LOCUS       NM_001033132             904 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus COMM domain containing 6 (Commd6), transcript variant
            1, mRNA.
ACCESSION   NM_001033132 XM_619280 XM_895615 XM_895623 XM_904963 XM_919071
            XM_919080
VERSION     NM_001033132.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 904)
  AUTHORS   Singla,A., Chen,Q., Suzuki,K., Song,J., Fedoseienko,A., Wijers,M.,
            Lopez,A., Billadeau,D.D., van de Sluis,B. and Burstein,E.
  TITLE     Regulation of murine copper homeostasis by members of the COMMD
            protein family
  JOURNAL   Dis Model Mech 14 (1) (2021)
   PUBMED   33262129
REFERENCE   2  (bases 1 to 904)
  AUTHORS   Fedoseienko,A., Wijers,M., Wolters,J.C., Dekker,D., Smit,M.,
            Huijkman,N., Kloosterhuis,N., Klug,H., Schepers,A., Willems van
            Dijk,K., Levels,J.H.M., Billadeau,D.D., Hofker,M.H., van
            Deursen,J., Westerterp,M., Burstein,E., Kuivenhoven,J.A. and van de
            Sluis,B.
  TITLE     The COMMD Family Regulates Plasma LDL Levels and Attenuates
            Atherosclerosis Through Stabilizing the CCC Complex in Endosomal
            LDLR Trafficking
  JOURNAL   Circ Res 122 (12), 1648-1660 (2018)
   PUBMED   29545368
REFERENCE   3  (bases 1 to 904)
  AUTHORS   de Bie,P., van de Sluis,B., Burstein,E., Duran,K.J., Berger,R.,
            Duckett,C.S., Wijmenga,C. and Klomp,L.W.
  TITLE     Characterization of COMMD protein-protein interactions in NF-kappaB
            signalling
  JOURNAL   Biochem J 398 (1), 63-71 (2006)
   PUBMED   16573520
REFERENCE   4  (bases 1 to 904)
  AUTHORS   Kurihara,L.J., Semenova,E., Miller,W., Ingram,R.S., Guan,X.J. and
            Tilghman,S.M.
  TITLE     Candidate genes required for embryonic development: a comparative
            analysis of distal mouse chromosome 14 and human chromosome 13q22
  JOURNAL   Genomics 79 (2), 154-161 (2002)
   PUBMED   11829485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB577089.1, BC132261.1 and CK128085.1.
            
            On Dec 12, 2009 this sequence version replaced NM_001033132.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.507289.1,
                                           SRR1660817.456540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BB577089.1         2-27
            27-545              BC132261.1         14-532
            546-904             CK128085.1         297-655
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 50.9 cM"
     gene            1..904
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /note="COMM domain containing 6"
                     /db_xref="GeneID:66200"
                     /db_xref="MGI:MGI:1913450"
     exon            1..83
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..299
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /note="isoform 1 is encoded by transcript variant 1; COMM
                     domain-containing protein 6"
                     /codon_start=1
                     /product="COMM domain-containing protein 6 isoform 1"
                     /protein_id="NP_001028304.1"
                     /db_xref="CCDS:CCDS37000.1"
                     /db_xref="GeneID:66200"
                     /db_xref="MGI:MGI:1913450"
                     /translation="MEESGFREPVLDAKSEVTGQLIDFQWKLGMAVSSDSCRSLKYPY
                     VAVMLKVADHSGQVSSKSIEMTIPQFQNFYKQFKEIAAVIETV"
     exon            84..95
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            96..248
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            249..875
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      801..806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      823
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /note="major polyA site"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      875
                     /gene="Commd6"
                     /gene_synonym="1110059J08Rik; 1700063H17Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcggaagtg ctggccggtg gatcacactg tggtcatgga ggagtctggg ttcagggagc
       61 ccgtgctgga tgccaagtcg gaggtcacgg gccagcttat agattttcag tggaaactgg
      121 gcatggctgt gagctctgac agctgcagat ctctcaagta tccttacgtg gcagtgatgc
      181 tgaaggtggc agatcactct ggccaagtaa gcagcaagtc catcgagatg acaattccac
      241 aatttcagaa tttctacaaa cagttcaaag aaattgccgc tgtaattgag actgtgtgaa
      301 aactgattcg ttattctaaa gtaatggacc cttccttcca aatgagaact gcatatggac
      361 cacaggacat ctatacagtg aaagctgtgc ttctggggct ggagagatgg cttgaaggtt
      421 aagagcactg gctgctctct cagaggaccc aggttcaatt cccagaacca catggaagct
      481 cacaactttc tgtaactccg gttccagggg acccggcgca catgcaggca aaacgccaac
      541 gctatagaat aaaaataatt aaaagagaat ttcacttcta gtttttaaaa acaatttttt
      601 aaaaaatcag ataaacattt attttagtgg tgaccaatac ttagcctagt cagtgagcta
      661 aaagtggctc tgttgaccac tggtgtgtat aattatgagt aattatatct tcataaatag
      721 atgactagtg atgctattaa atgcaataca gttttgtgta ttagaacatt ttcaaatctt
      781 attgataaca gatctaactt aataaaatct tgtctggaat ttatatgaag ttaagaaggt
      841 aattaataat cgattaaaac tgcttcacaa attcaaaaaa aaaaaaaaaa aaaaaaaaaa
      901 aaaa
//
