LOCUS       NM_147778                923 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus COMM domain containing 3 (Commd3), mRNA.
ACCESSION   NM_147778 XM_994513
VERSION     NM_147778.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Hancock,J.L., Kalimutho,M., Straube,J., Lim,M., Gresshoff,I.,
            Saunus,J.M., Lee,J.S., Lakhani,S.R., Simpson,K.J., Bush,A.I.,
            Anderson,R.L. and Khanna,K.K.
  TITLE     COMMD3 loss drives invasive breast cancer growth by modulating
            copper homeostasis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 90 (2023)
   PUBMED   37072858
  REMARK    GeneRIF: COMMD3 loss drives invasive breast cancer growth by
            modulating copper homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 923)
  AUTHORS   Shirai,T., Nakai,A., Ando,E., Fujimoto,J., Leach,S., Arimori,T.,
            Higo,D., van Eerden,F.J., Tulyeu,J., Liu,Y.C., Okuzaki,D.,
            Murayama,M.A., Miyata,H., Nunomura,K., Lin,B., Tani,A.,
            Kumanogoh,A., Ikawa,M., Wing,J.B., Standley,D.M., Takagi,J. and
            Suzuki,K.
  TITLE     Celastrol suppresses humoral immune responses and autoimmunity by
            targeting the COMMD3/8 complex
  JOURNAL   Sci Immunol 8 (81), eadc9324 (2023)
   PUBMED   37000855
REFERENCE   3  (bases 1 to 923)
  AUTHORS   Nakai,A., Fujimoto,J., Miyata,H., Stumm,R., Narazaki,M., Schulz,S.,
            Baba,Y., Kumanogoh,A. and Suzuki,K.
  TITLE     The COMMD3/8 complex determines GRK6 specificity for
            chemoattractant receptors
  JOURNAL   J Exp Med 216 (7), 1630-1647 (2019)
   PUBMED   31088898
REFERENCE   4  (bases 1 to 923)
  AUTHORS   Sato,N., Sugimura,Y., Hayashi,Y., Murase,T., Kanou,Y., Kikkawa,F.
            and Murata,Y.
  TITLE     Identification of genes differentially expressed in mouse fetuses
            from streptozotocin-induced diabetic pregnancy by cDNA subtraction
  JOURNAL   Endocr J 55 (2), 317-323 (2008)
   PUBMED   18323671
REFERENCE   5  (bases 1 to 923)
  AUTHORS   Haupt,Y., Barri,G. and Adams,J.M.
  TITLE     Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral
            insertion locus
  JOURNAL   Mol Biol Rep 17 (1), 17-20 (1992)
   PUBMED   1287475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145999.1, AK041634.1 and BE950806.1.
            
            On Feb 6, 2019 this sequence version replaced NM_147778.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145955.1, SRR7345562.4381180.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK145999.1         4-30
            28-908              AK041634.1         2-882
            909-923             BE950806.1         17-31               c
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 12.9 cM"
     gene            1..923
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /note="COMM domain containing 3"
                     /db_xref="GeneID:12238"
                     /db_xref="MGI:MGI:88218"
     exon            1..169
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..618
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /note="Bmi1 upstream; bmi-1 upstream gene protein"
                     /codon_start=1
                     /product="COMM domain-containing protein 3"
                     /protein_id="NP_680087.1"
                     /db_xref="CCDS:CCDS15710.1"
                     /db_xref="GeneID:12238"
                     /db_xref="MGI:MGI:88218"
                     /translation="MELSESVQRGIQTLADPGSFDSNAFALLLRAAFQSLLDARADEA
                     ALDHPYLKQIDPVVLKHCHAAAATCILEAGKHQVDKSTLSTYLEDCKFDRERIELFCT
                     EYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDS
                     QSYPEINFSCNMEQLQDLVGKLKDASKSLERATQL"
     exon            170..281
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     exon            282..345
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     exon            346..380
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     exon            381..441
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     exon            442..498
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     exon            499..558
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     exon            559..923
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /note="hexamer: AATAAA"
     polyA_site      915
                     /gene="Commd3"
                     /gene_synonym="Bup; D2Ertd542e"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtgtcg aaggtcacgg cgcgctcaca atggagctct cggagtctgt gcaaagaggc
       61 atccagacgc tggcggatcc cggttccttt gactccaacg ccttcgcgct tctcctccgg
      121 gcggctttcc agagcctgct ggacgcccgg gcggacgagg ccgcgctaga tcacccatac
      181 ttgaaacaga tcgacccagt ggttttaaag cattgtcatg cagcagctgc aacttgcatc
      241 ctggaggcag gaaagcacca agttgacaag tctactctaa gcacttattt agaagactgt
      301 aaatttgacc gagagcgaat agaactgttt tgcaccgagt atcagaacaa taagaattct
      361 ctagaaaccc tactgggaag tataggcaga tctctccctc atataactga tgtttcttgg
      421 cgcttggagt accagataaa gaccaaccaa cttcataaga tgtaccgacc tggatatttg
      481 gtgaccttaa atgtagagaa caatgattcc caatcctacc cagagattaa ttttagttgc
      541 aacatggaac agttacagga cttggtgggg aaacttaagg atgcttcaaa aagcctggaa
      601 agagcaactc agttgtaatt tggggaggct gatgacccca ggagcctaga ggaaaaccag
      661 acgcgccttg tctcctgctg gaccatcgtt cgcgcgagct ggatgtcatt ttcagtggaa
      721 aaagagctag cacccttttg aagtgatgcc aaccatcaat tttgacactt tttttacaca
      781 tgtgaaatgg ttaagaggga gactcttaag catctggatt ttcagtatta ctcttgcgtt
      841 ccttctatct tgagcgtctt caagccctat taaagtatcg taccctgaat aaatacggtg
      901 gtattcccac aagaagggcg gca
//
