LOCUS       NM_001313978            1442 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus collectin sub-family member 11 (Colec11), transcript
            variant 1, mRNA.
ACCESSION   NM_001313978 XM_006515219
VERSION     NM_001313978.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Wang JX, Cao B, Ma N, Wu KY, Chen WB, Wu W, Dong X, Liu CF, Gao YF,
            Diao TY, Min XY, Yong Q, Li ZF, Zhou W and Li K.
  TITLE     Collectin-11 promotes cancer cell proliferation and tumor growth
  JOURNAL   JCI Insight 8 (5), e159452 (2023)
   PUBMED   36883567
  REMARK    GeneRIF: Collectin-11 promotes cancer cell proliferation and tumor
            growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Kurz J, Weiss AC, Thiesler H, Qasrawi F, Deuper L, Kaur J, Rudat C,
            Ludtke TH, Wojahn I, Hildebrandt H, Trowe MO and Kispert A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Yuan H, Gao Z, Lu X and Hu F.
  TITLE     Role of collectin-11 in innate defence against uropathogenic
            Escherichia coli infection
  JOURNAL   Innate Immun 27 (1), 50-60 (2021)
   PUBMED   33241978
  REMARK    GeneRIF: Role of collectin-11 in innate defence against
            uropathogenic Escherichia coli infection.
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Howard MC, Nauser CL, Farrar CA, Wallis R and Sacks SH.
  TITLE     l-Fucose prevention of renal ischaemia/reperfusion injury in Mice
  JOURNAL   FASEB J 34 (1), 822-834 (2020)
   PUBMED   31914693
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Wu W, Liu C, Farrar CA, Ma L, Dong X, Sacks SH, Li K and Zhou W.
  TITLE     Collectin-11 Promotes the Development of Renal Tubulointerstitial
            Fibrosis
  JOURNAL   J Am Soc Nephrol 29 (1), 168-181 (2018)
   PUBMED   29142050
  REMARK    GeneRIF: Our findings demonstrate a pathogenic role for
            collectin-11 in the development of tubulointerstitial fibrosis and
            suggest that local collectin-11 promotes this fibrosis through
            effects on leukocyte chemotaxis and renal fibroblast proliferation.
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Rooryck C, Diaz-Font A, Osborn DP, Chabchoub E, Hernandez-Hernandez
            V, Shamseldin H, Kenny J, Waters A, Jenkins D, Kaissi AA, Leal GF,
            Dallapiccola B, Carnevale F, Bitner-Glindzicz M, Lees M, Hennekam
            R, Stanier P, Burns AJ, Peeters H, Alkuraya FS and Beales PL.
  TITLE     Mutations in lectin complement pathway genes COLEC11 and MASP1
            cause 3MC syndrome
  JOURNAL   Nat Genet 43 (3), 197-203 (2011)
   PUBMED   21258343
REFERENCE   8  (bases 1 to 1442)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 1442)
  AUTHORS   Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fukuda M, Fukuzawa J,
            Mori K, Jang SJ, Nomura N, Yoshida I, Suzuki Y, Kohgo Y and
            Wakamiya N.
  TITLE     Immunolocalization of a novel collectin CL-K1 in murine tissues
  JOURNAL   J Histochem Cytochem 56 (3), 243-252 (2008)
   PUBMED   18040075
  REMARK    GeneRIF: This profile of CL-K1 expression is unique among the
            collectins. [CL-K1]
REFERENCE   10 (bases 1 to 1442)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165283.2.
            
            [WARNING] On Jan 11, 2024 this sequence was replaced by
            NM_001313978.2.
            
            On Sep 18, 2015 this sequence version replaced XM_006515219.2.
            
            Summary: This gene encodes a member of the collectin family of
            C-type lectins that possess collagen-like sequences and
            carbohydrate recognition domains. Collectins are secreted proteins
            that play important roles in the innate immune system by binding to
            carbohydrate antigens on microorganisms, facilitating their
            recognition and removal. The encoded protein binds to multiple
            sugars with a preference for fucose and mannose. Mutations in the
            human gene are a cause of 3MC syndrome-2. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104381.1, BX524596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC165283.2         160207-160303       c
            98-253              AC165283.2         154379-154534       c
            254-325             AC165283.2         149836-149907       c
            326-397             AC165283.2         136017-136088       c
            398-451             AC165283.2         132933-132986       c
            452-547             AC165283.2         132217-132312       c
            548-1442            AC165283.2         131145-132039       c
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 10.98 cM"
     gene            1..1442
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /note="collectin sub-family member 11"
                     /db_xref="GeneID:71693"
                     /db_xref="MGI:MGI:1918943"
     exon            1..97
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..253
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..957
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collectin-11; collectin kidney protein 1;
                     collectin-L2"
                     /codon_start=1
                     /product="collectin-11 isoform 1 precursor"
                     /protein_id="NP_001300907.1"
                     /db_xref="CCDS:CCDS88320.1"
                     /db_xref="GeneID:71693"
                     /db_xref="MGI:MGI:1918943"
                     /translation="MMMRDLALAGMLISLAFLSLLPSGCPQQTTEDACSVQILVPGLK
                     GDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGTVGRHGKIGPIGAKGEKGDSGDIG
                     PPGPSGEPGIPCECSQLRKAIGEMDNQVTQLTTELKFIKNALPSPAAVAGVRETESKI
                     YLLVKEEKRYADAQLSCQARGGTLSMPKDEAANGLMASYLAQAGLARVFIGINDLEKE
                     GAFVYSDRSPMQTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHITMYFMCEFDKE
                     NL"
     exon            254..325
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..397
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..451
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..547
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..1442
                     /gene="Colec11"
                     /gene_synonym="CL-K1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggtctct gtaaataaca gccatgaggc tccttggagc agtgtctctg ccagccggtg
       61 actgtcagga cagctccttc gcctagtgtg catccaggag tcggtgtcct gcctgcactc
      121 atgatgatga gggacctggc tcttgcaggc atgctgatta gcctggcttt cctgtccctg
      181 ctgccatctg gatgtcctca gcagaccaca gaggacgcct gctctgtgca gattcttgtc
      241 cctggcctca aaggggatgc aggagaaaag ggagacaaag gagccccagg acggccagga
      301 agagtcggcc ctacaggaga aaaaggagac atgggggaca aaggacagaa aggcactgtg
      361 ggccgccatg gaaaaattgg tcccattggc gcaaaaggtg aaaaaggaga ttctggtgat
      421 atcggacccc ctggccccag tggagaacct ggtattccat gtgagtgcag tcagctgagg
      481 aaggctattg gggagatgga caaccaggtc actcaactga caactgagct aaaattcata
      541 aaaaatgcac tgccctcccc tgcagctgtt gctggcgtgc gcgagactga gagcaagatc
      601 tacctgctgg tgaaggagga gaagcggtac gcagatgccc agctgtcctg ccaagcccga
      661 ggcggcacac tgagcatgcc caaagacgag gcagccaatg gcctgatggc ttcatacctg
      721 gcacaggctg gcctggcccg agtcttcatc ggtatcaatg acctggagaa agaaggtgct
      781 ttcgtgtact cggaccgctc ccccatgcag accttcaaca agtggcgcag tggagagccc
      841 aacaacgcct atgatgagga ggactgtgtg gagatggtgg cctcaggtgg ctggaatgat
      901 gtggcctgcc acattaccat gtacttcatg tgcgagtttg acaaagagaa cttgtgagag
      961 ccgacagggg agatggccat ctgaacgcca ccttttatag acaccagcgg ccacaaacta
     1021 accctgagca ccagtcgcca tgtctgcggg ttcctctctg catggaagtg ccgggcctca
     1081 ttgacagttg gaagggctgt ttgaaccgta ggaggggaga aaccttgctt ccggggctgt
     1141 tctgaatagg tggcgtatta tcacctttgt cagacgttca ttatggctaa ccactcggaa
     1201 ggatgctgtg aagctcttgt cttggtccag catagtaaat tttgcagcag tcatcaaact
     1261 ggctataggg gcaggagttg ccgcccaccc tataaagtac acagagtgcc caggtggtga
     1321 ccaatgtttc tataggttat gctatcacat agattccttt cactattatc cgggtaggaa
     1381 gactgctgct ctgcttcaca tccatatttc aggaaaacaa ataaatcctc tgatttctgc
     1441 ta
//
