LOCUS       NP_056642                905 aa            linear   ROD 30-APR-2024
DEFINITION  coatomer subunit beta' [Mus musculus].
ACCESSION   NP_056642
VERSION     NP_056642.1
DBSOURCE    REFSEQ: accession NM_015827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 905)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 905)
  AUTHORS   Kim,S.S., Park,J., Kim,E., Hwang,E.M. and Park,J.Y.
  TITLE     beta-COP Suppresses the Surface Expression of the TREK2
  JOURNAL   Cells 12 (11), 1500 (2023)
   PUBMED   37296621
  REMARK    GeneRIF: beta-COP Suppresses the Surface Expression of the TREK2.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 905)
  AUTHORS   Marom,R., Burrage,L.C., Venditti,R., Clement,A., Blanco-Sanchez,B.,
            Jain,M., Scott,D.A., Rosenfeld,J.A., Sutton,V.R., Shinawi,M.,
            Mirzaa,G., DeVile,C., Roberts,R., Calder,A.D., Allgrove,J.,
            Grafe,I., Lanza,D.G., Li,X., Joeng,K.S., Lee,Y.C., Song,I.W.,
            Sliepka,J.M., Batkovskyte,D., Washington,M., Dawson,B.C., Jin,Z.,
            Jiang,M.M., Chen,S., Chen,Y., Tran,A.A., Emrick,L.T., Murdock,D.R.,
            Hanchard,N.A., Zapata,G.E., Mehta,N.R., Weis,M.A., Scott,A.A.,
            Tremp,B.A., Phillips,J.B., Wegner,J., Taylor-Miller,T., Gibbs,R.A.,
            Muzny,D.M., Jhangiani,S.N., Hicks,J., Stottmann,R.W.,
            Dickinson,M.E., Seavitt,J.R., Heaney,J.D., Eyre,D.R.,
            Westerfield,M., De Matteis,M.A. and Lee,B.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     COPB2 loss of function causes a coatopathy with osteoporosis and
            developmental delay
  JOURNAL   Am J Hum Genet 108 (9), 1710-1724 (2021)
   PUBMED   34450031
  REMARK    GeneRIF: COPB2 loss of function causes a coatopathy with
            osteoporosis and developmental delay.
REFERENCE   4  (residues 1 to 905)
  AUTHORS   DiStasio,A., Driver,A., Sund,K., Donlin,M., Muraleedharan,R.M.,
            Pooya,S., Kline-Fath,B., Kaufman,K.M., Prows,C.A., Schorry,E.,
            Dasgupta,B. and Stottmann,R.W.
  TITLE     Copb2 is essential for embryogenesis and hypomorphic mutations
            cause human microcephaly
  JOURNAL   Hum Mol Genet 26 (24), 4836-4848 (2017)
   PUBMED   29036432
REFERENCE   5  (residues 1 to 905)
  AUTHORS   Shi,F., Ding,S., Zhao,S., Han,M., Zhuang,Y., Xu,T. and Wu,X.
  TITLE     A piggyBac insertion disrupts Foxl2 expression that mimics BPES
            syndrome in mice
  JOURNAL   Hum Mol Genet 23 (14), 3792-3800 (2014)
   PUBMED   24565867
REFERENCE   6  (residues 1 to 905)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (residues 1 to 905)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 905)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (residues 1 to 905)
  AUTHORS   Tarsounas,M., Heng,H.H., Ye,C.J., Pearlman,R.E. and Moens,P.B.
  TITLE     Identification of the mouse beta'-COP Golgi component as a
            spermatocyte autoantigen in scleroderma and mapping of its gene
            Copb2 to mouse chromosome 9
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 201-204 (1999)
   PUBMED   10702668
REFERENCE   10 (residues 1 to 905)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK088064.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088064.1, AK153352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.4 cM"
     Protein         1..905
                     /product="coatomer subunit beta'"
                     /note="p102; beta'-COP; beta'-coat protein; coatomer
                     protein complex, subunit beta 2 (beta prime)"
                     /calculated_mol_wt=102319
     Region          8..297
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Region          13..52
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Site            order(14,32,36,42..43,55..56,74,78,84..85,97..98,115,120,
                     126..127,141,159,164,170..171,183..184,204,208,214..215,
                     227..228,245,250,256..257,269..270,288,292)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          19..55
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          55..94
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          97..136
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          103..140
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          140..180
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          145..182
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          183..224
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          189..226
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          227..266
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          232..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          304..778
                     /region_name="Coatomer_WDAD_beta-like"
                     /note="Coatomer WD Associated Region from Coatomer Subunit
                     Beta and Beta'; cd22947"
                     /db_xref="CDD:438572"
     Region          304..347
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Region          350..388
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          353..387
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Region          390..425
                     /region_name="WD 8"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          393..425
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Region          431..462
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Region          466..519
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Region          523..562
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Site            order(556,586,705..707,734..735,756..757,760)
                     /site_type="other"
                     /note="coatomer beta'-subunit binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438572"
     Region          563..587
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:438572"
     Site            627
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P35606; propagated from
                     UniProtKB/Swiss-Prot (O55029.2)"
     Region          746..783
                     /region_name="WD 9"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Region          837..873
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55029.2)"
     Site            859
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P35606; propagated from
                     UniProtKB/Swiss-Prot (O55029.2)"
     CDS             1..905
                     /gene="Copb2"
                     /coded_by="NM_015827.2:91..2808"
                     /db_xref="CCDS:CCDS40734.1"
                     /db_xref="GeneID:50797"
                     /db_xref="MGI:MGI:1354962"
ORIGIN      
        1 mplrldikrk ltarsdrvks vdlhptepwm laslyngsvc vwnhetqtlv ktfevcdlpv
       61 raakfvarkn wvvtgaddmq irvfnyntle rvhmfeahsd yirciavhpt qpfiltssdd
      121 mliklwdwdk kwscsqvfeg hthyvmqivi npkdnnqfas asldrtikvw qlgssspnft
      181 leghekgvnc idyysggdkp ylisgaddrl vkiwdyqnkt cvqtleghaq nvscasfhpe
      241 lpiiitgsed gtvriwhsst yrlestlnyg mervwcvasl rgsnnvalgy degsiivklg
      301 reepamsmda ngkiiwakhs evqqanlkam gdteikdger lplavkdmgs ceiypqtiqh
      361 npngrfvvvc gdgeyiiyta malrnksfgs aqefawahds seyairesns ivkifknfke
      421 kksfkpdfga esiyggfllg vrsvnglafy dwentelirr ieiqpkhifw sdsgelvcia
      481 teesffilky lsekvlaaqe thegvtedgi edafevlgei qeivktglwv gdcfiytssv
      541 nrlnyyvgge ivtiahldrt myllgyipkd nrlylgdkel nivsysllvs vleyqtavmr
      601 rdfsmadkvl ptipkeqrtr vahflekqgf kqqaltvstd pehrfelalq lgelkiayql
      661 aveaeseqkw kqlaelaisk cqfslaqecl hhaqdyggll llatasgnas mvnklaegae
      721 rdgknnvafm syflqgklda clellirtgr lpeaaflart ylpsqvsrvv klwrenlskv
      781 nqkaaeslad pteyenlfpg lkeafvveew vkethadlwp akqyplvtpn eernvmeeak
      841 gfqpsrptaq qepdgkpass pvimasqtth keeksllele vdldnleled idttdinlde
      901 dildd
//
