LOCUS       NM_178599               3894 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus COMM domain containing 8 (Commd8), transcript variant
            1, mRNA.
ACCESSION   NM_178599
VERSION     NM_178599.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3894)
  AUTHORS   Shirai,T., Nakai,A., Ando,E., Fujimoto,J., Leach,S., Arimori,T.,
            Higo,D., van Eerden,F.J., Tulyeu,J., Liu,Y.C., Okuzaki,D.,
            Murayama,M.A., Miyata,H., Nunomura,K., Lin,B., Tani,A.,
            Kumanogoh,A., Ikawa,M., Wing,J.B., Standley,D.M., Takagi,J. and
            Suzuki,K.
  TITLE     Celastrol suppresses humoral immune responses and autoimmunity by
            targeting the COMMD3/8 complex
  JOURNAL   Sci Immunol 8 (81), eadc9324 (2023)
   PUBMED   37000855
REFERENCE   2  (bases 1 to 3894)
  AUTHORS   Nakai,A., Fujimoto,J., Miyata,H., Stumm,R., Narazaki,M., Schulz,S.,
            Baba,Y., Kumanogoh,A. and Suzuki,K.
  TITLE     The COMMD3/8 complex determines GRK6 specificity for
            chemoattractant receptors
  JOURNAL   J Exp Med 216 (7), 1630-1647 (2019)
   PUBMED   31088898
REFERENCE   3  (bases 1 to 3894)
  AUTHORS   Lengeling,A., Wiltshire,T., Otmani,C. and Bucan,M.
  TITLE     A sequence-ready BAC contig of the GABAA receptor gene cluster
            Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5
  JOURNAL   Genome Res 9 (8), 732-738 (1999)
   PUBMED   10447508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122915.2.
            
            On Oct 12, 2017 this sequence version replaced NM_178599.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170011.1, AK077934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC122915.2         169642-169752       c
            112-267             AC122915.2         166914-167069       c
            268-420             AC122915.2         164285-164437       c
            421-576             AC122915.2         162471-162626       c
            577-3894            AC122915.2         158139-161456       c
FEATURES             Location/Qualifiers
     source          1..3894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..3894
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /note="COMM domain containing 8"
                     /db_xref="GeneID:27784"
                     /db_xref="MGI:MGI:1343485"
     exon            1..111
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..597
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /note="isoform a is encoded by transcript variant 1; COMM
                     domain-containing protein 8"
                     /codon_start=1
                     /product="COMM domain-containing protein 8 isoform a"
                     /protein_id="NP_848714.1"
                     /db_xref="CCDS:CCDS39108.1"
                     /db_xref="GeneID:27784"
                     /db_xref="MGI:MGI:1343485"
                     /translation="MEPEEGTPLWRLQKLPPEQGAGLLHKIIDGFCGRAYPAHQDYHS
                     VWNSAEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCHQEAVLKCLKSRRNEIK
                     QALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPYTVEM
                     SKEELQSLISSLEAANKVVLQLK"
     exon            112..267
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /inference="alignment:Splign:2.1.0"
     exon            268..420
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /inference="alignment:Splign:2.1.0"
     exon            421..576
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /inference="alignment:Splign:2.1.0"
     exon            577..3894
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /note="hexamer: AATACA"
     polyA_site      1461
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /note="major polyA site"
     regulatory      3874..3879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
                     /note="hexamer: CATAAA"
     polyA_site      3894
                     /gene="Commd8"
                     /gene_synonym="D5Buc26e"
ORIGIN      
        1 taaggttcag gcctgtcacg tgacaggtat ctctacttct cggggatgga gccggaagag
       61 gggacgccgc tttggcggct acagaagctg cctccggagc agggcgccgg gcttcttcac
      121 aaaatcattg atggcttctg tggccgagct tatcctgccc accaggatta tcacagtgtc
      181 tggaattcag ctgagtggaa gcatgttctc gaagatgtta ccacgttttt caaagcggtc
      241 gttggcaaaa acttctctga ggaagagaca ctccagcaac tgaaccaact gaattcatgt
      301 caccaagaag ctgttttgaa atgtttaaag agtaggagaa atgagatcaa gcaggccctg
      361 ttgggggaaa tagttgatat ttcttgtgcg cagctgcagg attttgattg gcagttaaag
      421 ctcgcgcttt ctagtgacaa gattgccacc ttgcagatgc cccttttgaa ccttcatctg
      481 gatgtgaagg aagatgacaa agtgaaaccg tacactgttg agatgagtaa agaggagtta
      541 cagagtctga tcagctcctt ggaggccgct aataaggtgg tcctgcagtt aaaataactg
      601 gaaatggtga ccatcaacac ctcagatttc agtgctgcac cgtggcagag ggagtgctgt
      661 ccatattcag cgggtggatg ctccatcagg ctgagcaggc agcagctctg agatcacaga
      721 gatggaaatc cgtcagaaac cctaagggac aggaaattgc atgactgata ggaagtgcat
      781 aggatgaaag aagaaagagc tgaagtcaca gcccgtgttt tcacagtgat cgctttgtct
      841 catttattaa acatctgaga aactttgtag ataacgtttt atcaagaggt aaaaataagt
      901 tctgaagtaa tgtaaacaca cagagcacag acacgctgga ctgttcttaa atgcaaacag
      961 caagacatgt attcttaata tgtaatttgt gatatttgaa aataatgttt taaggtgtat
     1021 ccaagctaca tatgtaatgt aggaggtttc atatctttct catgtttcaa agaaaagatt
     1081 tttaagttgt aaatttttaa agaaaatctg ttatcagaca tgaacaagaa aacatttaaa
     1141 atttgtatgc atagtttggg aataatttga ataacaaaat tcctaagaaa tttatgaact
     1201 aaaacaaaaa cttcaaaaaa atgcaaataa cattgttatt ttcacatcct cacttcttgg
     1261 gagaccatgg tctgaggaaa taagaaaact gtcaaagatg gtatagttac atattgttac
     1321 tcacatcaag ggtgttttta taaggtctga atatgaaatt tgagcttttg gatggtgaca
     1381 aagtaattgt aatacaaacc acttatcacc ctagctaact gaaaataagc attctgaaca
     1441 aatacaagct ggtcgtctct tcctgtgttg cttgatttca gtgacttccc aaatagctca
     1501 cttgttggta cagaattaac tggtcgctgc cgtgtgcagt tctgtggctc cataaggctc
     1561 cagtctgaca gccgggagcg gtgatgacta ctgttctcct cctacggctg caggcagcct
     1621 cagacaaggc tgctctatgg gctgcgacat agcagtgatt aggaaaggag cttgggccag
     1681 cgggttctca gtgtgctgct tttctcatca agaaattcgg gtgtggaaag tggacctatg
     1741 cggtatgttc acgcagttac tgatttcctt gttaggcaag tttattaagt cagcacggag
     1801 cattggcagc ttgtggaaca atgtatcagg cctggtccag cagtctctat tgcttccttc
     1861 ctttcagggc agcccttcat aggagaatac cttgttctct tccaccccca acagcctgtt
     1921 gcacagcttt tctgattggc acacagtttg attgacacac tataatgtcc atatttaaag
     1981 tgttggttca atacatttga ccaacagata ctcatgaaag catctccgta gtcaaggaat
     2041 acaggcccac atgcaagctt tctcttgtcc tcgatagtct ccatccctgg gcgttcaccc
     2101 ttggtcactt ctgctgcact tctagtcacc atgggttagg gaaaatgggc tcatacagta
     2161 tgtcttgttc ttctctttac tgttggtaat ggtgcaggac accgtgtttt ccaaccaagc
     2221 ttagtctgcc tccaaaacaa acaataacaa gccaaattaa atctgttttt tttttttttc
     2281 cccagcatct ttctttgttc ttggacaggg ccttaactgc tgcctgggct gtcctagaac
     2341 tcaactacgt agaccaggtt aggtcttgaa ctcatgacag tcttctggct tcagctttct
     2401 aaataattgg attgctgata tcagccagca tgcatgatgt tagcattatt tcaagttact
     2461 cttattgcac atgccagtac tttgttcctt cttatggctg aaaagcatca tgttgtataa
     2521 ttcttacagt ttatctgttg gtagcttttt ggtggtttca acatttgctt gtcctagtga
     2581 agagaatgct atgagcattt gtgtgcatat catgtaatga agaaatggtg tctttggagt
     2641 gacatagcca ggtcctgtga taggctcata cttatctttc tattactcat attccattcc
     2701 cgcttgtttg ttagcattct gatccacctt cccttagtgt gacaggtctt cctggtttca
     2761 gctattttgg tgtcatatta tgggatctca ttgtgttcct tttcttttct tttcttttct
     2821 tcccatttct tttctttttt ttaagattta tttatttatt tcatgtaaag gagtacacta
     2881 tagctatctt cagaccctct ggaagagcag tcagtgctct ccagccccct cattgtgttt
     2941 ctaacagtca cttaatgacc aatcgaattc atcatcactt aacatgttct gttgtctgtg
     3001 catctcgctg gactctgttc agacctagtg cctggttttt tttttgtttt ttgttttttt
     3061 tttttgagac aaggtttctc tgtgtagctc tgactgtcct ggaactcact ctgtagacca
     3121 ggctggcctc aaactcagaa atccgcctgc ctctgcctcc cgagtgctgg gattaaagtc
     3181 ttgcgccacc atgcccggcc ctagtgtctg tttttaaggc ggattcttag tcttgtttct
     3241 tagcactgtg ctctgacagt tcctttctaa atgcaaggcc ttcggatact ccgttccata
     3301 ctccaggatc tttttgtttt tcctgtactt aggtgatatt gatttcagag gtcagcttta
     3361 gagagaaagg ttaagaggct ggcagagttt ccatatcatg cctagtttct cctcgtaact
     3421 gattacactg tagggcactt gtaattggtg aaataaaaca tgaccattag ctaacttttc
     3481 taggttattt ggattcccta agaattttag ctgtttccct caccgttgct gaccttgatc
     3541 ttatggagaa atgtgtgtga ctcacaggaa cataccagtg tttttctcat agttaaactg
     3601 gagttacagg ttttgggaga gaagattgca aagacaaagt gccattttta tcacatgatt
     3661 tatgacctga tgcgactgta accacggtgg gaaggcaacg cctgttagat ttccacactg
     3721 tgaagtgact ttcttgtccc aggctcttct ctttgggtgg ggatagctgt gttcagcctg
     3781 gactagagcc atggggagct ctgctcctca ttaccccgtt gaagtgtcta tagaagttgt
     3841 gtgcaattca ctttttttcc ctgtgttttc tcccataaat tattttgtca tcta
//
