LOCUS       NM_009933               3990 bp    mRNA    linear   ROD 13-NOV-2023
DEFINITION  Mus musculus collagen, type VI, alpha 1 (Col6a1), mRNA.
ACCESSION   NM_009933
VERSION     NM_009933.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3990)
  AUTHORS   Molon S, Brun P, Scarpa M, Bizzotto D, Zuccolotto G, Scarpa M,
            Fassan M, Angriman I, Rosato A, Braghetta P, Castagliuolo I and
            Bonaldo P.
  TITLE     Collagen VI promotes recovery from colitis by inducing
            lymphangiogenesis and drainage of inflammatory cells
  JOURNAL   J Pathol 260 (4), 417-430 (2023)
   PUBMED   37272555
  REMARK    GeneRIF: Collagen VI promotes recovery from colitis by inducing
            lymphangiogenesis and drainage of inflammatory cells.
REFERENCE   2  (bases 1 to 3990)
  AUTHORS   Abbonante V, Malara A, Chrisam M, Metti S, Soprano P, Semplicini C,
            Bello L, Bozzi V, Battiston M, Pecci A, Pegoraro E, De Marco L,
            Braghetta P, Bonaldo P and Balduini A.
  TITLE     Lack of COL6/collagen VI causes megakaryocyte dysfunction by
            impairing autophagy and inducing apoptosis
  JOURNAL   Autophagy 19 (3), 984-999 (2023)
   PUBMED   35857791
  REMARK    GeneRIF: Lack of COL6/collagen VI causes megakaryocyte dysfunction
            by impairing autophagy and inducing apoptosis.
REFERENCE   3  (bases 1 to 3990)
  AUTHORS   Cai S, Si N, Wang Y and Yin N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3990)
  AUTHORS   Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR,
            Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O
            and Maynard C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 3990)
  AUTHORS   De A, Morales JE, Chen Z, Sebastian S and McCarty JH.
  TITLE     The beta8 integrin cytoplasmic domain activates extracellular
            matrix adhesion to promote brain neurovascular development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35217866
REFERENCE   6  (bases 1 to 3990)
  AUTHORS   Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg
            JR, Trask BJ, de Jong P, Reed RR, Simon MI et al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   7  (bases 1 to 3990)
  AUTHORS   Threadgill DS and Womack JE.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   8  (bases 1 to 3990)
  AUTHORS   MacDonald G, Chu ML and Cox DR.
  TITLE     Fine structure physical mapping of the region of mouse chromosome
            10 homologous to human chromosome 21
  JOURNAL   Genomics 11 (2), 317-323 (1991)
   PUBMED   1837533
REFERENCE   9  (bases 1 to 3990)
  AUTHORS   Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J,
            Chada K, Silan CM, Copeland NG and Jenkins NA.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (bases 1 to 3990)
  AUTHORS   Chu ML, Mann K, Deutzmann R, Pribula-Conway D, Hsu-Chen CC, Bernard
            MP and Timpl R.
  TITLE     Characterization of three constituent chains of collagen type VI by
            peptide sequences and cDNA clones
  JOURNAL   Eur J Biochem 168 (2), 309-317 (1987)
   PUBMED   3665927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X66405.1 and EF437374.1.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_009933.5.
            
            On Apr 21, 2009 this sequence version replaced NM_009933.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66405.1, SRR1660811.196435.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2470              X66405.1           1-2470
            2471-2749           EF437374.1         217-495
            2750-3461           X66405.1           2750-3461
            3462-3990           X66405.1           3463-3991
FEATURES             Location/Qualifiers
     source          1..3990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.71 cM"
     gene            1..3990
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /note="collagen, type VI, alpha 1"
                     /db_xref="GeneID:12833"
                     /db_xref="MGI:MGI:88459"
     exon            1..225
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..3209
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /note="collagen alpha-1(VI) chain; procollagen, type VI,
                     alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(VI) chain precursor"
                     /protein_id="NP_034063.1"
                     /db_xref="CCDS:CCDS23952.1"
                     /db_xref="GeneID:12833"
                     /db_xref="MGI:MGI:88459"
                     /translation="MRLAHALLPLLLQACWVATQDIQGSKAIAFQDCPVDLFFVLDTS
                     ESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGL
                     TRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHP
                     LEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWG
                     HSRDAEEVISQTIDTIVDMIKNNVEQVCCSFECQAARGPPGPRGDPGYEGERGKPGLP
                     GEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKG
                     ETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGMKGEKGEAGADGEAGRPGNSGSPGD
                     EGDPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQ
                     GDQGREGPVGIPGDSGEAGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERG
                     EDGPPGNGTEGFPGFPGYPGNRGPPGLNGTKGYPGLKGDEGEVGDPGEDNNDISPRGV
                     KGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSES
                     IGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRN
                     AQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPL
                     SVLCGADIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQGRPGISLVKENYAELLDDGF
                     LKNITAQICIDKKCPDYTCPITFSSPADITILLDSSASVGSHNFETTKVFAKRLAERF
                     LSAGRADPSQDVRVAVVQYSGQGQQQPGRAALQFLQNYTVLASSVDSMDFINDATDVN
                     DALSYVTRFYREASSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVG
                     PQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG"
     exon            226..355
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..556
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..716
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..845
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..866
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..887
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..932
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..986
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1031
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1058
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1085
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1130
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1184
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1247
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1310
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1364
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1400
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1463
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1526
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1589
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1652
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1703
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1739
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1802
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1868
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1904
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..1941
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..1950
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2084
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2194
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2378
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2556
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2586
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..3976
                     /gene="Col6a1"
                     /gene_synonym="Col6a-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctccctgg ctctctcctc agctctgggc tctgactgca gcaagcagag acaacctctc
       61 actctgcctt tcccagcgcc caccctgacc ctggcccaca tttgacggtg actcgcaggc
      121 cagccagaaa catgaggctg gcccacgctc tgctgcccct gctgctacaa gcctgctggg
      181 tggccacaca ggacatccag ggctccaaag cgattgcctt ccaagactgc cctgtggatc
      241 tattcttcgt gctcgacacc tcggagagtg tggccttgag gctgaaacct tatggggcct
      301 tggtggacaa ggtgaagtcc ttcactaagc gcttcattga caacctgaga gacaggtact
      361 accggtgtga ccgcaacctg gtttggaatg cgggtgcgct gcactacagt gacgaggtgg
      421 agatcatccg agggctcacg cgcatgccca gtggccgcga tgagctcaag gccagcgtgg
      481 atgcggtcaa gtacttcggg aaaggcacct acaccgactg cgccattaag aaggggctgg
      541 aggagctgct catagggggc tcccacctga aggagaacaa gtacttgatc gtggtgaccg
      601 acgggcatcc tctagagggc tacaaggaac catgcggggg tctggaagat gcagtaaatg
      661 aggccaaaca cctgggcatc aaggtctttt ctgtggccat cacacctgac cacctggagc
      721 cacgtctaag tatcattgcc acagaccaca cataccggcg caatttcacg gcagctgact
      781 gggggcatag ccgcgatgca gaagaggtca tcagccagac cattgacacc attgtggaca
      841 tgattaaaaa taacgtggaa caagtgtgtt gttcttttga gtgccaggct gccagaggac
      901 ctccagggcc ccgaggcgac cctgggtatg agggggagcg aggaaagcca ggtcttccgg
      961 gagagaaggg agaagctgga gaccctggac gacctgggga tcttggacca gtcgggtacc
     1021 agggtatgaa gggagaaaag gggagccgtg gagagaaggg ttccagagga ccgaaaggtt
     1081 acaagggcga gaaaggcaag cgcggaatcg acggggtcga cggcatgaag ggagagacgg
     1141 ggtacccagg actaccgggc tgcaagggct ccccaggatt tgatggcatt caaggacccc
     1201 cgggtcccaa gggtgatgct ggtgcctttg ggatgaaggg agaaaagggt gaagctggag
     1261 cagacggtga ggctgggaga ccagggaact cagggtcacc tggagatgag ggtgatcctg
     1321 gagagcctgg tccccccgga gaaaaaggag aggccggtga tgaaggaaat gctggcccag
     1381 acggtgcccc tggagagagg ggtggccctg gtgaaagagg acctcggggg acccctggtg
     1441 tgagaggacc aaggggagac ccgggtgaag ctggaccaca gggtgaccaa ggaagagagg
     1501 ggcccgtcgg catccctgga gactcgggtg aggctggccc cattggacct aaaggatacc
     1561 gaggtgatga gggtcctcca ggtcctgagg gcctcagagg agccccagga cctgttggtc
     1621 ctcctggaga ccccggactg atgggtgaga gaggtgagga tggaccacca ggaaacggca
     1681 cggaaggttt ccccggcttc cctgggtatc caggcaacag aggccctcct gggctaaatg
     1741 gcacaaaagg ctaccctggc ctcaaggggg atgagggtga agtgggagac ccaggagagg
     1801 ataacaacga catttcaccc cgtggggtca aaggggcaaa gggataccga ggcccagaag
     1861 gaccccaggg acctccagga catgtgggac cacctgggcc agatgagtgt gagatcctgg
     1921 atatcatcat gaaaatgtgc tcctgctgtg agtgcacatg tggacccatt gacatcctct
     1981 tcgtgctgga cagctcggag agcattggcc tacagaactt tgagattgcc aaggacttca
     2041 tcatcaaggt cattgaccgg ttgagcaagg atgagctggt caaatttgag ccagggcagt
     2101 ctcacgcggg cgtggtacag tacagccaca accagatgca agagcacgtg gacatgcgga
     2161 gccccaacgt ccgcaacgcc caggacttca aagaagctgt caagaagcta caatggatgg
     2221 ctggtggcac attcaccgga gaagcgctgc agtacacccg ggaccggcta ctcccaccca
     2281 cacagaacaa ccgaattgcc ctggtcatta cggatggacg ttctgacact caacgggaca
     2341 cgacacctct cagtgtgctc tgtggtgcag acattcaggt agtttctgtg ggaatcaagg
     2401 atgtgtttgg ctttgtggcg ggctccgacc agctcaatgt catttcctgc caaggcttat
     2461 cgcaaggtcg gccaggtatc tccctggtga aggagaacta tgcagagctt ctcgatgacg
     2521 gctttctgaa gaacataaca gcccagatct gtatagataa gaagtgtccg gattatacct
     2581 gtccaatcac attctcctcc ccggctgaca tcaccatcct gctagacagc tcagccagtg
     2641 tcggcagcca caacttcgaa accaccaagg tcttcgccaa gcgcctagct gagcgattcc
     2701 tgtcagcagg cagggcggat ccttcccagg atgtgcgggt ggccgtggta cagtatagtg
     2761 gccaggggca gcaacagcca ggtcgggcgg ctcttcagtt cttacagaat tacacagtgc
     2821 tggccagctc tgtggacagc atggatttca tcaacgacgc cacagacgtc aacgatgctc
     2881 tgagctacgt gactcgtttc taccgggaag cctcgtcagg tgccaccaag aagagagtgc
     2941 tgttgttttc agacggcaac tctcaggggg ccacagcaga ggccattgag aaggctgtgc
     3001 aggaggccca gcgtgcaggc attgagatct ttgtggtggt ggtgggaccc caggtgaacg
     3061 agccccacat ccgtgtgctt gtcactggca agactgcaga gtacgacgtg gcctttggcg
     3121 agcgccacct attccgtgta ccaaactacc aggccctgct acgtggcgta ctctaccaga
     3181 cagtctccag gaaggtggca ctgggctaga gggccacaca cgtggctgga cacacatggc
     3241 atggagacac atttcaacag gccttcccgc ccttcccact gacaaaacag gaataggaaa
     3301 tgtgacccaa ctggtcaact caactgtctt aaagggaacg ctgagatgca cactctttgc
     3361 tttgtgtaat gtcccctgtg gctcacctga gctcctatct agatcccgcc cttggtttgt
     3421 acatcatggt ggccatcttg ctgacccctc ccccatctgg gctggatcca gccatctcgt
     3481 cttcctcctc actgccccta acctatccgt ggtgtcttca caccatcact gcagtttccg
     3541 tctgtgttct gtcttccatg ctcaacatga agcagacctt ctcatgagtt cagcttgctg
     3601 gattatggct tttaggaaat tgaacacagg aggagttcca aacacaaact tggaggagac
     3661 ccctcctctt catcaggtgc ttgtcagtga cctacatgca tcttggtctg gtccttagtg
     3721 gctagtcctt ccactctgaa agcaaaggtg ctatctatct gtaagggctc tctctacaca
     3781 cccagaggct tagcttggac agttcacact caagtgtcct gtcagaatca atccagagct
     3841 ttctccctca aaatagtgac ttgtctcccc ctggtcccca aaggctcccc tttagttagt
     3901 ttcttcatgg ctcccccaca ttccccgtaa tctgatccaa gccagctatc tctgctaata
     3961 aaggtttcca tttttcaaaa aaaaaaaaaa
//
