LOCUS       NM_144514                818 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus COMM domain containing 1 (Commd1), transcript variant
            1, mRNA.
ACCESSION   NM_144514
VERSION     NM_144514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 818)
  AUTHORS   Zhang,L., Li,L., Li,Y., Jiang,H., Sun,Z., Zang,G., Qian,Y., Shao,C.
            and Wang,Z.
  TITLE     Disruption of COMMD1 accelerates diabetic atherosclerosis by
            promoting glycolysis
  JOURNAL   Diab Vasc Dis Res 20 (1), 14791641231159009 (2023)
   PUBMED   36803109
  REMARK    GeneRIF: Disruption of COMMD1 accelerates diabetic atherosclerosis
            by promoting glycolysis.
REFERENCE   2  (bases 1 to 818)
  AUTHORS   Vos,D.Y., Wijers,M., Smit,M., Huijkman,N., Kloosterhuis,N.J.,
            Wolters,J.C., Tissink,J.J., Pronk,A.C.M., Kooijman,S.,
            Rensen,P.C.N., Kuivenhoven,J.A. and van de Sluis,B.
  TITLE     Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte
            Lipoprotein Receptor Recycling to Control Postprandial
            Triglyceride-Rich Lipoproteins
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (1), e29-e45 (2023)
   PUBMED   36353989
REFERENCE   3  (bases 1 to 818)
  AUTHORS   Li,C., Peng,H. and Kang,Y.J.
  TITLE     Cardiomyocyte-Specific COMMD1 Deletion Suppresses Ischemia-Induced
            Myocardial Apoptosis
  JOURNAL   Cardiovasc Toxicol 21 (7), 572-581 (2021)
   PUBMED   33900545
  REMARK    GeneRIF: Cardiomyocyte-Specific COMMD1 Deletion Suppresses
            Ischemia-Induced Myocardial Apoptosis.
REFERENCE   4  (bases 1 to 818)
  AUTHORS   Li,C., Wang,T., Xiao,Y., Li,K., Meng,X. and James Kang,Y.
  TITLE     COMMD1 upregulation is involved in copper efflux from ischemic
            hearts
  JOURNAL   Exp Biol Med (Maywood) 246 (5), 607-616 (2021)
   PUBMED   33653183
  REMARK    GeneRIF: COMMD1 upregulation is involved in copper efflux from
            ischemic hearts.
REFERENCE   5  (bases 1 to 818)
  AUTHORS   Singla,A., Chen,Q., Suzuki,K., Song,J., Fedoseienko,A., Wijers,M.,
            Lopez,A., Billadeau,D.D., van de Sluis,B. and Burstein,E.
  TITLE     Regulation of murine copper homeostasis by members of the COMMD
            protein family
  JOURNAL   Dis Model Mech 14 (1) (2021)
   PUBMED   33262129
REFERENCE   6  (bases 1 to 818)
  AUTHORS   Wang,Y., Joh,K. and Mukai,T.
  TITLE     Identification of a novel isoform of Murr1 transcript, U2mu, which
            is transcribed from the portions of two closely located but
            oppositely oriented genes
  JOURNAL   Genes Genet Syst 77 (5), 377-381 (2002)
   PUBMED   12441649
  REMARK    GeneRIF: A novel transcript (U2mu) in mouse is transcribed from the
            portions of two independent genes, U2af1-rs1 and Murr1.
REFERENCE   7  (bases 1 to 818)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
REFERENCE   8  (bases 1 to 818)
  AUTHORS   Gregory,R.I., O'Neill,L.P., Randall,T.E., Fournier,C., Khosla,S.,
            Turner,B.M. and Feil,R.
  TITLE     Inhibition of histone deacetylases alters allelic chromatin
            conformation at the imprinted U2af1-rs1 locus in mouse embryonic
            stem cells
  JOURNAL   J Biol Chem 277 (14), 11728-11734 (2002)
   PUBMED   11821379
  REMARK    GeneRIF: Inhibition of histone deacetylases alters allelic
            chromatin conformation at the imprinted U2af1-rs1 locus in mouse
            embryonic stem cells
REFERENCE   9  (bases 1 to 818)
  AUTHORS   van De Sluis,B., Rothuizen,J., Pearson,P.L., van Oost,B.A. and
            Wijmenga,C.
  TITLE     Identification of a new copper metabolism gene by positional
            cloning in a purebred dog population
  JOURNAL   Hum Mol Genet 11 (2), 165-173 (2002)
   PUBMED   11809725
REFERENCE   10 (bases 1 to 818)
  AUTHORS   Nabetani,A., Hatada,I., Morisaki,H., Oshimura,M. and Mukai,T.
  TITLE     Mouse U2af1-rs1 is a neomorphic imprinted gene
  JOURNAL   Mol Cell Biol 17 (2), 789-798 (1997)
   PUBMED   9001233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY337798.1, AK133507.1 and BB053099.1.
            
            On Jan 5, 2006 this sequence version replaced NM_144514.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB203593.1, AK133507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 14673161
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY337798.1         2-26
            26-793              AK133507.1         2-769
            794-818             BB053099.1         250-274
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.22 cM"
     gene            1..818
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /note="COMM domain containing 1"
                     /db_xref="GeneID:17846"
                     /db_xref="MGI:MGI:109474"
     exon            1..206
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..596
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /note="isoform 1 is encoded by transcript variant 1;
                     U2af1-rs1 region 1; COMM domain-containing protein 1;
                     copper metabolism domain containing 1; protein Murr1"
                     /codon_start=1
                     /product="COMM domain-containing protein 1 isoform 1"
                     /protein_id="NP_653097.2"
                     /db_xref="CCDS:CCDS24472.1"
                     /db_xref="GeneID:17846"
                     /db_xref="MGI:MGI:109474"
                     /translation="MAGDLEGGKSLSGLLSGLAQNAFHGHSGVTEELLHSQLYPEVPP
                     EEFRPFLAKMRGLLKSIASADMDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKI
                     KIRESLMKQSRWDNGLRGLSWRVDGKSQSRHSTQIHSPVAIIELEFGKNGQESEFLCL
                     EFDEVKVKQILKKLSEVEESINRLMQAA"
     exon            207..488
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /inference="alignment:Splign:2.1.0"
     exon            489..818
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /inference="alignment:Splign:2.1.0"
     regulatory      767..772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /note="hexamer: AATAAA"
     regulatory      773..778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /note="hexamer: AATATA"
     polyA_site      792
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /note="major polyA site"
     polyA_site      801
                     /gene="Commd1"
                     /gene_synonym="Murr1; U2/Mu"
                     /note="major polyA site"
ORIGIN      
        1 agccgctggg cggcaggccc tccttagcca tggcgggcga tctggagggt ggcaagtccc
       61 tgagcgggct gctgagcggc ctagcgcaga acgcctttca cggacactcg ggtgtcacgg
      121 aggagctgct gcacagccaa ctctatccgg aagtgccacc ggaggagttc cgccccttcc
      181 tggcgaagat gagaggactt ctcaagtcta ttgcatctgc agacatggat ttcaaccagt
      241 tagaggcatt cctgactgct caaaccaaaa agcaaggtgg catcaccagt gagcaagctg
      301 cagtcatctc caagttttgg aagagccaca agataaaaat ccgagagagt ctcatgaagc
      361 agagccgctg ggacaacggc cttcggggcc tgagctggag agtcgatggc aagtctcagt
      421 cacggcactc aactcagata cacagccctg ttgccataat agagctggaa tttggaaaaa
      481 atggacagga atctgaattt ttgtgtctgg aatttgatga agttaaagtc aagcaaatcc
      541 tgaagaagct gtcagaggta gaagagagta tcaacaggct gatgcaggca gcctaactga
      601 agagagtatc aataggctga tgcaggcagc ctaactgaag gctggaggaa ggggcgtttg
      661 aagtgaagct gctcacagac tttctccact gaccctttga aagtcctgtt tgcccactgg
      721 tgttaccaaa agacattgta tacatgcatg aaagtcttca agaataaata aaaatatatt
      781 ttaaaaagtg ggtaaaaaag agaaacctct caaagtcc
//
