LOCUS       NM_021538               1063 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus coatomer protein complex, subunit epsilon (Cope),
            mRNA.
ACCESSION   NM_021538
VERSION     NM_021538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1063)
  AUTHORS   Peter,C.J., Evans,M., Thayanithy,V., Taniguchi-Ishigaki,N.,
            Bach,I., Kolpak,A., Bassell,G.J., Rossoll,W., Lorson,C.L., Bao,Z.Z.
            and Androphy,E.J.
  TITLE     The COPI vesicle complex binds and moves with survival motor neuron
            within axons
  JOURNAL   Hum Mol Genet 20 (9), 1701-1711 (2011)
   PUBMED   21300694
REFERENCE   2  (bases 1 to 1063)
  AUTHORS   Li,H., Bishop,K.M. and O'Leary,D.D.
  TITLE     Potential target genes of EMX2 include Odz/Ten-M and other gene
            families with implications for cortical patterning
  JOURNAL   Mol Cell Neurosci 33 (2), 136-149 (2006)
   PUBMED   16919471
REFERENCE   3  (bases 1 to 1063)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
REFERENCE   4  (bases 1 to 1063)
  AUTHORS   Clarke,D., Elgar,G. and Clark,M.S.
  TITLE     Comparative analysis of human 19p12-13 region in Fugu and mouse
  JOURNAL   Mamm Genome 12 (6), 478-483 (2001)
   PUBMED   11353399
REFERENCE   5  (bases 1 to 1063)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158553.13.
            
            On Feb 7, 2019 this sequence version replaced NM_021538.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039837.1, BC083336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC158553.13        161712-161877       c
            167-229             AC158553.13        159948-160010       c
            230-330             AC158553.13        158909-159009       c
            331-483             AC158553.13        157993-158145       c
            484-537             AC158553.13        156641-156694       c
            538-619             AC158553.13        156068-156149       c
            620-775             AC158553.13        154153-154308       c
            776-844             AC158553.13        152948-153016       c
            845-919             AC158553.13        151864-151938       c
            920-1063            AC158553.13        151642-151785       c
FEATURES             Location/Qualifiers
     source          1..1063
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1063
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /note="coatomer protein complex, subunit epsilon"
                     /db_xref="GeneID:59042"
                     /db_xref="MGI:MGI:1891702"
     exon            1..166
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..967
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /note="nonclathrin coat protein epsilon-COP; epsilon-coat
                     protein"
                     /codon_start=1
                     /product="coatomer subunit epsilon"
                     /protein_id="NP_067513.1"
                     /db_xref="CCDS:CCDS22365.1"
                     /db_xref="GeneID:59042"
                     /db_xref="MGI:MGI:1891702"
                     /translation="MAPPVPGAVSGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLS
                     SPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENQRDSIVL
                     ELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECMAMTIQILLKLD
                     RLDLARKELKKMQDQDEDATLTQLATAWVNLAVGGEKLQEAYYIFQELADKCSPTLLL
                     LNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLSQ
                     LKDAHRAHPFIKEYQAKENDFDRLAMQYAPSA"
     exon            167..229
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..330
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..483
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..537
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..619
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..775
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..844
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..919
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1063
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /note="hexamer: AATAAA"
     polyA_site      1051
                     /gene="Cope"
                     /gene_synonym="1110005D17Rik; Cope1"
                     /note="major polyA site"
ORIGIN      
        1 ctacgtgtcc cagaagaagg ttggttagag gtgcggtgac atggctcctc cggttcctgg
       61 cgcggtctct ggcggctccg gagaggtaga tgagctgttc gacgtgaaga acgctttcta
      121 catcggcagc taccagcagt gcatcaacga ggctcagcgc gtgaagctct ccagtcctga
      181 gcgggaagta gagagggatg tcttcctata cagagcatac ctcgcacaga ggaagtatgg
      241 cgtggtcctg gatgagatca aaccctcctc ggccccagaa ctccaggctg tgcgcatgtt
      301 tgctgagtac cttgccagtg agaaccagag ggacagcatc gtgctggagc tggatcggga
      361 gatgagcagg agtgtggatg tgaccaatac cactttcctg ctcatggctg cctccatcta
      421 cttccacgac cagaacccgg atgcagccct gcgaaccctg caccagggcg acggccttga
      481 gtgcatggcc atgacgattc agatcctcct caagctggac aggctggacc tagcccggaa
      541 ggagctgaag aagatgcagg accaagatga ggacgccacc cttacccagc tagccactgc
      601 ctgggtcaac ctggctgtgg gtggtgagaa gctacaagaa gcctactaca tattccaaga
      661 gctggccgac aagtgctccc ccacactgct gctgctcaat ggccaggcag cctgccactc
      721 agcacagggc cgctgggaga ctgcagaggg tgtgctgcaa gaggcactgg acaaggacag
      781 cggccaccct gagaccctca tcaatctcat tgtactgtca cagcacctgg gcaagccccc
      841 tgaggtgaca aaccgatact tgtcacagct gaaggatgca cacagggccc accccttcat
      901 caaggagtac caggccaagg agaacgattt cgatcgcctg gcaatgcagt atgcgcccag
      961 tgcttaaagt ggagatgccc tggtgacccc aactgtgtgc cgcgggatgc tgtcctccct
     1021 ttgtgtctgc caataaagtc tatccattat cgctctgcct gat
//
