LOCUS       NM_007739               5110 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus collagen, type VIII, alpha 1 (Col8a1), mRNA.
ACCESSION   NM_007739 XM_001001970
VERSION     NM_007739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5110)
  AUTHORS   Vo,N.D.N., Gassler,N., Wolf,G. and Loeffler,I.
  TITLE     The Role of Collagen VIII in the Aging Mouse Kidney
  JOURNAL   Int J Mol Sci 25 (9), 4805 (2024)
   PUBMED   38732023
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5110)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5110)
  AUTHORS   Angelozzi,M., Pellegrino da Silva,R., Gonzalez,M.V. and Lefebvre,V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   4  (bases 1 to 5110)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Saturne,M., Motch Perrine,S.M.,
            Zhou,X., Borges,A.C., Shewale,B., Richtsmeier,J.T., Zhang,B., van
            Bakel,H. and Jabs,E.W.
  TITLE     Single-cell analysis identifies a key role for Hhip in murine
            coronal suture development
  JOURNAL   Nat Commun 12 (1), 7132 (2021)
   PUBMED   34880220
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5110)
  AUTHORS   Zhou,C., Chen,D., Ren,J., Huang,D., Li,R., Luo,H., Guan,C., Cao,Y.
            and Wang,W.
  TITLE     FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme
            proliferation and differentiation via Lhx8/Suv39h1 complex
  JOURNAL   J Cell Mol Med 25 (6), 3051-3062 (2021)
   PUBMED   33580754
REFERENCE   6  (bases 1 to 5110)
  AUTHORS   Hirano,S., Yonezawa,T., Hasegawa,H., Hattori,S., Greenhill,N.S.,
            Davis,P.F., Sage,E.H. and Ninomiya,Y.
  TITLE     Astrocytes express type VIII collagen during the repair process of
            brain cold injury
  JOURNAL   Biochem Biophys Res Commun 317 (2), 437-443 (2004)
   PUBMED   15063777
  REMARK    GeneRIF: These data indicate that type VIII collagen plays an
            important role in glial scar formation during the repair process by
            astrocytes.
REFERENCE   7  (bases 1 to 5110)
  AUTHORS   Kvansakul,M., Bogin,O., Hohenester,E. and Yayon,A.
  TITLE     Crystal structure of the collagen alpha1(VIII) NC1 trimer
  JOURNAL   Matrix Biol 22 (2), 145-152 (2003)
   PUBMED   12782141
  REMARK    GeneRIF: Crystal structure of mouse alpha1(VIII)(3) NC1 domain
            trimer at 1.9 A resolution. Surface of collagen VIII NC1 trimer has
            three strips of partially exposed aromatic residues, likely
            involved in supramolecular assemblies.
REFERENCE   8  (bases 1 to 5110)
  AUTHORS   Muragaki,Y., Shiota,C., Inoue,M., Ooshima,A., Olsen,B.R. and
            Ninomiya,Y.
  TITLE     alpha 1(VIII)-collagen gene transcripts encode a short-chain
            collagen polypeptide and are expressed by various epithelial,
            endothelial and mesenchymal cells in newborn mouse tissues
  JOURNAL   Eur J Biochem 207 (3), 895-902 (1992)
   PUBMED   1499564
REFERENCE   9  (bases 1 to 5110)
  AUTHORS   Muragaki,Y., Jacenko,O., Apte,S., Mattei,M.G., Ninomiya,Y. and
            Olsen,B.R.
  TITLE     The alpha 2(VIII) collagen gene. A novel member of the short chain
            collagen family located on the human chromosome 1
  JOURNAL   J Biol Chem 266 (12), 7721-7727 (1991)
   PUBMED   2019595
REFERENCE   10 (bases 1 to 5110)
  AUTHORS   Iruela-Arispe,M.L. and Sage,E.H.
  TITLE     Expression of type VIII collagen during morphogenesis of the
            chicken and mouse heart
  JOURNAL   Dev Biol 144 (1), 107-118 (1991)
   PUBMED   1847345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY289783.1, AK046370.1, AV334655.2 and AC162943.2.
            
            On Jul 26, 2006 this sequence version replaced NM_007739.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032048.1, BC058281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY289783.1         2-23
            23-2506             AK046370.1         2-2485
            2507-2599           AV334655.2         542-634
            2600-5110           AC162943.2         163021-165531
FEATURES             Location/Qualifiers
     source          1..5110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.22 cM"
     gene            1..5110
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /note="collagen, type VIII, alpha 1"
                     /db_xref="GeneID:12837"
                     /db_xref="MGI:MGI:88463"
     exon            1..98
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..217
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..548
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2455
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /note="collagen alpha-1(VIII) chain; procollagen type VIII
                     alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(VIII) chain precursor"
                     /protein_id="NP_031765.2"
                     /db_xref="CCDS:CCDS37367.1"
                     /db_xref="GeneID:12837"
                     /db_xref="MGI:MGI:88463"
                     /translation="MAVPPRPLQLLGILFIISLNSVRLIQAGAYYGIKPLPPQIPPQI
                     PPQIPQYQPLGQQVPHMPLGKDGLSMGKEMPHMQYGKEYPHLPQYMKEIPPVPRMGKE
                     VVPKKGKGEVPLASLRGEQGPRGEPGPRGPPGPPGLPGHGMPGIKGKPGPQGYPGIGK
                     PGMPGMPGKPGAMGMPGAKGEIGPKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPG
                     QPGAKGERGPKGPPGPPGLQGPKGEKGFGMPGLPGLKGPPGMHGPPGPVGLPGVGKPG
                     VTGFPGPQGPLGKPGPPGEPGPQGLIGVPGVQGPPGMPGVGKPGQDGIPGQPGFPGGK
                     GEQGLPGLPGPPGLPGVGKPGFPGPKGDRGIGGVPGVLGPRGEKGPIGAPGMGGPPGE
                     PGLPGIPGPMGPPGAIGFPGPKGEGGVVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPP
                     GMRGLPGPIGPKGEGGHKGLPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIVGPSG
                     PIGPPGIPGPKGEPGLPGPPGFPGVGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPP
                     GPPGPPAVMPTPSPQGEYLPDMGLGIDGVKPPHAYAGKKGKHGGPAYEMPAFTAELTV
                     PFPPVGAPVKFDKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNN
                     EPMMYTYDEYKKGFLDQASGSAVLLLRPGDQVFLQMPSEQAAGLYAGQYVHSSFSGYL
                     LYPM"
     exon            549..5110
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2597..2602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /note="hexamer: AATAAA"
     polyA_site      2614
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /note="major polyA site"
     regulatory      5089..5094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5108
                     /gene="Col8a1"
                     /gene_synonym="Col8a-1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgcaagt tacccgcaga gcacagagga tcagagccct tccacggtcc tctccgtggg
       61 agcccgagtc cctgtctccc agatctgacg tgctcaagaa gctgttctgt aaatcaagta
      121 aaacctgtga agagagtgca cccagcccca gtggtattac aagaagagtc aagcaaggac
      181 tttggtcctc gattctactg gccagccaag cctaaatgtg atggctgtgc cacccaggcc
      241 tctacagctg ctgggaatac tgttcatcat ttccctgaac tctgtcagac tcattcaggc
      301 cggtgcctac tatggaatca agcctctgcc acctcaaatc cctcctcaga taccaccaca
      361 aattccacag taccagccct tgggccagca agtccctcac atgcctttgg gcaaagatgg
      421 cctttccatg ggcaaggaga tgcctcacat gcagtatggc aaagagtacc cacacctacc
      481 ccaatatatg aaggaaatcc cacctgtgcc aagaatgggc aaggaagtgg tgcccaaaaa
      541 aggcaaagga gaagtaccgt tagccagttt gcgcggagaa caaggtcccc gtggagaacc
      601 tggaccaaga ggaccacctg ggccgccagg tttaccaggt catggaatgc ctggaatcaa
      661 aggaaaacca gggccccagg gatatccagg aattggaaag cccggtatgc ctggaatgcc
      721 tgggaagcca ggagccatgg gaatgccagg ggcaaaaggc gaaattggac ccaaagggga
      781 aatcggacct atgggaatcc cagggccaca agggcctcca ggacctcatg gacttcctgg
      841 catcgggaaa ccgggtgggc cagggttacc agggcaacca ggagcaaaag gtgagagggg
      901 gcccaaagga ccaccaggac ctcccggcct tcagggtccc aaaggagaga agggcttcgg
      961 gatgcctggc ttgccaggtc tgaagggtcc tccaggtatg catggccctc ctggaccagt
     1021 tggactaccg ggagtaggaa aaccaggagt gacaggcttt cctggaccac agggtcccct
     1081 ggggaagcca gggcctccag gggaacctgg accacaaggc cttattggtg tgccaggagt
     1141 tcaaggacct cctgggatgc ctggagttgg aaagccaggt caggatggga tcccgggcca
     1201 accaggattt ccgggtggta aaggggaaca aggattgcca gggttgcctg gacccccagg
     1261 cctcccaggg gtcggaaagc caggtttccc aggacccaaa ggggaccggg gtattggggg
     1321 tgttcctggg gttcttgggc cgagagggga aaaaggaccc attggtgctc ctggaatggg
     1381 gggtccacct ggagagccag gcctacccgg tatcccgggt cccatgggcc ctccaggtgc
     1441 tattggtttc cctggaccca aaggagaagg tggagttgta ggaccacagg gtccaccagg
     1501 ccccaaggga gagcctggcc tccaaggctt ccctgggaag ccaggttttc ttggtgaagt
     1561 aggtccccct ggcatgaggg gtttgcctgg tcctatagga cccaagggag aaggtggtca
     1621 caaagggttg ccagggcttc ccggtgttcc agggctgctt ggacccaaag gagaacctgg
     1681 catacctggg gatcagggtc tacagggtcc cccagggatt ccagggatcg taggacctag
     1741 tggccctatt ggaccccctg ggattccggg ccccaaagga gaaccaggcc tcccagggcc
     1801 ccctgggttc cctggtgtag ggaagccagg agtagcagga cttcatgggc ccccggggaa
     1861 acctggtgcc cttgggcctc aaggccagcc tggccttcct ggacccccag gtcctccagg
     1921 acccccaggc cctccagctg tgatgcctac accatcaccc cagggagagt atctgccaga
     1981 tatgggacta ggaattgatg gggtgaaacc tccgcatgcc tatgcgggca aaaagggcaa
     2041 acacggaggg ccagcctatg agatgcctgc gtttactgcc gagctgactg tacctttccc
     2101 accggtgggg gccccagtga agtttgacaa gctgctctac aacggcagac agaactacaa
     2161 tccgcagaca ggcatcttca cctgtgaagt cccgggtgtc tactactttg cttatcatgt
     2221 tcactgcaag ggaggcaacg tatgggttgc tctcttcaag aacaacgagc ccatgatgta
     2281 cacatacgac gagtacaaga agggctttct ggaccaagca tctggaagcg cagtactgct
     2341 tctccgtccc ggagaccagg tgtttctcca aatgccttca gaacaggctg ctggactcta
     2401 tgccgggcaa tatgtccact cctccttttc aggatattta ttgtatccca tgtaaaaaaa
     2461 agagaaaaaa taagagattt aatagaagaa aagaaaatga cacaccaaaa aaaaaaatca
     2521 attgaaaaca atgcttcaaa acatttataa tagttggaaa gttatattta agtgaaagtt
     2581 tggaccatca tgtacaaata aaaactaaaa cgcatgttta gtcctgtgca cagcagattg
     2641 taatgggatc atgggaccga ggtatggatg aagtactgac acgtgtgttg tacccagcgg
     2701 actcattagc tgttccatgt tatatgattt cataacctgc ttattcaaat cagtcaaaat
     2761 atctcagtct ggagcatcat cgctaatgaa cagtattcat tctttgtgct cccttgtaaa
     2821 ggtatttttg aatatgcctt aagaggttga tggtgagagt tacatactgt atttatttgc
     2881 atgctttcct ctctatttca tgcaggtgtt ttactgtggg attttggagg gttcttctgt
     2941 agtgcagggt ccatggtaat ctctagtcca aaggatattt ctctgtgtta gaggcaatgc
     3001 tttgagctgc aggactacct agtcagaatt gtgtgtggat gtgtgtggtg tccccaaaag
     3061 aaaagctata ccaatggccc attgtgtatc tgctcagcag tctacttgcc tagcaactgg
     3121 gtgagatgca gggcaggaga tgctagcctg ggatgcaggg cagagcccac aggagctcat
     3181 agtttagctc agagtcatta aaatatcaac ccatctaaag ggtttcagtt cggaattttc
     3241 tgtaactttt cttttttcct tcttcaccct tccacataat atataacata gcctaagcaa
     3301 tataaacaaa tctttttttt acaaagcctt ccctcaaaca actttgccat ttcatgaaca
     3361 tttattatta atagcaatta tcagttgtgt aaaataaaac aaaaacacta atgtgtccac
     3421 agagccaagt gtagtgaggt ttcaccttgt ctgcacctgt cttagtagct gtcatttttt
     3481 tttcccagta actatgaatt ttaaaactat gacttatgcc atgaggttcc aaagtcaatt
     3541 gccaaaaatc caaaccattc tttttttttt ttaatttggg ggaaaaaatc agaattacat
     3601 aggaaaaatt atattttaaa agagtaatta taaggtttga tattcaaaag caggcatgtt
     3661 gcttccagca atagggacta cggttgtagg aagataattg tttctttaac atccgcctgg
     3721 ggaagagata gctggagtgt cataagccat agcacctcag gcctacgatg ccactgcacg
     3781 cttagcacca cagccaaacc atgttggaaa agagaaattg ttttttttca gattctaatt
     3841 aaggcacata gtaggttctt tggctgatgc tcaaaacacg accagttgaa cgttttccgt
     3901 tcatctgctc ttggttgctt aggggaataa tgtggaatga gagcaataga atgtattcta
     3961 cttttctcaa aagttaaaaa ccaggagctg aagagagaga catagattgg aaaatgcaca
     4021 gataaataca gtataaagca tggtctattt aaaatctgaa ttatttttac caccacagtt
     4081 cttcttgcca cggcttacta ttggtctttt ccctttatga ggcacagaca ccattttttt
     4141 cttgaatttt taaaaaaaga atgtgtttat tagcacaagg tttttcattc attgttaatt
     4201 acacaagagc accttcgaat ccaaacgaat ttcctaccaa accttcattt gcaaagtaaa
     4261 cagcatgtct ttggacagct ttccttgggg tcgctcctaa ggacactggc ttatagctgg
     4321 tcactatgga aatcatatgg gtccctcgct ctttctgctc aatagctacg ttgaaatggt
     4381 ctggccagat gggttgtaaa gttgctttta tctgtacatg tatggtattt tagtttccat
     4441 aaagaaagac agaaattatc tcttaagtta aaccaaattt cactttttga gatatcttcc
     4501 aacttattta ttggttgtta ctcaattgcc tgcctctgtg tgtgtgtgtg tgtgtgtgtg
     4561 tgtgtgtgtg tgtgtgtgtt atcaggcata tgcttctaag cttttaaatg gaggaggagc
     4621 aaaaatctat gccagatact gtatattcta ccatggtgct aatatcagag ctaaatgata
     4681 ctccatttaa tttaaagaag agttttaaat aattatctat gtacctgtgt ttcccttttg
     4741 agtgttgtcc atcatgtcca cagtggtgtg aaagcaagtg aatcaagtat gtgttctact
     4801 ttctagggac agtactatga tcacttttta atacaaaatt aactagagct tttccaagtg
     4861 aaatggacca aactggcatt gttctattta aacagagagt tttaatgcag tatgacgtcc
     4921 cacaggggaa aggaatgtct gtagaggaca gttgtcctca aatattttac agaaacaaag
     4981 aatgatgaaa agaccggtaa cttgcttgag ttcccatgaa tagatttgag actgaatggc
     5041 aaatcaattt tgtatttaaa ttttttgtac tgatttgaaa aacagatcat taaatatctc
     5101 taaaaatatg
//
