LOCUS       NM_001418791            1671 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus COMM domain containing 10 (Commd10), transcript
            variant 2, mRNA.
ACCESSION   NM_001418791 XM_006526224
VERSION     NM_001418791.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1671)
  AUTHORS   Chen,K.Y., De Giovanni,M., Xu,Y., An,J., Kirthivasan,N., Lu,E.,
            Jiang,K., Brooks,S., Ranucci,S., Yang,J., Kanameishi,S.,
            Kabashima,K., Brulois,K., Bscheider,M., Butcher,E.C. and
            Cyster,J.G.
  TITLE     Inflammation switches the chemoattractant requirements for naive
            lymphocyte entry into lymph nodes
  JOURNAL   Cell (2024) In press
   PUBMED   39708807
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1671)
  AUTHORS   Yamashita,M., Ogawa,C., Zhang,B., Kobayashi,T., Nomura,A.,
            Barker,C., Zou,C., Yamanaka,S., Hayashi,K.I., Shinkai,Y., Moro,K.,
            Fargarasan,S., Imami,K., Seita,J., Shirai,F., Sawasaki,T.,
            Kanemaki,M.T. and Taniuchi,I.
  TITLE     Cell-type specific, inducible and acute degradation of targeted
            protein in mice by two degron systems
  JOURNAL   Nat Commun 15 (1), 10129 (2024)
   PUBMED   39613744
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1671)
  AUTHORS   Moeller,J. and Meier,D.T.
  TITLE     Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune
            Cells Induces Sepsis Hypersensitivity
  JOURNAL   J Endocr Soc 8 (11), bvae171 (2024)
   PUBMED   39435302
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1671)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   5  (bases 1 to 1671)
  AUTHORS   Rauch,P.J., Gopakumar,J., Silver,A.J., Nachun,D., Ahmad,H.,
            McConkey,M., Nakao,T., Bosse,M., Rentz,T., Vivanco Gonzalez,N.,
            Greenwald,N.F., McCaffrey,E.F., Khair,Z., Gopakumar,M.,
            Rodrigues,K.B., Lin,A.E., Sinha,E., Fefer,M., Cohen,D.N.,
            Vromman,A., Shvartz,E., Sukhova,G., Bendall,S., Angelo,M.,
            Libby,P., Ebert,B.L. and Jaiswal,S.
  TITLE     Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated
            atherosclerosis and concordant macrophage phenotypes
  JOURNAL   Nat Cardiovasc Res 2 (9), 805-818 (2023)
   PUBMED   39196062
REFERENCE   6  (bases 1 to 1671)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (bases 1 to 1671)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (bases 1 to 1671)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (bases 1 to 1671)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1671)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            On Mar 23, 2023 this sequence version replaced XM_006526224.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.2285013.1,
                                           SRR17253011.3312678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC132100.3         68867-68945         c
            80-170              AC132100.3         67289-67379         c
            171-281             AC132100.3         64025-64135         c
            282-437             AC132100.3         59900-60055         c
            438-548             AC132100.3         37206-37316         c
            549-643             AC117239.4         59302-59396         c
            644-703             AC117239.4         32612-32671         c
            704-1671            AC117239.4         30928-31895         c
FEATURES             Location/Qualifiers
     source          1..1671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     gene            1..1671
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /note="COMM domain containing 10"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
     exon            1..79
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..803
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /note="isoform 2 is encoded by transcript variant 2; COMM
                     domain-containing protein 10; mDRWMS2; down-regulated in
                     W/WV mouse stomach 2; Tg(Vav1-cre)1Kio; Tg(Vav1-cre)A2Kio"
                     /codon_start=1
                     /product="COMM domain-containing protein 10 isoform 2"
                     /protein_id="NP_001405720.1"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
                     /translation="MAASAALILPESPSMKKAVPLINAIDTGRFPRLLSRILQKLHLK
                     AESSFSEEEEEKLQAAFSLEKQELHLVLETISFVLEQAVYHNVKPAALQQQLEMIHLR
                     KDKAEAFASAWSAMGQETVEKFRQRILGPHKLETVGWQLNLQMAHSAQAKLQSPQAVL
                     QLGVSKEDAKFQTVSSDHIHPTSPTPRSTSPHPNYASSFICPTWRKFSWNSITRSCSI
                     STTSWRPYKRSWTPSHDVLEDWLPSPSHSGHLTLSH"
     exon            80..170
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     exon            171..281
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     exon            282..437
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     exon            438..548
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     exon            549..643
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     exon            644..703
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1671
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1640..1645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /note="hexamer: AATAAA"
     polyA_site      1671
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /note="major polyA site"
ORIGIN      
        1 gcacagctga cagtcgcgcg ggcgagggag cttcaaggat ggcggcgtcc gcagcgctga
       61 tcctgcccga gagccccagc atgaagaaag cggtgccgct gataaatgca atagacacgg
      121 ggagattccc acgacttctc agccggattc ttcaaaagct ccacctgaag gccgagagca
      181 gtttcagtga agaagaggaa gaaaaacttc aggctgcatt ctctctagag aaacaagaac
      241 ttcacctggt tctggagaca atatcatttg ttttggaaca ggcagtgtat cacaacgtga
      301 agccagcagc actgcagcag caactagaga tgattcatct taggaaagac aaagcggaag
      361 cctttgccag tgcttggtcg gctatgggtc aggagacagt tgagaagttc cgccagagaa
      421 tcctgggccc tcacaagcta gagacagtgg gatggcagct taacctgcaa atggcccact
      481 ctgctcaagc aaagctgcag tctccccagg ccgtgctgca actgggagtg agcaaggaag
      541 acgccaagtt tcagactgtg tcttctgatc acattcaccc tacttcccca actcctagat
      601 ccacctcacc acaccccaac tatgcatcca gcttcatttg tccaacgtgg agaaagttct
      661 cgtggaattc aatcacaagg agctgttcga tttctacaac aagctggaga ccatacaagc
      721 gcagctggac tccctcacat gatgttctgg aagactggct tccttcgcca tcacattccg
      781 gccacctcac tctttcgcac tgaagagaga ctgcccaagt atattttcta gaggattcgg
      841 tgacactatt gctacagata atatgactta ttgcatctta gacaaatagc agtgatggga
      901 gatcacaata ggagcactgg gtttcgagtg tgccttctcg cctcacagga gccaagagca
      961 attgttgaga aaaacgaaag aagtaagaag tgaatgccat gctgtttttt ctttttttct
     1021 ctctctttaa caattatttt attagatatt ttcttcattt acatttcaat gctattccaa
     1081 aagtctccta taccctaacc ccaccctgct ccccaaccct cccactcctg cttcttggct
     1141 ctgacgttcc cctgtactgg ggcatagaaa gtttgcaaga ccaaagggcc tctgtttttt
     1201 ctgtcagatt gctttcaggg atcagggaag gtctgtaggc agaaggtatg atggtgccct
     1261 agcagagtat gaaaccttac tcattacagt aattaattag ggaagcagcc gcaggccgtc
     1321 aaatgttttg gcatttgtcc tgcagtgttc ttttgcttga agtatagtgc aagaaagaaa
     1381 tctaaaatgg taccagtact gctgtgagtt catcccactg cgctcccctt gactccccct
     1441 gaaggttcct gacgttaatg acttcaaaat catctaggtt tacatatatc tctgcagatt
     1501 actaacagtg cacttctcag tgtttcagat tgcaaatgaa aattgacctg taatgagtat
     1561 gacatgggaa tcttacattt tcactcgaaa actttatgca tcctcctttt atggatatat
     1621 gtgttcactg gtttcagtca ataaaaattt tctacctgag aattatttaa a
//
