LOCUS       NM_130449               3322 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus collectin sub-family member 12 (Colec12), mRNA.
ACCESSION   NM_130449
VERSION     NM_130449.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Bogie,J.F., Mailleux,J., Wouters,E., Jorissen,W., Grajchen,E.,
            Vanmol,J., Wouters,K., Hellings,N., van Horssen,J., Vanmierlo,T.
            and Hendriks,J.J.
  TITLE     Scavenger receptor collectin placenta 1 is a novel receptor
            involved in the uptake of myelin by phagocytes
  JOURNAL   Sci Rep 7, 44794 (2017)
   PUBMED   28317919
  REMARK    GeneRIF: CL-P1 is a novel receptor involved in myelin uptake by
            phagocytes and likely plays a role in multiple sclerosis lesion
            development.
            Erratum:[Sci Rep. 2017 Dec 22;7:46925. doi: 10.1038/srep46925..
            PMID: 29271403]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Prabhudas,M., Bowdish,D., Drickamer,K., Febbraio,M., Herz,J.,
            Kobzik,L., Krieger,M., Loike,J., Means,T.K., Moestrup,S.K.,
            Post,S., Sawamura,T., Silverstein,S., Wang,X.Y. and El Khoury,J.
  TITLE     Standardizing scavenger receptor nomenclature
  JOURNAL   J Immunol 192 (5), 1997-2006 (2014)
   PUBMED   24563502
  REMARK    Review article
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Jang,S., Ohtani,K., Fukuoh,A., Yoshizaki,T., Fukuda,M.,
            Motomura,W., Mori,K., Fukuzawa,J., Kitamoto,N., Yoshida,I.,
            Suzuki,Y. and Wakamiya,N.
  TITLE     Scavenger receptor collectin placenta 1 (CL-P1) predominantly
            mediates zymosan phagocytosis by human vascular endothelial cells
  JOURNAL   J Biol Chem 284 (6), 3956-3965 (2009)
   PUBMED   19073604
  REMARK    GeneRIF: CL-P1 predominantly mediated phagocytosis for fungi in
            vascular endothelia.
REFERENCE   7  (bases 1 to 3322)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3322)
  AUTHORS   Feinberg,H., Taylor,M.E. and Weis,W.I.
  TITLE     Scavenger receptor C-type lectin binds to the leukocyte cell
            surface glycan Lewis(x) by a novel mechanism
  JOURNAL   J Biol Chem 282 (23), 17250-17258 (2007)
   PUBMED   17420244
  REMARK    GeneRIF: Structural analysis of carbohydrate-recognition domain of
            SRCL in complex with Lewis(x) and mutagenesis show the basis for
            this specificity, which is analogous to how selectins and DC-SIGN
            bind to related fucosylated glycans [scavenger receptor C]
REFERENCE   9  (bases 1 to 3322)
  AUTHORS   Ohtani,K., Suzuki,Y., Eda,S., Kawai,T., Kase,T., Keshi,H.,
            Sakai,Y., Fukuoh,A., Sakamoto,T., Itabe,H., Suzutani,T.,
            Ogasawara,M., Yoshida,I. and Wakamiya,N.
  TITLE     The membrane-type collectin CL-P1 is a scavenger receptor on
            vascular endothelial cells
  JOURNAL   J Biol Chem 276 (47), 44222-44228 (2001)
   PUBMED   11564734
REFERENCE   10 (bases 1 to 3322)
  AUTHORS   Nakamura,K., Funakoshi,H., Tokunaga,F. and Nakamura,T.
  TITLE     Molecular cloning of a mouse scavenger receptor with C-type lectin
            (SRCL)(1), a novel member of the scavenger receptor family
  JOURNAL   Biochim Biophys Acta 1522 (1), 53-58 (2001)
   PUBMED   11718900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042772.1, AB078434.1 and AK141928.1.
            
            On Jan 18, 2008 this sequence version replaced NM_130449.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141928.1, BC057936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-649               AK042772.1         2-650
            650-2636            AB078434.1         636-2622
            2637-3322           AK141928.1         2624-3309
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.91 cM"
     gene            1..3322
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /note="collectin sub-family member 12"
                     /db_xref="GeneID:140792"
                     /db_xref="MGI:MGI:2152907"
     exon            1..112
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2334
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /note="scavenger receptor with C-type lectin; collectin
                     placenta protein 1"
                     /codon_start=1
                     /product="collectin-12"
                     /protein_id="NP_569716.2"
                     /db_xref="CCDS:CCDS37732.1"
                     /db_xref="GeneID:140792"
                     /db_xref="MGI:MGI:2152907"
                     /translation="MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIVLLY
                     ILCALLTITVAILGYKVVEKMDNVTDGMETSHQTYDNKLTAVESDLKKLGDQAGKKAL
                     STNSELSTFRSDILDLRQQLQEITEKTSKNKDTLEKLQANGDSLVDRQSQLKETLQNN
                     SFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQSQMYSQSVVIMNLNNLNLTQVQQRN
                     LISNLQQSVDDTSLAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALA
                     KANNDTLEDMNSQLSSFTGQMDNITTISQANEQSLKDLQDLHKDTENRTAVKFSQLEE
                     RFQVFETDIVNIISNISYTAHHLRTLTSNLNDVRTTCTDTLTRHTDDLTSLNNTLVNI
                     RLDSISLRMQQDMMRSKLDTEVANLSVVMEEMKLVDSKHGQLIKNFTILQGPPGPRGP
                     KGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGTIGPVGPPGERGSKGSKGSQGPK
                     GSRGSPGKPGPQGPSGDPGPPGPPGKDGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPG
                     LPGVPGMPGPKGPPGPPGPSGAMEPLALQNEPTPASEVNGCPPHWKNFTDKCYYFSLE
                     KEIFEDAKLFCEDKSSHLVFINSREEQQWIKKHTVGRESHWIGLTDSEQESEWKWLDG
                     SPVDYKNWKAGQPDNWGSGHGPGEDCAGLIYAGQWNDFQCDEINNFICEKEREAVPSS
                     IL"
     exon            113..163
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            164..286
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            287..385
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            386..1432
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1921
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2058
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2168
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2314
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..3322
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3274..3279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="Colec12"
                     /gene_synonym="CL-P1; Scara4; SRCL"
                     /note="major polyA site"
ORIGIN      
        1 agagtgcaga acgggacgct aggactggaa cgctgaaggc tgccatgggc gtgcagtgag
       61 agacactggt acgacttctc cgggcggagc gtgtcctcag tcaccatgaa agacgacttt
      121 gcagaggaag aggaggtgca gtccttcggt tacaagaggt ttggtattca ggaggggaca
      181 cagtgtacca aatgtaaaaa taactgggca ctgaagtttt cgattgtatt attatacatt
      241 ctgtgtgcct tactgaccat cacagtagcc attttgggat ataaagttgt agagaaaatg
      301 gacaatgtca cagatggcat ggagacatct caccagactt atgacaacaa actcactgct
      361 gtggaaagtg acctgaagaa attaggggat caagctggga agaaagctct aagtaccaac
      421 tctgagcttt ctaccttcag atcagatatt ctggatctcc gtcaacaact tcaggagatc
      481 acagaaaaaa ccagcaagaa caaagatacg ctggagaagt tgcaagcaaa tggggactca
      541 ttggttgata ggcagagtca gctgaaggaa actctgcaga ataattcttt cctcattacc
      601 accgtcaaca aaacactcca ggcatataat ggctatgtca caaatctgca acaagatact
      661 agtgtgctcc agggcaatct gcagagccaa atgtattctc agagcgtggt tatcatgaac
      721 ctcaacaacc tgaacctaac ccaggttcag cagaggaacc ttatctcaaa tctgcagcag
      781 tctgtggatg acacaagcct ggccatccag cgaattaaga atgatttcca aaatctgcag
      841 caggttttcc ttcaagccaa gaaggacacc gattggctaa aggaaaaagt acagagcttg
      901 cagacattgg ctgccaacaa ctctgccctg gccaaagcca acaatgacac cctagaggat
      961 atgaatagcc agctcagctc attcacaggt cagatggaca acattaccac tatctcacag
     1021 gccaacgagc agagcctgaa agaccttcag gacttacaca aggatacaga aaatagaaca
     1081 gctgtcaagt tcagccaact tgaggaacgc ttccaggtct ttgagacaga tattgtgaac
     1141 atcattagca acatcagcta cacagcccat cacctgagga cactgaccag caatctgaat
     1201 gatgttagga ccacatgcac agacaccttg accagacaca cggatgacct gacctccttg
     1261 aataacacac tagtcaacat ccgcttggat tctatttctc tcaggatgca gcaagacatg
     1321 atgaggtcaa agttagacac tgaagtggcc aacttatcag tggttatgga agagatgaaa
     1381 ctggttgact ccaagcacgg tcagctcatc aagaacttta ccattctaca aggtcctcct
     1441 ggccccagag gtccaaaagg tgacagagga tctcagggac cacctggtcc aactggcaac
     1501 aagggacaga aaggagagaa gggagagcct ggtccacctg gccctgcggg tgagaggggc
     1561 acaattggac cagtcggccc tcctggagag cgtggcagca aaggatccaa aggctcacag
     1621 ggtcccaaag gatctcgtgg gtccccaggg aagcctggcc ctcaaggacc tagtggggac
     1681 ccaggaccac caggtccacc aggcaaggat ggactccctg gccctcaggg ccctcctggc
     1741 ttccagggac tacagggcac tgtgggtgag cctggagtac ctggacctcg ggggttgcca
     1801 ggcttgccag gggtgccagg catgcctggg cctaagggac cacctggccc tccaggcccc
     1861 tcaggagcaa tggagccatt ggctctgcag aatgaaccaa ccccagcatc agaggtcaac
     1921 ggatgtccgc ctcactggaa gaacttcaca gataaatgct actatttttc attggaaaaa
     1981 gaaatttttg aagatgctaa gcttttctgt gaagacaaat cttcccatct cgttttcata
     2041 aactcaagag aagaacagca atggataaaa aagcataccg tggggagaga aagccattgg
     2101 atcggcctca cagactcaga acaggaaagc gaatggaagt ggctagacgg gtcacctgtt
     2161 gattacaaaa actggaaagc tggacaacca gataactggg gcagtggcca tgggccagga
     2221 gaagactgtg ctggcttgat ttacgcagga cagtggaatg acttccagtg tgatgaaatc
     2281 aataacttca tttgtgagaa ggaaagggag gcagtaccat catccatatt ataacagcat
     2341 gatataatag cagaaacata ttttctgatg cctctgaaag ccgaagaatg ctcgtttttg
     2401 attccatcac ttctcaccag attgaatgga aaaagctctg aaaagtagtt attcaaaata
     2461 aatggacacc tactgcacaa taacccaagg actagggggc taaaatgctc ccccaagttg
     2521 atatattgat ttccagtgta caaatggact gaatcgcata gattttctca gccattaacc
     2581 atagaattta tgcaaagtat atctttccaa atatggaatg ctccaatcag aaaaagacta
     2641 tcattggttg ttgagttact gactgtctta gtcagggttt ctattcctgc acaaacatca
     2701 tgaccaagaa ggaagttggg gaggaaaggg tttattcggc ttacacttcc atactgctgt
     2761 tcatcaccaa aggaagtcag gactggaact caagcagatc aggaagcaga agctgatgca
     2821 gaggccatgg agggatgttc tttactggct tgcttcccct ggcttgctca gcctgctctc
     2881 ttacagaacc aagactacca gcccagggat ggtcccaccc acaagggacc tttccccctt
     2941 gatcactaat tgagaaaatg ccttacagtt agatctcatg gaggcatttc ctcaactgaa
     3001 gctcctttct ctgtgataac tccagctgtg tcaagttgac acaaaactag ccagtacact
     3061 ggctctgtgt aaacagtgtg tttctaaaat cccaaatgta ggaaaaatat gcagatgcac
     3121 acatataggc cacattttag taataatatg aaatatactt aaagagcttt taaacttcgt
     3181 atttttatac aaaatatttg ccttttacaa tcattttcct ttttttaatg tacctatatg
     3241 atacataaag ccaaagataa taatagcggt actaataaaa tttcatggag tttctcttca
     3301 gatttaatct gtccagctga ag
//
