LOCUS       NM_199473               4331 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus collagen, type VIII, alpha 2 (Col8a2), mRNA.
ACCESSION   NM_199473 XM_284007
VERSION     NM_199473.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4331)
  AUTHORS   Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y and Wang
            W.
  TITLE     FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme
            proliferation and differentiation via Lhx8/Suv39h1 complex
  JOURNAL   J Cell Mol Med 25 (6), 3051-3062 (2021)
   PUBMED   33580754
REFERENCE   2  (bases 1 to 4331)
  AUTHORS   Bian Q, Cheng YH, Wilson JP, Su EY, Kim DW, Wang H, Yoo S,
            Blackshaw S and Cahan P.
  TITLE     A single cell transcriptional atlas of early synovial joint
            development
  JOURNAL   Development 147 (14) (2020)
   PUBMED   32580935
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4331)
  AUTHORS   Shpargel KB, Mangini CL, Xie G, Ge K and Magnuson T.
  TITLE     The KMT2D Kabuki syndrome histone methylase controls neural crest
            cell differentiation and facial morphology
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32541010
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4331)
  AUTHORS   Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein
            HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bjornstad JL
            and Tonnessen T.
  TITLE     Lack of collagen VIII reduces fibrosis and promotes early mortality
            and cardiac dilatation in pressure overload in mice
  JOURNAL   Cardiovasc Res 106 (1), 32-42 (2015)
   PUBMED   25694587
REFERENCE   5  (bases 1 to 4331)
  AUTHORS   Kim EC, Meng H and Jun AS.
  TITLE     N-Acetylcysteine increases corneal endothelial cell survival in a
            mouse model of Fuchs endothelial corneal dystrophy
  JOURNAL   Exp Eye Res 127, 20-25 (2014)
   PUBMED   24952277
REFERENCE   6  (bases 1 to 4331)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Kitamura H, Nakagawa T, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   7  (bases 1 to 4331)
  AUTHORS   Maeda YY, Funata N, Takahama S, Sugata Y and Yonekawa H.
  TITLE     Two interactive genes responsible for a new inherited cataract
            (RCT) in the mouse
  JOURNAL   Mamm Genome 12 (4), 278-283 (2001)
   PUBMED   11309658
REFERENCE   8  (bases 1 to 4331)
  AUTHORS   Warman ML, McCarthy MT, Perala M, Vuorio E, Knoll JH, McDaniels CN,
            Mayne R, Beier DR and Olsen BR.
  TITLE     The genes encoding alpha 2(IX) collagen (COL9A2) map to human
            chromosome 1p32.3-p33 and mouse chromosome 4
  JOURNAL   Genomics 23 (1), 158-162 (1994)
   PUBMED   7829066
REFERENCE   9  (bases 1 to 4331)
  AUTHORS   Muragaki Y, Jacenko O, Apte S, Mattei MG, Ninomiya Y and Olsen BR.
  TITLE     The alpha 2(VIII) collagen gene. A novel member of the short chain
            collagen family located on the human chromosome 1
  JOURNAL   J Biol Chem 266 (12), 7721-7727 (1991)
   PUBMED   2019595
REFERENCE   10 (bases 1 to 4331)
  AUTHORS   Iruela-Arispe ML and Sage EH.
  TITLE     Expression of type VIII collagen during morphogenesis of the
            chicken and mouse heart
  JOURNAL   Dev Biol 144 (1), 107-118 (1991)
   PUBMED   1847345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606976.25.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_199473.3.
            
            On Nov 17, 2006 this sequence version replaced NM_199473.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065148.1, SRR10662773.1631849.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL606976.25        3712-3848
            138-183             AL606976.25        13527-13572
            184-380             AL606976.25        26518-26714
            381-4331            AL606976.25        27298-31248
FEATURES             Location/Qualifiers
     source          1..4331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.29 cM"
     gene            1..4331
                     /gene="Col8a2"
                     /note="collagen, type VIII, alpha 2"
                     /db_xref="GeneID:329941"
                     /db_xref="MGI:MGI:88464"
     exon            1..137
                     /gene="Col8a2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..183
                     /gene="Col8a2"
                     /inference="alignment:Splign:2.1.0"
     exon            184..380
                     /gene="Col8a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2299
                     /gene="Col8a2"
                     /note="collagen alpha-2(VIII) chain; endothelial collagen;
                     procollagen, type VIII, alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(VIII) chain precursor"
                     /protein_id="NP_955767.1"
                     /db_xref="CCDS:CCDS18649.1"
                     /db_xref="GeneID:329941"
                     /db_xref="MGI:MGI:88464"
                     /translation="MQGALMPLPSLLLLLLGCGPRVSSGGGAGGAAGYAPVKYVQPMQ
                     KGPVGPPFREGKGQYLEMPLPMLPMDLKGEPGPPGKPGPRGPPGPPGFPGKPGTGKPG
                     VHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGPPGPPGLP
                     GPSGITVPGKPGAQGAPGPPGFRGEPGPQGEPGPRGDRGLKGDNGVGQPGLPGAPGQA
                     GAPGPPGLPGPAGLGKPGLDGIPGAPGDKGDSGPPGVPGSRGEPGAVGPKGPPGVDGV
                     GIPGAAGVPGPQGPVGAKGEPGLRGPPGLIGPVGYGMPGKPGPKGDRGPVGAPGLLGD
                     RGEPGEDGKPGEQGPQGLGGPPGLPGSAGLPGRRGPPGSKGEVGPGGPPGVPGIRGDQ
                     GPNGLAGKPGLPGERGLPGAHGPPGPTGPKGEPGFTGRPGGPGVAGALGQKGDLGLPG
                     QPGLRGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGKVGEPGSAGPTGPPGVP
                     GSPGLTGPPGPPGPPGPPGAPGALDETGIAGLHLPNGGVEGAVLGKGGKPQFGLGELS
                     AHATPAFTAVLTSPFPASGMPVRFDRTLYNGHSGYNPATGIFTCPVGGVYYFAYHVHV
                     KGTNVWVALYKNNVPATYTYDEYKKGYLDQASGGAVLQLRPNDQVWVQMPSDQANGLY
                     STEYIHSSFSGFLLCPT"
     exon            381..4331
                     /gene="Col8a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgcgggg cagcggggca gcgggcagag cgacgcggag ttctggcggt gcggaccccg
       61 acgacgccct ggccccgagc ctgcgccatc cgggtcgccc tcgagcgccg gagcgccgcc
      121 cggaggccgc cctgcaggct ctgcctgtcc tgggacgttc gtggccccgc ccacctaaaa
      181 aagcccatcc acagacgcca tgcagggggc tctgatgccc ctgccttcgc tgctgctgtt
      241 gctgttgggg tgtgggccaa gagtgtcctc tggcggcgga gctgggggtg cagcgggcta
      301 tgccccggta aagtatgtgc agcccatgca gaaaggaccc gtgggaccgc ctttccgaga
      361 gggcaaaggc cagtacttgg aaatgcctct accgatgctg ccaatggact tgaaaggaga
      421 gccaggtccc cctgggaagc cgggacctcg gggtccccct gggcctcctg gcttcccagg
      481 aaaaccaggc actggaaaac ctggggttca tggacagcca ggccctgctg gcccccctgg
      541 cttctcccga atgggcaaag ctggtccccc agggctccca ggcaaggttg gaccaccagg
      601 gcagccaggg ctacgggggg agccagggat acgaggggac cagggcctcc gggggccccc
      661 aggaccccct ggccttcctg gtccctcagg tattactgtc cctggaaaac caggtgccca
      721 gggggctcca gggcctccag gatttagggg ggagccagga ccccagggag agcctgggcc
      781 ccgaggagat aggggcctca aaggggataa tggagtgggc caaccagggc tgcctggagc
      841 ccctggacag gcaggtgccc ctgggccccc tgggctgccc ggtccagctg gcttgggcaa
      901 accaggtttg gatgggatac caggagcccc aggagacaaa ggtgattctg gcccccctgg
      961 ggttccaggt tctaggggag agccaggagc tgtgggtcca aaaggccctc ctggggtaga
     1021 tggtgtgggg ataccagggg cagcaggggt gccagggcca cagggtccag taggggctaa
     1081 aggagagcca gggctccggg gcccccctgg cctgataggc cctgttggct atgggatgcc
     1141 aggaaaacca ggacctaagg gagacagggg cccagttggg gccccagggc tcttaggaga
     1201 cagaggtgag ccaggagagg atgggaagcc aggggagcag ggtccacagg gacttggggg
     1261 tccacctggc cttcctgggt ctgcagggct tcctggtaga cgtgggcccc ctgggtcaaa
     1321 gggagaggta ggacctggag gtcccccagg agtgcctggc attcgaggag accaagggcc
     1381 taatggcctg gctgggaagc ctgggctccc tggtgagagg ggacttcctg gggcccatgg
     1441 accccctgga ccgactgggc ctaagggtga gccaggtttt acaggtcgcc ctggagggcc
     1501 aggggtggca ggagccctag gacagaaagg tgacttgggg cttcctgggc agcctggctt
     1561 gaggggtccc tctggaatcc cagggctcca gggcccagct ggccctattg ggcctcaggg
     1621 tctgccaggc ctgaagggtg aaccgggcct tccagggcct cctggagagg gaaaagtagg
     1681 ggagcctggc tctgctggtc ccacagggcc ccctggagtc cctggctccc caggactcac
     1741 aggtcctcct gggccccctg ggcctcctgg gcctcctggt gcccccggag ccctggatga
     1801 gactggtatc gcaggcttgc atctgcccaa tggtggcgtg gagggagctg tactgggcaa
     1861 aggaggcaag ccacagtttg ggctcggtga gctgtcagcc cacgccactc cagcctttac
     1921 tgcagtgctc acttccccct tccctgcctc aggcatgccg gttaggtttg accggactct
     1981 ctacaatggc cacagcggct acaacccagc cactggcatc ttcacctgcc ccgtgggagg
     2041 ggtctactac tttgcatacc atgtgcatgt caagggcacc aatgtgtggg tagccctgta
     2101 caagaacaat gtgccggcca cctacacgta cgacgaatac aagaagggct acctggacca
     2161 ggcttcggga ggggctgtgc tccagctgcg gcccaatgac caggtgtggg tgcagatgcc
     2221 ctcagatcag gccaatggtc tctactccac cgagtacatc cattcgtcct tctcaggatt
     2281 cttgctctgt cccacataac ccgtgggggg gcccctgctg ccctggcctc ctcctcttta
     2341 gcgatagaga gacctttcca gttacagaga tttccatcgg aaggaaagaa ccaaaaagct
     2401 gaacaggggc agcggcggcc ttcttcttgc cccgagaaga ctgacctgct ttctgtaggc
     2461 tgaagttgtt tctggaagag ggtggcctag tttcctttcc cccaggtgta ctgtgggggt
     2521 tgtccctctg ttctggacct gcctggtctg caggcagcac cccagagtac tcagcctggg
     2581 ccccctcatg agtcctggaa gctgctggga gagatggttt tcctgttggc cttcgatggc
     2641 atggaatgag cccagggctt cctgtgttcg ctgggtctct tccagctccc cgggagcctc
     2701 cagcatctga tacgacatta ggttctctga ggtttttgtt tcctgttggg agaaaggaag
     2761 aagggaatgg ggaccataga ggcagtccat atggatagat gcctggagtg atgttgtgag
     2821 ctcagaccag tcctggtggg gacagttgta tggcctctgg aagactcctg aagcagtcat
     2881 ctgtggagat ccgtgagagg acatggatca ggggcaagct ggtcactctt ccgtttccct
     2941 ggctgtctcc attggctctg gttcttcagt atgagggtgg acacatgggc tgagatggga
     3001 ctctgtgtag tgtctataca gattgcagag ccaaccagga ctgatgatca agcaaacacg
     3061 atgcccctcc ctctttcttc tcacctgctg ggggtttggg gtaattcatg atcagactgt
     3121 taggggaggc ttggcaaccc caaactaagt gtcttcaagg cagagagcct ctcgctaggc
     3181 cctctgaaca caggcacaca agcttatggg tgaagacgtc tgtttctcct taataagaac
     3241 catgctgtgg gtatttagtg tctactagag gggctcatct gtgggcactt cctccctctc
     3301 caccctccgc ttccaatttc ctgttttaag cagtggaggg cccaggaggc taaggctctg
     3361 aaagaaagga tgccagcagg ccccactgga atgagccggc tctagaggct cctacccgcc
     3421 tccctaatca ggatgctcct gcaggaaaca ggcgggcttg cttcccagct gggctcaatg
     3481 ctgggggtag ggatggtgga cattcttgca tatgtaggga tggctgcctt ctctggttca
     3541 tgactttcct cagccctcac ctagtcagcc cacttccctg accaagtggg aatctgggac
     3601 atcgaatagg caacccagct tgggctccaa tttgggcaca gtcagctgcc cgagtgacac
     3661 actgaggatg agggcctagt ctccttcccg cagcctgcaa ctgcaaggca gcctagtgga
     3721 ctgctcactt cagtttccaa agggggaatc tgcctgagac agcaaggaaa aaagtcctgc
     3781 ctgggactct gagtcctttt ttttttctgc cacacctaag aggaccagct agagactagt
     3841 atccctgtgg ggccttttca gtctcctcct tccccaggtc aaagccacta atccaatggg
     3901 ttctggcggt aagagattag tcaactccca gagggagccc tgaaggctgg ttcagggcag
     3961 agctgccaga ccccacccca aagcctttag agaaggattc tgaaacgtct gtggattgga
     4021 gctgtagatg tcactgacca gcgttgacaa acaatgtcag gctttaacta tgacaactcc
     4081 acttaccttg tgcatttttg tattttggtt cttcttcttc tttttttttt tttttttaaa
     4141 gattaagctt ttccacttga tatttcattt ctaacctggt acaggaagtt cctctctact
     4201 taccacatat cacatatcag gttcaggaaa aatgcaccgg gaatcagaga aaatgggatt
     4261 tcttttcaat tgaaaagaca acgacagtgc tgttattgac cacccccaat aaaacctgtt
     4321 gtagaaacac a
//
