LOCUS       NM_029838               7421 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus collagen, type XXV, alpha 1 (Col25a1), transcript
            variant 1, mRNA.
ACCESSION   NM_029838
VERSION     NM_029838.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7421)
  AUTHORS   Xu,J., Zhu,J., Li,Y., Yao,Y., Xuan,A., Li,D., Yu,T. and Zhu,D.
  TITLE     Three-dimensional mapping reveals heterochronic development of the
            neuromuscular system in postnatal mouse skeletal muscles
  JOURNAL   Commun Biol 5 (1), 1200 (2022)
   PUBMED   36347940
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7421)
  AUTHORS   Knoedler,J.R., Inoue,S., Bayless,D.W., Yang,T., Tantry,A.,
            Davis,C.H., Leung,N.Y., Parthasarathy,S., Wang,G., Alvarado,M.,
            Rizvi,A.H., Fenno,L.E., Ramakrishnan,C., Deisseroth,K. and
            Shah,N.M.
  TITLE     A functional cellular framework for sex and estrous cycle-dependent
            gene expression and behavior
  JOURNAL   Cell 185 (4), 654-671 (2022)
   PUBMED   35065713
  REMARK    Erratum:[Cell. 2024 Jul 11;187(14):3781. doi:
            10.1016/j.cell.2024.05.045.. PMID: 38810647]
REFERENCE   3  (bases 1 to 7421)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   4  (bases 1 to 7421)
  AUTHORS   Munezane,H., Oizumi,H., Wakabayashi,T., Nishio,S., Hirasawa,T.,
            Sato,T., Harada,A., Yoshida,T., Eguchi,T., Yamanashi,Y.,
            Hashimoto,T. and Iwatsubo,T.
  TITLE     Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in
            Intramuscular Motor Innervation and Congenital Cranial
            Dysinnervation Disorder
  JOURNAL   Cell Rep 29 (13), 4362-4376 (2019)
   PUBMED   31875546
  REMARK    GeneRIF: Roles of Collagen XXV and Its Putative Receptors
            PTPsigma/delta in Intramuscular Motor Innervation and Congenital
            Cranial Dysinnervation Disorder.
REFERENCE   5  (bases 1 to 7421)
  AUTHORS   Tanaka,T., Wakabayashi,T., Oizumi,H., Nishio,S., Sato,T.,
            Harada,A., Fujii,D., Matsuo,Y., Hashimoto,T. and Iwatsubo,T.
  TITLE     CLAC-P/collagen type XXV is required for the intramuscular
            innervation of motoneurons during neuromuscular development
  JOURNAL   J Neurosci 34 (4), 1370-1379 (2014)
   PUBMED   24453327
  REMARK    GeneRIF: CLAC-P/collagen XXV is a novel essential factor that
            regulates the initial phase of intramuscular motor innervation,
            which is required for subsequent target-dependent motoneuron
            survival and neuromuscular junction formation during development.
REFERENCE   6  (bases 1 to 7421)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 7421)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   8  (bases 1 to 7421)
  AUTHORS   Kay,J.N., Chu,M.W. and Sanes,J.R.
  TITLE     MEGF10 and MEGF11 mediate homotypic interactions required for
            mosaic spacing of retinal neurons
  JOURNAL   Nature 483 (7390), 465-469 (2012)
   PUBMED   22407321
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7421)
  AUTHORS   Tong,Y., Xu,Y., Scearce-Levie,K., Ptacek,L.J. and Fu,Y.H.
  TITLE     COL25A1 triggers and promotes Alzheimer's disease-like pathology in
            vivo
  JOURNAL   Neurogenetics 11 (1), 41-52 (2010)
   PUBMED   19548013
  REMARK    GeneRIF: COL25A1 leads to Alzheimer's disease-like pathology in
            vivo
REFERENCE   10 (bases 1 to 7421)
  AUTHORS   Hashimoto,T., Wakabayashi,T., Watanabe,A., Kowa,H., Hosoda,R.,
            Nakamura,A., Kanazawa,I., Arai,T., Takio,K., Mann,D.M. and
            Iwatsubo,T.
  TITLE     CLAC: a novel Alzheimer amyloid plaque component derived from a
            transmembrane precursor, CLAC-P/collagen type XXV
  JOURNAL   EMBO J 21 (7), 1524-1534 (2002)
   PUBMED   11927537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ117861.1, BC138051.1, AK035562.1 and AC110540.7.
            
            On Oct 7, 2011 this sequence version replaced NM_029838.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF315290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               CJ117861.1         1-139
            140-1781            BC138051.1         1-1642
            1782-2439           AK035562.1         1654-2311
            2440-2466           AC110540.7         80291-80317         c
            2467-3592           BC138051.1         2265-3390
            3593-7421           AC110540.7         65134-68962         c
FEATURES             Location/Qualifiers
     source          1..7421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 59.99 cM"
     gene            1..7421
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /note="collagen, type XXV, alpha 1"
                     /db_xref="GeneID:77018"
                     /db_xref="MGI:MGI:1924268"
     exon            1..936
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..2640
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /note="isoform 1 is encoded by transcript variant 1;
                     procollagen, type XXV, alpha 1; collagen alpha-1(XXV)
                     chain; collagen-like Alzheimer amyloid plaque component"
                     /codon_start=1
                     /product="collagen alpha-1(XXV) chain isoform 1"
                     /protein_id="NP_084114.2"
                     /db_xref="CCDS:CCDS38637.1"
                     /db_xref="GeneID:77018"
                     /db_xref="MGI:MGI:1924268"
                     /translation="MLVKKLAGKGGGRESGSEDPRPLGQRCAGTMPSCTALATLLSVV
                     AVAFCFYLGVKTNDLQARIAALESAKGTPSFHPLSDTVDELKAMVQEKVERLLAQKSY
                     EHMAKIRTAREAPLECNCPAGPPGKRGKRGRRGESGPPGQPGPQGPPGPKGDKGEQGD
                     QGPRMVFPKINHGFLSADQQLIKRRLIKGDQGQAGPPGPPGPPGPRGPPGDTGKDGPR
                     GMPGVPGEPGKPGEQGLMGPLGPPGQKGSIGAPGTPGMDGQKGEPGSPGAAGQSGLPG
                     PKGEPGKEGEKGDAGENGPKGDTGEKGDPGSSAAGIKGEPGESGRPGQKGEPGLPGLP
                     GLPGIKGEPGFIGPQGEPGLPGLPGTKGDRGEAGPPGRGERGDPGAPGPKGKQGESGA
                     RGPKGSKGDRGDKGDSGALGPRGPPGQKGDPGATEIIDYNGNLHEALQRITTLTVTGP
                     PGPPGPQGLQGPKGEQGSPGIPGVDGEQGLKGSKGDMGDPGVPGEKGGLGLPGLPGAN
                     GVKGEKGDTGLPGPQGPSIIGPPGPPGPHGPPGPMGPHGLPGPKGASGLDGKPGSRGA
                     DGPIGPHGPAGPKGERGEKGAMGEPGPRGPYGLPGKDGEPGLDGFPGPRGEKGDLGEK
                     GEKGFRGVKGEKGEPGQPGLDGLDAPCQLGPDGLPMPGCWQK"
     exon            937..1006
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1051
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1059
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1077
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1104
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1131
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1203
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1311
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1347
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1374
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1419
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1473
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1500
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1545
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1578
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1614
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1659
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1722
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1791
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1836
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1881
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1959
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..1983
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2028
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2073
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2154
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2217
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2268
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2295
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2331
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2385
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2439
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2466
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2520
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2598
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2637
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..7421
                     /gene="Col25a1"
                     /gene_synonym="2700062B08Rik; CLAC-P"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagcatcc cggggtattt aaggctcgca cacgcgggtc tgcggagata cttttggggc
       61 ctcgcagctt acgatcgctg cttgggtcac tcggtcctct ttttctctat tcctctacca
      121 cccacggggg ctgcgctctc gccgggtctc tgtatttcct tttctttttg gccttgaact
      181 gatccaggtg ggagacaggt cggcgggtgg aaaaaggtag agataggcag gcagactcaa
      241 caggtcggag cagagagagg ggctctcgga ccctgcgcct ccgcgcgggg gacccctaag
      301 gaggtgtcgg attggggggg tcaagagagc tgccctagtg ggtttcattt cagctgtgac
      361 cccaacaaca cccccggcgc cacacagtcc ccggccggag ggtgcttttc actcctagct
      421 ggaaggggag aaagaatctg gaggacggtc ggtccacgcc tgctgatccg gacgccgagc
      481 cacgcgcagg tccatctcta agcccgggct ccgactctac caactagttg tgcagccgca
      541 gggactgaac tttggaggaa ccgacccttc ctctcattct aagattactg gaggagatag
      601 aaggtggaag gcgtagcgga ggccagcgac cccgccacaa tgttggtgaa gaagcttgca
      661 gggaaaggag ggggacgaga gtctggatca gaagatccgc gccccttggg acagcgttgt
      721 gccggcacca tgccctcgtg cacggccctg gcgaccctct tgtcagtggt tgctgtggct
      781 ttctgttttt atcttggggt gaaaaccaac gacctccagg cgaggattgc tgctcttgaa
      841 tctgctaaag ggaccccttc cttccatccg ctgtctgaca ccgtggatga gctgaaggca
      901 atggttcagg agaaagtgga gcgtctcttg gctcagaaat cctacgaaca tatggctaaa
      961 ataagaacgg ccagggaggc acctttagag tgcaactgcc cagcaggtcc tccagggaaa
     1021 cgagggaaga gaggccgaag aggagaatct ggtcctcctg gtcagcctgg tcctcagggc
     1081 cctcctggtc caaaaggtga taagggagaa caaggtgatc agggacctcg gatggtgttt
     1141 cctaaaatca atcacggctt tctctctgct gatcagcagc tcattaaacg ccggctgatt
     1201 aagggtgacc aaggacaggc agggcctcca ggacctccag gccctcctgg tccaagaggc
     1261 ccacctgggg acacaggaaa ggacggcccc cgaggaatgc caggagtacc tggtgaacca
     1321 ggaaaaccag gagaacaagg cttgatggga cctctggggc ctccaggaca aaagggttcc
     1381 attggagcac ctgggacccc aggcatggat gggcaaaagg gtgagcctgg atcacctgga
     1441 gcagccgggc agagtggact accaggacct aagggagaac ctggaaaaga aggagaaaag
     1501 ggagatgctg gagaaaatgg tcccaaaggt gatacaggag aaaagggtga ccctggatca
     1561 tctgctgcag gaattaaggg agaacctgga gaatctggcc gcccggggca gaagggtgaa
     1621 ccagggctgc ctgggctgcc tggacttccg ggaataaagg gagaaccagg cttcattggt
     1681 cctcaaggag aaccagggtt accagggcta ccaggaacaa aaggtgatcg tggggaggcg
     1741 gggcctcctg gaagaggtga acgaggagat cctggagccc cggggccaaa ggggaagcaa
     1801 ggtgaatcag gagctagagg cccgaagggg tcaaagggtg atcgtggaga caaaggagac
     1861 tctggcgctc tgggaccacg gggtccacct ggacaaaagg gggatccagg agccacagag
     1921 atcatagact acaatggcaa cctccatgag gccttacaga gaattaccac cttaactgtc
     1981 acgggccccc ctggacctcc tggacctcaa ggactacaag ggccaaaggg tgagcaaggc
     2041 tctccaggaa tccccggagt tgatggagaa cagggactca aaggctccaa gggagacatg
     2101 ggggacccag gtgtgccagg tgaaaaagga ggactgggac ttcctggatt gccgggtgcc
     2161 aatggagtaa aaggagagaa aggagacacc ggtttgccag gtcctcaggg gccttctatc
     2221 ataggcccac caggccctcc aggtccccat ggcccacctg gtcccatggg gccccatgga
     2281 cttcctggac caaagggagc atctggctta gacggaaagc caggatcccg gggtgcagat
     2341 ggtcctatag gaccccacgg ccctgcagga cccaaaggag aaagaggaga gaaaggagct
     2401 atgggagagc ctggacccag agggccctat gggctgcctg gcaaagatgg agaacctggt
     2461 cttgatggct tccctggtcc tcgaggcgag aagggtgacc tgggagaaaa gggagaaaag
     2521 ggattccgtg gcgttaaggg ggaaaagggg gagccaggcc agcctggcct ggatgggctg
     2581 gatgctcctt gccaattggg acctgatggg ttacctatgc ctggctgctg gcaaaagtga
     2641 tgaatctaac cttccgagca tgaagttgtg tatataatgg tccacctttt atatttatag
     2701 ttgagaaact gaagtgcaga tttcgcaagt gtgagatcag ctcacccgac acactgcttc
     2761 tccctgtcca cagtagcacc cttatctatc tttcctcacg tctgaagtta ggcagtttac
     2821 ggaagtgagg aacccgcagg aagtatagcg tctctatttt atgtgaacat atgtatgtgt
     2881 ttatatggac atcagtgata gagatcagtt gattgctttt gctgtcttct tacttggggc
     2941 ttgttaattg catggacaaa aagtgccatg aaatagttta catgaaattg tgaccaaata
     3001 tggactcaaa gctatgaata cgcggcacac atttcccggt agcattcatt catgcctaca
     3061 ccacctactg aaactgacta aaaccagcat gaccgtgtgc caaacctgct tgtgcaaatg
     3121 cagatgcttg cttgcatgct gcctagtgag gtctgtgcct acatctgagc tcctgttcct
     3181 tttgtcatct caagggggtt acaccgtggc ttattgccaa aaagagataa gctgacggag
     3241 agtgtgcaca cacacagttg gtcttatatt ttgagggagt tgcagtcccg actgcagatc
     3301 cacacagttc ctgatcttgt gcgctcatgt gaccaccttg gttgaaatac caaagggtta
     3361 ggctgatggc tgcctctagt tttccttggg cgacgcttgg tggtgaagat gcgggacgag
     3421 gaccggttca gcactcctgc actgtcttcc atgtgaccaa gttggaagaa ggtttacaaa
     3481 cgctaacacc cagaacggca gaaattggtt tatttttacg tgatctgatc tgactccccc
     3541 cgggagaaag tcaggggtat gcagcagtgt tttggagaca gcagagcctt ggaatggaag
     3601 cccctgtcag tgcagattga aaggtgtgga catcctatca gagctcaggt tgctgaagag
     3661 agactgtgtc ccaagatggg accggacaga acaagctgtg ctacaaagca gactttacca
     3721 aaggtcgtcg gaaagtgtcc cttgcttcct tcctgggttg atccatacca aatgtttttc
     3781 tacaagttcg agaagcaaaa tgtagtttcc aatttttctc atacttttta ttttcttagt
     3841 ccaggaacag aaaccatttg cttcagtttg ggtctcatag gtttttaaac aatagtttta
     3901 gaaaagcttt cagatcataa tttaaatcca acagtaaaaa taacctcttc acatctcttt
     3961 ttgttgtttg tttgtttaat tgaagaaatt atagggagac tctatttttg acttaaccat
     4021 tgtaaagaat gaaggttaag cattttttca ctactttttg atttatattg acaaatgtgc
     4081 ctgtcagtta ttgtaaagtc aaatttttat cacattttgg tagcatgaac ttgcttcttc
     4141 taaacttttt ttttgtacat tgaagtttat ttctcacttt tgtttttaca tttctaagtg
     4201 tttgtcttat gcacagacca aatctgagat ctcagaaagc tctgatacac agttgctgta
     4261 agatgagtct cgttttgact gacttgctca aaactcacct acatagtctt agcctggaca
     4321 tttctttgca cggtggagac tttgcgacgt tttgaaataa cttattctat gtggaagggt
     4381 tgcttcagag aagcgccatc attgggaaca gtcactctgg cagcccatta gagaatttca
     4441 tttccctcgg tgattaaatg ccgtttttat gggaatgttt caagttctgt gcttggatat
     4501 ttagcaccag aggggaaatt agttcatgct taggataaca gcaatgaaga tacagtttca
     4561 agacatatct caagatgtca ttcatattgt gtaaccaaat gcttgatcat gcaaaatggt
     4621 gtcatctttt tatttcttta tgtcatttct gagattagaa tatactattt ctgataacat
     4681 tccacagcct gaagctaatt tagcattttt ttttaatgga gagtattttc taacaatttc
     4741 ttgtatggtg tagttagggt aaagtatttc tcaatatacg aaacaattcg tcttaaatca
     4801 tttgggggac aaaagtgagc ccaagactac acattatctt cagaaaaccg aagcaactat
     4861 aaaatcttga ggccacctgg tgactgtatc tcttcttatc ttcctttctg tttctccact
     4921 agaaagaggt gttgagagag attgttattt aaaagttaaa cagattcaaa tgagactaac
     4981 acaacaacaa aagaggtgtt aaagcactgg acataccctg taaagatacc acagagacta
     5041 tgtgtgcgca gggggtctgg tttgtaagac acatgtaaac ttccatttca tggacttcct
     5101 tggaacagac caacggaatg atgttagtcc tccgtgctca ctaagagtta gccttaaact
     5161 ttgggctatt aagacatcgt tagtcatcca ttttgtcatc aaactgaata atttccaaat
     5221 gaatcaataa taaatcatca ttgctggtac ataggttgtt aggtagcatt cttagacttc
     5281 tttaggagaa ttcgggaaaa atgcttatga agcacccatt ggaaataggt caaggccagg
     5341 tttttttcag agacagccaa cctctctaaa ggatgctatt gttatgttcc cctttgcagt
     5401 gttttccatt tgtgttgttg gtgctaatag atcttccttt ttatctttac ggatcgtgga
     5461 cctctattgt gggtaatttc atttctctgt ttaatggcat tcctaagctg ttagtgcaca
     5521 gttccacttt cggagttcat gactttgttg tagttcattg gccggccttt cctaatgtaa
     5581 agcagccttc tgcaggggct ccccttactc tgtggcagcc ttccacgggg cttcccgtcc
     5641 tctgtgctca ttttatacac cacatgcctt tatcggtttg cattgcctcc tcttttgagt
     5701 cactcgcctt tcagcttcca tatccagtgt tagagaagtc tgctctgact cgtagggcac
     5761 ctgggaaatg gctgtccttc tccatcatta aatgcagcct tggaggagtt ttccttatcc
     5821 tgttattttg tgaagaacat tggaatgccg ctccttccta ccagtagaaa gtttctggtt
     5881 ttgtatttac actctgtgca tctgatgtgt tagtggggca gttcacatat attacatgga
     5941 ctttgtgtgt atatatctgc tagcttgaaa aaaatcacca ttctgtacct tggggaagtt
     6001 gtccttgatc tcttacattt ttggtactta aggaaacgtg cctaaagtat ttccaaggat
     6061 gcttttaaat agtgctagtg aagcattaag aaataacagt tttaatccgc ccccactcca
     6121 ctctatctgt cttatggcag ttcagcttct tctcataagg ggtcaagaga aatgtggatg
     6181 ctgacatttg aaaccttgat tttcttcctt tcttgatatt cacattattt aatgctacca
     6241 agacaaagaa tttaataact tttacccctc aaaaagagtt ttgctatctt ataaggttca
     6301 aaggaacctt atcattccag atatgctgag aatggtcaga tctgttgctg ctgactgaca
     6361 gatctgagca gttataattc tgccaagctg tgataggctg taaaggtctt ctgcccctcc
     6421 tcctgttttc ctaacatatt ttctcttcca tcttcttctt ttgctccaca ttatatacca
     6481 gagacactcc tcctacttag attgctggtg aatttattta ggctttttct tacttttata
     6541 ctaataaaca tttgaatgac ttttttcttt ccactaaaat gtatgaactg cctcctctgc
     6601 ttactggcag agtgatttgg agacaggagg atggacctca tcgtgcttga tttcttgaca
     6661 agaaaaaaat accaacgttt tcaaaataag ttgatattct gacccatctc ggaaatacta
     6721 atgagtcaga ttcaaaaagg aatgtctccc atattgctga catctgggtg gatattcttt
     6781 acagtgttgt aaatgtttca ttgatctgga cattttttta aaagatgtat gtatctgatt
     6841 tatcttttgg aaatattata tttttatttg tattttttac attttaaagt tcatctctat
     6901 gtgcagctat ttttatattg ccaaaaactc acataaatac attgtaagag ggaaatgggg
     6961 ggaaaaatgg caagtgtaac cttgtgtggg tttttttttg ttaatgtttt atgggccagt
     7021 ctcatgtact tggttattct aagaatacgt tgtatctttc cactgtacat atggcaaaac
     7081 ctggtcatct cggtagtgta aatatttaaa agattgattt tccccatttg atttcctatt
     7141 tcaattgtaa tttttccgac tgtcatcact gaatcaaagg cctgcgaggg ttttgatttg
     7201 tggtttcaag gtgattgctt tgtgttcact ttctaatttg ttttttaatt actttccaaa
     7261 cttgttttca gggttcctag tttgtgagaa gttgaccttc ggaattattt ttacactatt
     7321 tatgacttat tttcataatg taaaaagtgt gtaattatta taacattaac ccaaacaatg
     7381 ataatgagtt gtattgttat aaagttttaa tgatattcct g
//
