LOCUS       NM_001417566            1692 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus COP9 signalosome subunit 3 (Cops3), transcript variant
            2, mRNA.
ACCESSION   NM_001417566
VERSION     NM_001417566.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Niu,J., Yan,T., Guo,W., Wang,W., Ren,T., Huang,Y., Zhao,Z., Yu,Y.,
            Chen,C., Huang,Q., Lou,J. and Guo,L.
  TITLE     The COPS3-FOXO3 positive feedback loop regulates autophagy to
            promote cisplatin resistance in osteosarcoma
  JOURNAL   Autophagy 19 (6), 1693-1710 (2023)
   PUBMED   36451342
  REMARK    GeneRIF: The COPS3-FOXO3 positive feedback loop regulates autophagy
            to promote cisplatin resistance in osteosarcoma.
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   He,Z.Z., Zhao,T., Qimuge,N., Tian,T., Yan,W., Yi,X., Jin,J.,
            Cai,R., Yu,T., Yang,G. and Pang,W.
  TITLE     COPS3 AS lncRNA enhances myogenic differentiation and maintains
            fast-type myotube phenotype
  JOURNAL   Cell Signal 95, 110341 (2022)
   PUBMED   35491006
  REMARK    GeneRIF: COPS3 AS lncRNA enhances myogenic differentiation and
            maintains fast-type myotube phenotype.
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Israel,S., Drexler,H.C.A., Fuellen,G. and Boiani,M.
  TITLE     The COP9 signalosome subunit 3 is necessary for early embryo
            survival by way of a stable protein deposit in mouse oocytes
  JOURNAL   Mol Hum Reprod 27 (8) (2021)
   PUBMED   34264319
  REMARK    GeneRIF: The COP9 signalosome subunit 3 is necessary for early
            embryo survival by way of a stable protein deposit in mouse
            oocytes.
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Lin,H., Yan,Y., Luo,Y., So,W.Y., Wei,X., Zhang,X., Yang,X.,
            Zhang,J., Su,Y., Yang,X., Zhang,B., Zhang,K., Jiang,N.,
            Chow,B.K.C., Han,W., Wang,F. and Rao,F.
  TITLE     IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic
            checkpoint to safeguard glucose-induced insulin secretion
  JOURNAL   Nat Commun 12 (1), 2461 (2021)
   PUBMED   33911083
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Ba,M.A., Surina,J., Singer,C.A. and Valencik,M.L.
  TITLE     Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12
            myoblast differentiation via NF-KappaB signaling pathway
  JOURNAL   BMC Pharmacol Toxicol 18 (1), 47 (2017)
   PUBMED   28623958
  REMARK    GeneRIF: This is the first study toward understanding the role of
            the CSN3 in skeletal muscle differentiation and proliferation. Our
            results show that knockdown of CSN3 in C2C12 cells leads to
            impaired differentiation, proliferation and cell cycle regulation
            of myoblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Yan,J., Walz,K., Nakamura,H., Carattini-Rivera,S., Zhao,Q.,
            Vogel,H., Wei,N., Justice,M.J., Bradley,A. and Lupski,J.R.
  TITLE     COP9 signalosome subunit 3 is essential for maintenance of cell
            proliferation in the mouse embryonic epiblast
  JOURNAL   Mol Cell Biol 23 (19), 6798-6808 (2003)
   PUBMED   12972600
  REMARK    GeneRIF: Cops3 encodes the third subunit of the COP9 signalosome,
            which controls a wide vasriety of molecules of different functions.
REFERENCE   8  (bases 1 to 1692)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1692)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   10 (bases 1 to 1692)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068808.20.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR15390196.252819.1,
                                           SRR17253014.1423916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC068808.20        114908-115050
            144-273             AC068808.20        117700-117829
            274-354             AC068808.20        119276-119356
            355-467             AC068808.20        121576-121688
            468-517             AC068808.20        121787-121836
            518-610             AC068808.20        124481-124573
            611-790             AC068808.20        126695-126874
            791-931             AC068808.20        128290-128430
            932-1105            AC068808.20        130272-130445
            1106-1192           AC068808.20        133334-133420
            1193-1306           AC068808.20        134602-134715
            1307-1387           AC068808.20        136221-136301
            1388-1692           AC068808.20        136612-136916
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.8 cM"
     gene            1..1692
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /note="COP9 signalosome subunit 3"
                     /db_xref="GeneID:26572"
                     /db_xref="MGI:MGI:1349409"
     exon            1..143
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1441
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /note="isoform 2 is encoded by transcript variant 2; COP9
                     signalosome complex subunit 3; signalosome subunit 3;
                     JAB1-containing signalosome subunit 3; COP9 complex S3;
                     COP9 (constitutive photomorphogenic), subunit 3; COP9
                     (constitutive photomorphogenic) homolog, subunit 3"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 3 isoform 2"
                     /protein_id="NP_001404495.1"
                     /db_xref="GeneID:26572"
                     /db_xref="MGI:MGI:1349409"
                     /translation="MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDT
                     VLGALDVQEHSLGVLAVLGQRQLVGIVSLLPCGFQGSTSSHHPWPFVKFSMPSVPDFE
                     TLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQM
                     NTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMI
                     YTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIV
                     GRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNI
                     QRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPE
                     KYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
                     "
     exon            144..273
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..354
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            355..467
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..517
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            518..610
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..790
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            791..931
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1105
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1192
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1306
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1387
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1692
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1670..1675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /note="hexamer: ATTAAA"
     polyA_site      1692
                     /gene="Cops3"
                     /gene_synonym="Csn3; Sgn3"
                     /note="major polyA site"
ORIGIN      
        1 agtgggtcgc cgggcccctc ctcctagagc agtcgctttt tcccgcgcga gcttacctct
       61 gttgctcggg ccaccagcgg ggggaaacat ggcgtctgct ctggagcagt tcgtgaacag
      121 tgtccgacag ctctcagctc aagggcaaat gactcagctt tgtgaactca tcaacaagag
      181 tggagaactc cttgcgaaga acttgtccca tctggacact gtgcttgggg ctttagatgt
      241 tcaagaacac tctttgggtg tccttgctgt tctaggtcag agacaacttg tgggaattgt
      301 ttccttgcta ccgtgtgggt ttcagggatc aacctcaagt catcaccctt ggccgtttgt
      361 gaagttctca atgcccagtg ttcctgactt cgaaacacta ttctcacagg ttcagctttt
      421 catcagtaca tgtaatggcg agcacattcg atatgcaaca gatacgtttg ctgggctttg
      481 ccatcagcta acaaatgcac ttgtggaaag aaaacagccc cttcgaggaa ttggcatcct
      541 taagcaagcc atagacaaga tgcagatgaa taccaaccaa ctgacctcag tacatgccga
      601 tctctgccag ctttgtttac tagcgaagtg ctttaaacct gcccttccat atcttgatgt
      661 ggatatgatg gatatctgta aagagaatgg agcctatgat gcaaaacact ttctgtgcta
      721 ctactattat ggaggaatga tctatacggg gctgaagaac tttgaaagag cgctgtactt
      781 ttatgagcag gctataacta ctcctgccat ggccgtcagc catatcatgt tggaatcata
      841 taaaaagtat attctagtgt ctttgatatt acttggcaaa gtacaacagc tgcctaaata
      901 cacctctcaa atagtgggta gatttattaa gcctctcagc aatgcttacc atgagttagc
      961 acaagtttat tcaaccaaca acccgtctga gctgcggaac ctggtgagca agcacagcga
     1021 gaccttcact cgagacaaca acatgggcct ggtgaagcag tgcctgtcgt ctctttataa
     1081 gaagaacatt cagaggctga caaagacttt tttaacacta tcattacaag atatggcaag
     1141 ccgtgtacag ttatctggac cacaggaggc agaaaaatat gttctacaca tgatagaaga
     1201 tggagaaatt tttgcaagta ttaaccagaa ggatggaatg gtcagtttcc atgataaccc
     1261 tgagaagtat aataacccag ccatgcttca taacatcgac caagagatgc taaaatgcat
     1321 agagctggat gagcgactga aggctatgga ccaggagatc acggtgaacc cccagtttgt
     1381 tcaaaagagc atgggctcac aagaagatga ctcaggaaac aagccctcca gctactcttg
     1441 aaactaaccc ccatcttgag gtaacagaac cttggcctgg caagtgtgaa gagcgcagca
     1501 ggaagtacca tgcgggttcc atgccggttc ctcctggaca gtcagaaatt cagtttaaca
     1561 tctgcagtcc tattgctttc agaaaaccat tctctgcaaa gaaaggaaaa aaaaaatcct
     1621 actttagagt ctgttgtgga tttatttatc ctcagattgt tattactgca ttaaagttac
     1681 ctttttgttt aa
//
