LOCUS       NM_016685               2447 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cartilage oligomeric matrix protein (Comp), mRNA.
ACCESSION   NM_016685
VERSION     NM_016685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2447)
  AUTHORS   Liu,A., Wang,Y., Zheng,S., Bao,Z., Zhu,H., Yin,L., Liu,C., Zhao,X.,
            Zhao,Z., Zhu,D. and Yu,H.
  TITLE     Endonuclear Circ-calm4 regulates ferroptosis via a circR-Loop of
            the COMP gene in pulmonary artery smooth muscle cells
  JOURNAL   Eur J Pharmacol 982, 176944 (2024)
   PUBMED   39187041
  REMARK    GeneRIF: Endonuclear Circ-calm4 regulates ferroptosis via a
            circR-Loop of the COMP gene in pulmonary artery smooth muscle
            cells.
REFERENCE   2  (bases 1 to 2447)
  AUTHORS   Wang,Y., Li,H.T., Liu,G., Jiang,C.S., Ni,Y.H., Zeng,J.H., Lin,X.,
            Wang,Q.Y., Li,D.Z., Wang,W. and Zeng,X.P.
  TITLE     COMP promotes pancreatic fibrosis by activating pancreatic stellate
            cells through CD36-ERK/AKT signaling pathways
  JOURNAL   Cell Signal 118, 111135 (2024)
   PUBMED   38479555
  REMARK    GeneRIF: COMP promotes pancreatic fibrosis by activating pancreatic
            stellate cells through CD36-ERK/AKT signaling pathways.
REFERENCE   3  (bases 1 to 2447)
  AUTHORS   Cai,X., Li,M., Zhong,Y., Yang,W. and Liang,Z.
  TITLE     COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-beta
            Signaling Pathway
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 305-316 (2023)
   PUBMED   37584842
  REMARK    GeneRIF: COMP Improves Ang-II-Induced Atrial Fibrillation via
            TGF-beta Signaling Pathway.
REFERENCE   4  (bases 1 to 2447)
  AUTHORS   Ruscitto,A., Chen,P., Tosa,I., Wang,Z., Zhou,G., Safina,I., Wei,R.,
            Morel,M.M., Koch,A., Forman,M., Reeve,G., Lecholop,M.K., Wilson,M.,
            Bonthius,D., Chen,M., Ono,M., Wang,T.C., Yao,H. and Embree,M.C.
  TITLE     Lgr5-expressing secretory cells form a Wnt inhibitory niche in
            cartilage critical for chondrocyte identity
  JOURNAL   Cell Stem Cell 30 (9), 1179-1198 (2023)
   PUBMED   37683603
REFERENCE   5  (bases 1 to 2447)
  AUTHORS   Chen,Y., Wu,J., Zhang,S., Gao,W., Liao,Z., Zhou,T., Li,Y., Su,D.,
            Liu,H., Yang,X., Su,P. and Xu,C.
  TITLE     Hnrnpk maintains chondrocytes survival and function during growth
            plate development via regulating Hif1alpha-glycolysis axis
  JOURNAL   Cell Death Dis 13 (9), 803 (2022)
   PUBMED   36127325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2447)
  AUTHORS   Costell,M., Gustafsson,E., Aszodi,A., Morgelin,M., Bloch,W.,
            Hunziker,E., Addicks,K., Timpl,R. and Fassler,R.
  TITLE     Perlecan maintains the integrity of cartilage and some basement
            membranes
  JOURNAL   J Cell Biol 147 (5), 1109-1122 (1999)
   PUBMED   10579729
REFERENCE   7  (bases 1 to 2447)
  AUTHORS   Murphy,J.M., Heinegard,R., McIntosh,A., Sterchi,D. and Barry,F.P.
  TITLE     Distribution of cartilage molecules in the developing mouse joint
  JOURNAL   Matrix Biol 18 (5), 487-497 (1999)
   PUBMED   10601736
REFERENCE   8  (bases 1 to 2447)
  AUTHORS   Aszodi,A., Chan,D., Hunziker,E., Bateman,J.F. and Fassler,R.
  TITLE     Collagen II is essential for the removal of the notochord and the
            formation of intervertebral discs
  JOURNAL   J Cell Biol 143 (5), 1399-1412 (1998)
   PUBMED   9832566
REFERENCE   9  (bases 1 to 2447)
  AUTHORS   Aszodi,A., Hauser,N., Studer,D., Paulsson,M., Hiripi,L. and
            Bosze,Z.
  TITLE     Cloning, sequencing and expression analysis of mouse cartilage
            matrix protein cDNA
  JOURNAL   Eur J Biochem 236 (3), 970-977 (1996)
   PUBMED   8665920
REFERENCE   10 (bases 1 to 2447)
  AUTHORS   Newton,G., Weremowicz,S., Morton,C.C., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Lawler,J.
  TITLE     Characterization of human and mouse cartilage oligomeric matrix
            protein
  JOURNAL   Genomics 24 (3), 435-439 (1994)
   PUBMED   7713493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY328097.1, AF033530.1, AC158553.13 and CJ324165.1.
            
            On Dec 11, 2007 this sequence version replaced NM_016685.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033530.1, BC128368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               BY328097.1         2-359
            359-1820            AF033530.1         349-1810
            1821-1848           AC158553.13        84427-84454         c
            1849-1979           AF033530.1         1839-1969
            1980-2424           CJ324165.1         3-447
            2425-2447           AF033530.1         2416-2438
FEATURES             Location/Qualifiers
     source          1..2447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..2447
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /note="cartilage oligomeric matrix protein"
                     /db_xref="GeneID:12845"
                     /db_xref="MGI:MGI:88469"
     exon            1..100
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            101..186
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            187..238
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            239..408
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            409..546
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            547..621
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            622..780
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            781..885
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            886..993
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1153
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1272
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1325
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1507
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1686
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1735
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1932
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2105
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2245
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2426
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2405..2410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /note="hexamer: AATAAA"
     polyA_site      2426
                     /gene="Comp"
                     /gene_synonym="TSP5"
                     /note="major polyA site"
ORIGIN      
        1 gacagcagct gcagctccgc cgccatgggc cccactgcct gcgttctagt gctcgccctg
       61 gctatcctgc gggcgacagg ccagggccag atcccgctgg gtggagacct ggccccacag
      121 atgctgcgag aacttcagga gactaatgcg gcgctgcaag acgtgagaga gctgttgcga
      181 cagcaggtca aggagatcac cttcctgaag aatacggtga tggaatgtga tgcttgcgga
      241 atgcagcccg cacgcactcc aggcctgagc gtgcggccag tgccgctctg cgcacccggc
      301 tcctgcttcc ccggcgtagt ctgctccgag acagctacgg gcgcgcgctg cggcccctgc
      361 cctcctggct acaccggcaa cggctcgcac tgcaccgacg ttaatgagtg caatgctcac
      421 ccctgtttcc cgcgggtgcg gtgcatcaat accagccctg gctttcactg cgaagcctgt
      481 ccccctgggt tcagcggacc cacccacgag ggcgtgggac tgaccttcgc taagtccaac
      541 aaacaagttt gcacggatat taatgagtgt gagaccgggc agcacaattg cgttcccaac
      601 tccgtgtgcg tcaacacccg gggctccttc cagtgcggcc cctgccagcc cggtttcgtg
      661 ggcgaccaga cgtcaggctg ccagcggcgt gggcagcact tctgccccga tgggtcaccc
      721 agcccgtgcc atgagaaagc aaactgcgtc ctggagcggg atggctcgag gtcttgcgtg
      781 tgtgcagttg gctgggccgg caacgggctc ctgtgcggcc gcgacacgga cctggacggt
      841 tttcctgacg agaagcttcg ctgctcagag cgccagtgtc gcaaggacaa ctgcgtgacg
      901 gtgcccaatt cggggcagga ggatgtggac cgggacggca tcggagatgc ttgtgacccg
      961 gatgcggacg gggatggagt ccctaacgag caagacaatt gcccgctggt tcgaaaccca
     1021 gaccagcgta actcggacag tgataagtgg ggagatgcct gcgacaactg ccggtccaag
     1081 aagaatgacg atcagaaaga tacagacctg gatggccggg gcgatgcctg cgacgacgac
     1141 atagatggcg accgaatacg aaatgtagct gacaactgtc cccgggtgcc caactttgac
     1201 cagagtgaca gtgatggtga tggtgttggg gatgcctgtg acaactgtcc ccagaaagat
     1261 aacccagacc agagggatgt ggaccacgac tttgtgggtg atgcctgtga tagtgaccaa
     1321 gaccaggatg gggatggtca ccaggactcc cgggacaact gccccacagt acccaacagt
     1381 gcccagcagg actcagatca tgatggcaag ggcgatgcct gtgatgacga tgatgacaat
     1441 gacggagttc ctgatagccg ggacaactgc cgcttggtgc ctaaccctgg ccaagaggac
     1501 aatgaccggg atggcgtggg tgacgcgtgt cagggtgact tcgatgctga caaggttata
     1561 gacaagatcg atgtgtgccc cgagaacgcc gaggtcaccc tcaccgactt cagggccttc
     1621 cagacggttg tgttggaccc cgagggtgat gcgcagatcg atcccaactg ggtggtgctc
     1681 aatcagggaa tggagatcgt tcagaccatg aacagtgacc ctggcctggc tgtgggttac
     1741 acagccttca acggcgtgga cttcgagggc acattccatg taaacaccgc cactgatgat
     1801 gactatgctg gtttcatctt cggctaccaa gacagctcca gtttctacgt agtcatgtgg
     1861 aaacagatgg agcagacgta ctggcaggcc aatcccttcc gggctgtggc tgagccaggg
     1921 attcagctca aggctgtcaa gtcctctaca ggtcccgggg aacagctccg aaacgcactg
     1981 tggcacacgg gggacacagc atcccaggtg cggctgctgt ggaaggatcc tcgaaacgtg
     2041 ggctggaagg ataaaacatc ctaccgctgg ttcctgcagc accggcctca agttggctac
     2101 atcagggtgc ggttctatga gggtcctgag ctagtagctg acagcaatgt ggtgttggac
     2161 acggccatgc gtggtggccg cctgggtgtc ttctgcttct cccaagagaa catcatctgg
     2221 gctaacctgc gctaccgttg caatgataca atccctgagg actacgagag tcaccggctg
     2281 cagagagtct agggaccagt ggggtcccgc tgcctgatgg actgtggtgg cacaagctac
     2341 gggtgtgtgt gtgggggggt ctggcatccc tctgaagggg tgtctggcct ggggaggaga
     2401 ggcaaataaa gtacgtatgt gggggaaaaa aaaaaaaaaa aaaaaaa
//
