LOCUS       NM_007734               8342 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus collagen, type IV, alpha 3 (Col4a3), mRNA.
ACCESSION   NM_007734
VERSION     NM_007734.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8342)
  AUTHORS   Duara,J., Torres,M., Gurumani,M., Molina David,J., Njeim,R.,
            Kim,J.J., Mitrofanova,A., Ge,M., Sloan,A., Muller-Deile,J.,
            Schiffer,M., Merscher,S. and Fornoni,A.
  TITLE     Oxysterol-binding protein-like 7 deficiency leads to ER
            stress-mediated apoptosis in podocytes and proteinuria
  JOURNAL   Am J Physiol Renal Physiol 327 (3), F340-F350 (2024)
   PUBMED   38961844
REFERENCE   2  (bases 1 to 8342)
  AUTHORS   Wang,Y., Zhu,R., Zhao,L., Wang,F., Zhang,Y., Liu,S., Ding,J. and
            Yang,L.
  TITLE     Characterization of Ocular Morphology in Col4a3-/- Mice as a Murine
            Model for Alport Syndrome
  JOURNAL   Transl Vis Sci Technol 13 (7), 16 (2024)
   PUBMED   39042048
  REMARK    GeneRIF: Characterization of Ocular Morphology in Col4a3-/- Mice as
            a Murine Model for Alport Syndrome.
REFERENCE   3  (bases 1 to 8342)
  AUTHORS   LeBleu,V.S., Kanasaki,K., Lovisa,S., Alge,J.L., Kim,J., Chen,Y.,
            Teng,Y., Gerami-Naini,B., Sugimoto,H., Kato,N., Revuelta,I.,
            Grau,N., Sleeman,J.P., Taduri,G., Kizu,A., Rafii,S.,
            Hochedlinger,K., Quaggin,S.E. and Kalluri,R.
  TITLE     Genetic reprogramming with stem cells regenerates glomerular
            epithelial podocytes in Alport syndrome
  JOURNAL   Life Sci Alliance 7 (6), e202402664 (2024)
   PUBMED   38561223
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8342)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8342)
  AUTHORS   Ge,M., Molina,J., Kim,J.J., Mallela,S.K., Ahmad,A., Varona
            Santos,J., Al-Ali,H., Mitrofanova,A., Sharma,K., Fontanesi,F.,
            Merscher,S. and Fornoni,A.
  TITLE     Empagliflozin reduces podocyte lipotoxicity in experimental Alport
            syndrome
  JOURNAL   Elife 12, e83353 (2023)
   PUBMED   37129368
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8342)
  AUTHORS   Tajbakhsh,S., Rocancourt,D. and Buckingham,M.
  TITLE     Muscle progenitor cells failing to respond to positional cues adopt
            non-myogenic fates in myf-5 null mice
  JOURNAL   Nature 384 (6606), 266-270 (1996)
   PUBMED   8918877
REFERENCE   7  (bases 1 to 8342)
  AUTHORS   Enders,G.C., Kahsai,T.Z., Lian,G., Funabiki,K., Killen,P.D. and
            Hudson,B.G.
  TITLE     Developmental changes in seminiferous tubule extracellular matrix
            components of the mouse testis: alpha 3(IV) collagen chain
            expressed at the initiation of spermatogenesis
  JOURNAL   Biol Reprod 53 (6), 1489-1499 (1995)
   PUBMED   8562707
REFERENCE   8  (bases 1 to 8342)
  AUTHORS   Miner,J.H. and Sanes,J.R.
  TITLE     Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal
            laminae: sequence, distribution, association with laminins, and
            developmental switches
  JOURNAL   J Cell Biol 127 (3), 879-891 (1994)
   PUBMED   7962065
REFERENCE   9  (bases 1 to 8342)
  AUTHORS   Wu,J.E. and Santoro,S.A.
  TITLE     Complex patterns of expression suggest extensive roles for the
            alpha 2 beta 1 integrin in murine development
  JOURNAL   Dev Dyn 199 (4), 292-314 (1994)
   PUBMED   7521231
REFERENCE   10 (bases 1 to 8342)
  AUTHORS   Saga,Y., Yagi,T., Ikawa,Y., Sakakura,T. and Aizawa,S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123746.20 and AC138214.8.
            
            On Nov 10, 2022 this sequence version replaced NM_007734.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC123746.20        90668-90913         c
            247-303             AC123746.20        36604-36660         c
            304-393             AC123746.20        34801-34890         c
            394-438             AC123746.20        29477-29521         c
            439-483             AC123746.20        28299-28343         c
            484-546             AC123746.20        27476-27538         c
            547-600             AC123746.20        26792-26845         c
            601-627             AC123746.20        25912-25938         c
            628-705             AC123746.20        24721-24798         c
            706-768             AC123746.20        23083-23145         c
            769-804             AC123746.20        22938-22973         c
            805-846             AC123746.20        21207-21248         c
            847-924             AC123746.20        20876-20953         c
            925-987             AC123746.20        17813-17875         c
            988-1047            AC123746.20        17214-17273         c
            1048-1092           AC123746.20        15853-15897         c
            1093-1146           AC123746.20        15150-15203         c
            1147-1188           AC123746.20        13481-13522         c
            1189-1273           AC123746.20        11494-11578         c
            1274-1309           AC123746.20        11169-11204         c
            1310-1474           AC123746.20        9015-9179           c
            1475-1564           AC123746.20        8338-8427           c
            1565-1660           AC123746.20        7829-7924           c
            1661-1731           AC123746.20        6722-6792           c
            1732-1914           AC123746.20        5320-5502           c
            1915-2083           AC123746.20        3952-4120           c
            2084-2176           AC123746.20        2098-2190           c
            2177-2278           AC123746.20        1332-1433           c
            2279-2376           AC138214.8         33751-33848
            2377-2527           AC138214.8         34263-34413
            2528-2641           AC138214.8         34733-34846
            2642-2809           AC138214.8         35864-36031
            2810-2899           AC138214.8         37470-37559
            2900-3034           AC138214.8         37887-38021
            3035-3133           AC138214.8         44291-44389
            3134-3223           AC138214.8         45170-45259
            3224-3363           AC138214.8         45705-45844
            3364-3490           AC138214.8         48603-48729
            3491-3571           AC138214.8         51440-51520
            3572-3670           AC138214.8         51864-51962
            3671-3718           AC138214.8         52924-52971
            3719-3904           AC138214.8         55422-55607
            3905-4035           AC138214.8         55941-56071
            4036-4108           AC138214.8         63774-63846
            4109-4180           AC138214.8         65984-66055
            4181-4306           AC138214.8         66143-66268
            4307-4405           AC138214.8         67024-67122
            4406-4618           AC138214.8         70426-70638
            4619-4796           AC138214.8         71196-71373
            4797-4911           AC138214.8         71482-71596
            4912-5084           AC138214.8         73017-73189
            5085-8342           AC138214.8         73984-77241
FEATURES             Location/Qualifiers
     source          1..8342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 42.32 cM"
     gene            1..8342
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /note="collagen, type IV, alpha 3"
                     /db_xref="GeneID:12828"
                     /db_xref="MGI:MGI:104688"
     exon            1..246
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            247..303
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            304..393
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            394..438
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            439..483
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            484..546
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            547..600
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            601..627
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            628..705
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            706..768
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            769..804
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            805..846
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            847..924
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            925..987
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1047
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1092
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1146
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1188
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1273
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1309
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1474
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1564
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1660
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1731
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1914
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2083
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2176
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2278
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2376
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2527
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2641
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2809
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2899
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3034
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3133
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3223
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3363
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3490
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3571
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3670
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3718
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3904
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..4035
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4108
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4180
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4306
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4405
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4406..4618
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4796
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4911
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            4912..5084
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     exon            5085..8342
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8319..8324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /note="hexamer: AATAAA"
     polyA_site      8342
                     /gene="Col4a3"
                     /gene_synonym="alpha3(IV); [a]3(IV)"
                     /note="major polyA site"
ORIGIN      
        1 agtgggtcga gcccttacaa aactcgcccc agtgggccag caaggcgagc gtcactgcgg
       61 ggcctctcca atctgtgtcc cgccggggac atggacgcct gagaacccgt gggtccggta
      121 ggtcacagaa cacagaaaac accgggactc gggaccgtca tgcactccaa gactgctcca
      181 aggttcctgg tgttcctgct gcttaccctg ctgctactcc tggctgcctc tcctgtggct
      241 agcaagggct gtgtctgcaa aggcaaagga caatgcctct gcgcggggac caaaggggag
      301 aagggggaga aaggggttcc tggttcccct ggatttcctg gccagaaagg atttccaggt
      361 cctgaaggct tgcctggacc acagggaccc aagggctccc caggacttcc gggactcact
      421 ggccccaaag gcatcagggg aataactgga ttaccagggt ttgcaggtcc tcctggactt
      481 ccaggcctcc caggccaccc tgggcctcgt gggctggctg gtttaccagg atgcaacgga
      541 tctaagggtg aacaaggatt cccgggcttt cccggcacac caggctatgc agggctccca
      601 ggtcctgatg gcttgaaagg acaaaagggt gagcctgctc aaggagaaga caggggattc
      661 aatggaaaag gtgaccctgg gcctccaggg gttccaggct tccagggttt tccgggactc
      721 ccaggttttc cagggcctgc cggtccacca ggacctccgg gattttttgg tttaccagga
      781 gcaatgggac ccagaggacc caaaggccac atgggcgata gcgtgatagg acaaaaagga
      841 gaaaggggta tgaaaggatt aacaggacct cctgggccac caggaacagt gatttttaca
      901 ctcacccagc catacaacaa atcggacttc aagggagaga aaggagatga gggagagagg
      961 ggtgaacccg gacctcctgg accctcgggg ccacctggag actcctatgg atcagaaaag
     1021 ggtgcgcctg gagagcctgg tcctcggggc aaacctggaa aagatggtgc ccctggcttc
     1081 cctggcactg agggagccaa aggcaacagg ggctttcctg ggttgagggg tgaagctggc
     1141 attaagggaa ggaaaggaga cattggcccc ccaggatttc ctggtccaac agaatattat
     1201 gacgcatacc tggaaaaggg agagagagga atgccaggcc ttcctgggcc caaaggagcc
     1261 cgtggcccac agggtccaag tggtccccct ggagtccctg gaagtcctgg actgtcaagg
     1321 cctggcctca gaggacccat tggatggcca ggcttgaaag ggagtaaagg agagagagga
     1381 ccccctggaa aagacactgt gggccctcct ggacccctgg gatgtcctgg ctcaccaggt
     1441 ccaccaggcc ctccaggacc tccaggatgt ccaggtgaca ttgtttttaa atgttcccct
     1501 ggtgagcatg gaatgccagg tgacacagga cctccaggag ttccaggact tgatggaccc
     1561 aaaggagaac caggcagtcc atgcaccgag tgtcactgct tcccagggcc ccctggagtc
     1621 ccaggatttc caggattaga tggtatcaaa ggaatcccag gaggacgagg tgtgcctggt
     1681 ctgaagggaa acccagggtc cccaggaagt gcaggtctcc caggatttgc aggattccca
     1741 ggtgaccaag ggcatccagg acttaaaggg gacaaagggg atacacctct accctggggg
     1801 caagtgggta atccaggtga tcctggactc agaggcctgc ccgggagaaa gggcttcgat
     1861 ggaactcctg gaggtccagg agcgaaagga ccaccaggac ctcagggcga accggccctg
     1921 agtggaagga aaggggacca aggacctcca ggacctcctg gattccctgg acccccagga
     1981 cctgcaggac cagctggacc accaggctat ggacctcaag gagagccagg tccaaaggga
     2041 gcccaaggag tccccggcgt cctgggacca cctggagaag ccggtcttaa aggagaaccc
     2101 agtacatcaa ctccagatct aggtccccca ggccctccag ggccccctgg tcaggctggc
     2161 cccagaggtc tacctggttt gcctggaccg gtgggaaaat gtgatcctgg tcttcctgga
     2221 cctgatggtg agccaggaat tccagaagct ggatgcccag ggcctccagg acctaaggga
     2281 aatcaaggtt tcccagggac aaaaggatca cctggttgtc ctggggaaat gggaaagcct
     2341 ggccgtcctg gagaaccagg catcccagga gccaagggag aaccatccgt aggcaggcct
     2401 gggaaaccag ggaaaccagg ctttccagga gaaagaggca atgctgggga aaatggagat
     2461 attggactcc ctgggcttcc aggcctccct ggaactccag gaagaggcgg gcttgacggg
     2521 cctccaggag acccaggaca gcctggatca cctggagcaa aaggatcccc aggaaggtgc
     2581 ataccaggac ccaggggcac ccaaggactt cccggcttga atggattgaa agggcaacca
     2641 ggtcgaagag gtgataccgg gccaaaggga gaccctggca tcccaggcat ggacaggtct
     2701 ggggtccccg gagatcctgg accaccagga acaccaggtt gtcctggtga gatgggacca
     2761 cctggacaaa aaggatatcc gggagctcca ggattcccag gaccaccagg cgagaaagga
     2821 gaggttggaa tgatgggcta tcctggaacc actggccctc cggggcttcc tgggaaacca
     2881 ggctcacagg ggcagcgagg tagcctcgga atcccaggaa tgaaagggga aaaaggacgc
     2941 ccaggagcca aaggcgaacg aggagagaaa ggaaaaccag ggccttctca aacaacactc
     3001 ttaaagggag acaaaggaga gcctggactt aaaggatttg ttgggaatcc aggtgagaaa
     3061 ggaaacagag gcaacccagg gttaccaggt ccgaaaggcc tcgagggatt gcctgggcta
     3121 ccaggtcctc caggccctag aggagatacg ggaagcagag gaaatcctgg aagaccagga
     3181 ccacacggca tgccaggaag catggggatc atgggggtgc caggccctaa agggagaaaa
     3241 ggaacttcag ggcttccagg tctagctgga agaccaggcc tgacagggat ccatggtccc
     3301 caaggagata agggggagcc gggttattca gaaggtgcaa gaccaggacc accaggacca
     3361 aagggcgatc caggattgcc aggtgacaaa ggaaagaaag gagaaagagg cgtacctggg
     3421 ccacctggac aatcggggcc tgccggacct gatggagccc ctgggagtcc tgggagtcct
     3481 ggtcacccag gaaaaccagg tcctgctggt gatttgggtc tgaaaggaca gaaaggcttc
     3541 ccaggccctc caggaagcac tggccctcca ggccctccag gactcccagg acttcctggg
     3601 ccaatgggta tgagaggtga ccaaggacgt gatggaattc ctggtcctcc aggagaaaaa
     3661 ggagaaacag gcttgctggg ggcctaccca ggcccaaaag ggagccctgg tgtaccaggt
     3721 gccaaaggag acaggggagt tccaggcttg tctggccttc ccggcaggaa gggggttatg
     3781 ggggatgttg gaccccaagg acccccaggc actgctggac tcccagggcc accaggtcta
     3841 cctggggcaa ttatccctgg ccccaaagga gacagaggtc ttcctggctt aagaggaaat
     3901 ccaggtgagc caggtccccc tggacctcca ggacctatcg gaaaaggcat aaaaggtgac
     3961 aaaggattta tgggcccacc tggccccaaa ggcctgcctg gaactgtagg ggacatgggc
     4021 ccaccaggtt tcccgggagc accaggtacc cccggtcttc ccggtgtcag aggtgatcca
     4081 ggattccctg gatttccagg cataaaagga gaaaagggta accctggatt tcttgggcca
     4141 attggacatc caggaccagt tgggcccaaa ggaccaccag gtccacgtgg aaaacctggc
     4201 actcttaagg tcatctctct tccgggaagc ccagggccac ctggtgtacc tggacagcca
     4261 ggaatgaaag gagaccctgg acccctggga ctgccaggaa tcccaggacc ctgtgggcca
     4321 agaggtaaac caggcaagga tgggaaacca ggaactccag gaccagctgg tacaaagggc
     4381 aacaagggct tgaaaggaca gcaaggccca cctggtctgg atggattgcc aggcttaaag
     4441 ggaaatcctg gtgacagggg aacgccggcc actggtacaa gaatgcgagg cttcatcttc
     4501 acccgacaca gtcaaaccac ggccattcct tcatgccctg aaggaacaca gccactctat
     4561 agtgggtttt ctcttctttt tgtacaagga aacaaacgtg cacatggaca agacctaggt
     4621 actctgggca gctgcctgca gcgattcacc acaatgccgt tcttattctg taacatcaat
     4681 aatgtatgta actttgcatc acgaaatgat tattcatact ggctgtcaac accagctctg
     4741 atgccaatgg acatggctcc aattagtggc agagctctcg aaccctatat tagcagatgc
     4801 accgtctgtg aaggtccagc aatggccata gctgttcaca gtcaaactac tgctatccct
     4861 ccgtgtcccc aggactgggt ttctctctgg aaaggttttt ctttcattat gttcacaagt
     4921 gcaggctctg agggtgctgg acaagcactt gcctcgcctg gctcctgcct ggaagaattc
     4981 cgagccagtc catttataga atgccatgga cgagggacat gtaactacta ctcaaactcc
     5041 tacagtttct ggctggcttc gctgaaccca gaaagaatgt tcagaaaacc tattccatca
     5101 actgtgaaag ctggagactt agagaaaatc ataagccgct gtcaggtgtg catgaagaaa
     5161 agacattgac gaaatcaaag aaaccagaac cgtttttttt tttttttttt ttttttttgt
     5221 tccttcttaa gtaacaaagt catgacttag aacatgaatt tacttaggtc tttctctcta
     5281 accttaaaga tgtagtagtg caaagtttca ctacacaaga aagcatttca ttcgttagtc
     5341 tgtgatgtgg gtctctaaac ctgtaggttt caaagttccc tgtggaaagg caacagcttg
     5401 ccacagaata tcgctgaaat cacattccag ttgtacccaa agagctgact aaatgttgat
     5461 tgtgtggaac ttgaactaca agctaagaga ggtctgtcct gtggatgcac ggtgtgttcc
     5521 ttgtctccca ctcctgagca aaggagtgcg gttccttcca tctcctccct gacaccttag
     5581 acttcaacta cagaaggaga agggagtata ccatcaagca caccgtgaag agaactggag
     5641 ggtcagagct gctgagtggt gtaagggcta gaacacagaa taaatgaggc cccatgatgt
     5701 ttcaggactc atttaaatat gcacaaggct aggaccaaag gaaacttcct gaagcgaatc
     5761 ataacaggct tgtatataaa gtgtagtttt gttttctgtt ttgttgacga tgtctatttg
     5821 cttattcact gagctctttt tactatgtca atagattcaa agctggtaaa acgtttaccc
     5881 ttggggaact aggttttact aggatggcat acacatacat tgaaacattt ctctttattg
     5941 ttttcacaag taacaaggac actgcttact aaatgtgcac tttatcccca ctcctatcaa
     6001 cgccgacctt aaataatttc accaggaaat aatcaggttt atccgacgca aacatttttt
     6061 tctttgctct aaacagtaca taacatggat ttacagattt gttcctttgt tagttttata
     6121 acttttcctt tggaaaacac acacgtacgc catgattttt atgttataga ttcttcgcaa
     6181 ccatgtggaa agagaccact gggtaaaacc ttactgtact gtacacagct gctatatgtc
     6241 ttaaaacatg ttcttaagta tacagataca ttccacagtt acttaattga gcttaacaag
     6301 ttgttttctt cagttccaaa ctatttccca tatactggac tggaccggcg gtgcaggggg
     6361 tagtgagaga gacttgcttc tgatctaccc tcaaaggaga taacaaaccc cgtgtgtgga
     6421 gactctcacg caggcaggaa gcccatcctc tgctgcttca cccccttccc tacacggaaa
     6481 acaaacaaag agtctcagct atggttgctg ttttagtttt cccttacttc tatttcacag
     6541 ttcagcaggc ctgagagaag atttaaaaat aagagcactt gttgctctgc agaagcccct
     6601 agtttagttc ctagtaccca cactggtact gtttcacagt agcctcttcc agatgaccca
     6661 acatccactt ctggactctg cacccacgct cagctagata tacaaaagtt ttaaaacttt
     6721 taaaataaga tctatgtcca ggctaagttc aaaacctcta acttctctta ggcatgccag
     6781 aagctaatgt ctgaaaaata ttaagaaatc gggaactttt taataatcag atagtgtcgt
     6841 actatttgaa gactcaaaga ggccaggcat tgtgaggcaa acctttgagt gtatttcttg
     6901 acccacggaa gtggacgtga tggtgctgat acttaagttc aggctggtgc tgtaaactca
     6961 actgctttgt atttggaaaa tgtgacccaa gagcacagac aagggttgtc attctttacc
     7021 attcgtgtga ccactacaag acattttaca cctgagctga gacatgcaac atctcattac
     7081 aagtatgtat ttcagctaac atttttgttt gaaaaatatc ctgttgtccc acatacattc
     7141 cagtagtgaa aacaaggact aatctccttg gccagtgtag gagtagcagc tgtggcattc
     7201 aggagcttgt cctaattgcc cattgtagat cattctaaac ctgcaaagtt tgaaactgta
     7261 actagcaaac agaaatctgt gtcttgtctt gatgagaagc atctcattgt acaacccagg
     7321 atgaccccca aatcaccaca agttttctgc ctcagccacc cagaattttg ttttcaaagt
     7381 tttcatcatc ctctcatgtt ctccactcaa taggcacaca cccaagaaac tggccacaat
     7441 ccttttcacc tttgtctctc tttaaaactc actggtgact ttcagggtaa tctatttcac
     7501 tactagactg gtgctgatgt cacaacagct acccttcatt tgctcatagg cccctttctt
     7561 cttctgtcct cttatcagta tttaaaacag gtaatactgg acaccttaat gcccaaagaa
     7621 gccatatcaa cagtcagtca tttgtacttc taagagtgag caataaaata cagcccgtgc
     7681 atagtacttc ccagatgttt atgagtaaat tatacattta aaattcaatt tcctatgtgg
     7741 ctggagaaat ggttcagtag ttcagagtgc tggtttctct gcagagaacc caagtatagt
     7801 tctcaatacc caggtcatgc agctcaggac tgctcaaagg gaccccgctg gcctccaagg
     7861 atacccacat ataggtggca ttcaaggata cccacatata ggtggcattc actagcacag
     7921 gcactgccac ataaatacaa ataaatcttt caacattttt aactgattaa caaaacgttt
     7981 gtttcaattt tggtgcttca actttggagt ttcacagtgt gctaaaacaa ccaacttgtc
     8041 aattgttctt tttttgcaag ataacacatt attaatttat ttataaaagt attaaaaatg
     8101 tttaaatttg aattttattg ttaattttac aaaggttttc tatatttcaa atgtagcttg
     8161 ctaccactaa acttaattta atattcttct caataaccac ttgaaattta tttaaaatat
     8221 atcaaatatt ttatattgtt atatcctgac aaaattataa tgtattacaa tgtactaata
     8281 tttctgtaaa tataactaaa gttctattgt tttgtcaaaa taaaagaaaa ggaacaattc
     8341 ta
//
