LOCUS       NM_001111062            2185 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus catechol-O-methyltransferase (Comt), transcript
            variant 1, mRNA.
ACCESSION   NM_001111062
VERSION     NM_001111062.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Utami,K.H., Yusof,N.A.B.M., Garcia-Miralles,M., Skotte,N.H.,
            Nama,S., Sampath,P., Langley,S.R. and Pouladi,M.A.
  TITLE     Dysregulated COMT Expression in Fragile X Syndrome
  JOURNAL   Neuromolecular Med 25 (4), 644-649 (2023)
   PUBMED   37684514
  REMARK    GeneRIF: Dysregulated COMT Expression in Fragile X Syndrome.
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Zhou,Q., Yang,L., Verne,M.L., Zhang,B.B., Fields,J. and Verne,G.N.
  TITLE     Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive
            Signaling via the Enteric
            Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor
            alpha Axis
  JOURNAL   Gastroenterology 164 (4), 630-641 (2023)
   PUBMED   36623778
  REMARK    GeneRIF: Catechol-O-Methyltransferase Loss Drives Cell-Specific
            Nociceptive Signaling via the Enteric
            Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor
            alpha Axis.
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Jimenez,H., Adrien,L., Wolin,A., Eun,J., Chang,E.H., Burstein,E.S.,
            Gomar,J., Davies,P. and Koppel,J.
  TITLE     The impact of pimavanserin on psychotic phenotypes and tau
            phosphorylation in the P301L/COMT- and rTg(P301L)4510 mouse models
            of Alzheimer's disease
  JOURNAL   Alzheimers Dement (N Y) 8 (1), e12247 (2022)
   PUBMED   35128032
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399. PMID: 9110179]
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Yeung,R.S., Bell,D.W. and Testa,J.R.
  TITLE     The Vpreb1 and comt genes are closely linked and sublocalized to
            rat chromosome 11q23
  JOURNAL   Mamm Genome 7 (3), 246-247 (1996)
   PUBMED   9162259
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Pauken,C.M., Nagle,D.L., Bucan,M. and Lo,C.W.
  TITLE     Molecular cloning, expression analysis, and chromosomal
            localization of mouse Hmg1-containing sequences
  JOURNAL   Mamm Genome 5 (2), 91-99 (1994)
   PUBMED   8180479
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Yeung,R.S., Buetow,K.H., Testa,J.R. and Knudson,A.G. Jr.
  TITLE     Susceptibility to renal carcinoma in the Eker rat involves a tumor
            suppressor gene on chromosome 10
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 8038-8042 (1993)
   PUBMED   8103600
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   Bucan,M., Gatalica,B., Nolan,P., Chung,A., Leroux,A.,
            Grossman,M.H., Nadeau,J.H., Emanuel,B.S. and Budarf,M.
  TITLE     Comparative mapping of 9 human chromosome 22q loci in the
            laboratory mouse
  JOURNAL   Hum Mol Genet 2 (8), 1245-1252 (1993)
   PUBMED   8401507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX237493.1, AK148311.1, AC133487.14 and AW908224.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148311.1, DV051152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               CX237493.1         1-333
            334-1485            AK148311.1         1-1152
            1486-1763           AC133487.14        84460-84737
            1764-2185           AW908224.1         1-422
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.4 cM"
     gene            1..2185
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /note="catechol-O-methyltransferase"
                     /db_xref="GeneID:12846"
                     /db_xref="MGI:MGI:88470"
     exon            1..361
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            362..418
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1216
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /EC_number="2.1.1.6"
                     /note="catechol-O-methyltransferase 1"
                     /codon_start=1
                     /product="catechol O-methyltransferase"
                     /protein_id="NP_001104532.1"
                     /db_xref="CCDS:CCDS28021.1"
                     /db_xref="GeneID:12846"
                     /db_xref="MGI:MGI:88470"
                     /translation="MLLAAVSLGLLLLAFLLLLRHLGWGLVAIGWFEFVQQPVHNLLM
                     GGTKEQRILRHVQQHAKPGDPQSVLEAIDTYCSEKEWAMNVGDAKGQIMDAVIREYRP
                     SLVLELGAYCGYSAVRMARLLPPGARLLTMEINPDYAAITQQMLDFAGLQDKVSILIG
                     ASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPG
                     TPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAVYQGPGSSPVKS"
     exon            419..686
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            687..880
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1012
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..2171
                     /gene="Comt"
                     /gene_synonym="Comt1; D16Wsu103e; D330014B15Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccctgc tagaagcagg tcccctccta atcagaaccc tggcctgtgt gggcacgccc
       61 acgcggacac gttccaggac agccccgcca ccgcgacccc ctgtggacac tcgcacaggc
      121 accctctccg cgtgcaccgc ccacgacccc accctacctc ccgctgcact cgccgcgccc
      181 cttgtcccgc gtgtcagagc ccgtgtccgc ggccggaagc gcctgctggg tccacgcagc
      241 gccgccacca tcgccgccac catcgccgcc atggtccggg gacctcaggc ggtcagggct
      301 gcccttcgca ctgcctgagc gtccgcgcct cggggtcaga cctgtgcgcg gccttgacga
      361 ggggatgaga gagtcctacc acagtgaaac tcaaagttac agacattctg gcccataaat
      421 gctgttggct gctgtctcat tgggtctcct gttgctggcc ttcctcctgc tcctgcgaca
      481 cctaggctgg ggcttggtgg ctattggttg gtttgagttc gtgcagcagc cggtccacaa
      541 cctgctcatg ggtggcacaa aggagcagcg catcctgcgc catgtgcagc aacacgcaaa
      601 gcctggagac ccccagagcg tcctggaggc cattgatacc tactgctcag agaaggagtg
      661 ggccatgaac gtgggtgacg caaaaggcca aatcatggat gcagtgattc gggagtacag
      721 gccctcgctg gtgctggagc taggagctta ttgtggctac tcagccgtgc gaatggcccg
      781 cctgctgcca cctggagcca ggcttctcac catggagatt aaccctgact acgctgccat
      841 cacccagcaa atgctggact tcgcaggcct acaggacaaa gtttccatcc tcatcggggc
      901 atcccaggac cttatccccc agctgaagaa gaagtacgat gtggacacat tagacatggt
      961 ctttcttgac cactggaaag accgctacct tccagacaca cttctcctgg aggaatgtgg
     1021 cctgctgcgc aaggggacgg tgctcctagc tgacaatgtc attgtcccgg gaacccctga
     1081 cttcctggcg tatgtgaggg ggagcagcag cttcgagtgc acacactaca gctcatacct
     1141 ggagtacatg aaagtggtgg acggcttgga gaaggcagtc taccagggtc caggcagcag
     1201 ccccgtgaag tcctgaccac tcagcctgat gagcttccgt cccagctccc ttctgcacga
     1261 tgacacacac tcactctgac cccctctatg cttctggggc ctttcctcag ggcctgtggc
     1321 tccagattgt catacactgg cacattaaag gtagtgagct caccatgcaa accactacaa
     1381 tacccctgga aaacacctgt gcatcaaagg ctgcattgag gccagagatg cagtagatca
     1441 cagtgcgtgc ctggcacgca aaacccctca cggtgaatcc tctgcaccca agaacaaaaa
     1501 gggagattta aaaaaaaaaa aaaaggggga ctggtgagat ggctcagtgg gtaagagcac
     1561 ccgactgctc ttctgaaggt ccagagttca aatcccagca accacatggt ggctcacaac
     1621 catccgtaac aagatctgat gccctcttct ggtgtgtctg aagacagcta cagtgtattt
     1681 acatataata aataaataaa tcttttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaaatc aaagcaggtg tcatcctgat ggcctcacta actggaagag
     1801 gagatttttt acaaagtttc agtgtgggat ccctaggcac tgccatcact cagcaagaag
     1861 tcaggaaact gaacatatcc agataccatt cggctgtcac caatggcagc aacgactcag
     1921 acggtactgt caccagcaac tcataccaca tttcatctta agaatgagtc acaaactttt
     1981 caggtatgat ggcgcatgcc tttaatccca gaatccagga ggcagaggca gatggatctg
     2041 agttctgtgc cagcctggtc tacacagtga gttccaggac agccagggct acatagaaat
     2101 actttgaaaa aaaaagtcat aatctctttt atattataaa agaaattaaa gatctaaata
     2161 tttggatata aaaaaaaaaa aaaaa
//
