LOCUS       NM_007743               5222 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus collagen, type I, alpha 2 (Col1a2), mRNA.
ACCESSION   NM_007743
VERSION     NM_007743.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5222)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   2  (bases 1 to 5222)
  AUTHORS   Chen,P.J., Wang,K., Lin,M.H., Sharma,R., Kalajzic,Z., O'Brien,M.
            and Yadav,S.
  TITLE     Alendronate partially rescues the periodontal defects in OIM mouse
            model of osteogenesis imperfecta
  JOURNAL   Sci Rep 15 (1), 88 (2025)
   PUBMED   39747677
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5222)
  AUTHORS   Hata,K., Wakamori,K., Hirakawa-Yamamura,A., Ichiyama-Kobayashi,S.,
            Yamaguchi,M., Okuzaki,D., Takahata,Y., Murakami,T., Uzawa,N.,
            Yamashiro,T. and Nishimura,R.
  TITLE     Serinc5 Regulates Sequential Chondrocyte Differentiation by
            Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes
  JOURNAL   J Cell Physiol 240 (1), e31490 (2025)
   PUBMED   39568258
REFERENCE   4  (bases 1 to 5222)
  AUTHORS   Cano-Carrillo,S., Garcia-Padilla,C., Aranega,A.E.,
            Lozano-Velasco,E. and Franco,D.
  TITLE     Mef2c- and Nkx2-5-Divergent Transcriptional Regulation of Chick
            WT1_76127 and Mouse Gm14014 lncRNAs and Their Implication in
            Epicardial Cell Migration
  JOURNAL   Int J Mol Sci 25 (23), 12904 (2024)
   PUBMED   39684625
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5222)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Feb;112:105573. doi:
            10.1016/j.ebiom.2025.105573. PMID: 39874704]
REFERENCE   6  (bases 1 to 5222)
  AUTHORS   Andrikopoulos,K., Suzuki,H.R., Solursh,M. and Ramirez,F.
  TITLE     Localization of pro-alpha 2(V) collagen transcripts in the tissues
            of the developing mouse embryo
  JOURNAL   Dev Dyn 195 (2), 113-120 (1992)
   PUBMED   1297453
REFERENCE   7  (bases 1 to 5222)
  AUTHORS   Phillips,C.L., Morgan,A.L., Lever,L.W. and Wenstrup,R.J.
  TITLE     Sequence analysis of a full-length cDNA for the murine pro alpha
            2(I) collagen chain: comparison of the derived primary structure
            with human pro alpha 2(I) collagen
  JOURNAL   Genomics 13 (4), 1345-1346 (1992)
   PUBMED   1505972
REFERENCE   8  (bases 1 to 5222)
  AUTHORS   Siegel,D., Irving,N.G., Friedman,J.M. and Wainwright,B.J.
  TITLE     Localization of the cystic fibrosis transmembrane conductance
            regulator (Cftr) to mouse chromosome 6
  JOURNAL   Cytogenet Cell Genet 61 (3), 184-185 (1992)
   PUBMED   1385049
REFERENCE   9  (bases 1 to 5222)
  AUTHORS   Steinmeyer,K., Klocke,R., Ortland,C., Gronemeier,M., Jockusch,H.,
            Grunder,S. and Jentsch,T.J.
  TITLE     Inactivation of muscle chloride channel by transposon insertion in
            myotonic mice
  JOURNAL   Nature 354 (6351), 304-308 (1991)
   PUBMED   1659665
REFERENCE   10 (bases 1 to 5222)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY138414.1, AK159212.1 and
            AK132496.1.
            
            On Dec 2, 2015 this sequence version replaced NM_007743.2.
            
            Summary: This gene encodes the alpha-2 subunit of the
            fibril-forming type I collagen, the most abundant protein of bone,
            skin and tendon extracellular matrices. The encoded protein, in
            association with alpha-1 subunit, forms heterotrimeric type I
            procollagen that undergoes proteolytic processing during fibril
            formation. Mice harboring certain mutations in the encoded gene
            exhibit symptoms of moderate to severe forms of osteogenesis
            imperfecta. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132496.1, AK159578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY138414.1         2-80
            80-84               AK159212.1         2-6
            85-5222             AK132496.1         2-5139
FEATURES             Location/Qualifiers
     source          1..5222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.81 cM"
     gene            1..5222
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="collagen, type I, alpha 2"
                     /db_xref="GeneID:12843"
                     /db_xref="MGI:MGI:88468"
     exon            1..292
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..4341
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="collagen alpha-2(I) chain; collagen COL1A2; alpha-2
                     type I collagen; procollagen, type I, alpha 2"
                     /codon_start=1
                     /product="collagen alpha-2(I) chain preproprotein"
                     /protein_id="NP_031769.2"
                     /db_xref="CCDS:CCDS39420.1"
                     /db_xref="GeneID:12843"
                     /db_xref="MGI:MGI:88468"
                     /translation="MLSFVDTRTLLLLAVTSCLATCQYLQSGSVRKGPTGDRGPRGQR
                     GPAGPRGRDGVDGPMGPPGPPGSPGPPGSPAPPGLTGNFAAQYSDKGVSSGPGPMGLM
                     GPRGPPGAVGAPGPQGFQGPAGEPGEPGQTGPAGPRGPAGSPGKAGEDGHPGKPGRPG
                     ERGVVGPQGARGFPGTPGLPGFKGVKGHSGMDGLKGQPGAQGVKGEPGAPGENGTPGQ
                     AGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGELGPV
                     GNPGPAGPAGPRGEVGLPGLSGPVGPPGNPGTNGLTGAKGATGLPGVAGAPGLPGPRG
                     IPGPAGAAGATGARGLVGEPGPAGSKGESGNKGEPGSVGAQGPPGPSGEEGKRGSPGE
                     AGSAGPAGPPGLRGSPGSRGLPGADGRAGVMGPPGNRGSTGPAGIRGPNGDAGRPGEP
                     GLMGPRGLPGSPGNVGPSGKEGPVGLPGIDGRPGPIGPAGPRGEAGNIGFPGPKGPSG
                     DPGKPGERGHPGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGP
                     SGTTGEVGKPGERGLPGEFGLPGPAGPRGERGTPGESGAAGPSGPIGSRGPSGAPGPD
                     GNKGEAGAVGAPGSAGASGPGGLPGERGAAGIPGGKGEKGETGLRGDTGNTGRDGARG
                     IPGAVGAPGPAGASGDRGEAGAAGPSGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQ
                     PGAKGEKGTKGPKGENGIVGPTGSVGAAGPSGPNGPPGPVGSRGDGGPPGMTGFPGAA
                     GRTGPPGPSGIAGPPGPPGAAGKEGIRGPRGDQGPVGRTGETGASGPPGFVGEKGPSG
                     EPGTAGAPGTAGPQGLLGAPGILGLPGSRGERGLPGIAGALGEPGPLGISGPPGARGP
                     PGAVGSPGVNGAPGEAGRDGNPGSDGPPGRDGQPGHKGERGYPGSIGPTGAAGAPGPH
                     GSVGPAGKHGNRGEPGPAGSVGPVGAVGPRGPSGPQGIRGDKGEPGDKGHRGLPGLKG
                     YSGLQGLPGLAGLHGDQGAPGPVGPAGPRGPAGPSGPVGKDGRSGQPGPVGPAGVRGS
                     QGSQGPAGPPGPPGPPGPPGVSGGGYDFGFEGDFYRADQPRSQPSLRPKDYEVDATLK
                     SLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWNSDYYWIDPNQGCTMDAIKVYCDFS
                     TGETCIQAQPVNTPAKNSYSRAQANKHVWLGETINGGSQFEYNVEGVSSKEMATQLAF
                     MRLLANRASQNITYHCKNSIAYLDEETGSLNKAVLLQGSNDVELVAEGNSRFTYSVLV
                     DGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFRVEVGPVCFK"
     exon            293..303
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            304..318
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            319..354
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            355..465
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            466..519
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            520..564
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            565..618
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            619..672
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            673..726
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            727..780
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            781..834
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            835..879
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            880..933
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            934..978
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1032
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1131
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1176
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1275
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1329
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1437
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1491
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1590
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1644
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1743
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1797
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1851
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1905
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1959
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2004
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2103
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2211
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2265
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2319
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2373
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2427
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2535
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2589
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2643
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2805
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2913
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3021
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3075
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3183
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3237
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3345
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3399
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3507
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3766
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3951
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4194
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..5222
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4657..4662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="hexamer: AATAAA"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="hexamer: AATAAA"
     polyA_site      4677
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="major polyA site"
     polyA_site      4689
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="major polyA site"
     regulatory      5184..5189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="hexamer: AATAAA"
     polyA_site      5214
                     /gene="Col1a2"
                     /gene_synonym="Col1a-2; Cola-2; Cola2; oim"
                     /note="major polyA site"
ORIGIN      
        1 attggtggag acgtttttgg aggcaccctc cggctgggga aacttttccc atataaataa
       61 ggcaggtctg ggctttatta ttttagcacc acggcagcag gaggtttcga ctaagttgga
      121 gggaacggtc cacgattgca tgcctgcgcc cgccaggtga tacctccgct ggtgacccag
      181 gggctctgca acacaaggag tctgcatgtc taagtggtag acatgctcag ctttgtggat
      241 acgcggactc tgttgctgct tgcagtaact tcgtgcctag caacatgcca atatttgcaa
      301 tcgggatcag tacgaaaggg ccccactgga gacagaggac cacgtggaca aaggggtccc
      361 gcaggtcccc gaggcagaga tggtgttgat ggtcccatgg gccctcctgg tccccctggc
      421 tcccctggtc ctcccggctc ccctgccccc cctggtctta ctgggaactt tgctgctcag
      481 tattctgaca aaggagtttc atctggccct ggaccaatgg gtttaatggg acccagaggc
      541 cctcctggtg ctgttggagc ccctggccct caaggtttcc aaggacctgc tggtgaacct
      601 ggtgagcctg gtcaaacggg tcctgcaggt ccccgtggtc cagctggctc tcctggcaag
      661 gctggtgagg atggtcaccc tggaaaaccc ggaagacctg gggagagagg agtcgttgga
      721 ccacagggtg ctcgtggttt ccccgggact cctggacttc ctggcttcaa aggcgtgaaa
      781 ggacacagtg gtatggatgg attaaaggga cagcctggtg cacagggtgt gaagggtgaa
      841 cccggtgccc ctggagagaa tggaactcca ggtcaagcag gagcccgagg gcttcctggt
      901 gagagagggc gtgtcggagc tcctggtcca gctggtgccc gaggcagtga tggaagcgtt
      961 ggccccgtcg gccctgctgg tcccattggg tctgctggac cccctggttt cccaggtgct
     1021 cctggtccca agggtgaact tgggcccgtt ggtaaccctg gccctgctgg tcctgctggt
     1081 ccccgtggtg aagtgggtct tccaggtctt tctggccctg ttggacctcc tggcaaccct
     1141 ggaacaaatg ggctcactgg cgccaagggt gctactggac tccctggtgt cgctggggct
     1201 cccggtctcc ctggcccccg tggtattcct ggccccgctg gtgctgctgg tgctacaggt
     1261 gccagaggac ttgttggtga gcctggtcct gctggctcca aaggagaatc cggtaacaag
     1321 ggtgagcctg gctctgttgg agcccaaggt cctcctggtc ccagcggtga agaaggaaag
     1381 agagggtctc ccggagaagc tggatctgct ggccctgcag ggcctccagg gcttagaggc
     1441 agccctggtt ctcgaggtct tcctggagct gatggcagag ctggtgtaat gggtcctcct
     1501 ggcaatcgtg gttcaaccgg ccctgctgga atccgaggtc ctaatggaga tgccggtcga
     1561 cctggggaac ctggtctcat gggacccaga ggtcttcctg ggtctcctgg aaatgttggc
     1621 ccatctggta aagaaggccc tgtgggtctc cctggcattg atggcagacc tggcccaatc
     1681 ggcccagctg gaccaagagg tgaagctggc aacatcggat tccctggacc caaaggcccc
     1741 tctggtgatc ctggcaaacc tggtgagaga ggacaccccg gtcttgctgg tgctcgggga
     1801 gctccaggac ccgatggcaa caatggagct cagggccccc ctggacccca gggtgttcaa
     1861 ggtggcaaag gtgaacaagg ccctgctggt cctcctggct tccagggtct ccctggtccc
     1921 tcaggtacta ctggagaagt tggcaagccc ggagaaaggg gtcttcctgg tgaattcggt
     1981 ctccctggtc ctgctggtcc aagaggagaa cgtggtaccc cgggtgagag tggagctgct
     2041 ggcccttctg gtcctattgg aagccgaggt cccagtggag ccccagggcc tgatggaaac
     2101 aagggtgaag ctggtgcagt cggtgctcca ggcagtgctg gtgcctctgg gcctggtggg
     2161 cttccaggag agaggggtgc tgctggcata cctgggggca aaggagaaaa gggtgaaact
     2221 ggtctccgag gtgacactgg caacactggt agagatggtg ctcgtggcat tcctggtgct
     2281 gtaggtgccc ctggtcctgc tggggcctca ggtgaccggg gtgaagctgg tgctgccggt
     2341 ccttctggcc cagctggtcc tcggggtagc cctggtgaac gtggtgaagt tggccctgct
     2401 ggccccaatg gatttgctgg tcctgctggt gctgctggcc aacccggtgc taaaggagag
     2461 aagggaacca aagggcctaa gggtgaaaat ggcattgttg gtccaaccgg gtctgttgga
     2521 gctgctggcc catctggtcc taatggccca cctggtcctg ttggaagtcg tggtgatgga
     2581 gggccccctg gtatgactgg cttccctggt gctgctggac ggactggtcc ccccggaccc
     2641 agtggtattg ctggcccccc tggcccccct ggtgctgctg gaaaggaagg gattcgtggt
     2701 ccccgtggcg accaaggtcc agttggccga actggagaaa caggtgcatc tggaccccct
     2761 ggatttgttg gtgaaaaggg tccctctgga gaacctggta ccgcaggagc ccctggtacc
     2821 gcaggtcctc agggtcttct tggtgctccc ggtattctgg gtctccctgg ctctagaggt
     2881 gaacgtggtc tgccaggtat tgctggtgct ctgggtgaac ctggtcctct gggcatctca
     2941 ggccctcctg gtgcccgtgg tccccctggt gctgtgggca gccctggagt taatggtgcc
     3001 cctggtgaag ctggtcgtga tggtaaccct ggcagcgatg gtcccccagg tcgtgatggt
     3061 cagcctggac acaagggaga gcgtggttac cctggcagca ttggtccgac tggtgctgca
     3121 ggtgcccctg gtcctcacgg ttctgtgggt cctgctggga aacatggaaa ccgaggtgaa
     3181 cctggtcctg ccggttctgt tggtcctgtt ggtgctgttg gtccaagagg tcctagtggt
     3241 cctcaaggca tccgaggtga caaaggagaa cctggtgata aagggcacag gggtcttcct
     3301 ggcttaaaag gatacagtgg attgcagggt cttcctggtc ttgctggcct acatggtgac
     3361 caaggagctc ctggtcctgt gggtcctgct ggtcccaggg gtcctgctgg gccttctgga
     3421 cccgttggca aagatggtag atctgggcaa cctggcccag tcgggcctgc tggtgttcgt
     3481 ggttctcagg gtagccaagg tcccgctggt ccccctggtc cccctggacc tcctggtcct
     3541 cctggtgtca gcggaggtgg ctatgacttt ggttttgaag gagacttcta cagggctgac
     3601 cagcctcgct cccagccttc actcagaccc aaggactatg aagttgatgc aactctgaaa
     3661 tctctcaata accagattga gacccttctc actcctgaag gctctagaaa gaaccctgct
     3721 cgcacgtgcc gggacttaag actcagccac ccagagtgga acagcgatta ctactggatt
     3781 gaccctaacc aaggatgtac tatggatgcc atcaaagtgt actgtgattt ctctactggt
     3841 gaaacctgca tccaggccca acctgtaaac accccagcga agaactcata cagccgcgcc
     3901 caggccaaca agcatgtctg gttaggagag actatcaatg gtggcagcca gtttgaatac
     3961 aacgtagaag gggtgtcctc caaggaaatg gcaactcagc tcgccttcat gcgcctgcta
     4021 gccaaccgtg cttctcagaa catcacctac cactgcaaga acagcattgc gtacctggat
     4081 gaggagacgg gcagcttgaa caaggctgtg cttctgcagg gttccaacga tgttgaactt
     4141 gttgctgagg gcaacagcag gttcacctac tctgtcctag tcgatggctg ctccaaaaag
     4201 acaaatgaat ggggcaagac aatcattgaa tacaaaacaa ataagccatc tcgcctgccg
     4261 ttccttgaca ttgcacctct ggacattggt ggtgctgacc aagaattccg tgtggaggtt
     4321 ggccccgtct gtttcaaata agtgaactca acctaaatta aaaaccaaaa acccctgaaa
     4381 aaactttctc tttgccgttt cctcctttaa aaaaaaaaac aaaaaacaaa aactgaaagc
     4441 tgaatccttc catgtcttct atgcatctac atcttaaact gtgggcaaaa gagaaggatt
     4501 ggtcagagca gtgtgcaata tgatccaact aagtctcctc ccttggcccc tccccaaaat
     4561 gtttgcagtg ttatttttgt gggttttttt ttaacaccct gacacctgtt gtggacattg
     4621 tcaacctttg taagaaaacc caaataaaaa ttgaaaaata aaataaaaag aaacccatga
     4681 acattcgcac cacttgtggc ttctgactat cttccacaga gggaagttta aaacccaaac
     4741 ttccaaaggt ttgaactacc tcaagacact ttgcagtgag tgtagaccat cccaatgaga
     4801 gttgaccaag gctgacacga actgaggtac ttgttttgtt ttgcttgcaa cacaaaggtg
     4861 ctaattagta gtatttcaga tacttgaaga atatgaacgg tgctggaaga attacagaag
     4921 aaacaatcct ccacattgat gtgcattgtg tgtgattttt aaatttgact tagcagtcct
     4981 ctttctcatc ttatccccaa ctacaggaat gcaggccact tgccccaggt tctctcttca
     5041 ttagattcag cattcattct ttaacagcct cattttcctt cttgcccatg gttccaaaga
     5101 agtcttgttt cttggacaag cagaaaaatt gaattgtacc tattttgtat atgtgagatg
     5161 tttaaataaa ttgtgaaaaa taaaataaag catttttggt tttccaaaag aaaatattga
     5221 gt
//
