LOCUS       NM_007737               6615 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus collagen, type V, alpha 2 (Col5a2), mRNA.
ACCESSION   NM_007737
VERSION     NM_007737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6615)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   2  (bases 1 to 6615)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Schwaderer,A.L., Hains,D.S. and Calve,S.
  TITLE     FOXD1 is required for 3D patterning of the kidney interstitial
            matrix
  JOURNAL   Dev Dyn 252 (4), 463-482 (2023)
   PUBMED   36335435
REFERENCE   3  (bases 1 to 6615)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6615)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Hains,D.S., Schwarderer,A.L. and Calve,S.
  TITLE     3D Mapping Reveals a Complex and Transient Interstitial Matrix
            During Murine Kidney Development
  JOURNAL   J Am Soc Nephrol 32 (7), 1649-1665 (2021)
   PUBMED   33875569
REFERENCE   5  (bases 1 to 6615)
  AUTHORS   Dupays,L., Towers,N., Wood,S., David,A., Stuckey,D.J. and Mohun,T.
  TITLE     Furin, a transcriptional target of NKX2-5, has an essential role in
            heart development and function
  JOURNAL   PLoS One 14 (3), e0212992 (2019)
   PUBMED   30840660
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6615)
  AUTHORS   Chen,X., Li,X., Wang,W. and Lufkin,T.
  TITLE     Dlx5 and Dlx6: an evolutionary conserved pair of murine homeobox
            genes expressed in the embryonic skeleton
  JOURNAL   Ann N Y Acad Sci 785, 38-47 (1996)
   PUBMED   8702182
REFERENCE   7  (bases 1 to 6615)
  AUTHORS   Yoshioka,H., Iyama,K., Inoguchi,K., Khaleduzzaman,M., Ninomiya,Y.
            and Ramirez,F.
  TITLE     Developmental pattern of expression of the mouse alpha 1 (XI)
            collagen gene (Col11a1)
  JOURNAL   Dev Dyn 204 (1), 41-47 (1995)
   PUBMED   8563024
REFERENCE   8  (bases 1 to 6615)
  AUTHORS   Andrikopoulos,K., Liu,X., Keene,D.R., Jaenisch,R. and Ramirez,F.
  TITLE     Targeted mutation in the col5a2 gene reveals a regulatory role for
            type V collagen during matrix assembly
  JOURNAL   Nat Genet 9 (1), 31-36 (1995)
   PUBMED   7704020
REFERENCE   9  (bases 1 to 6615)
  AUTHORS   Neuhaus,H., Bettenhausen,B., Bilinski,P., Simon-Chazottes,D.,
            Guenet,J.L. and Gossler,A.
  TITLE     Etl2, a novel putative type-I cytokine receptor expressed during
            mouse embryogenesis at high levels in skin and cells with
            skeletogenic potential
  JOURNAL   Dev Biol 166 (2), 531-542 (1994)
   PUBMED   7813775
REFERENCE   10 (bases 1 to 6615)
  AUTHORS   Andrikopoulos,K., Suzuki,H.R., Solursh,M. and Ramirez,F.
  TITLE     Localization of pro-alpha 2(V) collagen transcripts in the tissues
            of the developing mouse embryo
  JOURNAL   Dev Dyn 195 (2), 113-120 (1992)
   PUBMED   1297453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK147328.1, AK132413.1,
            AK139130.1 and AK003709.1.
            
            On Feb 7, 2006 this sequence version replaced NM_007737.1.
            
            Summary: This gene encodes the alpha-2 subunit of type V collagen,
            one of the low abundance fibrillar collagens that gets incorporated
            into growing fibrils with type I collagen. The encoded protein, in
            association with alpha-1 and/or alpha-3 subunits, forms homo- or
            heterotrimeric type V procollagen that undergoes proteolytic
            processing. Mice lacking the encoded protein die in utero.
            Transgenic mice that produce a structurally abnormal form of the
            encoded protein survive poorly and exhibit skin fragility, skeletal
            abnormalities and alterations in the collagen fiber organization.
            [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139130.1, AK132413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AK147328.1         2-220
            220-3553            AK132413.1         2-3335
            3554-3559           AK147328.1         3555-3560
            3560-5090           AK132413.1         3342-4872
            5091-6324           AK139130.1         4666-5899
            6325-6615           AK003709.1         413-703
FEATURES             Location/Qualifiers
     source          1..6615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.69 cM"
     gene            1..6615
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="collagen, type V, alpha 2"
                     /db_xref="GeneID:12832"
                     /db_xref="MGI:MGI:88458"
     exon            1..462
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..4862
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="collagen alpha-2(V) chain; procollagen, type V,
                     alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(V) chain preproprotein"
                     /protein_id="NP_031763.2"
                     /db_xref="CCDS:CCDS35555.1"
                     /db_xref="GeneID:12832"
                     /db_xref="MGI:MGI:88458"
                     /translation="MMANWVGARPLLILSVLLGYCVSIKAQEQENDEYDEEIACTQHG
                     QMYLNRDIWKPSPCQICVCDNGAILCDKIECPEVLNCANPITPTGECCPVCPQTGGGD
                     TSFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGDRGPKGRPGPRGPQGIDG
                     EPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGP
                     RGPQGLQGQQGGVGPAGPPGEPGEPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNTGEV
                     GFSGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEIGAPGAKGEAGPTGPMGAMGPLG
                     PRGMPGERGRLGPQGAPGKRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAGPTGA
                     RGPEGPQGQRGETGPPGPAGSQGLPGAVGTDGTPGAKGPTGSAGTSGPPGLAGPPGSP
                     GPQGSTGPQGIRGQSGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPG
                     TVGPPGPMGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGGQGDPGRPGEPGL
                     PGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDL
                     GKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPG
                     PPGEGGKAGDQGVPGEPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGP
                     KGNPGPTGTIGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLP
                     GPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPG
                     VKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPHGVPGLKGGRGTQGPPGATGFPGSAGR
                     VGPPGPAGAPGPAGPAGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGSPGDKGDPGED
                     GQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPG
                     PVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGP
                     VGAPGDAGQRGEPGSRGPVGPPGRAGKRGLPGPQGPRGDKGDNGDRGDRGQKGHRGFT
                     GLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVG
                     EAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDENMPDPLPEFTEDQAAPDDTNKT
                     DPGIHVTLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHPTKQSGEYWIDPNQGSAED
                     AIKVYCNMETGETCISANPASVPRKTWWASKSPDNKPVWYGLDMNRGSQFTYGDYQSP
                     NTAITQMTFLRLLSKEASQNLTYICRNTVGYMDDQAKNLKKAVVLKGSNDLEIKGEGN
                     IRFRYTVLQDTCSKRNGNVGKTIFEYRTQNVARLPIIDVGPVDIGNADQEFGLDIGPV
                     CFM"
     exon            463..684
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            685..698
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..731
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..764
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..818
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            819..929
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1007
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1052
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1106
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1160
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1214
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1268
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1322
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1367
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1421
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1466
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1520
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1619
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1664
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1763
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1817
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1925
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1979
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2078
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2132
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2231
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2285
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2339
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2393
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2447
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2492
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2591
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2699
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2753
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..2807
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2861
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2915
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3023
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3077
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3131
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3293
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3401
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3509
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3563
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3671
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3725
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3833
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..3887
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..3995
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4287
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4475
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4715
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..6615
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5136..5141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5159
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="major polyA site"
     regulatory      5631..5636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5653
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
     regulatory      6302..6307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      6327
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
     regulatory      6593..6598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6615
                     /gene="Col5a2"
                     /gene_synonym="1110014L14Rik"
ORIGIN      
        1 gtctctgttg agaagcttcc tctgtgctta aaatctacaa gaagcactga aaactcaagt
       61 cgcagaggcg cgcgctctga tttggttgtt taccatcaat cagacggttg cttggcagac
      121 actggatggt tatgagcctg aacaagctga aaggggcagg aaaagaagtg gaggcagcat
      181 tcttcctatt taaagctgca ccgcttgaaa aaagttttcg cagactgtgc cggacctggt
      241 gctgaaacag actgaggcag cgcggggact ggtgctgaaa aagagccccc agcggaattc
      301 atggtgctac agtgacctca gtatctactc ttcgatccca ggaggaccca catgtctcat
      361 atttagacat gatggcaaac tgggtgggag caagacctct cctcattctt tctgttttat
      421 tagggtactg tgtctcaata aaagcccagg aacaagagaa tgatgaatat gatgaagaaa
      481 tagcctgtac tcaacatgga cagatgtatt taaatagaga catttggaaa ccttctccat
      541 gtcagatctg tgtctgtgac aatggtgcca ttctttgtga caagatagag tgcccagagg
      601 tgctcaactg tgccaatcct ataacaccca ctggggagtg ctgtccggtg tgcccacaaa
      661 ctggaggtgg agatactagt tttggtagag gaagaaaggg acaaaaagga gaaccaggat
      721 tagtgcctgt tgtaacaggt atacgcggtc gtccaggacc tgcaggcccc ccaggatcac
      781 aaggaccaag aggggaccga ggccctaaag gaagacctgg tcctcgtggt cctcagggaa
      841 ttgatggaga gccaggtgtg cctggtcagc caggtgctcc agggcctcct gggcacccct
      901 ctcacccagg acctgatggc atgagcaggc ctttttcagc tcagatggct gggctggatg
      961 aaaaatctgg acttggaagt caagtaggac tcatgcctgg ctctgtgggt cctgttggcc
     1021 caagaggacc tcagggttta caaggacagc aaggtggtgt gggacccgca ggacctcctg
     1081 gtgagcctgg cgagcctgga ccaatgggtc caattggttc tcgtggacca gagggcccac
     1141 ctgggaagcc cggagaagat ggtgaacctg gaagaaatgg gaatacaggt gaagtgggat
     1201 tctcaggatc accaggtgct cgaggcttcc ctggtgctcc tggtctccct ggcttgaaag
     1261 gtcacagagg acacaaaggt cttgaaggcc ccaaaggtga aattggagca cctggtgcta
     1321 agggtgaagc tggccccact ggtccaatgg gtgctatggg ccctctggga ccaagaggaa
     1381 tgccaggaga gaggggaaga cttgggccac agggtgctcc tggaaaacgg ggtgcccacg
     1441 gtatgcctgg aaaacctgga ccaatgggtc ctcttgggat acctggctct tccggttttc
     1501 caggaaatcc tggaatgaag ggagaagcag gtcctactgg agcccgaggc cctgaaggtc
     1561 ctcaggggca gagaggtgaa actgggccac ctggtccagc tggctctcag ggtcttcctg
     1621 gtgcagtggg gactgatggt acacctggcg ccaaaggccc cacaggctct gcaggaacct
     1681 ctggccctcc tggcttggca gggccccctg ggtctcctgg ccctcaaggc agtactggac
     1741 ctcagggaat ccgaggacaa tcgggtgatc caggagttcc aggtttcaaa ggagaagctg
     1801 gtccaaaggg agaaccaggg ccacatggta ttcagggtcc cattggtcca cctggtgaag
     1861 aaggcaaaag aggtcctcgg ggtgatccag gcacagttgg tcctccagga ccaatgggag
     1921 aaaggggcgc tcctggcaat cgtggttttc cagggtctga tggtttacct ggaccaaagg
     1981 gtgctcaggg agagcgtggt cctgtaggtt cttcggggcc taaaggaggc cagggagatc
     2041 caggacgtcc aggagaacct gggcttccag gtgctcgggg tctgacagga aatcctggtg
     2101 ttcaaggtcc tgaaggaaaa cttgggcctt tgggtgctcc tggggaagat ggtcggccag
     2161 gtcctccagg ctccattggg atcagaggac agcctggaag catgggcctt ccaggcccca
     2221 aaggtagcag tggtgacctt ggaaaaccag gagaagcagg aaatgctggt gtgcctgggc
     2281 aaaggggggc tcctggcaaa gatggagaag ttggtccttc aggccctgtg ggacctccgg
     2341 gcctagctgg ggaaagagga gagcagggac ctccaggccc cactggcttt cagggacttc
     2401 ctggacctcc agggccacct ggagaaggtg gaaaggctgg tgatcaaggt gttcctggag
     2461 agcctggagc agttggccca ttaggacctc ggggagaaag agggaatcct ggagaaagag
     2521 gagagccagg gataactgga ctgcctgggg agaaaggcat ggctggagga catggccctg
     2581 atggtccaaa gggcaaccca ggtccaactg ggaccattgg agacacaggg ccaccaggtc
     2641 ttcagggcat gccaggagaa agaggaattg caggaacacc tggccctaag ggtgaccgag
     2701 gtggcatagg agagaaaggt gctgaaggaa cagcaggaaa tgacggggca aggggtcttc
     2761 caggtccctt gggacctcca ggtcctgcag gccctactgg agaaaagggt gaacctggtc
     2821 ctagaggctt agttggccct cctggctccc gtggcaatcc tggttctcgt ggtgaaaatg
     2881 gtccaactgg agctgttggt tttgctggac cccagggtcc cgatggacag cctggtgtca
     2941 agggtgagcc tggagagcca ggacagaagg gagatgctgg gtctcctgga ccccaagggc
     3001 tagcaggatc acctggcccc catggtccac atggtgttcc tggactgaaa ggcggtagag
     3061 gaacccaggg tccacctggt gctacagggt ttcctggttc tgctggcaga gttgggcctc
     3121 caggccctgc tggagctcca ggacctgcag ggcccgcagg agaacctggg aaggaaggac
     3181 ctcctggtct tcgtggtgac cctggctctc atgggcgagt gggagataga ggaccagctg
     3241 gcccacctgg tagcccagga gataaagggg acccaggaga agatggacaa cctggtccag
     3301 atggtcctcc tggtcccgct ggtaccactg ggcaaagagg aattgttgga atgcccggac
     3361 aacgtgggga acgaggaatg cctggccttc ctggcccagc gggtacacca ggaaaagtag
     3421 gaccaactgg tgcgacagga gataaaggtc cccctggacc tgtaggacct ccaggttcca
     3481 atggtcctgt aggagaacct gggccagaag gtccggctgg taatgatggt accccaggac
     3541 gggatggtgc tgttggagaa cggggtgacc gtggagaccc cgggcctgct ggtctaccag
     3601 gctctcaggg tgcccctgga actcctggcc ctgttggtgc ccctggagat gcaggacaaa
     3661 gaggagagcc aggttctcga ggccctgtag gaccacctgg tcgagctgga aagcgtggtt
     3721 tacctggacc acaaggacct cgaggtgaca agggtgacaa tggagacaga ggtgaccgag
     3781 gtcagaaagg ccacagaggg ttcactggcc tgcagggtct tcctggacct cctggtccaa
     3841 atggtgaaca aggaagtgct ggcattcctg gtcctttcgg tccaagaggt cctccaggac
     3901 cagtaggtcc ttcaggaaag gaaggaaacc ctgggccact tggaccaatt ggacctcctg
     3961 gtgtgcgggg cagtgtagga gaagcaggac cagagggtcc tcctggtgaa cctgggcctc
     4021 ctggccctcc aggtccccct ggccatctta ctgctgctct tggtgatatc atgggacact
     4081 atgatgagaa catgccagat ccacttccag agtttacgga agaccaggca gctccagatg
     4141 acacaaacaa aacagaccct gggatccatg ttaccctgaa gtctctcagt agtcagattg
     4201 aaaccatgcg tagccctgat ggttccaaga aacacccagc ccgcacttgt gatgatttaa
     4261 agctttgcca tcccacaaag cagagcggtg aatattggat tgatcctaac cagggatcag
     4321 ctgaagatgc aatcaaagtt tactgcaata tggaaacagg agagacatgt atttcagcaa
     4381 acccagccag tgttccacgt aaaacctggt gggccagcaa atcccctgac aataagcctg
     4441 tgtggtacgg tcttgacatg aatagaggat ctcagttcac atatggagat taccagtctc
     4501 ctaacacagc tatcactcag atgacctttt tgcgtctttt atcaaaagaa gcctcgcaga
     4561 accttactta catctgtagg aacactgttg gatatatgga tgatcaagct aaaaacctca
     4621 agaaagctgt ggtccttaaa gggtcaaacg acttagaaat aaaaggagaa ggaaacatca
     4681 gattcagata cacagttctt caagacacct gctctaagcg aaatggaaat gtaggcaaaa
     4741 ctatctttga atacagaaca cagaatgtgg cccgcttgcc catcatagat gttggtcctg
     4801 tggatattgg caatgcagac caggaatttg gccttgatat tgggccagtt tgtttcatgt
     4861 aacagaagcc cagacatatc gacaatgagc actaccatca atgaccacca caagaactgt
     4921 gactgtttaa agttcatcct gagactcttg aagtaatggc tggtcctgca tcagctttgt
     4981 acatacgatc tgaagtgcct gaccacctta tccttcagaa tatttatttt acttacaatc
     5041 ctcaagttta attgacttaa ttttttcaat atggccgttt agattaaagc aaccaatgac
     5101 aatgaccatc tttacaaaaa gtaaactgat caaaaaataa atatgttttc atcaattcat
     5161 ttcactgtaa tgaatacgtt gcttagtatt tatgagaaaa ttcttcttcc tagcaggtag
     5221 cttacatgat ggggtatgta aagcctcagc atgtgttgat tttgcttggc tgcagtctga
     5281 aaagtagaga gtaatgcccc ctgtgtcctc ttattgtcag aacatcagtg acaaatgaag
     5341 acccccatgc atgtcttaat attatactaa cattatagaa aaaattaagg tgaatataac
     5401 acgtttccac tgtcttaaat gatatcttta aataacatgt aaccattgac ttttaggagg
     5461 aaaaaaatcc ataaaattgc ttcaacttta caatttattt tgcaaaaact gatacagtta
     5521 gagttttttc ctcattcaaa tttaagggta acattttctt tttgttgtaa tctttcaata
     5581 cagatagaag ttatatttgt ggtttcctat gtaagaagat attggatgaa attaaaaaaa
     5641 attacccaca caattttcta acacacgtgc ccagtaatga atgttaagac tctcccacag
     5701 tcacagtctc attttcctga agcatatcat aagaaatgaa caagaagtcc agcattataa
     5761 tgatcactca aataaaatgt gaggattgga attagaacat tcataagaaa atatgaccca
     5821 acatttctta gcatgaccta cctcatctct gcaagctggg atagatttcc tgttcttgtt
     5881 tatttttagg tgttgaaagg tgctatgctt ctgttgttat tccaagactg gagataggca
     5941 gggttaaaaa tattataact tttcttttaa tgatggtgct aaaattattt ctataaaatt
     6001 ctttaaagat aaagattgtt tcatcaatgc tatttgtgaa cacagaactg ttaaacatcc
     6061 catttgagag atagatcatt attcctgggt cttttaactg ttccttttat gatgtattta
     6121 gaacattgtg taatgcttgc aagtgtctta acctaggaca cataggtccc cttgtgtctc
     6181 aagatttttt ccttaattgc agttgtttgc tccattgttg tttcttactt aaataatctg
     6241 ggccatccca aaggacaagg cccacataga actttgatca tgtatctctg caaagcatcg
     6301 aattaaatgc atgcttctgt catgtcagtc atcttcagtt tgttgaatcc tttgaacata
     6361 ttaggtcctt ttagtttcca ggagtgaaaa ctaagatctc ctggtagttt ttgttcacaa
     6421 tttagtagac gatgcaacaa gtacctacca ttttgtctgc actggcttaa aaataaacct
     6481 atctgtaaca ttgcctgcaa aggcatgttg acatcaatga agacagtcta tgcgttagaa
     6541 aactcaggct agtgattggt aaagagtaaa ggaaatgaaa aatccattat tgaataaact
     6601 aataataaaa catgc
//
