LOCUS       NM_009932               6467 bp    mRNA    linear   ROD 16-SEP-2023
DEFINITION  Mus musculus collagen, type IV, alpha 2 (Col4a2), mRNA.
ACCESSION   NM_009932
VERSION     NM_009932.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6467)
  AUTHORS   Branyan K, Labelle-Dumais C, Wang X, Hayashi G, Lee B, Peltz Z,
            Gorman S, Li BQ, Mao M and Gould DB.
  TITLE     Elevated TGFbeta signaling contributes to cerebral small vessel
            disease in mouse models of Gould syndrome
  JOURNAL   Matrix Biol 115, 48-70 (2023)
   PUBMED   36435425
  REMARK    GeneRIF: Elevated TGFbeta signaling contributes to cerebral small
            vessel disease in mouse models of Gould syndrome.
REFERENCE   2  (bases 1 to 6467)
  AUTHORS   Ramadan R, Wouters VM, van Neerven SM, de Groot NE, Garcia TM,
            Muncan V, Franklin OD, Battle M, Carlson KS, Leach J, Sansom OJ,
            Boulard O, Chamaillard M, Vermeulen L, Medema JP and Huels DJ.
  TITLE     The extracellular matrix controls stem cell specification and crypt
            morphology in the developing and adult mouse gut
  JOURNAL   Biol Open 11 (12) (2022)
   PUBMED   36350252
REFERENCE   3  (bases 1 to 6467)
  AUTHORS   Reissig LF, Geyer SH, Winkler V, Preineder E, Prin F, Wilson R,
            Galli A, Tudor C, White JK, Mohun TJ and Weninger WJ.
  TITLE     Detailed characterizations of cranial nerve anatomy in E14.5 mouse
            embryos/fetuses and their use as reference for diagnosing subtle,
            but potentially lethal malformations in mutants
  JOURNAL   Front Cell Dev Biol 10, 1006620 (2022)
   PUBMED   36438572
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6467)
  AUTHORS   Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y,
            Zhang Z and Yuan S.
  TITLE     hnRNPU in Sertoli cells cooperates with WT1 and is essential for
            testicular development by modulating transcriptional factors Sox8/9
  JOURNAL   Theranostics 11 (20), 10030-10046 (2021)
   PUBMED   34815802
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6467)
  AUTHORS   Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y and Wang
            W.
  TITLE     FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme
            proliferation and differentiation via Lhx8/Suv39h1 complex
  JOURNAL   J Cell Mol Med 25 (6), 3051-3062 (2021)
   PUBMED   33580754
REFERENCE   6  (bases 1 to 6467)
  AUTHORS   Kuo DS, Labelle-Dumais C and Gould DB.
  TITLE     COL4A1 and COL4A2 mutations and disease: insights into pathogenic
            mechanisms and potential therapeutic targets
  JOURNAL   Hum Mol Genet 21 (R1), R97-R110 (2012)
   PUBMED   22914737
  REMARK    Review article
REFERENCE   7  (bases 1 to 6467)
  AUTHORS   Bruggeman LA, Burbelo PD, Yamada Y and Klotman PE.
  TITLE     A novel sequence in the type IV collagen promoter binds nuclear
            proteins from Engelbreth-Holm-Swarm tumor
  JOURNAL   Oncogene 7 (8), 1497-1502 (1992)
   PUBMED   1630813
REFERENCE   8  (bases 1 to 6467)
  AUTHORS   Saus J, Quinones S, MacKrell A, Blumberg B, Muthukumaran G,
            Pihlajaniemi T and Kurkinen M.
  TITLE     The complete primary structure of mouse alpha 2(IV) collagen.
            Alignment with mouse alpha 1(IV) collagen
  JOURNAL   J Biol Chem 264 (11), 6318-6324 (1989)
   PUBMED   2703491
REFERENCE   9  (bases 1 to 6467)
  AUTHORS   Schwarz,U., Schuppan,D., Oberbaumer,I., Glanville,R.W.,
            Deutzmann,R., Timpl,R. and Kuhn,K.
  TITLE     Structure of mouse type IV collagen. Amino-acid sequence of the
            C-terminal 511-residue-long triple-helical segment of the alpha
            2(IV) chain and its comparison with the alpha 1(IV) chain
  JOURNAL   Eur J Biochem 157 (1), 49-56 (1986)
   PUBMED   3011432
REFERENCE   10 (bases 1 to 6467)
  AUTHORS   Oberbaumer,I.
  TITLE     New pUC-derived expression vectors for rapid construction of cDNA
            libraries
  JOURNAL   Gene 49 (1), 81-91 (1986)
   PUBMED   2436975
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ125538.1, AK053858.1,
            AC114598.9, BC138040.1, AK075619.1 and CO044160.1.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_009932.5.
            
            On Aug 8, 2015 this sequence version replaced NM_009932.3.
            
            Summary: This gene encodes the alpha-2 subunit of the type IV
            collagens, an essential component of basement membranes. The
            encoded protein forms a triple helical heterotrimer comprised of
            alpha-1 and alpha-2 subunits that assembles into a type IV collagen
            network. Canstatin, a peptide derived fom the C-terminus of the
            collagen chain, is a matrikine that has been shown to inhibit
            angiogenesis. Homozygous knockout mice for this gene exhibit
            impaired basement membrane integrity and embryonic lethality. This
            gene shares a bi-directional promoter with a related gene on
            chromosome 8. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04695.1, SRR10223970.10323.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CJ125538.1         2-25
            25-1317             AK053858.1         1-1293
            1318-1318           AC114598.9         21777-21777         c
            1319-1969           AK053858.1         1295-1945
            1970-5914           BC138040.1         1658-5602
            5915-6444           AK075619.1         617-1146
            6445-6467           CO044160.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..6467
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.62 cM"
     gene            1..6467
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /note="collagen, type IV, alpha 2"
                     /db_xref="GeneID:12827"
                     /db_xref="MGI:MGI:88455"
     exon            1..310
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..399
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..5479
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /note="canstatin; collagen alpha-2(IV) chain; procollagen,
                     type IV, alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(IV) chain precursor"
                     /protein_id="NP_034062.3"
                     /db_xref="CCDS:CCDS40220.1"
                     /db_xref="GeneID:12827"
                     /db_xref="MGI:MGI:88455"
                     /translation="MDRVRFKASGPPLRGWLLLATVTVGLLAQSVLGGVKKLDVPCGG
                     RDCSGGCQCYPEKGARGQPGAVGPQGYNGPPGLQGFPGLQGRKGDKGERGVPGPTGPK
                     GDVGARGVSGFPGADGIPGHPGQGGPRGRPGYDGCNGTRGDAGPQGPSGSGGFPGLPG
                     PQGPKGQKGEPYALSKEDRDKYRGEPGEPGLVGYQGPPGRPGPIGQMGPMGAPGRPGP
                     PGPPGPKGQPGNRGLGFYGQKGEKGDIGQPGPNGIPSDITLVGPTTSTIHPDLYKGEK
                     GDEGEQGIPGVISKGEEGIMGFPGIRGFPGLDGEKGVVGQKGSRGLDGFQGPSGPRGP
                     KGERGEQGPPGPSVYSPHPSLAKGARGDPGFQGAHGEPGSRGEPGEPGTAGPPGPSVG
                     DEDSMRGLPGEMGPKGFSGEPGSPARYLGPPGADGRPGPQGVPGPAGPPGPDGFLFGL
                     KGSEGRVGYPGPSGFPGTRGQKGWKGEAGDCQCGQVIGGLPGLPGPKGFPGVNGELGK
                     KGDQGDPGLHGIPGFPGFKGAPGVAGAPGPKGIKGDSRTITTKGERGQPGIPGVHGMK
                     GDDGVPGRDGLDGFPGLPGPPGDGIKGPPGDAGLPGVPGTKGFPGDIGPPGQGLPGPK
                     GERGFPGDAGLPGPPGFPGPPGPPGTPGQRDCDTGVKRPIGGGQQVVVQPGCIEGPTG
                     SPGQPGPPGPTGAKGVRGMPGFPGASGEQGLKGFPGDPGREGFPGPPGFMGPRGSKGT
                     TGLPGPDGPPGPIGLPGPAGPPGDRGIPGEVLGAQPGTRGDAGLPGQPGLKGLPGETG
                     APGFRGSQGMPGMPGLKGQPGFPGPSGQPGQSGPPGQHGFPGTPGREGPLGQPGSPGL
                     GGLPGDRGEPGDPGVPGPVGMKGLSGDRGDAGMSGERGHPGSPGFKGMAGMPGIPGQK
                     GDRGSPGMDGFQGMLGLKGRQGFPGTKGEAGFFGVPGLKGLPGEPGVKGNRGDRGPPG
                     PPPLILPGMKDIKGEKGDEGPMGLKGYLGLKGIQGMPGVPGVSGFPGLPGRPGFIKGV
                     KGDIGVPGTPGLPGFPGVSGPPGITGFPGFTGSRGEKGTPGVAGVFGETGPTGDFGDI
                     GDTVDLPGSPGLKGERGITGIPGLKGFFGEKGAAGDIGFPGITGMAGAQGSPGLKGQT
                     GFPGLTGLQGPQGEPGRIGIPGDKGDFGWPGVPGLPGFPGIRGISGLHGLPGTKGFPG
                     SPGVDAHGDPGFPGPTGDRGDRGEANTLPGPVGVPGQKGERGTPGERGPAGSPGLQGF
                     PGISPPSNISGSPGDVGAPGIFGLQGYQGPPGPPGPNALPGIKGDEGSSGAAGFPGQK
                     GWVGDPGPQGQPGVLGLPGEKGPKGEQGFMGNTGPSGAVGDRGPKGPKGDQGFPGAPG
                     SMGSPGIPGIPQKIAVQPGTLGPQGRRGLPGALGEIGPQGPPGDPGFRGAPGKAGPQG
                     RGGVSAVPGFRGDQGPMGHQGPVGQEGEPGRPGSPGLPGMPGRSVSIGYLLVKHSQTD
                     QEPMCPVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYY
                     ASRNDKSYWLSTTAPLPMMPVAEEEIKPYISRCSVCEAPAVAIAVHSQDTSIPHCPAG
                     WRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYFANKYS
                     FWLTTIPEQNFQSTPSADTLKAGLIRTHISRCQVCMKNL"
     exon            400..454
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..535
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..670
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..715
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..832
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..904
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..940
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1003
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1039
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1081
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1174
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1210
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1261
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1306
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1360
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1427
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1538
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1688
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1781
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1936
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2009
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2116
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2318
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2378
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2435
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2543
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2765
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2927
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3098
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3242
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3365
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3547
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3548..3611
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3686
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3794
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3902
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..3974
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4100
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4217
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..4379
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4478
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4625
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4742
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4743..4934
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4935..5221
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5222..6450
                     /gene="Col4a2"
                     /gene_synonym="Col4a-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcgcggg cggcgtctcc aaggggagga ccctgcggcg cgggtaagag gcggaggctg
       61 cgcgccgctc gggacttggt gtcgcaggga gtccgaacgc cggggctctg cgctccgcac
      121 ccagctcctc ccgcgccccg attccacgag ccccttggct cgccaatccc gggcaagcac
      181 cagcaaggca cgccggggcc gagagtccgg cgcccacgga gcagagccag gccggcctgg
      241 ccgccggtgt gccacgggcc aacgcttctt caggggccca tgcgcgcggg cagcagctcc
      301 tgaccctgag gttaggaagg gatcgagccg agtctagagc tcaaagactg ggatcatgga
      361 ccgagtgcgg ttcaaagcgt ctggccctcc cctgcgaggg tggctgctgc tagcaactgt
      421 gacagtggga ctcctggctc agagcgtctt ggggggtgtg aagaagttgg atgtgccctg
      481 cggagggaga gactgcagtg ggggttgcca gtgctacccg gagaaaggag caaggggtca
      541 gccaggggca gtgggccccc aggggtacaa tggcccccca gggttgcaag gattcccagg
      601 actacagggc cgcaaaggag acaagggcga acggggagtt cctggaccaa ctggaccaaa
      661 aggagatgtg ggagcgagag gcgtctctgg attccccggt gcagatggaa ttcctgggca
      721 tccagggcaa ggcggacccc gaggaaggcc aggctacgat ggttgcaacg gaaccagggg
      781 agacgcgggt ccacaggggc cctctggatc tgggggcttc cctggcctcc ctgggcccca
      841 aggacccaag gggcagaaag gcgagcctta cgcactctct aaagaagacc gtgacaaata
      901 ccggggtgaa cctggagagc ctggcctggt tggctaccag ggacctcctg gccgcccagg
      961 gcccatagga cagatgggtc ccatgggagc acctggaaga ccgggaccac cgggaccccc
     1021 tggacccaag ggacaaccag gcaaccgagg gctcggtttt tacggacaga agggtgaaaa
     1081 gggtgacata ggacagccag gacccaacgg gatcccatct gacatcacac ttgttgggcc
     1141 cacaacatca acgatccacc cggatctgta caagggtgaa aaaggagacg aaggagagca
     1201 agggataccc ggcgtaatct caaaaggcga ggaaggcatc atggggttcc caggaatacg
     1261 gggttttcct ggccttgatg gagaaaaagg agtcgtagga cagaaaggaa gcagaggcct
     1321 ggatggtttc caaggcccca gtggacctcg aggacccaag ggagaacggg gggaacaagg
     1381 acccccagga ccctctgtct actcgcccca tccatccctg gcaaaaggtg cccgaggtga
     1441 cccaggattc caaggtgctc atggggagcc aggaagccga ggcgaaccgg gagagcctgg
     1501 aaccgcgggt cctccaggcc catccgtcgg agatgaagat tcaatgagag gccttccagg
     1561 ggagatggga cccaaaggct tctcaggaga accagggtcc cctgcacgct atcttggccc
     1621 accaggagca gatggaagac caggtcccca aggagtccct ggacctgcag gcccacctgg
     1681 accagatggc ttcctgtttg gcctgaaagg atcagaaggg agagtgggct acccgggacc
     1741 ttcaggtttc ccaggaacac gagggcagaa aggatggaaa ggtgaagctg gagactgcca
     1801 atgtggccag gtcatcgggg gtcttccggg actgccagga cccaaaggtt ttcccggtgt
     1861 caatggggag ctcggaaaga aaggcgacca aggagaccca ggcctgcacg gtatccctgg
     1921 gttcccagga ttcaagggag ccccgggcgt tgctggagct cctggaccca aaggaataaa
     1981 gggagactct agaacaatca ccaccaaagg ggagcgagga cagccaggta tccctggtgt
     2041 acacggaatg aaaggtgatg acggcgtccc aggacgggat gggctggatg gattccctgg
     2101 cctgcctggc cccccgggcg atggcatcaa aggccctcca ggggatgcag gtctccctgg
     2161 tgtacccgga accaagggct ttccaggaga catcggtcct ccaggacagg gcttaccagg
     2221 tccgaaaggc gagcgtggtt tccctggaga cgctgggttg cctggacctc cgggcttccc
     2281 tggtcctcca ggtcccccag gaaccccagg acagagagat tgtgacacgg gtgtgaaaag
     2341 acctatcgga ggcggccagc aagtggtcgt tcagccaggt tgcattgaag gccccacagg
     2401 atcacctggc cagccaggac ccccaggccc cacaggtgcc aaaggcgtca gaggaatgcc
     2461 aggattccca ggagcttctg gagaacaagg gctcaagggc tttccaggag acccaggtcg
     2521 agaaggcttc ccagggcccc cagggttcat gggaccccga ggatccaaag gtaccacagg
     2581 cctccctggc ccagatggac ccccaggccc cattggactt ccaggaccag ctggaccccc
     2641 tggggacaga gggattccag gagaagtgct aggggcccag cctgggacac gaggagatgc
     2701 tggacttcca ggacagcctg ggctgaaagg gctcccagga gaaacaggag caccgggatt
     2761 cagaggaagc caagggatgc ccgggatgcc agggcttaaa ggtcagccag gcttcccagg
     2821 accttcggga cagccaggac agtctgggcc cccaggacaa catggattcc caggaactcc
     2881 tggccgagag gggcctttgg ggcagccagg ctcccctggc cttggaggtt tgcctggaga
     2941 caggggcgag cctggtgacc ctggtgtccc tggccctgtg ggcatgaaag gtctgtctgg
     3001 ggacagaggt gacgccggta tgtcaggcga gcgtggtcac cctggaagcc ctggatttaa
     3061 aggaatggca gggatgcctg gtatccctgg gcagaaaggt gatcgagggt cgcctggaat
     3121 ggacggtttc cagggcatgt tgggacttaa gggaagacag ggcttcccag ggaccaaagg
     3181 agaagctgga ttttttggag ttcctggttt gaagggcctg cctggcgagc caggggttaa
     3241 aggaaaccga ggagaccggg ggcccccagg accacctcct ctcatcctgc cggggatgaa
     3301 ggacatcaag ggagaaaagg gagatgaagg accaatgggc ctgaaagggt atctgggctt
     3361 aaaaggcatc caaggaatgc ccggagtccc cggagtgtct ggattccctg ggctacctgg
     3421 aaggcctggc ttcatcaaag gagtcaaggg agacatcgga gtccctggca caccaggctt
     3481 gccgggattc cctggggtgt ctggccctcc tggaattacc gggtttccag gattcacagg
     3541 cagccggggc gagaagggta ctccaggagt agcaggagtt tttggcgaga ccggccctac
     3601 tggggacttt ggtgacattg gggacactgt ggacttacca gggagcccag gcctgaaggg
     3661 ggaacggggc atcacgggaa ttccaggtct caagggattc tttggagaga aaggagctgc
     3721 gggtgacatt ggatttcctg ggataacggg catggctgga gctcagggct ctcctggact
     3781 taaaggacag acaggctttc cagggctcac agggctgcaa gggccacagg gagagcctgg
     3841 acggatcgga atacccggtg acaagggtga tttcggctgg ccaggcgtac caggtctacc
     3901 aggttttcct gggatccggg gcatcagcgg attgcacggc ctgccaggca ccaaaggctt
     3961 ccctggatca ccaggtgttg atgctcatgg agacccaggg ttcccaggcc ccactggaga
     4021 caggggtgac cggggagagg ccaacacact tccaggcccc gtgggagttc cagggcagaa
     4081 aggggagcgg ggaaccccag gggaacgtgg cccagctgga agcccaggac ttcagggttt
     4141 ccctggtatc tctccaccat ccaacatctc tgggtcacct ggtgatgtag gcgcaccagg
     4201 aatatttggc ttgcaaggct accaaggccc tccaggacca cctgggccaa acgcacttcc
     4261 tggaatcaaa ggagatgagg ggagctctgg agctgcagga ttccctggac agaaaggatg
     4321 ggttggggac ccagggcccc agggccagcc tggtgtactc ggtcttccgg gggagaaagg
     4381 gcccaagggt gaacaaggat tcatgggcaa caccgggccc tctggggccg tgggtgacag
     4441 aggccccaaa ggacccaaag gcgaccaagg attcccaggt gctcctggct ctatggggtc
     4501 cccaggaatt cctggcatcc cccagaagat tgctgtccag cctggaacgc tgggtcccca
     4561 gggcaggaga ggccttcctg gggccctggg agagataggg ccgcagggcc ctcctggaga
     4621 tccaggcttc cgtggggccc caggcaaggc tgggcctcag ggcagaggtg gcgtgtctgc
     4681 tgttccaggg ttccggggag accaagggcc catgggacac cagggtccag ttggccagga
     4741 aggggagcca ggccgtccag ggagcccagg cctgccaggg atgccaggcc gcagtgtgag
     4801 catcggctac ctcctggtga agcacagcca aacggaccag gaacccatgt gccctgtggg
     4861 catgaacaag ctctggagtg ggtacagcct gctatatttt gagggccagg agaaagcgca
     4921 caaccaggac ctaggactgg caggctcctg cctggcacgc ttcagcacca tgcctttcct
     4981 gtactgcaat ccgggtgacg tctgctacta tgccagccgc aacgacaagt cctactggct
     5041 ctccaccacg gcccctctgc ccatgatgcc cgtggctgag gaggaaatca agccctacat
     5101 cagccgctgc tctgtgtgcg aggctccggc cgtggccatt gccgtgcaca gccaggatac
     5161 ctctataccc cactgcccgg ctgggtggcg gagtttgtgg atcggatatt cattcctcat
     5221 gcacactgca gccggggatg aaggcggtgg ccagtcactg gtgtcgccgg gcagctgtct
     5281 agaggacttc cgtgcaacgc catttatcga gtgtaacggg ggccgtggta cctgccacta
     5341 cttcgctaac aagtacagct tctggctgac cacgatccca gagcagaact tccagagcac
     5401 accatccgct gacacgctca aggctggcct catccgcacg cacatcagcc gctgccaagt
     5461 gtgcatgaag aatctgtgag gctcccgccc tgcccacggc agctgtgtgg gaaggccacg
     5521 ttggtgctta tccttctgta tttgtttcaa ctttgtttga gacaatgtct cacttttcat
     5581 ccctgcctag cctggaacta tgtaaccccg ggctggcctc caacttgtgg caaacctcct
     5641 gcctcagctt cccagatgct gggattatgg gcatgcgcca ccacacccag cttggtgctt
     5701 actcttaact tattacctca gatgctgatc ccaaagttga tcttagtgtt ttcaaactac
     5761 caaagcaatt ctgcaccagc actcattcca accgtctgtc agcaagtggg cactagctcc
     5821 tccgggatct accagccttg gctcacagcc ctgctaacac ccaccttgga gagccaacac
     5881 ctaggagcaa cccacggacc tctccccatg taggacataa acatcatgct accaggtgtc
     5941 cccaacaata gctgtctctg tgtccctgtg cttcccctgg caacaggctg ctcaccttcc
     6001 tgcagtcttc ctaaaatgag gcagagtcta ggggacagca aaggaatcta tggccaatga
     6061 tagctgagct cactgaccca tttccaccca aggatgcatg cagtgtgctt ctgtctagac
     6121 ctggtttctt ggaggaggag atgatagcac ttttttctat caaatccata actgccacct
     6181 cccaagtccc tacgtgttgg cccctgcctt tttaagaccc tgacggcagc tggcacacag
     6241 ctcatggctc tagccaaacc cacagcaaag gagacatctc tctagccctc accagcatct
     6301 gctggaaggt acacttagca aatcattgac agtggcgtcc tacaacctgt gtcaccctaa
     6361 acacctccct ccacaacctg ttccctgcgg caagctgttc tatggctttt ctgtgtaaca
     6421 ccataaataa aagatattct aaggacttga aaaaaaaaaa aaaaaaa
//
