LOCUS       NM_025685               7635 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus collagen, type XXVII, alpha 1 (Col27a1), mRNA.
ACCESSION   NM_025685
VERSION     NM_025685.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7635)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7635)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 7635)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   5  (bases 1 to 7635)
  AUTHORS   Plumb,D.A., Ferrara,L., Torbica,T., Knowles,L., Mironov,A. Jr.,
            Kadler,K.E., Briggs,M.D. and Boot-Handford,R.P.
  TITLE     Collagen XXVII organises the pericellular matrix in the growth
            plate
  JOURNAL   PLoS One 6 (12), e29422 (2011)
   PUBMED   22206015
REFERENCE   6  (bases 1 to 7635)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   7  (bases 1 to 7635)
  AUTHORS   Mayo,J.L., Holden,D.N., Barrow,J.R. and Bridgewater,L.C.
  TITLE     The transcription factor Lc-Maf participates in Col27a1 regulation
            during chondrocyte maturation
  JOURNAL   Exp Cell Res 315 (13), 2293-2300 (2009)
   PUBMED   19414009
  REMARK    GeneRIF: Results suggest that Lc-Maf may affect the process of
            endochondral ossification by participating in the regulation of
            Col27a1 expression.
REFERENCE   8  (bases 1 to 7635)
  AUTHORS   Plumb,D.A., Dhir,V., Mironov,A., Ferrara,L., Poulsom,R.,
            Kadler,K.E., Thornton,D.J., Briggs,M.D. and Boot-Handford,R.P.
  TITLE     Collagen XXVII is developmentally regulated and forms thin
            fibrillar structures distinct from those of classical vertebrate
            fibrillar collagens
  JOURNAL   J Biol Chem 282 (17), 12791-12795 (2007)
   PUBMED   17331945
REFERENCE   9  (bases 1 to 7635)
  AUTHORS   Boot-Handford,R.P., Tuckwell,D.S., Plumb,D.A., Rock,C.F. and
            Poulsom,R.
  TITLE     A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a
            unique expression pattern and unusual molecular characteristics
            establishes a new clade within the vertebrate fibrillar collagen
            family
  JOURNAL   J Biol Chem 278 (33), 31067-31077 (2003)
   PUBMED   12766169
  REMARK    GeneRIF: type XXVII collagen has unusual molecular features such as
            no minor helical domain, a major helical domain that is short and
            interrupted, and a short chain selection sequence within the NC1
            domain (COLLAGEN TYPE XXVII)
REFERENCE   10 (bases 1 to 7635)
  AUTHORS   Pace,J.M., Corrado,M., Missero,C. and Byers,P.H.
  TITLE     Identification, characterization and expression analysis of a new
            fibrillar collagen gene, COL27A1
  JOURNAL   Matrix Biol 22 (1), 3-14 (2003)
   PUBMED   12714037
  REMARK    GeneRIF: molecular cloning
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK157951.1, AL691496.13,
            AY167568.2 and AL683828.8.
            
            On Oct 12, 2006 this sequence version replaced NM_025685.2.
            
            Summary: This gene encodes the alpha-1 subunit of type XXVII
            collagen, one of the low abundance fibril-forming collagens found
            in cartilage. The encoded protein forms a homotrimeric triple
            helical procollagen that undergoes proteolytic processing during
            fibril formation. Transgenic mice lacking a portion of the
            collagenous domain in the encoded protein exhibit skeletal
            abnormalities, chondrodysplasia and die at birth because of a lung
            defect. [provided by RefSeq, Dec 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY167568.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               AK157951.1         2-542
            542-2277            AL691496.13        97884-99619
            2278-5952           AY167568.2         1864-5538
            5953-7635           AL683828.8         46927-48609
FEATURES             Location/Qualifiers
     source          1..7635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..7635
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /note="collagen, type XXVII, alpha 1"
                     /db_xref="GeneID:373864"
                     /db_xref="MGI:MGI:2672118"
     exon            1..470
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            471..541
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            542..2277
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2331
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2385
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2439
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2493
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2538
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2592
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2637
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2691
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2736
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2790
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2835
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2889
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2934
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..2988
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3042
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3096
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3150
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3204
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3249
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3303
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3348
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3402
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3456
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3510
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3564
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3618
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3663
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3708
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3762
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3816
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3870
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..3924
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..3978
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4086
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4087..4140
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4248
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4302
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4356
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4413
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4467
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4468..4521
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4575
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4629
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4737
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4845
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..4953
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4954..5007
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5070
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5071..5124
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5125..5160
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5161..5178
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5179..5214
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5215..5241
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5242..5307
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5308..5476
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5477..5586
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5587..5805
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5806..7635
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7607..7612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7635
                     /gene="Col27a1"
                     /gene_synonym="5730512J02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccttttcctc tcctccccca ggccggcggg gaggcagctt ccaccgccct ccgcgcgcgc
       61 tctcccggcc ttgctctgcc tccagagacc gctagcggcc cgcctccaaa agtttgatca
      121 tctctctctc cctgcctttt cttgcttctt ccttttcggt ggaagcagaa aaagagcgag
      181 gcaggggcga gcgcggctcc ggcagtcctg ggaccatggg cctggcgcgg gcgaccgccg
      241 ggctggggcc gtgctgtccg tctgctccgg cgcccctggg cgcaggactg ggctgggggt
      301 gcgccggcag cgcgctttga gccggcctgg cgcggcgcgg cggggggctg gcggccccat
      361 ggggcgcgcc cacacttgcc ccccgggctc cgcagcatga agtaggggcc tgccatgggc
      421 acgggattcg cgcggggggc ccgaggcaca gcggcgtcag gacccggggg ggggtttctc
      481 ttcgcctgga tcttggtctc atttacctgt cacctggcct ccacccaagg agctcctgaa
      541 gatgtggatg tcctccagcg gctgggcctc agctggacga aggccggggg tggccggagt
      601 cctacacccc ctggtgtcat tcctttccca tctggcttca tcttcacaca gcgggccaag
      661 ctgcaggccc ccacagccaa tgttcttccc accaccctgg ggcgggagct ggcattggtg
      721 ttgagcctct gttcacatcg tgtgaaccat gccttcctct ttgccatccg cagcaggaaa
      781 cacaagctgc aactgggtct gcagttcctc cccggcagga cgatcatcca cctggggcct
      841 cggcaatcag tggccttcga cttggatgtg catgatgggc gctggcacca cctggcccta
      901 gagttgcgtg gccgcacagt cacaatggtg acagcctgtg ggcagcacag ggtacctgtc
      961 ccactgcctt cccgtaggga ctccatgctt gacccccagg gctcctttct cttggggaag
     1021 gtgaaccccc gtgctgtcca gtttgaaggt gcactctgtc agttcagcat ccaccctgtg
     1081 gcgcaggtcg ctcacaatta ctgtgcccac ctgagagagc ggtgccgaca ggtggacaca
     1141 tatagtcccc aggtgggaac cctctttcct tgggactctg gcccagcctt tgctttgcat
     1201 cctgaaccag ccttgcttgg cttggggaat ctgaccagaa ctccagcaac cctgggggcc
     1261 aggcctgtaa gcagggcact tgcagtgact ctggctcctg ccatgcccac caagcccctg
     1321 aggactgtcc acccagatgt ctctgaacac agctcttccc agaccccact gtcacctgcc
     1381 aaacagtcgg ccaggaaaac accttccccc tcctcgtcag cttccctggc taattccacc
     1441 agggtttatc gtccagctgc tgcccagcca agacagatca caactactag ccccaccaaa
     1501 cgttccccca ccaagccttc tgtttctccc ctttcagtta cccccatgaa aagtccccat
     1561 gcaacccaga aaacaggtgt cccttcattc acaaagcctg ttccacccac tcagaagcca
     1621 gcgcccttca cctcctacct agcaccttcc aaagcctcta gtcccactgt gaggcctgtt
     1681 cagaagactt tcatgacacc ccgacctcca gtccccagcc cccagcccct gcgccctact
     1741 actggcttat ctaagaagtt cactaacccc actgttgcaa aatctaagtc caagacgacc
     1801 agttgggcca gcaagccggt cttggcccgc tccagtgtcc ctaaaacgct tcagcaaact
     1861 gttttgtccc agtctcctgt ttcctatctg ggctctcaga cactggctcc agccctccct
     1921 cctttgggtg ttggaaatcc tagaacgatg cctcccacac gtgactctgc tttaactcct
     1981 gctggaagca agaaattcac aggacgggaa acctccaaga aaaccagaca gaagagcagc
     2041 ccccggaagc ccgaacctct cagccctggg aagtcagcca gggatgcctc accaagagac
     2101 ctgacaacca agcctagccg gccgtccacc ccagccctgg tccttgcccc agcttacctc
     2161 ctgtcctcca gcccccagcc caccagcagc agcttccctt tcttccacct gctgggccct
     2221 acacctttcc cgatgctgat ggggcctcca ggctccaagg gagactgtgg cttgccgggt
     2281 ccccctgggc ttccaggatt acctggatct ccgggcgcac gaggtcctcg gggtcctcct
     2341 gggccgtacg ggaacccagg cccacctggc cctccaggag ccaaaggaca gaaaggggac
     2401 ccaggactct caccaggaca ggctcacgat ggagcaaagg gcaacatggg cttgcctggg
     2461 ctctccggaa atccaggacc cttgggaagg aagggacaca agggccatcc tggagcagca
     2521 gggcaccctg gagaacaggg gcagccagga cctgagggca gtccaggggc caaaggttac
     2581 cctggcaggc aggggttccc tggacctgta ggagaccctg gccccaaagg cagcaggggt
     2641 tacattggtc ttccggggct ctttggcctg ccagggtcgg atggagagcg gggtctccct
     2701 ggcgttcctg gcaagagggg cgagatgggt aggccgggct tccctggaga ctttggggaa
     2761 agaggccccc ctggacttga tggcaaccct ggagaaattg gcctgccggg gccaccagga
     2821 gtgctcgggc tcattggtga cacaggagca ctgggcccag ttggctaccc aggaccgaaa
     2881 ggcatgaagg gactgatggg cggcgtgggg gagcccggac tgaaaggtga taagggtgaa
     2941 caaggggtgc caggtgtgtc gggagatcct ggcttccaag gagacaaggg gagtcatggc
     3001 ttgccagggc tcccgggtgg ccgggggaag ccagggcctc tgggaaaagc tggagacaaa
     3061 ggatcacttg ggtttcctgg acctcctgga cctgagggtt tcccaggaga cattggccct
     3121 ccaggggaca atggccctga aggcatgaag ggtaagcctg gagcccgagg cctgcctgga
     3181 cctcctgggc agctggggcc tgagggagat gaaggaccca tggggccacc aggagtccca
     3241 ggcttggagg gtcagcctgg aaggaaaggg tttcctggga ggcctggcct ggatggctcg
     3301 aagggggaac caggggatcc tggacggcca ggacctgtgg gtgaacaggg gcttatggga
     3361 ttcattggtc ttgtcggaga gcctggaatt gttggggaga agggagaccg tggggtgatg
     3421 ggacccccag gtgcacctgg acccaagggg tcgatgggcc atcctggaac acccggtggt
     3481 attgggaacc ctggagagcc tggaccctgg ggccctccag gatctcgagg cctgccaggc
     3541 atgaggggag ccaaggggca ccggggccct cgaggacctg atggaccagc tggggagcag
     3601 ggatccaagg gcctgaaggg tcgtgtagga cctcggggca gacctggcca gccaggacag
     3661 cagggtgcag ctggtgagcg aggccactca ggtgcaaaag gcttccttgg catccctggt
     3721 ccctcaggcc ctccaggtgc caagggcctc ccaggagaac cgggctctca gggacctcag
     3781 gggccagttg gtcctccagg agaaatgggg cccaagggac cgccgggtgc agtgggagag
     3841 cctggccttc ctggggactc cggaatgaag ggtgacctcg gacctctggg cccccctggg
     3901 gagcaaggtc ttattgggca gcggggagag ccaggccttg agggagacca tggccctgtg
     3961 gggccagatg ggctgaaggg cgacaggggc gacccagggc ccgatggcga gcatggtgaa
     4021 aagggccagg aagggctgaa aggagaggat gggtcccctg ggcccccggg catcactggc
     4081 gtcccgggtc gtgaggggaa gccgggcaag cagggtgaga aaggccagag gggagctaag
     4141 ggtgccaagg gccaccaagg atatctggga gagatgggca tccccggaga acctgggccc
     4201 cctgggaccc caggtcctaa agggtcccgg ggcaccctag gaccaacggg tgctccagga
     4261 cggatgggag cccaaggaga accaggattg gccggttata atggacacaa aggcatcaca
     4321 ggacccctcg ggcctcccgg gcccaaaggc gagaaggggg accagggcga ggatggcaag
     4381 accgaggggc cccctgggcc accaggagat cggggtcctg tgggtgatcg aggagaccgt
     4441 ggggagccag gcgaccctgg ataccctggt caagagggag ttcaaggcct ccgtggagaa
     4501 ccgggccagc agggacagcc tgggcatcca ggaccccggg ggcgcccagg acccaaagga
     4561 tcaaaaggcg aagagggccc aaagggaaag ccaggcaagg ctgggccatc aggccggagg
     4621 gggacccagg gccttcaagg actgccaggc ccccgaggcg tggtggggag acagggccct
     4681 gagggcactg ctggatctga tgggattcct ggcagagatg gtcggccagg atatcaggga
     4741 gaccagggaa atgatgggga ccctggccct gtgggccctg ctgggagaag aggaaatcca
     4801 ggtgtggctg gcttgcctgg agcacagggg cctccgggat tcaagggtga aagtgggtta
     4861 cctgggcaac tgggtccccc tggaaaacga gggacagaag gtggaacagg gcttcctggg
     4921 aaccaggggg agccaggatc caaaggccag ccgggtgact ctggcgagat gggcttccca
     4981 ggagtggctg gcctctttgg acccaagggc ccccctggag acattggctt caaaggcatc
     5041 caaggtcctc gggggcctcc tggcttgatg ggaaaggaag gtatcattgg cccccccgga
     5101 atgctgggac cttctggact cccgggtccc aaaggtgaca gaggcagccg aggagacttg
     5161 ggactgcaag gcccaagggg tcctcctggt ccaaggggcc ggccaggtcc cccgggccct
     5221 ccttggcatc ccatccagtt tcagcaagat gaccttggag cagctttcca gacatggatg
     5281 gatgctcaag gagccgtcag atcggagggg tacagctatc cggaccagct ggcgctagac
     5341 cagggagggg agatcttcaa aaccttacac tacctcagca acctcatcca gagcattaag
     5401 acacccttgg gcaccaagga gaacccagcc cgggtctgcc gggacctcat ggactgtgag
     5461 cagaggatgg cggatggtac ctactgggtg gaccccaacc tcggctgctc ctctgacacc
     5521 attgaagtct cctgcaactt tacacagggt gggcagacgt gcctgaagcc catcacggcc
     5581 tccaaggccg agtttgctgt gagtcgggtc cagatgaatt tcttgcacct gctgagctct
     5641 gaggggacac agcatatcac aatccactgt ctgaacatga cggtgtggca ggagggaccg
     5701 ggacgctcct ctgccagaca ggctgtgcgc ttccgtgcct ggaacggaca ggtcttcgaa
     5761 gctgggggtc agttcaggcc agaggtgtct atggatggct gcaaggtcca tgatggccgc
     5821 tggcatcaga cactgttcac cttccggacc caggaccccc agcagctgcc catcgtcagt
     5881 gtggacaatc tcccgcctgt ctcatcaggg aagcagtacc gcctggaagt tggacctgcg
     5941 tgcttcctct gacctctgac ctctaggctc atctaagcct tgtggggaaa gggaagagat
     6001 ggggacagct ggtcccagga gatgcaggcc cttgccttag gatcctggtg caggtcctag
     6061 ttgttatctg ctcagccgga gttgagaagg agtaacaggt ctgaggctgt cccggagaac
     6121 cacccatccc agctcagccc caagaaccaa ccaaagagcc agtcaaaagc aagctgggtt
     6181 tgcagcccac tccagcccat ggcctgttgc ccagctctgt agacatccct gctccccagc
     6241 tgcccaaaga ccccctcccc attgatgcca cctcaaggaa agggggcatg ttgccagctg
     6301 gttcccgcta gggagctttc gatgtgcaat attagaaagg agacatggaa aaaaaaagag
     6361 gaggaaaagg aaagaaatct atatatatta tttaaacaaa gagaaggtgt gttactattt
     6421 ttttcacttg ggagaggtga ggaagagcaa gagaagctgg gggtgtggag aggcaggtcc
     6481 cccaggctgg gatgctggcc cctagactag ggtgctgacc cctgggctgg ggtgctgtgt
     6541 gctacctccc actgtgaaat cgctggtgct cacaattgtc tcttgtaatg tatgtgattt
     6601 ttttaaggag aaaaagaaac ttatttaaga ttctgaaggt gctactattt tctgttgcca
     6661 caggctttaa agaaactttc tgaatggggc ctggcccact tctctttctc tcctccaaat
     6721 gaggagttaa aaatgttact agcatagccc acccgtgtaa tccgttgaaa aggaacaaaa
     6781 ggaaaaaaga aaagaaagaa aagaaaaaaa aagaaaaaga aaaaacaaaa caaaacaaaa
     6841 aaatcctcct agaaaccaga agtagagaga tttctgctaa ttctgggctt tgaagcgtac
     6901 gtcttttgag ggggcatttt gatgtggtcc tccttgcttc tggagggact tggttccctt
     6961 tagaaaacct gccctgggaa aagacttctt ggttttgagg aagatccttg gttagcgatg
     7021 atcttggagg tggactaagt ccagagccat ccctgaagcc aggtgactgt cccaaggtct
     7081 tccctcccgg gagcccaacc tttcgagtgc agccaaacct tactgctttt acaacattgc
     7141 acagctgtgt agaaaccccg tgttctttcc cataggtgcc aatttgggtg ggggaggaag
     7201 gaacaattac aagatcccca tctgtctgcc catgccacct aaacaagtca ggactccaat
     7261 tggattttga agttatttta attatagaat tattttttta gaagaaagat ggatgtgata
     7321 gtctatattt gtgtgtttct aaagttgtgt cttgtggggg aattggattc cattttagtt
     7381 atttaatacc tcactcccac ccacctgcat actgcttgtg tgtcccggcc tgtcccgcaa
     7441 gcctagttgt gctttttgtt gtctgttccc cgtgccccct cctgtgtctc actctgtctt
     7501 cttgtcactt gatgtgcatt tgctgttgtt ctttcgtttc tgtctaaatg tcagtgtgtt
     7561 caaaccccca gagggttctg tttttcccat tcccttctgg actttaaata aatatttaaa
     7621 actgagcaat ggaaa
//
