LOCUS       NM_146211               3189 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus collagen beta(1-O)galactosyltransferase 1 (Colgalt1),
            transcript variant 1, mRNA.
ACCESSION   NM_146211
VERSION     NM_146211.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   He,L., Ye,X., Gao,M., Yang,J., Ma,J., Xiao,F. and Wei,H.
  TITLE     Down-regulation of GLT25D1 inhibited collagen secretion and
            involved in liver fibrogenesis
  JOURNAL   Gene 729, 144233 (2020)
   PUBMED   31759980
  REMARK    GeneRIF: Results demonstrate that Glt25d1 knockout results in
            embryonic lethality and down-regulation of Glt25d1 may inhibit
            collagen secretion during liver fibrogenesis.
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Terajima,M., Taga,Y., Sricholpech,M., Kayashima,Y., Sumida,N.,
            Maeda,N., Hattori,S. and Yamauchi,M.
  TITLE     Role of Glycosyltransferase 25 Domain 1 in Type I Collagen
            Glycosylation and Molecular Phenotypes
  JOURNAL   Biochemistry 58 (50), 5040-5051 (2019)
   PUBMED   31726007
  REMARK    GeneRIF: GLT25D1 catalyzes galactosylation of Hyl throughout the
            type I collagen molecule and that this modification may regulate
            maturation of collagen cross-linking, fibrillogenesis, and
            mineralization
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Geister,K.A., Lopez-Jimenez,A.J., Houghtaling,S., Ho,T.H.,
            Vanacore,R. and Beier,D.R.
  TITLE     Loss of function of Colgalt1 disrupts collagen post-translational
            modification and causes musculoskeletal defects
  JOURNAL   Dis Model Mech 12 (6) (2019)
   PUBMED   31101663
  REMARK    GeneRIF: Colgalt1 mutant could serve as a model of a human
            connective tissue disorder and/or congenital muscular dystrophy or
            myopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Ye,X., He,L., Ma,J., Li,Y., Zhang,M., Yang,J., Zhang,J., Xiao,F.
            and Wei,H.
  TITLE     Downregulation of Glt25d1 aggravates carbon tetrachloride-induced
            acute hepatic injury through activation of the TGF-beta1/Smad2
            signaling pathway
  JOURNAL   Mol Med Rep 18 (4), 3611-3618 (2018)
   PUBMED   30132521
  REMARK    GeneRIF: The downregulation of Glt25d1 deteriorated CCl4induced
            liver injury in mice, which may involve triggering inflammatory
            responses, apoptosis and TGFbeta1/Smad2 signaling pathway
            activation.
REFERENCE   5  (bases 1 to 3189)
  AUTHORS   Geister,K.A., Timms,A.E. and Beier,D.R.
  TITLE     Optimizing Genomic Methods for Mapping and Identification of
            Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice
  JOURNAL   G3 (Bethesda) 8 (2), 401-409 (2018)
   PUBMED   29208648
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3189)
  AUTHORS   Tao,G., Levay,A.K., Peacock,J.D., Huk,D.J., Both,S.N.,
            Purcell,N.H., Pinto,J.R., Galantowicz,M.L., Koch,M., Lucchesi,P.A.,
            Birk,D.E. and Lincoln,J.
  TITLE     Collagen XIV is important for growth and structural integrity of
            the myocardium
  JOURNAL   J Mol Cell Cardiol 53 (5), 626-638 (2012)
   PUBMED   22906538
REFERENCE   7  (bases 1 to 3189)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036165.1, BC056951.1 and BE692044.1.
            
            On Mar 26, 2008 this sequence version replaced NM_146211.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032165.1, AK036165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AK036165.1         2-110
            110-3176            BC056951.1         1-3067
            3177-3189           BE692044.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..3189
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /note="collagen beta(1-O)galactosyltransferase 1"
                     /db_xref="GeneID:234407"
                     /db_xref="MGI:MGI:1924348"
     exon            1..421
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2030
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /EC_number="2.4.1.50"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; procollagen galactosyltransferase 1;
                     hydroxylysine galactosyltransferase 1; glycosyltransferase
                     25 family member 1; glycosyltransferase 25 domain
                     containing 1"
                     /codon_start=1
                     /product="procollagen galactosyltransferase 1 isoform 1
                     precursor"
                     /protein_id="NP_666323.2"
                     /db_xref="CCDS:CCDS22401.1"
                     /db_xref="GeneID:234407"
                     /db_xref="MGI:MGI:1924348"
                     /translation="MAALPRGSRGLPLLPLLLLLPPLGGPRGADGYFPEERWSPESPL
                     QAPRVLIALLARNAAPALPATLGALEQLRHPRERTALWVATDHNTDNTSAILREWLVA
                     VKGLYHSVEWRPAEEPSSYPDEEGPKHWSDSRYEHVMKLRQAALKSARDMWADYILFM
                     DIDNLITNPDTLSLLIAENKTVVAPMLDSRAAYSNFWCGMTSQGYYKRTPAYIPIRKR
                     DRRGCFAVPMVHSTFLIDLRKAASRNLAFYPTHPDYTWSFDDIIVFAFSCKQAEVQMY
                     VCNKEVYGFLPVPLRAHSSLQDEAESFMHVQLEVMVKHPPVQLSRFISAPRKTSDKMG
                     FDEVFMINLKRRRDRRERMLRALHEQEIDCQLVEAVDGKAMNTSQVEAMGIQMLPGYR
                     DPYHGRPLTKGELGCFLSHYNIWKEVVDRGLQKSLVFEDDLRFEIFFKRRLMNLMRDV
                     EREGLDWDLIYVGRKRMQVEHPEKAVPHVRNLVEADYSYWTLAYVISLQGAQKLLAAK
                     PLAKMLPVDEFLPVMFDKHPMSEYKSHFSPRNLRAFSVEPLLIYPTHYTGDDGYVSDT
                     ETSVVWNNEQVKTDWDRAKSQKMREQQALSREAKNSDVLQSPLDSTARDEL"
     exon            422..532
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..650
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..785
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..990
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1110
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1187
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1294
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1427
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1555
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1762
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..3181
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3155..3160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /note="hexamer: ATTAAA"
     polyA_site      3181
                     /gene="Colgalt1"
                     /gene_synonym="2810024B22Rik; Glt25d1"
                     /note="major polyA site"
ORIGIN      
        1 aaaggcgtag ccttgtcatg cctctctcca ggactcacag tatgacccgc gggccacttc
       61 cctttaagga gcgtgtcagg ggtgggacct ggatgtgtcc ttcccgccgc cgactccttt
      121 aaggcgcggc cctcgtcccc cggcagaaaa gctgcttaaa ggcgacgcgt ggcgcgatgg
      181 cggcgttgcc acgcgggtca cgcgggctgc cgctgctgcc actgctccta ctgctgccgc
      241 cgctgggcgg cccgcgcggc gcggacggct actttccaga ggagcgctgg agccccgagt
      301 ccccgctaca ggcgccgcgc gtgctcatcg cgctgctggc gcggaacgcg gcacccgcgc
      361 tgcccgccac gctgggcgcc ctggagcagc tgcgccaccc acgggagcgc acggcgctgt
      421 gggtggccac agatcacaac actgacaaca cttcagccat acttcgagag tggctggtgg
      481 cagtgaaggg tttataccac tctgtggagt ggcgaccggc agaggaaccc agctcttacc
      541 cagacgaaga aggccccaaa cactggtccg attcccgcta cgagcatgtc atgaaactgc
      601 gccaagcagc cttgaagtca gctagggaca tgtgggctga ctacattctg ttcatggaca
      661 tcgacaactt gatcaccaac cccgacactc tgagcctgct catcgctgag aacaagacag
      721 tggtggcccc catgctggac tcccgagcgg catactccaa cttctggtgt gggatgactt
      781 cgcagggcta ctacaagcgc acccctgcct atatccccat ccgaaaacga gaccgcaggg
      841 gctgctttgc agttcccatg gtgcactcta ccttcctcat tgacctgcgt aaggctgcat
      901 ccaggaacct ggccttttac ccaacacacc cagactacac ctggtctttt gatgacatca
      961 tcgtctttgc cttctcctgt aaacaggcag aggtgcaaat gtacgtgtgc aataaggagg
     1021 tgtacggctt cctgcccgtg ccactgcgtg cgcacagcag cctgcaggac gaagcagaga
     1081 gcttcatgca cgtgcagctg gaggtcatgg tgaaacatcc accagtgcag ctctcccgat
     1141 tcatctcagc acccaggaag acttctgaca agatgggctt cgatgaggtc ttcatgatca
     1201 acctgaagcg gaggcgggac cggcgagaac gcatgctgcg ggcactacat gagcaggaga
     1261 ttgactgcca gctggtggag gctgtagatg gcaaagccat gaacaccagc caggtggaag
     1321 ccatgggcat ccagatgctg cctggctacc gggaccccta ccatgggcgg ccactcacca
     1381 agggagagct gggctgcttt ctcagccact acaacatctg gaaggaggtg gttgaccggg
     1441 gactacagaa atcactagtg tttgaggatg atctgcgttt tgagatcttc ttcaagagac
     1501 gtctgatgaa cctcatgcgg gatgtggagc gtgaggggct ggactgggac ctcatctacg
     1561 tgggccggaa gcgcatgcag gtggagcacc ctgaaaaggc tgtgccccat gtaaggaacc
     1621 tggtagaggc tgattactcc tactggacgc tagcctatgt aatctccctg caaggtgctc
     1681 agaagttgct tgctgccaag ccactggcca aaatgctacc tgttgatgag tttctgcctg
     1741 tcatgtttga caagcaccca atgtcagaat acaagagtca cttctctccc cgcaacctgc
     1801 gtgccttctc tgtggagccc ctccttatct accctacaca ctacacaggg gatgatggct
     1861 atgtgagtga cacagagacc tcagttgtgt ggaataatga gcaggttaag actgactggg
     1921 accgagccaa gtcccagaag atgcgggaac agcaagcact gagccgtgag gccaagaact
     1981 cagatgtgct ccagtctcca ctggacagca ctgcccgtga tgagctttga ggcaactggc
     2041 aaacagccaa agccactgct acacacctaa acttcatgtg cttgcctggg actatagggc
     2101 cactcaggca gacaacagag agctctacaa gcacagaggt ctccatgtct tcctgtttag
     2161 cagccactta cacacaggca gcatttatgg agtacttact gtatgccaga aatagggctg
     2221 accaccaaga gattggtcag gaacaagcac agtcagttgg gtccaccatg aaggaagttc
     2281 tcttgttaga gcaatgaaag aggcatgatt cccccttatc agtgatgaac tgatcatcag
     2341 tcttttattg ttcagactga gtcaggtatt agggatacat actcattttt aaaatccgtt
     2401 tgagtattta ttgagggctt actgtatatt aggtaccatt cttagctctg ggaatactga
     2461 aataagaaaa aaaaatcaag caaaatatac caagcagctg ctatgtgcca ggtcttagga
     2521 agcactgatg agttaagtgt ctactatgtg tcactcagta ggtgctggag atggatgtcc
     2581 cagtggtgct tatccttgta gtgggcatga tatgcttacg gtggaaacag tcttattgac
     2641 cctgtgtgct aggctacacg ctgagcacaa tgacagagtc taaacagaat gtaacaagca
     2701 tttattgagc acctagagta tcaggccttt gactcccagt tggttgagaa atagccaccc
     2761 tccaacctgt ctgccggagg acactgggct tcccttgtct agaagggagc attgctctcc
     2821 ttcccttggt tgactgctag gttcaaggat actcatgacc ttgcaagtcc cccacccccc
     2881 gtgtccctgg gctggggctc ccttgcccac cccttacttc cagagcttct ctctgccctt
     2941 gtatctcagg tgtcccttgg ctgctcatat gtttggggcc ttgaggtgcc cacctgtatt
     3001 ggggtgctcc tcttggcctg agcagtgtgt ttaccagcag gccagggtgt tgctgtccct
     3061 tcaaaaccaa attgactgtc aactggacag tgggtaccat cttcttggga tgactgcttg
     3121 cctgctcagg tcttggtaac ttgctcatgt ttgtattaaa ttcttattgg ttttcactga
     3181 aaaaaaaaa
//
