LOCUS       NM_015827               3043 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus COPI coat complex subunit beta 2 (Copb2), mRNA.
ACCESSION   NM_015827
VERSION     NM_015827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Kim,S.S., Park,J., Kim,E., Hwang,E.M. and Park,J.Y.
  TITLE     beta-COP Suppresses the Surface Expression of the TREK2
  JOURNAL   Cells 12 (11), 1500 (2023)
   PUBMED   37296621
  REMARK    GeneRIF: beta-COP Suppresses the Surface Expression of the TREK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Marom,R., Burrage,L.C., Venditti,R., Clement,A., Blanco-Sanchez,B.,
            Jain,M., Scott,D.A., Rosenfeld,J.A., Sutton,V.R., Shinawi,M.,
            Mirzaa,G., DeVile,C., Roberts,R., Calder,A.D., Allgrove,J.,
            Grafe,I., Lanza,D.G., Li,X., Joeng,K.S., Lee,Y.C., Song,I.W.,
            Sliepka,J.M., Batkovskyte,D., Washington,M., Dawson,B.C., Jin,Z.,
            Jiang,M.M., Chen,S., Chen,Y., Tran,A.A., Emrick,L.T., Murdock,D.R.,
            Hanchard,N.A., Zapata,G.E., Mehta,N.R., Weis,M.A., Scott,A.A.,
            Tremp,B.A., Phillips,J.B., Wegner,J., Taylor-Miller,T., Gibbs,R.A.,
            Muzny,D.M., Jhangiani,S.N., Hicks,J., Stottmann,R.W.,
            Dickinson,M.E., Seavitt,J.R., Heaney,J.D., Eyre,D.R.,
            Westerfield,M., De Matteis,M.A. and Lee,B.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     COPB2 loss of function causes a coatopathy with osteoporosis and
            developmental delay
  JOURNAL   Am J Hum Genet 108 (9), 1710-1724 (2021)
   PUBMED   34450031
  REMARK    GeneRIF: COPB2 loss of function causes a coatopathy with
            osteoporosis and developmental delay.
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   DiStasio,A., Driver,A., Sund,K., Donlin,M., Muraleedharan,R.M.,
            Pooya,S., Kline-Fath,B., Kaufman,K.M., Prows,C.A., Schorry,E.,
            Dasgupta,B. and Stottmann,R.W.
  TITLE     Copb2 is essential for embryogenesis and hypomorphic mutations
            cause human microcephaly
  JOURNAL   Hum Mol Genet 26 (24), 4836-4848 (2017)
   PUBMED   29036432
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Shi,F., Ding,S., Zhao,S., Han,M., Zhuang,Y., Xu,T. and Wu,X.
  TITLE     A piggyBac insertion disrupts Foxl2 expression that mimics BPES
            syndrome in mice
  JOURNAL   Hum Mol Genet 23 (14), 3792-3800 (2014)
   PUBMED   24565867
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Tarsounas,M., Heng,H.H., Ye,C.J., Pearlman,R.E. and Moens,P.B.
  TITLE     Identification of the mouse beta'-COP Golgi component as a
            spermatocyte autoantigen in scleroderma and mapping of its gene
            Copb2 to mouse chromosome 9
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 201-204 (1999)
   PUBMED   10702668
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK088064.1.
            
            On Apr 6, 2007 this sequence version replaced NM_015827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088064.1, AK153352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3043              AK088064.1         2-3044
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.4 cM"
     gene            1..3043
                     /gene="Copb2"
                     /note="COPI coat complex subunit beta 2"
                     /db_xref="GeneID:50797"
                     /db_xref="MGI:MGI:1354962"
     exon            1..93
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2808
                     /gene="Copb2"
                     /note="p102; beta'-COP; beta'-coat protein; coatomer
                     protein complex, subunit beta 2 (beta prime)"
                     /codon_start=1
                     /product="coatomer subunit beta'"
                     /protein_id="NP_056642.1"
                     /db_xref="CCDS:CCDS40734.1"
                     /db_xref="GeneID:50797"
                     /db_xref="MGI:MGI:1354962"
                     /translation="MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNH
                     ETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYI
                     RCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFAS
                     ASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQN
                     KTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWC
                     VASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTE
                     IKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQ
                     EFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFY
                     DWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTED
                     GIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGY
                     IPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHF
                     LEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQ
                     FSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDA
                     CLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLF
                     PGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKGFQPSRPTAQQEPDGK
                     PASSPVIMASQTTHKEEKSLLELEVDLDNLELEDIDTTDINLDEDILDD"
     exon            94..231
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..318
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..445
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..594
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..741
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..841
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..984
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1184
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1295
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1384
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1491
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1635
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1766
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1974
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2085
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2300
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2393
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2574
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2643
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2712
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..3043
                     /gene="Copb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggttgg ccggtccacg ggtcggtggg ttcctgagtg tgtcgccttg agcctgtgac
       61 gggcaggggc tcgctcggac agtcggagcc atgcctcttc gacttgacat caagagaaag
      121 ctgactgcta ggtctgaccg agttaagagc gtggatttgc atcccacaga gccatggatg
      181 ttggctagtc tttacaatgg cagtgtgtgt gtttggaatc atgaaactca gacactggtg
      241 aagacgtttg aagtatgtga tcttcctgtt cgagctgcaa agtttgtcgc aaggaagaac
      301 tgggtggtga caggagcaga cgatatgcag atcagagtgt tcaattataa caccctggag
      361 agggtgcata tgtttgaagc acactcggat tacattcgtt gtattgctgt tcatcccacc
      421 cagccgttca ttctcaccag cagtgatgac atgcttatta agctctggga ctgggataaa
      481 aaatggtctt gttcacaagt gtttgaagga cacacgcact acgttatgca gattgtgata
      541 aaccccaaag ataacaatca gtttgccagt gcatctctcg acaggaccat caaggtgtgg
      601 cagctgggct cctcatcacc aaacttcact ctggaaggac atgaaaaagg cgtgaattgc
      661 attgactact acagtggtgg tgacaagcca tacctcattt caggtgcaga tgaccggctt
      721 gttaaaatat gggattatca gaacaaaacg tgtgtgcaga ccctggaggg gcatgcccag
      781 aatgtgtcgt gtgcgagctt ccatcctgag ctgcccatca tcatcacagg gtcagaagac
      841 ggaactgtgc gaatctggca ttctagcacc taccggcttg agagcacgct gaattacgga
      901 atggagaggg tgtggtgtgt ggccagtctg agagggtcca acaatgtcgc tctgggctat
      961 gatgaaggga gcatcattgt taagcttggt cgggaggaac ctgccatgtc catggatgcc
     1021 aatggaaaga taatctgggc caagcattca gaagtccagc aggccaacct gaaagcaatg
     1081 ggtgacactg agattaaaga tggagaaaga ttgccactgg cagtaaagga catgggcagt
     1141 tgtgaaatat atccacagac cattcagcac aatcctaatg ggaggtttgt tgtggtatgt
     1201 ggtgatgggg agtatatcat ctacacagca atggcattga ggaacaagag cttcgggtct
     1261 gcccaggagt ttgcatgggc ccacgattct tcagagtatg caataagaga aagcaacagt
     1321 attgtaaaga tatttaaaaa ctttaaggaa aaaaaatcat ttaaacccga ttttggagct
     1381 gaaagtatct atgggggctt cttgctggga gtcagatctg taaatggctt agccttctat
     1441 gactgggaga atactgaact catccgcaga attgaaattc agcccaagca catcttctgg
     1501 tctgactctg gagagctggt ctgtatcgcc accgaggagt cattttttat tcttaaatat
     1561 ctgtcagaaa aagtcttggc tgcacaggaa acacatgagg gagttactga agatggcatt
     1621 gaagacgcct ttgaggttct tggtgaaatt caggaaattg tgaaaactgg gctgtgggta
     1681 ggtgactgct tcatttacac aagttctgtg aacagattaa actattacgt gggaggagag
     1741 atagtcacca tcgcccacct ggacaggaca atgtatcttc tgggctatat tccaaaagac
     1801 aatagacttt atctggggga taaggaattg aatattgtta gctactccct gttggtttca
     1861 gtcctggaat accagactgc tgtcatgcgg agggatttta gcatggcgga taaagtcctc
     1921 cctaccatcc ccaaagaaca gaggaccaga gttgcacact ttttggaaaa acagggcttc
     1981 aagcagcaag cacttacagt atccacagat cctgaacatc gttttgagct tgctcttcaa
     2041 cttggagagt tgaaaattgc ttaccagtta gcagtggaag cagagtcgga gcagaagtgg
     2101 aaacaacttg ctgaacttgc cattagtaaa tgtcagttca gcctagccca ggagtgtctg
     2161 caccatgctc aggattatgg tggtctgctg ctcttggcca ctgcttctgg aaatgctagt
     2221 atggtgaaca agctggcaga aggtgcggag agagacggca aaaataacgt ggcattcatg
     2281 agctattttt tacagggcaa gcttgatgct tgcctagagc tcttgatcag aacaggaaga
     2341 ctcccagaag ctgccttcct ggcccgaact tacttaccca gtcaggtctc aagggtggtg
     2401 aaactgtgga gggagaatct ctcaaaagtc aaccagaaag cagcagaatc ccttgctgat
     2461 cctacagagt atgaaaacct tttccctgga ttaaaagaag cctttgttgt tgaagaatgg
     2521 gtgaaggaga cacatgcgga tttgtggcca gccaagcagt accctcttgt cacgccaaat
     2581 gaagagagaa atgttatgga agaggcaaaa ggctttcagc cctcaagacc cacagcccag
     2641 caggaacctg atggaaaacc tgcttctagc ccagttatca tggcctccca aactacccac
     2701 aaagaagaaa agagtttact agaactagaa gttgatttgg ataacttgga attagaggat
     2761 attgacacaa cagacattaa tctggatgaa gatattctgg atgattaaag tttgccattt
     2821 actgcagtaa gagattatta tggcattttc aaatcaatca ccatcctgac cagaactttg
     2881 gaaatccttg atttgcatat gtaaacaagg gggaacatag ccacttcatc ttcaggagtt
     2941 gatgggcagc gtttaagtta ctatgttctc cttggtaact gaaacagaaa cttgcttttt
     3001 ttcatattgt tactagatca cccgtcataa aatcttttga att
//
