LOCUS       NM_009930               5564 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus collagen, type III, alpha 1 (Col3a1), mRNA.
ACCESSION   NM_009930
VERSION     NM_009930.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5564)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   2  (bases 1 to 5564)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 5564)
  AUTHORS   Wang,L., He,L., Yi,W., Wang,M., Xu,F., Liu,H., Nie,J., Pan,Y.H.,
            Dang,S. and Zhang,W.
  TITLE     ADAMTS18-fibronectin interaction regulates the morphology of liver
            sinusoidal endothelial cells
  JOURNAL   iScience 27 (7), 110273 (2024)
   PUBMED   39040056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5564)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   5  (bases 1 to 5564)
  AUTHORS   Feng,X., Molteni,H., Gregory,M., Lanza,J., Polsani,N., Gupta,I.,
            Wyetzner,R., Hawkins,M.B., Holmes,G., Hopyan,S., Harris,M.P. and
            Atit,R.P.
  TITLE     Apical expansion of calvarial osteoblasts and suture patency is
            dependent on fibronectin cues
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38602508
REFERENCE   6  (bases 1 to 5564)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   7  (bases 1 to 5564)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   8  (bases 1 to 5564)
  AUTHORS   Metsaranta,M., Toman,D., De Crombrugghe,B. and Vuorio,E.
  TITLE     Specific hybridization probes for mouse type I, II, III and IX
            collagen mRNAs
  JOURNAL   Biochim Biophys Acta 1089 (2), 241-243 (1991)
   PUBMED   2054384
REFERENCE   9  (bases 1 to 5564)
  AUTHORS   Andujar,M.B., Couble,P., Couble,M.L. and Magloire,H.
  TITLE     Differential expression of type I and type III collagen genes
            during tooth development
  JOURNAL   Development 111 (3), 691-698 (1991)
   PUBMED   1879336
REFERENCE   10 (bases 1 to 5564)
  AUTHORS   Schurr,E., Skamene,E., Morgan,K., Chu,M.L. and Gros,P.
  TITLE     Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1
            identifies conserved linkage of structural protein genes between
            murine chromosome 1 and human chromosome 2q
  JOURNAL   Genomics 8 (3), 477-486 (1990)
   PUBMED   1981051
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY139268.1, BC043089.1 and
            AK019448.2.
            
            On Apr 7, 2009 this sequence version replaced NM_009930.1.
            
            Summary: This gene encodes the alpha-1 subunit of the
            fibril-forming type III collagen found in bone, cartilage, dentin,
            tendon, bone marrow stroma and other connective tissue. The encoded
            protein forms homotrimeric type III procollagen that undergoes
            proteolytic processing during fibril formation. A majority of mice
            lacking the encoded protein die within two days of birth but about
            5% of the animals survive to adulthood. The surviving mice exhibit
            severe cortical malformation and experience significantly shorter
            lifespan. The mutant mouse named 'tight skin 2' exhibiting systemic
            sclerosis phenotype was found to harbor a missense point mutation
            in this gene. A pseudogene of this gene has been defined on
            chromosome 8. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220558.1, AK159920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               BY139268.1         1-125
            126-4878            BC043089.1         1-4753
            4879-5564           AK019448.2         2244-2929
FEATURES             Location/Qualifiers
     source          1..5564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.67 cM"
     gene            1..5564
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /note="collagen, type III, alpha 1"
                     /db_xref="GeneID:12825"
                     /db_xref="MGI:MGI:88453"
     exon            1..295
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..4605
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /note="collagen alpha-1(III) chain; procollagen, type III,
                     alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(III) chain preproprotein"
                     /protein_id="NP_034060.2"
                     /db_xref="CCDS:CCDS35554.1"
                     /db_xref="GeneID:12825"
                     /db_xref="MGI:MGI:88453"
                     /translation="MMSFVQSGTWFLLTLLHPTLILAQQSNVDELGCSHLGQSYESRD
                     VWKPEPCQICVCDSGSVLCDDIICDEEPLDCPNPEIPFGECCAICPQPSTPAPVLPDG
                     HGPQGPKGDPGPPGIPGRNGDPGLPGQPGLPGPPGSPGICESCPTGGQNYSPQFDSYD
                     VKSGVGGMGGYPGPAGPPGPPGPPGSSGHPGSPGSPGYQGPPGEPGQAGPAGPPGPPG
                     ALGPAGPAGKDGESGRPGRPGERGLPGPPGIKGPAGMPGFPGMKGHRGFDGRNGEKGE
                     TGAPGLKGENGLPGDNGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPP
                     GPPGTAGFPGSPGAKGEVGPAGSPGSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGSPG
                     GKGEMGPAGIPGAPGLIGARGPPGPAGTNGIPGTRGPSGEPGKNGAKGEPGARGERGE
                     AGSPGIPGPKGEDGKDGSPGEPGANGLPGAAGERGPSGFRGPAGPNGIPGEKGPPGER
                     GGPGPAGPRGVAGEPGRDGTPGGPGIRGMPGSPGGPGNDGKPGPPGSQGESGRPGPPG
                     PSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGLPGPAGKNGETGPQGPPGPTGP
                     AGDKGDSGPPGPQGLQGIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGKGDSGAPGER
                     GPPGTAGIPGARGGAGPPGPEGGKGPAGPPGPPGASGSPGLQGMPGERGGPGSPGPKG
                     EKGEPGGAGADGVPGKDGPRGPAGPIGPPGPAGQPGDKGEGGSPGLPGIAGPRGGPGE
                     RGEHGPPGPAGFPGAPGQNGEPGAKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQ
                     GVKGERGSPGGPGTAGFPGGRGLPGPPGNNGNPGPPGPSGAPGKDGPPGPAGNSGSPG
                     NPGIAGPKGDAGQPGEKGPPGAQGPPGSPGPLGIAGLTGARGLAGPPGMPGPRGSPGP
                     QGIKGESGKPGASGHNGERGPPGPQGLPGQPGTAGEPGRDGNPGSDGQPGRDGSPGGK
                     GDRGENGSPGAPGAPGHPGPPGPVGPSGKSGDRGETGPAGPSGAPGPAGARGAPGPQG
                     PRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAIGSPGPAGPRGPVGPHGP
                     PGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGGAAAIA
                     GVGGEKSGGFSPYYGDDPMDFKINTEEIMSSLKSVNGQIESLISPDGSRKNPARNCRD
                     LKFCHPELKSGEYWVDPNQGCKMDAIKVFCNMETGETCINASPMTVPRKHWWTDSGAE
                     KKHVWFGESMNGGFQFSYGPPDLPEDVVDVQLAFLRLLSSRASQNITYHCKNSIAYMD
                     QASGNVKKSLKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYQTRKAMR
                     LPIIDIAPYDIGGPDQEFGVDIGPVCFL"
     exon            296..495
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..546
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..660
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..735
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..789
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..843
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..897
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..951
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1005
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1059
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1104
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1158
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1203
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1257
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1356
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1401
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1500
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1554
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1662
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1716
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1815
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1869
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1968
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2022
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2076
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2130
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2184
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2229
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2328
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2436
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2490
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2544
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2598
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2652
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2760
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2814
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2868
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3030
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3138
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3246
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3300
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3408
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3462
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3570
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3624
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3732
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..4027
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4215
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..4458
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..5564
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4853..4858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /note="hexamer: AATAAA"
     polyA_site      4878
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /note="major polyA site"
     regulatory      5421..5426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /note="hexamer: AATAAA"
     polyA_site      5439
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
     regulatory      5543..5548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
                     /note="hexamer: AATAAA"
     polyA_site      5562
                     /gene="Col3a1"
                     /gene_synonym="Col3a-1; Tsk-2; Tsk2"
ORIGIN      
        1 ggatgggttc tgctctcata tttcagaaag gggctggaaa gtgagggaag ccaaactttt
       61 tcctatttaa ggccagagca gagggaagcg agcggctgag ttttatgacg ggcccggtgc
      121 tgaagggcag ggacaactga tggtgctact ctgagctgct tcttcctctc tcctcttttg
      181 cacaaagagt ctcatgtctg atatttagac atgatgagct ttgtgcaaag tggaacctgg
      241 tttcttctca cccttcttca tcccactctt attttggcac agcagtccaa cgtagatgaa
      301 ttgggatgca gccaccttgg tcagtcctat gagtctagag atgtctggaa gccagaacca
      361 tgtcaaatat gtgtctgtga ctcaggatct gtcctttgcg atgacataat ctgtgatgag
      421 gagccactag actgccccaa cccagagatc ccatttggag aatgttgtgc aatatgccca
      481 cagccttcta cacctgctcc tgtgcttcct gatggccatg gacctcaagg ccccaaggga
      541 gatccgggtc ctcctggcat tcctgggaga aatggtgacc ctggccttcc aggacaacca
      601 ggtctccctg ggcctcctgg ctcccctgga atctgtgaat catgtccaac tggtggccaa
      661 aattattctc cccaattcga ctcatatgat gtcaagtctg gagtgggagg aatgggtggc
      721 tatccgggac cagctggtcc accaggccct ccaggacccc ctggttcttc tggacatcct
      781 ggatctcctg gttctcctgg ataccaaggt ccccctggtg aacctggtca agctggtccg
      841 gcaggccctc caggacctcc tggtgctctt ggtccagctg gtcctgctgg aaaggatgga
      901 gagtcaggaa gacctggacg acctggagag cgtggactgc ctggacctcc aggtatcaaa
      961 ggcccagctg gcatgcctgg attccctggt atgaaaggac acagaggctt tgatggacgc
     1021 aatggagaaa agggagaaac aggtgctcct ggactgaagg gtgaaaatgg tcttccagga
     1081 gacaacggag ctcctggccc catgggtcct agaggggctc ctggtgagcg aggacgacca
     1141 ggccttcctg gagctgcagg tgctcgaggc aatgatggtg ctcggggcag tgatgggcaa
     1201 cctggtcccc ctggccctcc tggaactgca ggattccctg gatcccctgg tgctaagggt
     1261 gaagttggac ctgcagggtc ccctggctca aatggctcac caggacaaag aggggagcct
     1321 ggaccgcagg gacatgctgg tgctcaaggg cctcctggcc ctcccgggaa taacggcagt
     1381 cctggtggaa agggtgaaat gggtccagct ggcattcctg gagcccctgg actaatagga
     1441 gcaaggggcc cccctggacc agcaggaact aatggtatac ccggaacacg aggtccttca
     1501 ggtgaacccg gcaagaacgg tgcgaaggga gagccaggag cacgcggtga acggggcgaa
     1561 gctggttccc caggaattcc aggacctaag ggcgaagatg gcaaagatgg atcacctgga
     1621 gaacctggtg caaatgggct tccaggagcc gcaggagaaa ggggtcctag tggcttccga
     1681 ggacctgcag ggccaaatgg catcccagga gaaaagggtc ctcccggaga gcgtggtggc
     1741 ccaggtcctg caggacccag aggagtagct ggagaacctg gccgagatgg aacccctgga
     1801 ggtccaggga tacggggtat gcccggaagt ccaggtggac caggcaatga tggaaaacca
     1861 ggacctcctg gaagtcaagg agaaagtggt cgccctggtc cccctggccc atctggtccc
     1921 agaggtcagc ctggtgtcat gggtttccct ggtcctaaag gaaatgatgg tgcccctggc
     1981 aagaatggag aacggggtgg ccctggagga cctggccttc caggtcctgc tggaaagaat
     2041 ggggagactg gacctcaggg tcccccagga cctactggcc cagctggtga caagggagat
     2101 tctggacccc ctggtccaca aggattacaa ggcatacctg gtaccggtgg tcctccagga
     2161 gaaaatggga aaccaggtga accaggtcca aagggtgaag tcggtgctcc tggagctcct
     2221 ggaggcaagg gtgattctgg tgcacctgga gaacgtgggc ctcctggaac agcaggaatc
     2281 cctggtgcta gaggtggagc tggaccccct ggccctgagg gaggaaaggg ccctgctggt
     2341 ccccctggcc ctcctggtgc ttctggttct cctggtctgc aagggatgcc aggggaaaga
     2401 ggaggtcctg gaagtcctgg cccaaagggt gaaaagggtg aaccaggtgg tgcaggtgct
     2461 gacggagttc caggaaagga tgggccaagg ggtcctgctg gccctattgg tccccctggc
     2521 ccagctggtc agcctggaga taagggtgaa ggtggttccc ctggacttcc aggtatagct
     2581 ggacctcgag gtggccctgg tgagagaggt gaacatggcc ctccaggacc tgctggcttc
     2641 ccgggtgctc ctggacagaa tggtgaacca ggtgctaaag gagaaagagg tgcccctgga
     2701 gagaaaggtg aaggaggccc tccaggacct gcaggaccca ctggcagttc tggacctgct
     2761 ggtccgcctg gtcctcaggg tgtaaagggt gaacgtggta gtcctggtgg tcctggtact
     2821 gctggctttc ccggtgggcg tggtcttcct ggtcctcctg gcaataatgg taatccaggg
     2881 cccccaggac ccagtggtgc tcctggcaag gacggccctc caggtcctgc aggcaacagt
     2941 ggttctcctg gcaaccctgg aatagctgga ccaaaaggtg atgctggaca gcctggagag
     3001 aaggggccac ctggtgctca gggtcctccg ggttccccag gcccacttgg aattgcaggg
     3061 ctaactggag cacgaggtct tgctggacca ccaggcatgc caggtccacg gggtagccct
     3121 ggacctcagg gtatcaaggg tgaaagtgga aaaccaggag ccagtggcca taatggggaa
     3181 cgtggtcctc ctggacccca aggtcttcct ggtcagcctg gtacagctgg tgaacctgga
     3241 agggatggaa accctggatc agatggtcag ccaggtcgag atggatctcc tggtggcaag
     3301 ggtgatcgtg gtgaaaatgg ttctcctggt gccccaggcg ctcctggtca tccaggccca
     3361 cctggccctg ttggtccatc tggaaagagt ggtgacagag gagaaactgg ccctgctggt
     3421 ccttctggtg ctccaggccc tgctggagct cgaggtgctc cgggtcccca aggtccacga
     3481 ggtgacaaag gtgaaactgg tgaacgtggc tctaatggca tcaaaggaca tcgaggattc
     3541 cctggcaatc caggtcctcc aggttctcct ggtgctgctg gtcaccaggg tgcaattggt
     3601 agtccaggac ctgcaggtcc cagaggacca gttggaccac atggacctcc tggaaaagat
     3661 ggaacaagtg ggcatccagg tcctattgga ccaccaggtc ctagaggaaa cagaggtgaa
     3721 agaggatctg agggctcgcc aggccaccct ggacagccag gaccccctgg accccctggt
     3781 gcccctggtc cctgctgtgg tggtggtgct gctgccattg ctggagttgg aggtgaaaag
     3841 tctggtggct tttcacccta ttatggagac gatccaatgg atttcaagat caacactgaa
     3901 gagattatgt cttcactcaa gtctgttaat ggacaaatag agagtcttat aagccctgat
     3961 ggttctcgaa aaaaccctgc tcggaactgc agagacctaa aattctgcca ccccgaactc
     4021 aagagtggag aatactgggt tgatcctaac caaggctgca agatggatgc tataaaagta
     4081 ttctgtaaca tggaaactgg ggaaacatgc ataaatgcca gccccatgac tgtcccacgt
     4141 aagcactggt ggacagattc tggtgcagag aagaaacatg tttggtttgg agaatctatg
     4201 aatggtggtt ttcagttcag ctatggccct cctgatcttc ctgaagatgt cgttgatgtg
     4261 cagctggcat tcctcagact tctttccagc cgggcctccc agaacattac ataccactgc
     4321 aaaaacagta ttgcctatat ggatcaggcc agtggcaatg taaagaagtc tctgaagctg
     4381 atgggatcaa atgaaggcga attcaaggct gaaggaaaca gcaaattcac ttacacagtt
     4441 ctagaggatg gctgtactaa acacactggg gaatggagca agacagtctt tgaatatcaa
     4501 acacgcaagg caatgagact acccatcata gatatcgcac cctatgacat tgggggtcct
     4561 gatcaagaat ttggtgtgga cattggccct gtttgctttt tataagccaa actctctgaa
     4621 accccagcaa aacaaaaacc acatccatgt gttcatcttg ttttaatctt atcaaccagt
     4681 gcaagtgacc aactaaattc cagttattta tttccaaact tttggaaaaa gcataatttg
     4741 acaaaaaaag aatacaattt tttgctgttt caaccaccca atacaggtca aatgcttttg
     4801 ttttattttt ttaccaattc caacttcaaa atgtctcaat ggtgctataa taaataaacg
     4861 tcaacacttt tatgataaca ctgtgttaca ttctttgaac tctagcccat ctgcagagca
     4921 acggtcatac tcattcacca gcatagaata tctttatttc caaaacagga aagaacaaaa
     4981 ttagacatgt cctcctccct atgttaacta cctcaactgg tcagaacaga tagcttctga
     5041 gacctgaaga ctatacaatc atgtaaaact tgacaaaact tatgaatttc attggttagc
     5101 catgtagagc gttaactaga attaaaaaaa actagactat agagcaggaa tttgaaggag
     5161 tactttcagt tcacaattgt cttcatcata ggtataaatg cttttaaagg tgcttctctt
     5221 ctgctgttgc tggtgaactt gcaagtatct ggaagggctt taaagacaca tgttaaggtg
     5281 ctaatgtatt ttcacattta gaactccaga tcaaaattgg taccttcatt caagccataa
     5341 atgcaaagta tctatatttg tcttctgcca gaaatattga ctggcatgcc acaggatctt
     5401 ctcttctttt attctataaa aataaacaac gaaaaacaag tttggttttt tttttttctc
     5461 acaataacac agagaatgtt ttaaactttt tcttttgtaa gcttgtatgt agttgttgat
     5521 ctttttttcc ttccagtcat ataataaaat atcataatga aaca
//
