LOCUS       NM_009939               3332 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus COP9 signalosome subunit 2 (Cops2), transcript variant
            2, mRNA.
ACCESSION   NM_009939
VERSION     NM_009939.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3332)
  AUTHORS   Lin,H., Yan,Y., Luo,Y., So,W.Y., Wei,X., Zhang,X., Yang,X.,
            Zhang,J., Su,Y., Yang,X., Zhang,B., Zhang,K., Jiang,N.,
            Chow,B.K.C., Han,W., Wang,F. and Rao,F.
  TITLE     IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic
            checkpoint to safeguard glucose-induced insulin secretion
  JOURNAL   Nat Commun 12 (1), 2461 (2021)
   PUBMED   33911083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3332)
  AUTHORS   Alves,C.R.R., Neves,W.D., de Almeida,N.R., Eichelberger,E.J.,
            Jannig,P.R., Voltarelli,V.A., Tobias,G.C., Bechara,L.R.G., de Paula
            Faria,D., Alves,M.J.N., Hagen,L., Sharma,A., Slupphaug,G.,
            Moreira,J.B.N., Wisloff,U., Hirshman,M.F., Negrao,C.E., de
            Castro,G. Jr., Chammas,R., Swoboda,K.J., Ruas,J.L., Goodyear,L.J.
            and Brum,P.C.
  TITLE     Exercise training reverses cancer-induced oxidative stress and
            decrease in muscle COPS2/TRIP15/ALIEN
  JOURNAL   Mol Metab 39, 101012 (2020)
   PUBMED   32408015
  REMARK    GeneRIF: Exercise training reverses cancer-induced oxidative stress
            and decrease in muscle COPS2/TRIP15/ALIEN.
REFERENCE   3  (bases 1 to 3332)
  AUTHORS   Zhang,W., Ni,P., Mou,C., Zhang,Y., Guo,H., Zhao,T., Loh,Y.H. and
            Chen,L.
  TITLE     Cops2 promotes pluripotency maintenance by Stabilizing Nanog
            Protein and Repressing Transcription
  JOURNAL   Sci Rep 6, 26804 (2016)
   PUBMED   27226076
  REMARK    GeneRIF: Cops2, but not the whole COP9 signalosome, is essential
            for pluripotency maintenance in mouse embryonic stem cells.
            Down-regulation of Cops2 reduces expression of pluripotency genes,
            slows proliferation rate, arrests G2/M cell cycle, and compromises
            ESC embryoid differentiation. Cops2 binds to Nanog protein and
            prevents degradation. Cops2 functions as transcriptional
            corepressor to facilitate pluripotency maintenance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3332)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3332)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   6  (bases 1 to 3332)
  AUTHORS   Yang,X., Menon,S., Lykke-Andersen,K., Tsuge,T., Di,Xiao., Wang,X.,
            Rodriguez-Suarez,R.J., Zhang,H. and Wei,N.
  TITLE     The COP9 signalosome inhibits p27(kip1) degradation and impedes
            G1-S phase progression via deneddylation of SCF Cul1
  JOURNAL   Curr Biol 12 (8), 667-672 (2002)
   PUBMED   11967155
REFERENCE   7  (bases 1 to 3332)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3332)
  AUTHORS   Deng,X.W., Dubiel,W., Wei,N., Hofmann,K., Mundt,K., Colicelli,J.,
            Kato,J., Naumann,M., Segal,D., Seeger,M., Carr,A., Glickman,M. and
            Chamovitz,D.A.
  TITLE     Unified nomenclature for the COP9 signalosome and its subunits: an
            essential regulator of development
  JOURNAL   Trends Genet 16 (5), 202-203 (2000)
   PUBMED   10782111
  REMARK    Erratum:[Trends Genet 2000 Jul;16(7):289]
REFERENCE   9  (bases 1 to 3332)
  AUTHORS   Schaefer,L., Beermann,M.L. and Miller,J.B.
  TITLE     Coding sequence, genomic organization, chromosomal localization,
            and expression pattern of the signalosome component Cops2: the
            mouse homologue of Drosophila alien
  JOURNAL   Genomics 56 (3), 310-316 (1999)
   PUBMED   10087198
REFERENCE   10 (bases 1 to 3332)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ052709.1, AK084421.1 and BQ031086.1.
            
            On Oct 24, 2013 this sequence version replaced NM_009939.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. This
            results in a shorter protein (isoform b) compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084421.1, AK132207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                CJ052709.1         1-81
            82-3314             AK084421.1         3-3235
            3315-3332           BQ031086.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..3332
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /note="COP9 signalosome subunit 2"
                     /db_xref="GeneID:12848"
                     /db_xref="MGI:MGI:1330276"
     exon            1..147
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1425
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /note="isoform b is encoded by transcript variant 2; COP9
                     signalosome complex subunit 2; alien-like; alien homolog;
                     JAB1-containing signalosome subunit 2; thyroid
                     receptor-interacting protein 15; TR-interacting protein
                     15; COP9 (constitutive photomorphogenic) homolog, subunit
                     2"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 2 isoform b"
                     /protein_id="NP_034069.2"
                     /db_xref="CCDS:CCDS16679.1"
                     /db_xref="GeneID:12848"
                     /db_xref="MGI:MGI:1330276"
                     /translation="MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKE
                     DDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA
                     VTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYL
                     EREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALY
                     EQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTC
                     LKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNH
                     SNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQC
                     ILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA"
     exon            148..261
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            262..339
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            340..465
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            466..555
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            556..633
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            634..808
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            809..987
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1040
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1138
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1221
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1280
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3316
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /note="major polyA site"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
     regulatory      3288..3293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
                     /note="hexamer: AATAAA"
     polyA_site      3316
                     /gene="Cops2"
                     /gene_synonym="Csn2; Sgn2; TRIP-15; Trip15"
ORIGIN      
        1 gaggagactc gggagtgacg cttctgggcc gcggagcact gtgggaggag gctgtctcta
       61 atttctcctc tccccctccc ccctccggcc aagatgtctg acatggagga tgatttcatg
      121 tgcgatgatg aggaggacta cgacctggag tactctgaag acagtaactc tgagcccaat
      181 gtggatttgg aaaatcagta ctataattcc aaagcactga aagaagatga cccaaaagca
      241 gcattaagca gcttccaaaa ggttttggag cttgaaggtg agaagggaga atggggattc
      301 aaagcgctaa aacagatgat caagattaac ttcaagttga caaactttcc agaaatgatg
      361 aacagatata agcaactatt gacctatatt cggagtgcag tcaccaggaa ctattctgaa
      421 aagtccatta attctatcct tgattatatc tccacttcta aacagatgga tttactgcag
      481 gaattttatg aaacaacact ggaagctttg aaagatgcta agaatgatag actgtggttt
      541 aagacaaaca caaagcttgg aaaattatat ttagaacgag aagaatatgg aaagcttcaa
      601 aaaattttac gacagttaca tcagtcttgt cagactgatg atggagaaga tgacctgaaa
      661 aaaggtaccc agttattaga aatctatgct ttggaaattc aaatgtacac tgcacagaag
      721 aacaacaaaa agcttaaagc actctatgag caatcacttc acatcaagtc tgccatccct
      781 cacccactaa tcatgggtgt catcagagaa tgcggtggta agatgcactt gagagaaggt
      841 gaatttgaaa aggcacacac tgattttttt gaagccttca agaattatga tgaatcagga
      901 agcccaagac gaaccacttg tttaaaatat ttggttttag caaatatgct aatgaaatca
      961 ggaataaatc cgtttgactc acaagaggcc aagccgtata aaaatgatcc agaaattcta
     1021 gcaatgacaa atttagtaag tgcctatcag aataatgaca tcactgaatt tgaaaagatt
     1081 ctgaaaacaa atcacagcaa catcatggat gatcctttca taagagagca cattgaagaa
     1141 cttttacgaa acatcagaac acaagtcctc ataaagttaa ttaagcctta cacaagaata
     1201 catattcctt ttatttctaa ggagctaaac atagacgtag ctgatgtgga gagcttgctg
     1261 gtgcagtgca tactggataa cactattcat ggccgaattg atcaagtcaa ccagctcctt
     1321 gaactggatc atcagaagag gggtggtgcc cgatacactg cgctagataa atggaccaac
     1381 caactaaatt ctctgaacca ggctgtggtc agtaaactgg cttaacggag accgagcttt
     1441 gcggacatgc ttaaggcaac agtgcagaga tgtgaccctt gaggactgga aagacaaagc
     1501 tccagtgggt tggtgtgtcc tgaaagggat ggagttatgg cagaagtgct tttgtgatca
     1561 actggtttgt ggtttgctgc tgcatttatc ccaagaaaac agctttaatc tccagaagaa
     1621 aaccaaaaca ccatgggatt tatgctgtgt tgacatcttg ccctaaacat acaacaccat
     1681 agtaatttgt catgggcgac atgatcagag agaagatttt tgtcatgatt ttaaaaacac
     1741 tgacacgcta ctgttggtta aatttaaaca tgttgtacct gcagaaattc tctcacaaat
     1801 aacctgcaat aacttgaaat tcataccctt ttgaacactt ccttttctca tgtataaatg
     1861 aaaatgtttg ctgcattttg caaaatgtca attctccaaa actgtgtccg tctatttctg
     1921 ttcttgcagc tagtaaaggt tagacaaccc gaattctcag tggcacgctg tcacctaggg
     1981 ctcaagcagc aaaataaaca gtgcagctca gaaattatag cttggttctt gatgtgtttt
     2041 tattacattc ggggttgctc ttttgttttt agtatcttaa agatttcagg ttattttgtc
     2101 ttcagttaag atttaaaagc ctgagagcaa atagttaaag ctagttattt gcttccaggt
     2161 ttttaaaatt aaagttcatt gatagagtaa gaactccttt ctaacagagc ccttacatag
     2221 aacttgtttt gacagtgata ctttaaagga ttatgatgct ttttttttta aagactggta
     2281 atttcttttt aaaagaatac gtgttaactc tcagaatgtc actttagaca aatatgccag
     2341 aatctagaca gcgaagtgaa tgttacctgc atagtgacca tgctgaaagg ttattttcta
     2401 atgccagcaa caaccattgc ccgaagcctc ttgggtttgc tcttggagaa ttacagtcaa
     2461 agttaattta ggtaactcac tactaacttc atgtttacac cttgtttgaa aagattatta
     2521 acaagcttgt ctgtctttac cctaatttgg ccccaaatac cagtttcaaa gaaataccta
     2581 aatttagata atgtagaaag tatgcatctg gctttgaaag caatccccaa ataattttca
     2641 agtattttgt gcagtggcag aatagttagg aatgaactat ggccttcgat ggtggcagaa
     2701 ctcagcccat ttgaatgtat tgagttttgg atgtatttgt ttcttttttt aagttcacat
     2761 tatcatatag tgtcaaaaga aggaactaag attaacataa tgtgcttggt tttctattgc
     2821 tcattattat gtaaacagtt gagtggcagt gcagaaggaa gactgtgtga ctgaagagtg
     2881 gcaaccaaga attttgatca ttaaatcaga ttttataaac agtagaaaga gcatggactt
     2941 aaaacaaggc atgcttattt ggttttgtca aaattttacg aaaatatgtg atatatattt
     3001 atactaaaac tatataatcc ttagatttag gaaagcagtc agttaatgtc tagcagaata
     3061 aagcagtatt aaatacagat atacgttgaa aattgtagaa aaccgaaaga agacgaaaga
     3121 caaaatgtca atggtaggga ataaaaagtt taagatatta taaaagtatg tgtattttct
     3181 tctattctac ataaatcatt tgtgaaaagt gtgttcacgt tttttacagg agtgatatca
     3241 attaggattt atttttccaa tacaatttgg agaccctttg ttacccaaat aaaaatgaca
     3301 agtttctgtg cctgtaaaaa aaaaaaaaaa aa
//
