LOCUS       NM_025556                802 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus coordinator of PRMT5, differentiation stimulator
            (Coprs), transcript variant 1, mRNA.
ACCESSION   NM_025556 XM_980275 XM_980316
VERSION     NM_025556.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 802)
  AUTHORS   Paul,C., Delpech,H., Haouzi,D., Hamamah,S., Sardet,C. and
            Fabbrizio,E.
  TITLE     Coprs inactivation leads to a derepression of LINE1 transposons in
            spermatocytes
  JOURNAL   FEBS Open Bio 9 (1), 159-168 (2018)
   PUBMED   30652083
  REMARK    GeneRIF: It shows that in mice, genetic inactivation of coprs
            (which is highly expressed in testis and encodes a histone-binding
            protein required for the targeting of Prmt5 activity) affects the
            maturation of spermatogonia to spermatids.
            Erratum:[FEBS Open Bio. 2019 Feb 28;9(3):558. doi:
            10.1002/2211-5463.12607.. PMID: 30868064]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 802)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 802)
  AUTHORS   Paul,C., Sardet,C. and Fabbrizio,E.
  TITLE     The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated
            factor Copr5 during adipogenic conversion
  JOURNAL   Biol Open 4 (3), 312-316 (2015)
   PUBMED   25681392
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 802)
  AUTHORS   Paul,C., Sardet,C. and Fabbrizio,E.
  TITLE     The histone- and PRMT5-associated protein COPR5 is required for
            myogenic differentiation
  JOURNAL   Cell Death Differ 19 (5), 900-908 (2012)
   PUBMED   22193545
  REMARK    GeneRIF: Data extend the role of COPR5 from an adaptor protein
            required for nuclear functions of PRMT5 to an essential coordinator
            of myogenic differentiation.
REFERENCE   5  (bases 1 to 802)
  AUTHORS   Lacroix,M., El Messaoudi,S., Rodier,G., Le Cam,A., Sardet,C. and
            Fabbrizio,E.
  TITLE     The histone-binding protein COPR5 is required for nuclear functions
            of the protein arginine methyltransferase PRMT5
  JOURNAL   EMBO Rep 9 (5), 452-458 (2008)
   PUBMED   18404153
REFERENCE   6  (bases 1 to 802)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008882.1 and BY647791.1.
            
            On Apr 28, 2009 this sequence version replaced NM_025556.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008882.1, AK010573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-795               AK008882.1         2-796
            796-802             BY647791.1         379-385
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 6.41 cM"
     gene            1..802
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /note="coordinator of PRMT5, differentiation stimulator"
                     /db_xref="GeneID:66423"
                     /db_xref="MGI:MGI:1913673"
     exon            1..105
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..558
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cooperator of PRMT5; coordinator of PRMT5 and
                     differentiation stimulator"
                     /codon_start=1
                     /product="coordinator of PRMT5 and differentiation
                     stimulator isoform 1"
                     /protein_id="NP_079832.1"
                     /db_xref="CCDS:CCDS40237.1"
                     /db_xref="GeneID:66423"
                     /db_xref="MGI:MGI:1913673"
                     /translation="MDPQAATGRGPGERSSQEAPSAEAGFATADLSGRETETELAVDR
                     LASGAQSIPADIPAHAEGPSSEEEGFAVEKEADGELYAWELSEGPSCPPMEQAADLFN
                     EDWDLELKADQGNPYDADDIQGSISQEIKPWVCCAPQGDMIYDPSWHHPPPLIPHYSK
                     MVFETGQFDDAED"
     exon            106..172
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /inference="alignment:Splign:2.1.0"
     exon            173..388
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /inference="alignment:Splign:2.1.0"
     exon            389..802
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      776..781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /note="hexamer: AATAAA"
     polyA_site      796
                     /gene="Coprs"
                     /gene_synonym="1700029I03Rik; 2410022L05Rik; Copr5"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgtccc aggcgcctgg ctgtgggcgg ccgggcatgg accctcaggc agccaccggt
       61 cggggcccgg gcgagcggag ttcgcaggag gcccccagcg cggaggctgg ctttgccaca
      121 gctgacctct ctggtcggga gacggagact gagctggccg tggatcgact agccagtgga
      181 gctcagagca tccctgctga cattcctgcc catgccgagg gcccaagttc tgaggaggaa
      241 ggctttgcag tggagaagga agctgatggg gagttgtatg cctgggagct gtcagagggt
      301 ccatcctgcc cacccatgga acaggctgca gatcttttta atgaggactg ggacttggag
      361 ctgaaagcag accaaggaaa tccttacgat gctgatgaca tccaggggag catttcccaa
      421 gagatcaagc cttgggtgtg ctgtgcacca cagggagaca tgatatacga ccccagttgg
      481 caccatccac ctccactcat accacactac tccaagatgg tcttcgaaac aggacagttt
      541 gatgatgccg aagactagaa gtgtcacttt ccacagtgga gtgggggagt ttttgtgtcc
      601 tccagatcac aagttgtttc ctgtgtttca agtgagatac tctgtccgtt ctcagcgact
      661 cctcagtgtg ggctatagac aggcattaac tggggcatgt tgttgtggtg gttgttgtta
      721 atggactctg gagtgtgttg gaatttttgt ctgtgttaga gttgtgttct ttataaataa
      781 agttagggaa aaatcaccta gt
//
