LOCUS       NM_026965               2241 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus catechol-O-methyltransferase domain containing 1
            (Comtd1), mRNA.
ACCESSION   NM_026965
VERSION     NM_026965.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Bi,H., Tranell,J., Harper,D.C., Lin,W., Li,J., Hellstrom,A.R.,
            Larsson,M., Rubin,C.J., Wang,C., Sayyab,S., Kerje,S., Bed'hom,B.,
            Gourichon,D., Ito,S., Wakamatsu,K., Tixier-Boichard,M., Marks,M.S.,
            Globisch,D. and Andersson,L.
  TITLE     A frame-shift mutation in COMTD1 is associated with impaired
            pheomelanin pigmentation in chicken
  JOURNAL   PLoS Genet 19 (4), e1010724 (2023)
   PUBMED   37068079
  REMARK    GeneRIF: A frame-shift mutation in COMTD1 is associated with
            impaired pheomelanin pigmentation in chicken.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Edinger,R.S., Yospin,J., Perry,C., Kleyman,T.R. and Johnson,J.P.
  TITLE     Regulation of epithelial Na+ channels (ENaC) by methylation: a
            novel methyltransferase stimulates ENaC activity
  JOURNAL   J Biol Chem 281 (14), 9110-9117 (2006)
   PUBMED   16469734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK054334.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026965.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054334.1, AK007659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2241              AK054334.1         2-2242
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.92 cM"
     gene            1..2241
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /note="catechol-O-methyltransferase domain containing 1"
                     /db_xref="GeneID:69156"
                     /db_xref="MGI:MGI:1916406"
     exon            1..132
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..827
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /note="O-methyltransferase-containing protein"
                     /codon_start=1
                     /product="catechol O-methyltransferase domain-containing
                     protein 1"
                     /protein_id="NP_081241.1"
                     /db_xref="CCDS:CCDS26868.1"
                     /db_xref="GeneID:69156"
                     /db_xref="MGI:MGI:1916406"
                     /translation="MAQPVPRLSIPAALALGSAALGAAFATGLLLGKRWPPWGSRRQE
                     RLLPPEDNPLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIK
                     AKKALDLGTFTGYSALALALALPEAGRVVTCEVDAEPPKLGRPMWKQAEVEQKIDLRL
                     QPALQTLDELLAAGEAGTFDIAVVDADKENCTAYYERCLQLLRPGGVLAVLRVLWRGE
                     VLQPQPRNKTVECVRNLNERILRDARVYISLLPLDDGLSLAFKI"
     exon            133..260
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     exon            261..366
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     exon            367..485
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     exon            486..540
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     exon            541..674
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     exon            675..2241
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /note="hexamer: AATAAA"
     polyA_site      923
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /note="major polyA site"
     regulatory      1025..1030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
                     /note="hexamer: AATAAA"
     polyA_site      1044
                     /gene="Comtd1"
                     /gene_synonym="1810030M08Rik; MT773"
ORIGIN      
        1 agcacacgtg acctccgccg ccgctgctaa cctgcaccat ggctcagccc gtccctcggc
       61 tatctatccc agccgcactg gccctgggct cggccgcgct gggcgccgcc ttcgctactg
      121 gtctcttgct ggggaaacgg tggcctccat gggggtccag gcggcaagag cgcctgctgc
      181 cacctgagga caatcccctg tggcagtatc tgctgagccg ctccatgaga gagcacccgg
      241 cgctgcggag cctgcgactg ctgaccctgg agcagccgca gggggattcc atgatgacct
      301 gtgaacaggc ccagcttctg gccaacctgg cgcggctcat taaggccaag aaagctctgg
      361 atctgggtac tttcacgggc tactcggccc tggccctagc cttggcgctt ccggaggctg
      421 gccgcgtggt gacctgcgag gttgacgcag agcccccgaa gctgggacgg cccatgtgga
      481 agcaggcaga agtggagcag aagatcgacc ttcggctgca gcccgccctg cagacattgg
      541 atgagctcct agcggcgggc gaggccggaa ccttcgacat agccgtggtg gacgcggaca
      601 aagagaactg taccgcctac tacgagcgct gtctgcagct cctacgtccc ggaggcgtgc
      661 tcgctgtact cagagtcctg tggcgcggag aagtgctgca gcctcagccc aggaacaaga
      721 ctgttgaatg tgtgcggaac ctgaacgaac gcatcctgag ggacgccagg gtctacatca
      781 gcctcctgcc cctggatgat ggcctctcct tggcctttaa gatctagggt taacacgaag
      841 cttagggcct gggtgtgaga acctaagacc cccagccagt gacctgactt ttaaacctga
      901 caataaaggt actggacacg cgaccttctg agcatcctct tccagcgttc acttggtgga
      961 gggttccctc cctgcaggtc tccctggcac caaggcttgt ggccttatct gaccgcatag
     1021 ttttaataaa ttgtcctagc tgtactcact gagtagagtt ccaacaggct tggatataag
     1081 ggaagaccct atctgtctct ggcctcccag ccacatgcca cagagatgtc gagatagggc
     1141 cttttatagc tggcagtcta ctcatgtttt cacagggctg aagcctcccc agcctaactt
     1201 gtgtgcagtg gaagcccaga ctacaggacc taaggttggc tggcatttct atctgctccc
     1261 tcatcccctt aagtcctaag ggaggagact gatggccaag gtgcaaagca gacagagtgg
     1321 gaagccaacc tcattcaaga aacctcagga acttgaagct tttgcagcac tgtccttttg
     1381 ggggacacta taaggagcca acctttattg acctgaggcc tggtgctttg ctgctctaga
     1441 agaaaggtaa agttctttgt actgaggcag aaaggacagt ttctgggaca ccacaggttt
     1501 gccactctgg ggtaagaaag gcccaagtga tgtgcactta gcagctgcta caagtacaga
     1561 tgtgtgagcc cacaactgag tccctgccac acaccaccaa ccctctgggg actagctgtg
     1621 ccctacccct tcttcacaag tcacaagtac atactgaggt gcacacaggg gacctggtcc
     1681 aatccatttt gaagtgcctt tgatgcactg gtagcccaca tgagtccact cgctcagcag
     1741 agccagcatg aagaacactt gttagctgag ggtcacaggg cagtaacatg caccatttct
     1801 attgggtaag tcccaaagta cccattttct tagctgtcct ctcaagttta aactacacct
     1861 cagaagtgac actcacctct cacctgtgac acaccacctc cccagggaag ctggcacggt
     1921 cctacttttc caaccaggat cactaggtaa tacatatcac ccaggtgatg gcgaaggggg
     1981 ctgcctggtc cagaccccag ctcagctttt caacgctgtc aatagaagag aatggtgccc
     2041 actttctcct ctcttggcct gttgcttcca tctacccagg ctccactttc tgtagcgtgg
     2101 ctcagaagga aggggatgca tgcctattta gccactcagc accacccctg catctccctt
     2161 catcatccat gggttaacag tgattcactc taactttgca caaacttaga aactgcagag
     2221 tattaaagta tgtatccttg t
//
