LOCUS       NM_029635               1175 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus COMM domain containing 9 (Commd9), mRNA.
ACCESSION   NM_029635
VERSION     NM_029635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Singla,A., Chen,Q., Suzuki,K., Song,J., Fedoseienko,A., Wijers,M.,
            Lopez,A., Billadeau,D.D., van de Sluis,B. and Burstein,E.
  TITLE     Regulation of murine copper homeostasis by members of the COMMD
            protein family
  JOURNAL   Dis Model Mech 14 (1) (2021)
   PUBMED   33262129
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Miyata,N., Morris,L.L., Chen,Q., Thorne,C., Singla,A., Zhu,W.,
            Winter,M., Melton,S.D., Li,H., Sifuentes-Dominguez,L., Llano,E.,
            Huff-Hardy,K., Starokadomskyy,P., Lopez,A., Reese,T.A., Turer,E.,
            Billadeau,D.D., Winter,S.E. and Burstein,E.
  TITLE     Microbial Sensing by Intestinal Myeloid Cells Controls
            Carcinogenesis and Epithelial Differentiation
  JOURNAL   Cell Rep 24 (9), 2342-2355 (2018)
   PUBMED   30157428
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Fedoseienko,A., Wijers,M., Wolters,J.C., Dekker,D., Smit,M.,
            Huijkman,N., Kloosterhuis,N., Klug,H., Schepers,A., Willems van
            Dijk,K., Levels,J.H.M., Billadeau,D.D., Hofker,M.H., van
            Deursen,J., Westerterp,M., Burstein,E., Kuivenhoven,J.A. and van de
            Sluis,B.
  TITLE     The COMMD Family Regulates Plasma LDL Levels and Attenuates
            Atherosclerosis Through Stabilizing the CCC Complex in Endosomal
            LDLR Trafficking
  JOURNAL   Circ Res 122 (12), 1648-1660 (2018)
   PUBMED   29545368
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Bartuzi,P., Billadeau,D.D., Favier,R., Rong,S., Dekker,D.,
            Fedoseienko,A., Fieten,H., Wijers,M., Levels,J.H., Huijkman,N.,
            Kloosterhuis,N., van der Molen,H., Brufau,G., Groen,A.K.,
            Elliott,A.M., Kuivenhoven,J.A., Plecko,B., Grangl,G.,
            McGaughran,J., Horton,J.D., Burstein,E., Hofker,M.H. and van de
            Sluis,B.
  TITLE     CCC- and WASH-mediated endosomal sorting of LDLR is required for
            normal clearance of circulating LDL
  JOURNAL   Nat Commun 7, 10961 (2016)
   PUBMED   26965651
  REMARK    GeneRIF: Increased total plasma cholesterol levels are seen in
            hepatic COMMD9-deficient mice.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Li,H., Koo,Y., Mao,X., Sifuentes-Dominguez,L., Morris,L.L., Jia,D.,
            Miyata,N., Faulkner,R.A., van Deursen,J.M., Vooijs,M.,
            Billadeau,D.D., van de Sluis,B., Cleaver,O. and Burstein,E.
  TITLE     Endosomal sorting of Notch receptors through COMMD9-dependent
            pathways modulates Notch signaling
  JOURNAL   J Cell Biol 211 (3), 605-617 (2015)
   PUBMED   26553930
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1175)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL929534.12.
            
            On May 1, 2007 this sequence version replaced NM_029635.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007640.1, BC060058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL929534.12        133878-133935
            59-184              AL929534.12        142751-142876
            185-324             AL929534.12        144656-144795
            325-359             AL929534.12        146484-146518
            360-463             AL929534.12        147485-147588
            464-1175            AL929534.12        148544-149255
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.07 cM"
     gene            1..1175
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /note="COMM domain containing 9"
                     /db_xref="GeneID:76501"
                     /db_xref="MGI:MGI:1923751"
     exon            1..58
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..604
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /codon_start=1
                     /product="COMM domain-containing protein 9"
                     /protein_id="NP_083911.1"
                     /db_xref="CCDS:CCDS16465.1"
                     /db_xref="GeneID:76501"
                     /db_xref="MGI:MGI:1923751"
                     /translation="MAALTAEHFVALQSLLKASSKDVVRQLCQESFSSSCLDSESLLD
                     KTCSSLSVPQGEAAQLLQALHHFTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKII
                     VEHISTWRAEAQANQISLPRLVDLDWRVDIKTSSDNISRMAVPTCLLQMKIQEDPSLC
                     GEKPSISAVTMELSKETLDTMLDGLGRIRDQLSAVANK"
     exon            59..184
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            185..324
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            325..359
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..463
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1175
                     /gene="Commd9"
                     /gene_synonym="1810029F08Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaagatg gcggccttga cagcagagca tttcgtggcg ctccagagcc tactgaaggc
       61 ctcctcaaaa gatgttgtcc gacaactgtg ccaagaaagc ttctccagtt catgccttga
      121 ctcagaaagc ctcctagata agacgtgctc cagcttgtct gtgccccagg gggaggcagc
      181 gcaactgctg caggctctgc accacttcac caggctggtg gccttccgtg acctgtcctc
      241 tgctgaggcg attctggctc tctttccgga aaatttccac caaaacctca aaaacctgct
      301 gacaaaaatc atcgtggagc acatatcgac ttggagagct gaagcccaag caaaccagat
      361 ctctctgcca cgcctggtgg acctggactg gagagtggac atcaaaacct cctctgacaa
      421 catcagccgc atggctgtcc ccacctgcct gctccagatg aagatccagg aggatcctag
      481 tctgtgtgga gagaaaccct ccatctcggc tgtgaccatg gagctgagca aagagacgct
      541 ggacaccatg ttagatgggc tgggtcgcat tcgggaccag ctttctgctg tagctaataa
      601 ataaggcaac cagctattgg cctgcgaagg tgtggttgtc cgcacagagg ctgacggtgg
      661 gcagacagtg tgatggaggg gctgctgcta ctcagaaggc tcagtagagg aacggaagcc
      721 cacgcccatt gttcctctct tttcttcctc ctgtttttcc tgaagatgag aagaagcctc
      781 catctctgag aaggccctgt gtggtgctaa gctaccgcca gccgtggcag cccgagggaa
      841 tgtgttcttt atcagccgcc tgtgcgtgct gctgtggaga gctcaggccg gcaccgtggc
      901 actcacctag tgaggttacc tccagcatta gctcgggtga gctcacttcc agccctggaa
      961 tacatggagg ggattagggg tgaggccagc agtgcctgct ccccggcaga gagaagccag
     1021 cagacagata gcagcacggt cccctcagac ccttctctga gcttgcagcc ctgctgggcc
     1081 acagctccag ttcggaaaac tggaacacac catttgccac tattcccggg ctagaaagta
     1141 gaaagggttg gaaataaata acggtgatgg ttctg
//
