                     /db_xref="CDD:375846"
     CDS             1..406
                     /gene="Cops4"
                     /gene_synonym="D5Ertd774e; SGN4"
                     /coded_by="NM_012001.3:54..1274"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19463.1"
                     /db_xref="GeneID:26891"
                     /db_xref="MGI:MGI:1349414"
ORIGIN      
        1 maaavrqdla qlmnssgshk dlagkyrqil ekaiqlsgte qlealkafve amvnenvslv
       61 isrqlltdfc thlpnlpdst akevyhftle kiqprvisfe eqvasirqhl asiyekeedw
      121 rnaaqvlvgi pletgqkqyn vdykletylk iarlyleddd pvqaeayinr asllqnestn
      181 eqlqihykvc yarvldyrrk fieaaqryne lsyktivhes erlealkhal hctilasagq
      241 qrsrmlatlf kdercqqlaa ygilekmyld riirgnqlqe faamlmphqk attadgssil
      301 draviehnll sasklynnit feelgallei paakaekias qmitegrmng fidqidgivh
      361 fetrealptw dkqiqslcfq vnnllekisq tapewtaqam eaqmaq
//
