LOCUS       NM_053185               6648 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus collagen, type IV, alpha 6 (Col4a6), mRNA.
ACCESSION   NM_053185
VERSION     NM_053185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6648)
  AUTHORS   Thomas MH, Gui Y, Garcia P, Karout M, Gomez Ramos B, Jaeger C,
            Michelucci A, Gaigneaux A, Kollmus H, Centeno A, Schughart K,
            Balling R, Mittelbronn M, Nadeau JH, Sauter T, Williams RW,
            Sinkkonen L and Buttini M.
  TITLE     Quantitative trait locus mapping identifies a locus linked to
            striatal dopamine and points to collagen IV alpha-6 chain as a
            novel regulator of striatal axonal branching in mice
  JOURNAL   Genes Brain Behav 20 (8), e12769 (2021)
   PUBMED   34453370
  REMARK    GeneRIF: Quantitative trait locus mapping identifies a locus linked
            to striatal dopamine and points to collagen IV alpha-6 chain as a
            novel regulator of striatal axonal branching in mice.
REFERENCE   2  (bases 1 to 6648)
  AUTHORS   Tang S, Yonezawa T, Maeda Y, Ono M, Maeba T, Miyoshi T, Momota R,
            Tomono Y and Oohashi T.
  TITLE     Lack of collagen alpha6(IV) chain in mice does not cause
            severe-to-profound hearing loss or cochlear malformation, a
            distinct phenotype from nonsyndromic hearing loss with COL4A6
            missense mutation
  JOURNAL   PLoS One 16 (4), e0249909 (2021)
   PUBMED   33848312
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6648)
  AUTHORS   Komori T, Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa
            T, Maeba T, Kimura-Ono A, Takarada T, Momota R, Maekawa K, Kuboki T
            and Oohashi T.
  TITLE     Type IV collagen alpha6 chain is a regulator of keratin 10 in
            keratinization of oral mucosal epithelium
  JOURNAL   Sci Rep 8 (1), 2612 (2018)
   PUBMED   29422532
  REMARK    GeneRIF: These findings indicate that alpha112:alpha556 (IV)
            network, which is the only network that includes the alpha6(IV)
            chain, is one regulator of KRT10 expression in keratinization of
            oral mucosal epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6648)
  AUTHORS   Naba A, Clauser KR, Mani DR, Carr SA and Hynes RO.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6648)
  AUTHORS   Murata T, Katayama K, Oohashi T, Jahnukainen T, Yonezawa T, Sado Y,
            Ishikawa E, Nomura S, Tryggvason K and Ito M.
  TITLE     COL4A6 is dispensable for autosomal recessive Alport syndrome
  JOURNAL   Sci Rep 6, 29450 (2016)
   PUBMED   27377778
  REMARK    GeneRIF: although alpha5 and alpha6 (IV) chains are induced in the
            glomerular basement membrane in autosomal recessive Alport
            syndrome, their induction does not seem to play a major
            compensatory role
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6648)
  AUTHORS   Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S,
            Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H,
            Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y,
            Komukai M, Kagechika H, Kadowaki T, Kurabayashi M and Nagai R.
  TITLE     Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a
            target for angiotensin II signaling and an essential regulator of
            cardiovascular remodeling
  JOURNAL   Nat Med 8 (8), 856-863 (2002)
   PUBMED   12101409
REFERENCE   7  (bases 1 to 6648)
  AUTHORS   Nagai N, Nakano K, Sado Y, Naito I, Gunduz M, Tsujigiwa H,
            Nagatsuka H, Ninomiya Y and Siar CH.
  TITLE     Localization of type IV collagen a 1 to a 6 chains in basement
            membrane during mouse molar germ development
  JOURNAL   Int J Dev Biol 45 (7), 827-831 (2001)
   PUBMED   11732842
REFERENCE   8  (bases 1 to 6648)
  AUTHORS   Bhatt RS, Tomoda T, Fang Y and Hatten ME.
  TITLE     Discoidin domain receptor 1 functions in axon extension of
            cerebellar granule neurons
  JOURNAL   Genes Dev 14 (17), 2216-2228 (2000)
   PUBMED   10970885
REFERENCE   9  (bases 1 to 6648)
  AUTHORS   Saito K, Naito I, Seki T, Oohashi T, Kimura E, Momota R, Kishiro Y,
            Sado Y, Yoshioka H and Ninomiya Y.
  TITLE     Differential expression of mouse alpha5(IV) and alpha6(IV) collagen
            genes in epithelial basement membranes
  JOURNAL   J Biochem 128 (3), 427-434 (2000)
   PUBMED   10965041
REFERENCE   10 (bases 1 to 6648)
  AUTHORS   Lu W, Phillips CL, Killen PD, Hlaing T, Harrison WR, Elder FF,
            Miner JH, Overbeek PA and Meisler MH.
  TITLE     Insertional mutation of the collagen genes Col4a3 and Col4a4 in a
            mouse model of Alport syndrome
  JOURNAL   Genomics 61 (2), 113-124 (1999)
   PUBMED   10534397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB041351.1, CF538953.1, CF747750.1, CV555853.1, CF539876.1,
            CN535678.1 and AL691493.17.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_053185.3.
            
            On Apr 8, 2008 this sequence version replaced NM_053185.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AB041351.1         1-215
            216-681             CF538953.1         213-678
            682-1718            AB041351.1         682-1718
            1719-1881           CF747750.1         541-703
            1882-2342           CV555853.1         187-647
            2343-2816           CF539876.1         159-632
            2817-4864           AB041351.1         2817-4864
            4865-5454           CN535678.1         105-694
            5455-6648           AL691493.17        4736-5929           c
FEATURES             Location/Qualifiers
     source          1..6648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.8 cM"
     gene            1..6648
                     /gene="Col4a6"
                     /note="collagen, type IV, alpha 6"
                     /db_xref="GeneID:94216"
                     /db_xref="MGI:MGI:2152695"
     exon            1..268
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..5333
                     /gene="Col4a6"
                     /note="procollagen, type IV, alpha 6"
                     /codon_start=1
                     /product="collagen alpha-6(IV) chain precursor"
                     /protein_id="NP_444415.2"
                     /db_xref="CCDS:CCDS41153.1"
                     /db_xref="GeneID:94216"
                     /db_xref="MGI:MGI:2152695"
                     /translation="MHPGLWLFLVSLCLTKELAESGQKMSYGKPCGSRDCHGVCTCFP
                     EKGARGHPGPIGTQGPAGPEGFTGPTGLSGLKGERGSPGPLGPYGSKGDKGPIGVPGF
                     VGISGIPGHPGQPGPRGPPGPDGCNGTQGAVGFPGPDGYPGILGPPGLPGHKGAKGEP
                     VPFQGSITGIRGDPGLPGLDGIPGPSGSSGSPGDAGPIGPPGLQGPPGLPGLPGPEGN
                     MGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPPGFPGMSGPP
                     GVPEFGSTGEKGEKGILGLPGPRGPMGSEGIQGHPGRQGKKGTSGFPGINGFPGIKGE
                     KGDIGVRGPDSFTDADGAVISGYPGDPGVLGLPGLRGDEGVQGQRGPSGTPGLPSLTG
                     LPGALGPQGFPGLKGDQGNSGRTTFGEAGLPGRVGLPGLPGLPGPSGPPGRTFETGHL
                     SNIEPGFPGLQGEQGPKGHQGLKGVKGDSGFCACEGGAPNIGPHGEPGLPGIQGPIGL
                     QGFKGTKGDPGSRGASGPAGTPGLFGPRGQTGLKGKKGEPTVSRGSKMSGDKGDPGPQ
                     GTPGLAGTPGKDGRPGLPGLPGIQGDGGSGFPGERGLPGLPGEKGHDGPIGPPGIGLP
                     GPPGPRGLPGDKGVDGLPGQQGLRGAQGVTLPCIIPGSYGPSGFPGAPGFPGSKGARG
                     LPGIPGKPGTHGSKGGPGSPGLMHLPGLPGFPGVRGEKGLPGFPGLPGKDGYPGKAGS
                     PGLPGFKGAAGDIFGAENGASGEQGLQGLPGDKGFPGDSGLPGPKGLNGKPGMLGPKG
                     ERGNPGTSGPPGQPGPSGSTDPFGIKGTSGFPGAPGLPGISGHPGKKGQRGDIGQPGS
                     TGKRGLPGIKGLPGPQGSPGFLGSPGLSGVTGLPGIEGQKGEKGSSGPVGFPGLPGLP
                     GLPGADGLKGFSGSFGKVGQPGQTGTSGEKGDRGDPGPVGISSPRPPMLNLWFKGEKG
                     SRGSAGSDGFPGPRGDKGEPGIPGLPGPPGATGQTNTIKGLNGRPGSPGSMGRRGLPG
                     LKGSLGIAGFPGMPGKSGSQGLTGTSGLLGATGIPGLKGDQGQTLGISGSPGPKGQPG
                     ELGFKGVKGKDGLVGDRGYPGNKGDGGKVGITGDPGFPGSPGLQGISGMNGDPGLPGS
                     SGHLGSIGRPGPSGLIGPKGFPGAPGLHGLNGLPGTKGTHGTPGASITGVPGPAGLPG
                     PKGERGVPGIVIGDPGKQGSKGQKGDQGSPGLQGPAGTPGAPGISLPSVIAGQPGDPG
                     RPGLDGERGRPGPPGPPGPPGPSSDQGDPGDSGFPGIPGLQGFKGNQGLPGFSGLSGE
                     LGLKGMRGEPGLMGTPGKIGQPGDPGFPGMKGKAGPRGFSGPQGAPGHTPIAEAMQVP
                     PGPLGLPGIDGIPGLIGDPGSQGSVGLQGSKGLPGIPGKDGPSGLPGPSGILGDPGLP
                     GLQGPPGFEGAPGNQGPIGQPGMPGHGVRVGYTLVKHSQSEQVPLCPTGMSRLWVGYS
                     LLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIP
                     MMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDIIVPQCPLGWHSLWIGYSFLMHTAAG
                     AEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERGQFREEPV
                     SETLKTGQLHTRVSRCQVCMKTP"
     exon            269..320
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            321..404
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            405..539
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            540..584
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            585..701
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            702..770
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            771..806
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            807..869
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            870..905
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            906..947
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1040
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1094
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1154
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1199
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1253
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1323
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1431
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1581
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1686
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1847
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2027
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2211
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2283
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2391
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2613
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2775
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2946
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3090
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3216
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3398
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3462
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3537
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3645
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3753
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3825
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3951
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4068
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4230
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4329
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4476
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            4477..4593
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4785
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            4786..5072
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     exon            5073..6648
                     /gene="Col4a6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6627..6632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col4a6"
     polyA_site      6648
                     /gene="Col4a6"
ORIGIN      
        1 cttcctccct gggctcatgg aactatctcc tgagtgctag aagttgtagc gggcaccact
       61 gcgtgtgttt tcctttgggg cacttttttt ttctagcggc tgattttagt ttcttccaaa
      121 ttaagccact tcgcccccct tccccacact gtcctgaata aggaacaaac tgccaagcat
      181 caacggagcc cagatgagcc cgcgccgcgg agcagcttag cagtctcctg ggacccagct
      241 ccggagcagc cacaagcatg caccctggat tgtggctgtt cctggtttcc ttatgcttga
      301 ccaaagaact ggcagaatcg ggacagaaga tgtcctatgg aaagccatgt gggagccgag
      361 attgccatgg agtctgtaca tgctttcctg agaaaggagc aagagggcac cctggaccaa
      421 ttggaactca aggtccagcc ggtccggaag ggtttactgg tccaactggt ttatcaggtt
      481 tgaaaggaga aagaggctcc ccaggccctc tgggaccata tggatcaaaa ggagataagg
      541 gtcccattgg agttcctggc tttgttggca tcagtggtat tccgggccac cctggacagc
      601 caggtccaag aggtccacct ggcccagatg gctgtaatgg aactcaagga gctgttggat
      661 ttccaggccc tgatggctac cctgggattt taggaccacc tgggctgcct ggtcacaaag
      721 gtgccaaagg agagcctgtt ccttttcaag gcagcattac aggaataagg ggagatcctg
      781 ggctgcctgg actagatgga atccctggtc catcaggatc ctccggctct cctggagatg
      841 caggacccat aggaccacca ggcttacaag gtcccccagg cctccccgga cttcccggtc
      901 ctgagggaaa tatggggtta ggtttccaag gagaaaaagg agtcaagggg gatgttggcc
      961 tccctggccc tgcaggacca cctccatcta ctggggaact agaattcatg ggattcccca
     1021 aaggaaagaa aggttccaag ggtgagccag ggcctccagg tttcccagga atgagtggcc
     1081 ctccaggtgt cccggaattt ggatctactg gagaaaaagg agaaaagggg attcttggtt
     1141 tgccaggacc taggggtccc atgggttcag aaggaataca aggccatcca gggagacagg
     1201 gaaagaaggg gacttcaggt tttcctggga ttaacgggtt cccaggaatt aagggtgaaa
     1261 agggagacat tggtgttcga ggcccagaca gtttcactga tgcagatggc gctgtgatct
     1321 caggttatcc tggagaccct ggtgtgctgg gccttccagg ccttagagga gatgaaggcg
     1381 tccaaggcca acgtggccct tctggaaccc ctggcctccc atcattaaca ggtcttccag
     1441 gtgccctagg gcctcaggga tttcctggcc tgaaaggaga ccaaggaaac tcaggacgta
     1501 ccacctttgg agaagctggc ctacctggca gggttggttt accaggttta ccaggcctgc
     1561 caggcccatc aggcccacct ggtcgcacat ttgagactgg acatctgtcc aacatagagc
     1621 ctgggttccc tggtctccaa ggagaacaag gtccaaaagg acatcaaggc ctcaaaggag
     1681 taaaaggaga ctctggtttt tgtgcttgtg aaggtggtgc ccccaacatt ggaccacatg
     1741 gggaaccagg tctgcctggg atacaaggtc ccattggtct acagggtttt aaggggacta
     1801 aaggagatcc aggctcaagg ggagcatctg gtcctgcagg gacgccaggg ctatttggac
     1861 ctagaggtca gactggcctc aaaggaaaga aaggagaacc aactgtcagt agaggatcaa
     1921 aaatgtcagg ggacaaaggt gaccctggtc ctcagggtac cccaggtttg gcaggaactc
     1981 cgggcaagga tggaagacca ggtttaccag gcctcccagg cattcaggga gatggtgggt
     2041 ctggcttccc aggtgaaaga gggttaccag gacttcctgg tgaaaaaggc catgatggtc
     2101 caattggacc accaggaatt gggctgccag gacctcctgg gccccgtgga cttcctggag
     2161 ataaaggagt agatgggtta ccagggcaac aaggcctccg tggagctcaa ggagtcacct
     2221 tgccttgtat cattcctggg tcatatggtc catcaggatt tcctggagct cctggattcc
     2281 caggctctaa gggagctcgg ggcctccctg gaattccagg caagcctggc actcacggaa
     2341 gcaaaggagg gcctgggagt ccagggttaa tgcatctccc aggattgcca gggtttcctg
     2401 gagttcgtgg ggagaaggga ttacctgggt ttcctgggct tcctggaaaa gatggctacc
     2461 ctgggaaagc tggcagtcca gggttaccag gtttcaaggg agctgctggt gacatatttg
     2521 gtgctgaaaa tggtgcttcg ggggagcaag gcctacaggg attgccaggg gacaaaggat
     2581 ttcctggaga ctctggcctt ccaggaccca agggtttgaa tgggaaacct ggtatgctag
     2641 gccccaaggg tgagcggggc aaccctggaa catcaggacc accaggacag ccaggaccct
     2701 cagggtctac tgacccattt ggcatcaagg gcacatctgg attcccagga gcaccaggcc
     2761 ttccaggcat ctcagggcac cctggaaaga aaggtcaaag aggagacata ggtcagcctg
     2821 gatcaactgg aaaaagaggt ctacctggga taaaaggcct tcctggtcct caagggtcac
     2881 ctggcttcct ggggagccca ggtttgtcag gcgtcactgg gttgccgggc atcgaaggcc
     2941 aaaagggtga aaaggggtcc tctggaccag taggatttcc tgggttacct ggtcttcctg
     3001 gtcttcctgg agctgatgga ttaaagggat tttctgggtc atttggaaag gtgggacaac
     3061 ctggacagac tggtacttcc ggagaaaaag gagacagagg ggatccaggg ccagttggca
     3121 tatctagtcc aagacctcca atgctaaacc tttggttcaa aggagaaaaa ggctctcgag
     3181 gttctgctgg atcggatgga tttcctgggc ccagaggtga caaaggagag cctggcatcc
     3241 cagggttacc aggtccacct ggagctactg gacaaaccaa taccatcaaa gggctcaatg
     3301 ggaggccagg ttctcctgga tctatgggaa gaaggggatt acctggcctg aaggggtctc
     3361 ttgggattgc aggtttccca ggaatgccag ggaaaagcgg ttcacagggg ctcactggga
     3421 cttctggcct cctgggagca actggtatcc caggtttaaa aggagatcaa ggccaaacac
     3481 ttggcatttc tggaagccca ggacccaagg gacagcctgg agaattaggt tttaaaggtg
     3541 tcaaaggaaa agatggacta gttggtgata gaggttaccc aggaaacaaa ggtgatggtg
     3601 gaaaagttgg aattactgga gatcctggct tccctggctc cccaggactt caagggattt
     3661 caggtatgaa tggagaccca ggcctcccag gttcctctgg ccatctgggg tcaattggcc
     3721 gccctggacc ctcaggctta ataggaccta aaggattccc tggagctcct ggtttacatg
     3781 gactgaatgg acttccaggc accaagggca cccatggcac tccaggagcc agtatcactg
     3841 gtgttcctgg gccggctggc ctgcctggtc ccaaagggga aaggggagtg ccaggaattg
     3901 tcatcggaga tccagggaaa caaggttcaa agggacaaaa aggtgaccaa ggttccccag
     3961 gtcttcaagg tcctgctggt acccctggag ccccaggcat ctccttgccc tcagtcatag
     4021 caggacagcc tggtgaccct gggcggccag gcctagatgg agaacgaggc cgcccaggcc
     4081 ctccaggtcc tccaggtccc cctgggccat cctcagatca aggcgatcct ggagactctg
     4141 gcttccctgg gattccaggc cttcaagggt tcaagggaaa ccaaggactt ccaggtttct
     4201 ctggcctctc tggagagcta gggctaaagg gcatgagagg ggaacctggc ctcatgggga
     4261 ctcctggcaa gatcgggcaa ccaggagacc caggatttcc tgggatgaag gggaaggcgg
     4321 ggccaagagg cttttccggc ccacagggag ctccaggaca cacaccaatt gctgaagcta
     4381 tgcaggttcc tccaggacct ttgggtctgc caggcattga tggtatccca ggcctcatag
     4441 gagaccctgg gtctcaaggc tctgtgggtc tgcaaggttc caaaggccta cctggcatcc
     4501 ctggtaagga tggccccagt gggcttccag gcccatctgg aatccttggt gatcctggtc
     4561 tccctggact acaaggacct ccaggatttg aaggagctcc gggaaatcag ggccccattg
     4621 ggcagcctgg gatgcctggg cacggtgtga gagtgggcta cacactagta aaacacagtc
     4681 agtcagaaca ggtgccacta tgccccactg ggatgagccg gctctgggtg ggttacagct
     4741 tgctcttcgt ggaggggcag gagaaagccc ataaccagga tctgggattt gctggctcct
     4801 gcctgccccg attcagcacc atgcccttca tatactgcaa catcaatgaa gtgtgccact
     4861 atgccagacg caatgataaa tcttactggc tctccactac tgcccccatt cccatgatgc
     4921 ctgtgggcca gacccagatt ccccagtata tcagccgctg ctctgtatgt gaggcaccct
     4981 cacaagccat tgctgtacac agtcaggaca tcattgtccc acagtgccct ctgggctggc
     5041 acagcctctg gatcggatac tccttcctca tgcacactgc tgctggggct gagggtggag
     5101 gccagtccct agtctcccct ggctcgtgtc ttgaggactt ccgggccact cctttcattg
     5161 agtgcagcgg cgcccgtggt acatgccact actttgccaa caagtacagt ttctggctga
     5221 caacggtgga ggagagaggg cagtttcggg aagagcccgt gtctgagacg ctgaaaactg
     5281 ggcagcttca caccagggtg agccgctgcc aggtgtgtat gaaaaccccg tagggtactg
     5341 cccgtcatcc agcccacctc acaacactca cctcaacagt ctgagaaagg aaggcctgag
     5401 cccatctgcc tgtcaagttg tacatcaatg cctcgtttgg actggactac tggacaatgg
     5461 tcatcccaac cctcagaccc aacagatgag cccactgtgc taggatttgc tttcctgttt
     5521 ccatccatct ggtgctaaca ttccatttag atatgtgtgt gattactcat ggctacctta
     5581 ggaaggtgtg ctaagctgtc acttgcgaag atggctagag ctctcttcac tgccttaagc
     5641 tggaagttct ttataacagc gaagttatgt ctttatgaca agacgtcacc acacatcatt
     5701 tgagtcaaac taaagctcag gatttccacc ctaaaaatac gtttctggct gaatatgata
     5761 gataattcaa gtctgcctag ggctagccct ccctactgaa ggcagcctat tatatttaga
     5821 caggcagtag tgttggaatg agaaaccagc ctatagccag aactgagctg tgattccttg
     5881 cagagttttg ttaagcccat gccccatctt gagtaggaaa ggctgaaagg ccagtatttg
     5941 gtcctagaca aatcactgtc ccctggtccc acatctagag atataagaca agttggccca
     6001 gtccaaagtg gaaccaagaa ttcgataagt gtgatcaagc ttgtcacaga aagacatgag
     6061 aatcacttct ccttcttctt ggcctagggc agaaggagaa atacatatag aggtagcagt
     6121 tttgcttctg agtccaggaa ccaaaaggta aagctcatgt ccccattcct cagaagtccc
     6181 tagttattcc aaatgccacc cagatttatg cagggtgaca aactgaagct gcagtgtgtt
     6241 ggctccttgc atgctgaggc tcttagaggt gttctgataa aatggccatc caaacaccct
     6301 cccacgggta gccttttaaa ctatttgaca gggttttttt tttttaattt cataaaaatc
     6361 tagcacacac caatgttagc agacccgagg tacattctga gctggccatg aagtatactg
     6421 ccttctgttt gaagcagttc attttaatta ccagttgcgg agaacacaat cagttccact
     6481 gacatgaagc gctcccttgc aggtgattgg cttccttgag tactatgtaa accgtgccca
     6541 cgcaggcaaa gcataacaag tacattctga gctcttgtta tcacctccta gataagtaac
     6601 aaatggtgtc agctttgtac atagcaaata aaattaatga aatacgaa
//
