LOCUS       NM_033370               3315 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coatomer protein complex, subunit beta 1 (Copb1),
            mRNA.
ACCESSION   NM_033370
VERSION     NM_033370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3315)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3315)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3315)
  AUTHORS   Peterson,T.A. and Stamnes,M.
  TITLE     ARF1-regulated coatomer directs the steady-state localization of
            protein kinase C epsilon at the Golgi apparatus
  JOURNAL   Biochim Biophys Acta 1833 (3), 487-493 (2013)
   PUBMED   23195223
REFERENCE   4  (bases 1 to 3315)
  AUTHORS   Takatalo,M.S., Tummers,M., Thesleff,I. and Ronnholm,R.
  TITLE     Novel Golgi protein, GoPro49, is a specific dental follicle marker
  JOURNAL   J Dent Res 88 (6), 534-538 (2009)
   PUBMED   19587158
REFERENCE   5  (bases 1 to 3315)
  AUTHORS   Bi,J., Tsai,N.P., Lu,H.Y., Loh,H.H. and Wei,L.N.
  TITLE     Copb1-facilitated axonal transport and translation of kappa
            opioid-receptor mRNA
  JOURNAL   Proc Natl Acad Sci U S A 104 (34), 13810-13815 (2007)
   PUBMED   17698811
  REMARK    GeneRIF: provides evidence for a microtubule-dependent, active
            axonal kappa opioid receptor mRNA-transport process that involves
            Copb1 and can stimulate localized translation
REFERENCE   6  (bases 1 to 3315)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3315)
  AUTHORS   Sagiv,Y., Legesse-Miller,A., Porat,A. and Elazar,Z.
  TITLE     GATE-16, a membrane transport modulator, interacts with NSF and the
            Golgi v-SNARE GOS-28
  JOURNAL   EMBO J 19 (7), 1494-1504 (2000)
   PUBMED   10747018
REFERENCE   8  (bases 1 to 3315)
  AUTHORS   Bogan,J.S. and Lodish,H.F.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   9  (bases 1 to 3315)
  AUTHORS   LI,W., Elliott,R.W., Novak,E.K. and Swank,R.T.
  TITLE     cDNA sequence and mapping of the mouse Copb gene encoding the beta
            subunit of the COPI coatomer complex
  JOURNAL   Somat Cell Mol Genet 25 (3), 177-183 (1999)
   PUBMED   11441537
REFERENCE   10 (bases 1 to 3315)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161930.7.
            
            On Nov 17, 2006 this sequence version replaced NM_033370.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030837.1, AK172214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC161930.7         151386-151460       c
            76-225              AC161930.7         150650-150799       c
            226-455             AC161930.7         146826-147055       c
            456-625             AC161930.7         145588-145757       c
            626-740             AC161930.7         143508-143622       c
            741-833             AC161930.7         142204-142296       c
            834-971             AC161930.7         137405-137542       c
            972-1091            AC161930.7         135130-135249       c
            1092-1199           AC161930.7         134307-134414       c
            1200-1346           AC161930.7         134074-134220       c
            1347-1492           AC161930.7         133567-133712       c
            1493-1589           AC161930.7         131719-131815       c
            1590-1750           AC161930.7         129977-130137       c
            1751-1871           AC161930.7         128955-129075       c
            1872-2099           AC161930.7         123727-123954       c
            2100-2279           AC161930.7         123383-123562       c
            2280-2424           AC161930.7         119983-120127       c
            2425-2544           AC161930.7         118423-118542       c
            2545-2690           AC161930.7         116306-116451       c
            2691-2780           AC161930.7         114402-114491       c
            2781-2936           AC161930.7         113243-113398       c
            2937-3315           AC161930.7         112339-112717       c
FEATURES             Location/Qualifiers
     source          1..3315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.31 cM"
     gene            1..3315
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /note="coatomer protein complex, subunit beta 1"
                     /db_xref="GeneID:70349"
                     /db_xref="MGI:MGI:1917599"
     exon            1..75
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            76..225
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2996
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /note="beta-COP; beta-coat protein"
                     /codon_start=1
                     /product="coatomer subunit beta"
                     /protein_id="NP_203534.1"
                     /db_xref="CCDS:CCDS21759.1"
                     /db_xref="GeneID:70349"
                     /db_xref="MGI:MGI:1917599"
                     /translation="MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKK
                     VIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVC
                     DAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIY
                     TIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQT
                     FGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPT
                     AIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPAHERVLQDLVMDILRVLSTPDL
                     EVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSV
                     RFPDMAANVIPVLMEFLSDSNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIK
                     SVKIYRGALWILGEYCSTKEDIQSVMTEVRRSLGEIPIVESEIKKEAGELKPEEEITV
                     GPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIAL
                     RYVALVQEKKKQNSFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECS
                     PLMNDIFNKECRQSLSQMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEM
                     NCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIV
                     LDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGI
                     IFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVN
                     TNMTDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSIFGEDALANVSIEKP
                     VHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKTSL"
     exon            226..455
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..625
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..740
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            741..833
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..971
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1091
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1199
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1346
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1492
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1589
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1750
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1871
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2099
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2279
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2424
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2544
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2690
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2780
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2936
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3315
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3257..3262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3276
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3313
                     /gene="Copb1"
                     /gene_synonym="2610019B04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcggcag cggctgtccg gaccggtagt cggcggtccc acggttccct cccggcctcc
       61 gcccctcgga gccagatttt cctggcacct ttcgtccttt tcatcttgta ttgggttgat
      121 tataaacaga aaccatgacg gcagccgaga acgtgtgcta tacgttaatt aacgtgccaa
      181 tggattcaga acccccttcg gaaatcagct taaaaaatga cctggagaaa ggcgatgtga
      241 agtcaaagac tgaagctttg aagaaagtga tcattatgat tctgaatggg gaaaagcttc
      301 ccggactcct gatgacaatc attcgcttcg tgctgcctct tcaggatcac accatcaaaa
      361 agttgctcct ggtcttctgg gagattgttc ctaaaacaac tccagatgga aggctcttac
      421 atgaaatgat tcttgtgtgt gatgcataca gaaaggatct ccagcacccc aatgagttta
      481 ttcgtggatc tactcttcgt ttcctttgca aattgaagga agcagaattg ctggaacctt
      541 taatgcctgc tatccgtgcg tgcttggaac atcgtcacag ctatgttagg agaaatgctg
      601 ttttggccat ctataccatc tacagaaatt ttgaacatct tatacctgat gctcctgaac
      661 tgatacatga ttttcttgtg aatgagaagg atgcaagctg caaaagaaat gcatttatga
      721 tgctaattca cgcagatcag gatcgagctt tggattattt aagtacatgt attgatcaag
      781 ttcagacatt tggagacatt ctacagttgg ttattgttga actaatttat aaggtctgtc
      841 atgctaatcc atcagaaagg gcccgcttca ttcgctgtat ctataactta ctgcagtcat
      901 ctagtcctgc tgtaaaatat gaggctgctg ggacactggt aacactgtca agtgcaccaa
      961 ctgcaataaa ggctgctgct cagtgttaca ttgatttaat tattaaggag agtgataaca
     1021 atgtaaagct catcgtcctg gaccgcttgg tggaattaaa agagcatcct gctcatgaac
     1081 gagtcctgca ggatctggtc atggacatcc taagagtact gagtacgcca gacttagaag
     1141 tgcgtaagaa aacgctgcag ttagcactgg atcttgtctc atctaggaat gttgaagagt
     1201 tggttattgt cttaaagaag gaagtaatta aaacaaataa tgtgtctgag catgaagaca
     1261 ctgacaaata ccgacagctt ctcgtgcgaa cactgcattc ctgctctgtc cgatttccag
     1321 atatggctgc aaatgttatt cctgtgttaa tggaatttct cagtgacagt aatgaagcag
     1381 cagctgctga tgtcttagag tttgttcgtg aagccattca gcgctttgac aacctgagaa
     1441 tgctgattgt tgagaagatg ctggaagtct tccatgctat taagtctgtc aagatttacc
     1501 gaggagcatt gtggatcctg ggagagtact gcagtacaaa ggaagacatt cagagtgtga
     1561 tgactgaggt ccgcaggtcc cttggggaga taccaattgt agaatcagaa ataaagaaag
     1621 aagctggcga gttaaaacca gaagaagaaa taactgttgg gcccgttcag aaattggtta
     1681 cggagatggg cacctatgct actcagagtg cgctcagcag ttccagacct accaagaaag
     1741 aagaagacag accacccttg agagggttcc tcctggatgg agatttcttt gttgctgctt
     1801 ccctcgccac aactctaacc aagattgcat tgcgctatgt agcgttggtt caggagaaga
     1861 aaaagcaaaa ttcttttgtt gctgaggcta tgttgcttat ggcaactatc cttcatttgg
     1921 gaaaatcctc tcttcctaag aagccaatta ctgatgatga tgtagatcga atttccctgt
     1981 gcctcaaggt cttatctgaa tgctcacctt taatgaatga catctttaat aaggagtgca
     2041 gacagtctct ttcccaaatg ttatctgcca aactcgaaga agagaaacta tcccagaaga
     2101 aagaatctga aaagagaaat gtgacagtac agcctgatga ccccatttcc ttcatgcaac
     2161 taactgcgaa gaatgaaatg aactgcaagg aagatcagtt ccagctgagt ttgttggcag
     2221 caatgggtaa tactcagagg aaagaggcag ctgatcccct agcatccaaa cttaacaagg
     2281 tcactcagtt gacaggcttc tcggatccag tgtatgcaga agcctatgtt catgtcaatc
     2341 agtacgacat cgtcctggat gttctggttg taaaccaaac cagtgatact ttgcagaact
     2401 gcacattaga gttagccact ctaggggatc tgaaacttgt ggaaaaacca tctcctttga
     2461 ctcttgctcc tcatgacttt gcaaatatta aagctaatgt caaggtagca tcaacagaaa
     2521 acggaataat ttttggcaat atagtttatg atgtttctgg agcagcaagt gacagaaact
     2581 gtgtggtcct cagtgacatc cacattgaca tcatggacta tatccagcct gcaacttgca
     2641 ctgatgctga gttccgtcag atgtgggccg aatttgaatg ggaaaataaa gtgacagtta
     2701 acaccaacat gactgacctg aatgactact tacagcacat cctcaagtcg accaacatga
     2761 agtgcctgac tccagagaag gccctttctg gatactgtgg ctttatggca gccaatcttt
     2821 atgcacgttc tatatttgga gaggatgcac ttgcaaatgt cagcattgag aagccagttc
     2881 accagggacc agatgctgcc gttactggcc atataagaat tcgtgcaaaa agtcagggaa
     2941 tggccttgag ccttggagat aaaatcaacc tgtctcaaaa gaagactagt ctataaggat
     3001 gaacaaaagg tctttgaaag tttatgctta aaatttaggt gtgggctgat tggactccaa
     3061 catcttttgt actcttttca tgctttatgt tatgtagaat ttgagttcat gctgaatgca
     3121 ttccagccag taatttatag cctttcccct aaatcaagaa tgagtttaaa attatagtct
     3181 gtcttttatc ttaacagttc tgaatgctgt cctcaaagta tataatgttt ctcatatgta
     3241 ccaagaccat tttcacaata aacagatctg ttcatacatt tttgttattt tataaataaa
     3301 ttacttaatt ttaga
//
