LOCUS       NM_015734               8420 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus collagen, type V, alpha 1 (Col5a1), mRNA.
ACCESSION   NM_015734
VERSION     NM_015734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8420)
  AUTHORS   Jacobson,K.R., Saleh,A.M., Lipp,S.N., Tian,C., Watson,A.R.,
            Luetkemeyer,C.M., Ocken,A.R., Spencer,S.L., Kinzer-Ursem,T.L. and
            Calve,S.
  TITLE     Extracellular matrix protein composition dynamically changes during
            murine forelimb development
  JOURNAL   iScience 27 (2), 108838 (2024)
   PUBMED   38303699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8420)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Schwaderer,A.L., Hains,D.S. and Calve,S.
  TITLE     FOXD1 is required for 3D patterning of the kidney interstitial
            matrix
  JOURNAL   Dev Dyn 252 (4), 463-482 (2023)
   PUBMED   36335435
REFERENCE   4  (bases 1 to 8420)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Colling,H.A., Tuttle,T.G., Miles,D.T.,
            McCreery,K.P. and Calve,S.
  TITLE     Mechanical loading is required for initiation of extracellular
            matrix deposition at the developing murine myotendinous junction
  JOURNAL   Matrix Biol 116, 28-48 (2023)
   PUBMED   36709857
REFERENCE   5  (bases 1 to 8420)
  AUTHORS   Fett,J., Dimori,M., Carroll,J.L. and Morello,R.
  TITLE     Haploinsufficiency of Col5a1 causes intrinsic lung and respiratory
            changes in a mouse model of classical Ehlers-Danlos syndrome
  JOURNAL   Physiol Rep 10 (8), e15275 (2022)
   PUBMED   35439366
  REMARK    GeneRIF: Haploinsufficiency of Col5a1 causes intrinsic lung and
            respiratory changes in a mouse model of classical Ehlers-Danlos
            syndrome.
REFERENCE   6  (bases 1 to 8420)
  AUTHORS   Greenspan,D.S., Northrup,H., Au,K.S., McAllister,K.A.,
            Francomano,C.A., Wenstrup,R.J., Marchuk,D.A. and Kwiatkowski,D.J.
  TITLE     COL5A1: fine genetic mapping and exclusion as candidate gene in
            families with nail-patella syndrome, tuberous sclerosis 1,
            hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome
            type II
  JOURNAL   Genomics 25 (3), 737-739 (1995)
   PUBMED   7759113
REFERENCE   7  (bases 1 to 8420)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   8  (bases 1 to 8420)
  AUTHORS   Pilz,A., Prohaska,R., Peters,J. and Abbott,C.
  TITLE     Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78,
            Pbx3, and Notch1 genes in the region of mouse chromosome 2
            homologous to human chromosome 9q
  JOURNAL   Genomics 21 (1), 104-109 (1994)
   PUBMED   8088777
REFERENCE   9  (bases 1 to 8420)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   10 (bases 1 to 8420)
  AUTHORS   Mattei,M.G., Bruce,B. and Karsenty,G.
  TITLE     Mouse alpha 1 type V collagen gene maps to the [A2-B] region of
            chromosome 2
  JOURNAL   Genomics 16 (3), 786-788 (1993)
   PUBMED   8325657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713878.1, AB009993.1, BQ885116.1, BQ768928.1, AK148055.1,
            AL731778.12 and BP759660.1.
            
            On Jan 10, 2008 this sequence version replaced NM_015734.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB009993.1, BC138447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               BY713878.1         3-262
            261-2283            AB009993.1         1-2023
            2284-2625           BQ885116.1         278-619
            2626-3679           AB009993.1         2366-3419
            3680-4164           BQ768928.1         250-734
            4165-4947           AB009993.1         3905-4687
            4948-5025           AK148055.1         1092-1169
            5026-5982           AB009993.1         4766-5722
            5983-7897           AL731778.12        6430-8344
            7898-8420           BP759660.1         29-551              c
FEATURES             Location/Qualifiers
     source          1..8420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..8420
                     /gene="Col5a1"
                     /note="collagen, type V, alpha 1"
                     /db_xref="GeneID:12831"
                     /db_xref="MGI:MGI:88457"
     exon            1..500
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..5908
                     /gene="Col5a1"
                     /note="collagen alpha-1(V) chain; alpha1(V) collagen;
                     procollagen type V alpha 1; pro-alpha1(V) collagen"
                     /codon_start=1
                     /product="collagen alpha-1(V) chain precursor"
                     /protein_id="NP_056549.2"
                     /db_xref="CCDS:CCDS15831.1"
                     /db_xref="GeneID:12831"
                     /db_xref="MGI:MGI:88457"
                     /translation="MDVHTRWKAARPGALLLSSPLLLFLLLLWAPPSSRAAQPADLLE
                     MLDFHNLPSGVTKTTGFCATRRSSSEPDVAYRVSKDAQLSMPTKQLYPESGFPEDFSI
                     LTTVKAKKGSQAFLVSIYNEQGIQQLGLELGRSPVFLYEDHTGKPGPEEYPLFPGINL
                     SDGKWHRIALSVYKKNVTLILDCKKKITKFLSRSDHPIIDTNGIVMFGSRILDDEIFE
                     GDIQQLLFVSDNRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYPEGEGETYYYEYP
                     YYEDPEDPGKEPAPTQKPVEAARETTEVPEEQTQPLPEAPTVPETSDTADKEDSLGIG
                     DYDYVPPDDYYTPPPYEDFGYGEGVENPDQPTNPDSGAEVPTSTTVTSNTSNPAPGEG
                     KDDLGGEFTEETIKNLEENYYDPYFDPDSDSSVSPSEIGPGMPANQDTIFEGIGGPRG
                     EKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTTGPTGQMGDPGERGPPGRPGLPG
                     ADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPMGL
                     TGRPGPMGPPGSGGLKGEPGDMGPQGPRGVQGPPGPTGKPGRRGRAGSDGARGMPGQT
                     GPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGIPGDDGERGDDGEVGPRGLPGEPGPRG
                     LLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGP
                     PGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGAD
                     GIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPG
                     PLGPTGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGP
                     TGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKD
                     GLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPG
                     AAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGSEGPPGPPGPAGS
                     PGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGLPGEKGPQGPAGRDGLQGPVGLPGPA
                     GPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRG
                     QQGLFGQKGDEGSRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGA
                     PGADGPQGPPGGIGNPGAVGEKGEPGEAGDPGLPGEGGPLGPKGERGEKGEAGPSGAA
                     GPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPG
                     PTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGP
                     DGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPP
                     GEQGEKGDRGLPGPQGSSGPKGDQGITGPSGPLGPPGPPGLPGPPGPKGAKGSSGPTG
                     PKGEAGHPGLPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGAGESYVDYADGMEE
                     IFGSLNSLKLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFK
                     VYCNFTAGGSTCVFPDKKSEGARITSWPKENPGSWFSEFKRGKLLSYVDAEGNPVGVV
                     QMTFLRLLSASAHQNVTYNCYQSVAWQDAATGSYDKAIRFLGSNDEEMSYDNNPYIRA
                     LVDGCATKKGYQKTVLEIDTPKVEQVPIVDIMFNDFGEASQKFGFEVGPACFLG"
     exon            501..668
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..882
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1045
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1177
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1309
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1549
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1723
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1780
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1822
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1885
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1960
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2053
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2110
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2164
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2218
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2272
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2326
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2380
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2425
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2479
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2524
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2578
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2623
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2677
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2722
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2776
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2821
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2875
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2983
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3037
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3091
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3136
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3190
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3235
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3289
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3343
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3397
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3505
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3595
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3649
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3757
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3865
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..3919
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..3973
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4081
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4135
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4243
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4297
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4405
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4406..4459
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4513
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4567
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..4621
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4729
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4783
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4784..4837
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4945
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..4999
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5035
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5036..5089
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5090..5345
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5346..5458
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5459..5527
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5528..5761
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5762..8402
                     /gene="Col5a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6391..6396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a1"
                     /note="hexamer: ATTAAA"
     polyA_site      6418
                     /gene="Col5a1"
     regulatory      8021..8026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a1"
                     /note="hexamer: AATAAA"
     polyA_site      8045
                     /gene="Col5a1"
                     /note="major polyA site"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col5a1"
                     /note="hexamer: AATAAA"
     polyA_site      8402
                     /gene="Col5a1"
ORIGIN      
        1 aaaagtgctc agcgccgaag gcgaggtccg cactcctggt ccccgcggct ggcgcaggac
       61 ctcactccag cggagcgccc acggggagcg ggtcgcgggg cagcagcggt gaggaggcca
      121 cgagactaga aggaggagga cagggagtgc gcgagcagcc agcgaggggg tcccggccgt
      181 cccgggccac agtcgatccc tgcgccgtgg gcgagcgcgc ccgctgcctc ttccagaaca
      241 gccaccgccg cgggggagat cgggcgggtg ccgagcttcc tatgactccc tgaagttgtc
      301 gtgctcccct agcgtccgcc acccgggacg tgtctctggt ccccgtgcat cgtgtgcgtc
      361 tcccgctccc cggcccgcgc accccgccgg catggacgta cacacccgct ggaaagctgc
      421 gcgcccaggc gccctgctgc tgtcttcgcc gctactcctg ttcctgctgc tgctgtgggc
      481 gccgccttcg agccgcgcag ctcagccagc agatcttctg gagatgctag attttcacaa
      541 tttgccctca ggggtaacga aaaccacagg tttctgtgct actcgaagat cttccagcga
      601 gccggatgtt gcctaccgag tctctaaaga tgcacagctc agcatgccca ccaagcagct
      661 gtaccctgag tctggttttc ccgaggactt ctccatcctg acaaccgtga aagccaagaa
      721 aggcagccag gccttcctag tctccattta caatgagcag ggcatccagc agttggggct
      781 ggagctgggc cgctcccctg tcttcctcta tgaggaccac acagggaagc ccgggcctga
      841 agagtatccg cttttccctg gcatcaactt gtccgatggc aagtggcacc gaattgctct
      901 cagtgtctac aagaaaaatg tcaccttgat cctcgactgt aagaagaaga ttacgaagtt
      961 cctcagccgc agtgaccacc ccataataga caccaatggg attgtcatgt ttggctcccg
     1021 gattctggat gatgaaatat ttgagggtga catccaacag ttgcttttcg tctctgacaa
     1081 ccgagctgcc tatgactact gtgagcacta cagccccgac tgtgacactg cggtccctga
     1141 cacacctcag tcacaggacc ctaacccgga tgaatattac ccagaaggag agggtgagac
     1201 ctattactat gagtatccat attatgaaga ccctgaagac ccgggaaagg agcctgcccc
     1261 tactcagaag ccagtggaag ctgccagaga aaccacagag gttcctgagg agcagaccca
     1321 gcccctaccc gaagccccta cagtgcctga gaccagtgac acggctgaca aggaggacag
     1381 tctagggatc ggggactatg actacgtgcc cccagatgac tattacactc cacccccata
     1441 tgaagacttt ggatatggcg agggtgtgga gaaccctgac cagcccacca accccgactc
     1501 aggggctgag gtccccacca gcaccactgt tacctccaac acctccaatc cagctccagg
     1561 agaagggaag gatgacctgg gcggcgaatt caccgaggaa accatcaaga atctagagga
     1621 aaactactat gacccgtact ttgaccccga ctccgactcc agtgtctctc catcagagat
     1681 agggccaggc atgcccgcta accaggacac catctttgag gggattggag gaccccgagg
     1741 tgagaaaggg caaaagggag aaccagccat cattgagccg gggatgctga tcgaggggcc
     1801 ccctggccct gaaggccctg ctggtcttcc aggacctcca ggaactacag gtcctactgg
     1861 ccaaatgggt gaccctggag aaaggggtcc ccctgggcgc ccaggtcttc ctggagctga
     1921 tggcttgcct ggccccccag gtaccatgct catgctgccg ttccggtttg gaggcggtgg
     1981 cgatgccggt tctaagggcc ccatggtctc tgcgcaggag tcccaggccc aggctatcct
     2041 ccagcaagcc aggttggcac tgaggggacc agctggccca atgggtctca ccgggagacc
     2101 tggccccatg ggtcctcctg ggagtggcgg tttgaaaggt gagccaggag acatgggacc
     2161 tcagggtcct cgaggtgtgc aaggcccacc tggcccaaca gggaagcctg gaagacgggg
     2221 ccgtgctgga agtgatggag ccagaggcat gcctggacaa acaggcccca agggtgaccg
     2281 tggctttgat ggtctggctg ggttgccggg agagaaaggc catagaggtg accctggtcc
     2341 ttctggcccg cccggaatcc caggagatga tggagaaagg ggtgacgatg gagaagttgg
     2401 gcccagggga ctgcccgggg agcctggacc acgtggtctg cttgggccaa aaggcccccc
     2461 agggcctcct ggacctcctg gtgtaacggg tatggatggc cagcctggcc caaaaggaaa
     2521 tgtgggtccc cagggagagc ctgggccgcc aggacagcag ggtaatcctg gtgcccaggg
     2581 tcttccaggt ccccagggtg ccattggtcc tccaggagaa aagggtcctt tggggaaacc
     2641 aggtctccca ggaatgccag gcgctgatgg acccccgggg caccctggaa aagaaggtcc
     2701 tccaggagag aaaggaggcc agggtcctcc tggcccccag ggtcccattg gctaccccgg
     2761 tccacgagga gtcaaggggg cagatggcat ccgaggtctg aagggcacca agggggagaa
     2821 gggtgaagac ggcttccctg ggtttaaagg cgacatggga ataaagggtg accgggggga
     2881 aatcggccca cctggtcccc gaggagaaga tggtcctgaa ggtccaaagg gtcgaggtgg
     2941 tcccaatggt gatcctggtc ccctggggcc cactggggaa aagggaaagc ttggcgtgcc
     3001 cggattaccg gggtacccag gaagacaagg gccaaagggt tccattggat tccctggctt
     3061 cccgggcgcc aacggagaga agggtggcag ggggacacct ggaaagccag gaccacgggg
     3121 acagagaggc ccaacgggcc cgcggggtga acgaggccca cgaggcatca cggggaagcc
     3181 tggccctaag ggcaactccg gaggtgatgg cccagctggc cctcctggtg aacggggacc
     3241 caacggaccc caaggtccca ccggctttcc tggacccaag ggtcccccgg gcccaccagg
     3301 caaggacgga ctccctggac accctgggca gagaggggag accggtttcc aaggcaagac
     3361 tggccctcca gggcccccag gagtggttgg ccctcagggt cccacaggag agacgggccc
     3421 catgggtgag cgtggccatc ctggtcctcc aggccctcct ggtgaacagg gcctcccagg
     3481 tgctgctggg aaagaaggaa cgaagggtga cccaggtcct gctggcctcc ctgggaagga
     3541 tggccctcca ggattgcgtg gattccctgg ggaccgaggg ctacctggcc ccgtgggagc
     3601 ccttggactc aaaggcagtg aaggcccccc tggcccacca ggtcctgcgg gttctccagg
     3661 ggagagagga ccagctggtg ccgctgggcc catcggaatt ccagggagac ctgggcctca
     3721 gggacctccg gggcctgctg gagagaaagg acttcctggc gagaaaggtc cacaaggccc
     3781 agctggccga gatggcctcc aaggtcccgt ggggctccct ggaccagccg gcccagtggg
     3841 tcctcctgga gaagatggag ataagggaga gatcggagag ccagggcaga agggaagcaa
     3901 gggcgacaaa ggcgagcagg gtcctcctgg gcctaccggt cctcaaggcc cgattggaca
     3961 gccaggccct tcgggagcag atggtgaacc tggccctcgt ggacagcagg gcctgtttgg
     4021 gcagaaagga gatgaaggtt caagaggttt cccaggaccc cccgggccag tgggattgca
     4081 gggtttgcca ggacctccag gagaaaaggg cgagacagga gacgtgggcc agatgggccc
     4141 tcctggtcca ccaggccccc gaggaccctc tggagctcca ggtgccgatg gaccacaggg
     4201 tcctcctgga gggattggca accctggtgc agtcggagaa aagggagaac ctggtgaagc
     4261 tggagatcct ggccttccag gagaaggagg tcccctggga cctaaaggag aaagagggga
     4321 gaagggagag gctggcccct ctggtgctgc tggaccccct ggacccaaag gccctcctgg
     4381 agatgatggc cccaaaggca gccctggccc tgtgggcttt cctggagatc ctggtccccc
     4441 tggagagcca ggccccgcag gtcaagacgg cccacctggt gacaaagggg acgatggtga
     4501 acctgggcag acggggtccc cgggccctac tggtgaacct ggtccatctg ggcctccagg
     4561 aaagaggggt cccccaggcc ctgcaggccc tgaaggcagg cagggggaga aaggagccaa
     4621 gggagaagct ggcttagaag gccctcctgg gaagactggc cccattggcc cccaaggggc
     4681 ccctgggaag cctggccccg atggtctccg tggaatccct ggtcctgtgg gtgagcaagg
     4741 cctcccagga tccccaggcc ccgatggtcc acccggcccc atgggtcctc caggactccc
     4801 tggcctcaaa ggagactccg gtcccaaagg tgaaaagggc catccaggcc tgattggact
     4861 catcggccct ccgggagagc aaggtgaaaa gggtgaccgt ggactcccag gcccccaggg
     4921 ttcatctggt cctaaaggag atcagggcat cacaggtcct tctggcccac ttgggcctcc
     4981 tggtcctcct ggcttgccgg gccctccagg tcccaaaggt gctaagggct cttcgggtcc
     5041 caccggcccg aagggtgagg caggccaccc aggactcccc ggcccacctg gccctccggg
     5101 tgaggtcatc cagcccctgc caatccaggc ctccaggact cggcggaaca ttgatgccag
     5161 ccagctcctg gacgatgggg ctggggagag ctacgtggat tatgcagatg gcatggaaga
     5221 gatctttggt tccctcaact ccctgaagct ggagattgaa cagatgaagc gaccactggg
     5281 cacccagcag aacccagccc gtacctgcaa ggatctacag ctctgtcatc ctgacttccc
     5341 agatggcgaa tactgggtcg atcccaacca agggtgctcc agggactcct tcaaagtcta
     5401 ctgcaatttc acagctggag ggtccacgtg cgtcttccct gacaagaagt ctgagggagc
     5461 cagaatcact tcttggccca aagaaaaccc aggttcctgg ttcagtgaat tcaagcgtgg
     5521 gaaactgctc tcctatgtgg atgctgaagg caaccccgtg ggcgtggtac aaatgacctt
     5581 cctgcggctg ctgagcgcct ctgcccacca gaacgtcacc tacaactgct accagtccgt
     5641 ggcctggcag gatgccgcca caggcagcta tgataaggct atccgcttct tgggctccaa
     5701 cgatgaggaa atgtcttatg ataacaaccc ctacatccgt gccctggtgg atggctgtgc
     5761 taccaagaaa ggctaccaga agacggtgct ggagatcgac acgcccaaag tagagcaagt
     5821 ccccattgtg gacatcatgt tcaacgactt tggcgaagcc tcacagaaat ttggatttga
     5881 agtggggcca gcttgcttcc taggctagga gctgctgagc ccaccggtct ccagagcaac
     5941 ctcgtgacct cagcacccca cctgtgggcg tcctgtgcac ggcccatccc ggacagtgaa
     6001 catttctcac ccctgcctgc ctgactcatc tgtgcctcgg accctccgtg gcattggacc
     6061 ccatgcccag agagaacaaa gggaaagagc cgtgtcccca cggagccgaa tcacatgacc
     6121 tagccacacc acagcctctt gccacccttc agctctcagg ataggttcat taaaggtgtt
     6181 aatggaccgt tggccgggag tgggggcggg acagtatttg aagatcactt taaaaaaaat
     6241 tcaacttgaa gatatgtatt ccccctgacc ttcaaaagat gttctgaggt ggtcttgtaa
     6301 aggtcgccaa agcctccatt tttttttaaa acaaccctca acacatccac tcagaggcca
     6361 aatgtcattc cacacgtgcc tttccgatgg attaaaggtg cttatgtttt tgtgagaatt
     6421 ttaagtaaat atttgtattg tattgttata aatgttaagt gtgcctggct ttcagtcttg
     6481 catggaaacc cagccttagg cccatggggg cagcgggcag ctgggacaag tcacccgctc
     6541 gggctcgaaa tccggctctc ggtagagggc atcgccttac ccccaccccc acaagaatgt
     6601 gcaataattt ggaaatttgc ccagtcagca agaagcggca ttgccactgc aggtgcctgg
     6661 gcccctttcc agactcttta tttttttctt tttgattagc tctggataat tttttatggg
     6721 gaggggaaaa aggcatttga tatcctgcct ttcctacagc actcagatta aaacacaggc
     6781 ttaaattaat tctgattgct tcctttttcc ttgttccttc ctgcagaggc tgatgggaca
     6841 gtgtccaggg ctggagagcc acgtgttctg tagatgataa ataactatga acatttggtg
     6901 ctgaattttt tacacttgtc tcttgtggtg ctatgtgtcc ggagaccctt aggtggccct
     6961 agggtgcctg ccatgcctca ttccctcccc caccttcctt tatcctggcc atttctccac
     7021 attctgagat ttttgccaag gacctgaaga ccagattggt gccagagacc tttcttccct
     7081 cctggcacct tgtactcatg atggtgggga gtcccttcct gaagcctgtc cccctctctg
     7141 ggctctgctt atgtcatttg aaaacacatg agcaaaacaa agacttcgtg catggccggc
     7201 ccatggtgta cccatggtct tgttcagttg ctgaatgttt gtggtgctaa tctctgtgtg
     7261 tgtgccaaga tggaatggaa gctgctgtgt gcccacctga cagccagact tcattgagag
     7321 ccataggtgg cttgagaaat gtgggatgga ctctggctcc agggtcgctg agctgactga
     7381 gtttccagca gaggagtgtc ctgggtgctg cagtcagtgc tggggtccat agggatccct
     7441 ctggatgctg ccctcttcct cctctccctc ctcctccagg gtgtgtgtgg tggctgggcg
     7501 ggaggggtgc tgccttctga gtgcagaggt ctccaggtcc aacaaggaaa acctcactga
     7561 gagttacctg ccttccacca cgagaaagct gtggtgccca cagagagtca ctctggtgct
     7621 tgtgtcccca ccccacccct gaagtgaaga aaacgaccgt gaggcacccg ggagcagcca
     7681 ggattgatga acgccaccaa cacgcatccc ccaaagttcc ctgaagaaca agttctactc
     7741 ttgccaaaga aatgcctggc ctggagagct ctcctggaag ccaggatgcc atcgtgagcc
     7801 agggactgct gtgcatgcct ctgcatgaga aaaagccata ttggaagacg gccatacgcc
     7861 ctgtggattc tgtgtaggtc atgtgattcg gattctgcct cccactccat ctgactttgc
     7921 tctgtcctgt tcttctgtcg gtcccttcca cgttgtaatt tgcattgaaa cccaaaatgt
     7981 gttctgttct cctcagtcca ctttagctcc aatattttac aataaaatta cttcttatat
     8041 ttgcagaaat gcctctggca tcattttccg tttccatttt ctctggtgtg tgcgctctct
     8101 acatatatat atatatatat gtatatatat atatatatat atatatatat ttttaaaaat
     8161 tgaacaaatg ctgctgaaaa tacacacaaa gtaaacagaa gggctgtgtg ataaaaacta
     8221 taggaccttg ggtcctttaa aattccaggc caaacggtac attgtatatt tcccagcagt
     8281 ctaaactaag cctcagattt taacttctcc ccaggaagag tgttataaaa tattttaaaa
     8341 ctgtgtaaca aaggaatcgt tgtaacagtg tctcaataaa gcagtttact gtttacaccc
     8401 caaaaaaaaa aaaaaaaaaa
//
