LOCUS       NM_007733              10542 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus collagen, type XIX, alpha 1 (Col19a1), mRNA.
ACCESSION   NM_007733
VERSION     NM_007733.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10542)
  AUTHORS   Amos,C., Fox,M.A. and Su,J.
  TITLE     Collagen XIX is required for pheromone recognition and
            glutamatergic synapse formation in mouse accessory olfactory bulb
  JOURNAL   Front Cell Neurosci 17, 1157577 (2023)
   PUBMED   37091919
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10542)
  AUTHORS   Sato,H., Jin,K., Yano,S., Yasuda,A., Adachi,S., Yoshioka,H.,
            Kitamura,H. and Sasaki,T.
  TITLE     Abnormalities in esophageal smooth muscle induced by mutations in
            collagen XIX
  JOURNAL   Histochem Cell Biol 157 (2), 205-216 (2022)
   PUBMED   34993640
  REMARK    GeneRIF: Abnormalities in esophageal smooth muscle induced by
            mutations in collagen XIX.
REFERENCE   3  (bases 1 to 10542)
  AUTHORS   Su,J., Basso,D., Iyer,S., Su,K., Wei,J. and Fox,M.A.
  TITLE     Paracrine Role for Somatostatin Interneurons in the Assembly of
            Perisomatic Inhibitory Synapses
  JOURNAL   J Neurosci 40 (39), 7421-7435 (2020)
   PUBMED   32847968
REFERENCE   4  (bases 1 to 10542)
  AUTHORS   Oprisoreanu,A.M., Smith,H.L., Arya,S., Webster,R., Zhong,Z.,
            Eaton-Hart,C., Wehner,D., Cardozo,M.J., Becker,T., Talbot,K. and
            Becker,C.G.
  TITLE     Interaction of Axonal Chondrolectin with Collagen XIXa1 Is
            Necessary for Precise Neuromuscular Junction Formation
  JOURNAL   Cell Rep 29 (5), 1082-1098 (2019)
   PUBMED   31665626
  REMARK    GeneRIF: Interaction of Axonal Chondrolectin with Collagen XIXa1 Is
            Necessary for Precise Neuromuscular Junction Formation.
            Erratum:[Cell Rep. 2020 Aug 25;32(8):108113. doi:
            10.1016/j.celrep.2020.108113. PMID: 32846137]
REFERENCE   5  (bases 1 to 10542)
  AUTHORS   Li,H., Jones,K.L., Hooper,J.E. and Williams,T.
  TITLE     The molecular anatomy of mammalian upper lip and primary palate
            fusion at single cell resolution
  JOURNAL   Development 146 (12) (2019)
   PUBMED   31118233
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10542)
  AUTHORS   Sumiyoshi,H., Mor,N., Lee,S.Y., Doty,S., Henderson,S., Tanaka,S.,
            Yoshioka,H., Rattan,S. and Ramirez,F.
  TITLE     Esophageal muscle physiology and morphogenesis require assembly of
            a collagen XIX-rich basement membrane zone
  JOURNAL   J Cell Biol 166 (4), 591-600 (2004)
   PUBMED   15302855
  REMARK    GeneRIF: Collagen XIX has a role in esophageal muscle development
            and function
REFERENCE   7  (bases 1 to 10542)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   8  (bases 1 to 10542)
  AUTHORS   Sumiyoshi,H., Laub,F., Yoshioka,H. and Ramirez,F.
  TITLE     Embryonic expression of type XIX collagen is transient and confined
            to muscle cells
  JOURNAL   Dev Dyn 220 (2), 155-162 (2001)
   PUBMED   11169848
REFERENCE   9  (bases 1 to 10542)
  AUTHORS   Khaleduzzaman,M., Sumiyoshi,H., Ueki,Y., Inoguchi,K., Ninomiya,Y.
            and Yoshioka,H.
  TITLE     Structure of the human type XIX collagen (COL19A1) gene, which
            suggests it has arisen from an ancestor gene of the FACIT family
  JOURNAL   Genomics 45 (2), 304-312 (1997)
   PUBMED   9344653
REFERENCE   10 (bases 1 to 10542)
  AUTHORS   Sumiyoshi,H., Inoguchi,K., Khaleduzzaman,M., Ninomiya,Y. and
            Yoshioka,H.
  TITLE     Ubiquitous expression of the alpha1(XIX) collagen gene (Col19a1)
            during mouse embryogenesis becomes restricted to a few tissues in
            the adult organism
  JOURNAL   J Biol Chem 272 (27), 17104-17111 (1997)
   PUBMED   9202028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247446.1, BC118970.2, AK149136.1, AK019854.1, AC130201.3 and
            AC153653.4.
            
            On Sep 14, 2006 this sequence version replaced NM_007733.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000636.1, BC118970.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               BY247446.1         1-439
            440-1066            BC118970.2         393-1019
            1067-3200           AK149136.1         1060-3193
            3201-4257           AK019854.1         2306-3362
            4258-7349           AC130201.3         120279-123370
            7350-10542          AC153653.4         1-3193
FEATURES             Location/Qualifiers
     source          1..10542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 9.99 cM"
     gene            1..10542
                     /gene="Col19a1"
                     /note="collagen, type XIX, alpha 1"
                     /db_xref="GeneID:12823"
                     /db_xref="MGI:MGI:1095415"
     exon            1..88
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..215
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..3535
                     /gene="Col19a1"
                     /note="collagen alpha-1(XIX) chain; collagen alpha-1(Y)
                     chain; procollagen, type XIX, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XIX) chain precursor"
                     /protein_id="NP_031759.2"
                     /db_xref="CCDS:CCDS14854.1"
                     /db_xref="GeneID:12823"
                     /db_xref="MGI:MGI:1095415"
                     /translation="MRHTGSWKLWTWVTTFLLPACTCLTVRDKPETTCPTLRTERYQD
                     DRNKSELSGFDLGESFALRHAFCEGDKTCFKLGSVLLIRDTVKIFPKGLPEEYAIAVM
                     FRVRRSTKKERWFLWKILNQQNMAQISVVIDGTKKVVEFMFRGAEGDLLNYVFKNREL
                     RPLFDRQWHKLGIGVQSRVLSLYMDCNLIASRHTEEKNSVDFQGRTIIAARASDGKPV
                     DIELHQLRIYCNANFLAEESCCNLSPTKCPEQDDFGSTTSSWGTSNTGKMSSYLPGKQ
                     ELKDTCQCIPNKEEAGLPGTLRSIGHKGDKGEPGEHGLDGTPGLPGQKGEQGLEGIKG
                     EIGEKGEPGAKGDSGLDGLNGQDGLKGDSGPQGPPGPKGDKGDMGPPGPPALTGSIGI
                     QGPQGPPGKEGQRGRRGKTGPPGNPGPPGPPGPPGLQGLQQPFGGYFNKGTGEHGASG
                     PKGEKGDTGLPGFPGSVGPKGHKGEPGEPLTKGEKGDRGEPGLLGPQGIKGEPGDPGP
                     PGLLGSPGLKGQQGPAGSMGPRGPPGDVGLPGEHGIPGKQGVKGEKGDPGGRLGPPGL
                     PGLKGDAGPPGISLPGKPGLDGNPGSPGPRGPKGERGLPGLHGSPGDTGPPGVGIPGR
                     TGSQGPAGEPGIQGPRGLPGLPGTPGMPGNDGAPGKDGKPGLPGPPGDPIALPLLGDI
                     GALLKNFCGNCQANVPGLKSIKGDDGSTGEPGKYDPAARKGDVGPRGPPGFPGREGPK
                     GSKGERGYPGIHGEKGDEGLQGIPGLSGAPGPTGPPGLTGRTGHPGPTGAKGDKGSEG
                     PPGKPGPPGPPGVPLNEGNGMSSLYKIQGGVNVPGYPGPPGPPGPKGDPGPVGEPGAM
                     GLPGLEGFPGVKGDRGPAGPPGIAGISGKPGAPGPPGVPGEQGERGPIGDTGFPGPEG
                     PSGKPGINGKDGLPGAQGIMGKPGDRGPKGERGDQGIPGDRGPQGERGKPGLTGMKGA
                     IGPVGPAGSKGSTGPPGHQGPPGNPGIPGTPADAVSFEEIKHYINQEVLRIFEERMAV
                     FLSQLKLPAAMLSAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSP
                     GLPGSSAVGLPGSPGAPGPQGPPGPSGRCNPEDCLYPAPPPHQQAGGK"
     exon            216..281
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            282..381
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..505
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..781
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..862
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..988
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1051
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1096
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1141
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1195
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1249
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1285
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1339
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1393
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1447
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1489
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1552
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1588
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1624
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1678
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1732
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1786
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1876
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1921
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1999
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2035
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2089
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2143
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2185
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2290
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2344
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2398
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2452
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2506
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2551
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2602
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2647
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2674
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2728
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2773
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2818
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2881
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2917
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..2962
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3133
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3200
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3329
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3407
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..10542
                     /gene="Col19a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8241..8246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col19a1"
                     /note="hexamer: AATAAA"
     polyA_site      8265
                     /gene="Col19a1"
     regulatory      10516..10521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col19a1"
                     /note="hexamer: AATAAA"
     polyA_site      10537
                     /gene="Col19a1"
                     /note="major polyA site"
ORIGIN      
        1 tgggagctgg agcgggccac tccgcggcgg tgcggcagcc ctgtccggac tccaccgcgc
       61 ctcccagggg ctctgacacc aacccaagat ctgtggccat ttgtttccat ggttacaagg
      121 cacaatgagg cacactggct cttggaaatt gtggacctgg gtgacaacct tcctgcttcc
      181 tgcatgtacc tgtctgacag tcagggacaa gccagaaaca acctgcccta cactgagaac
      241 agagagatat caagatgaca gaaacaaatc tgaattgtca ggctttgatc tgggagaaag
      301 ctttgctctg aggcatgcgt tttgcgaagg tgataaaacc tgtttcaagt tgggaagtgt
      361 gcttcttatc agagacactg ttaagatatt tcccaaaggc cttccagagg aatacgctat
      421 agctgtcatg tttcgggtac gaagaagcac caaaaaggaa cggtggtttt tatggaagat
      481 tttaaaccag cagaatatgg cccagatatc tgtagtgatt gatggtacga agaaggtggt
      541 agaatttatg ttccgaggtg ctgagggaga tctgttgaac tatgttttta agaatcgaga
      601 actccgtcca ctctttgatc gtcaatggca taaacttggc attggcgtgc aatcccgagt
      661 cctttctctc tatatggatt gcaatttaat tgcaagtcga cacacggaag aaaagaattc
      721 tgtggatttt caaggaagga caattattgc tgcacgagct tcagatggca aacctgtgga
      781 tatcgaactt caccaactta gaatctactg caatgcaaac ttcctagctg aagaatcatg
      841 ttgcaactta tcacctacta agtgtccaga gcaagacgac tttggaagta ctacttcatc
      901 ctgggggacc tctaacactg gtaaaatgtc ttcatatctg ccaggaaagc aggaacttaa
      961 agacacatgc cagtgtattc caaacaagga ggaagcagga ttaccaggaa ctctcagatc
     1021 cattggacat aagggcgaca aaggagagcc gggtgaacat ggcttagatg gtactccagg
     1081 attacctggt caaaagggag aacaaggact tgaaggcatc aagggagaaa ttggtgaaaa
     1141 gggtgaacca ggagccaaag gagactctgg tctggatggc ctcaatggac aagatggttt
     1201 gaaaggtgac tcgggtcctc aaggtccacc tggcccaaaa ggagacaagg gtgatatggg
     1261 acctccaggg ccaccagcct taactggctc cataggaatc caaggtcccc agggtccacc
     1321 tggcaaagaa ggccaaaggg gaagacgagg gaaaacagga cccccaggaa atccaggacc
     1381 tccaggacca cccggacctc ctgggttaca aggactacag cagccttttg gtggatattt
     1441 caataaggga actggtgagc acggagctag tggccccaaa ggagaaaagg gcgatactgg
     1501 gctgcctgga tttccagggt ctgttggccc taaaggacac aaaggagaac ctggggagcc
     1561 tttaacaaaa ggtgaaaagg gagatagagg agaacccggc ctattaggac cacagggaat
     1621 aaagggggaa cctggagatc ctggtccccc tggtttacta ggaagcccag ggctaaaggg
     1681 tcagcaagga cctgcaggtt ccatggggcc cagaggacca ccaggagatg ttggattgcc
     1741 aggagaacat ggtattccag gaaaacaagg cgttaaggga gaaaagggag atccgggtgg
     1801 aaggctaggc cctcctggac ttccaggtct gaagggtgat gctgggcctc cagggataag
     1861 cctgccaggg aaaccagggt tagatggaaa tccaggatca cctggtccac gtgggccaaa
     1921 gggtgaaaga ggtctgcctg ggctccacgg ttcccccggg gacacaggcc caccaggtgt
     1981 aggaatccct ggtagaacag gctcccaagg accagccgga gagccaggta ttcagggtcc
     2041 tcgaggtctg cctggattgc caggaactcc agggatgcca gggaatgacg gagctccagg
     2101 gaaggatgga aagccaggcc ttccaggccc cccaggtgac ccgatcgcac ttcctctctt
     2161 gggagacatt ggagccctgc tgaagaactt ctgtggcaac tgtcaagcca atgtccctgg
     2221 gctgaaaagc atcaaaggcg atgacggaag cactggggag cctggaaagt atgatcctgc
     2281 agccaggaag ggtgatgtag ggccacgagg tcctccggga ttcccaggca gagaagggcc
     2341 aaagggaagc aaaggagagc ggggctaccc tggaatacac ggggagaaag gcgatgaggg
     2401 tcttcaagga atccctggcc tctcgggagc tcctggccca actggacccc ctggcttaac
     2461 aggaagaact ggacatcctg gtcccactgg agcaaaaggt gacaagggta gtgagggacc
     2521 ccctgggaaa cctggacctc ctggaccccc tggtgtcccg ctcaatgagg gaaacggcat
     2581 gagcagttta tataaaatcc agggaggggt gaatgttccc ggttacccag gacctccggg
     2641 ccccccaggt ccaaaaggtg atcctggccc agtgggagag cctggtgcaa tgggcttgcc
     2701 aggactagaa ggatttcctg gtgtaaaggg agatcgaggc ccagcaggcc ccccaggcat
     2761 agccggcata tcgggaaaac caggtgcccc aggccctcca ggagtaccag gggagcaggg
     2821 tgaaagagga cctattggag atacaggttt tcctggacca gagggaccct cggggaagcc
     2881 aggcataaat ggaaaagatg gattaccagg tgctcagggc atcatgggta aacctggcga
     2941 cagaggcccc aaaggagaac gcggtgatca gggaattcca ggagacagag gccctcaagg
     3001 tgaacgtggg aagccaggtc ttacgggcat gaagggggct ataggccctg tgggaccagc
     3061 aggaagcaag ggctccactg ggccacctgg ccaccaaggc cctccaggca atcctggcat
     3121 ccctggcact ccggctgatg ctgtttcatt tgaagaaata aaacactaca ttaatcaaga
     3181 agtcctaagg atttttgaag agaggatggc tgtgtttcta tcccagctta aactgccagc
     3241 agcaatgttg tctgctcaag ctcatggaag gcctggccca ccagggaagg acgggttacc
     3301 tggaccccca ggagatccag ggccccaagg ctaccgagga cagaagggag aaagaggtga
     3361 acctggaatt gggctgccgg ggagtccggg tcttcctgga tcttcagcag tgggtttgcc
     3421 gggctcacca ggtgccccgg ggcctcaagg acccccggga cccagtggaa gatgtaatcc
     3481 agaagattgc ctctatcctg cacctcctcc ccaccagcag gcaggcggga agtgaaaaag
     3541 acggaggaag acatcgcgtc tagtgctatc tccaggccac ttgagccgcc actgcaggct
     3601 tcacaaccac gtgctctcaa ggcttatgag tttttggact gctttatttt agttttctga
     3661 tacagaagca gacatccaaa gcaaccatct gagtcctatt ctgacagtaa gagcagatcc
     3721 gtattttcag atgtttgcca acttctttcc atatgttctg tttcattgtg gctctgagtt
     3781 ctacggcttc ggaagaaaaa tgcaagcgag cctgtcatgg gctcttcaga aaaaatcacg
     3841 tgagacgatt tggtacacag acgacacaga ccttgtgaac tcgtcaacgt gactaggttt
     3901 tgattcctga attttaactt ttctaattta tcttgattat tttgttcata tttaaattta
     3961 ctatcgttac tttagttttt ctttctgctc ttttgagatt gaagtagtac attactgctg
     4021 ttgactgtct taggactgat ttttacaaga agtcctatac tgtcctacat tcattcgatt
     4081 tatgcagaaa aaaatatgca ataagagatt cgcttctaac ttattaaaaa caaaactatg
     4141 tgagactgtt tatcaagaag cccccaaact catcatagcc aacatgcttt tggctttttt
     4201 tggagcacgc ctcactgaca cgaacacatg ctacatttaa aaaaaaaaaa aaaaaaatga
     4261 agaatcaact tgaccctata cccaagtctg tgagtctccg atggtgaact aaaagtggtt
     4321 tgtcttctcg aagccattct tggtggtaaa ggcgccatgc tgtctttggt acctgacagg
     4381 ttttagcagc ctagcaagac ctttgtgctt ctttatgcat tcttttttct gactttatga
     4441 tccccaggcc cgacccgcca tcagagaaaa gcacaggatt tgtaatgacg cagaaaagag
     4501 gagtcctcgt cttggaaact gagagcggag ggtcagcaaa ggcatgttga gtgagtgaag
     4561 ccctcgtgct cttaagaaga ttaatgtttt ctcagaaacc atcgaaaggt ccagctcagc
     4621 agaggaaagc caagagactt cacccgaaag tcactacgag cttcaaaacc gcgtgctcgg
     4681 ggttagggat ttgacttcgc agtggagagc ttgcctagca agcagcgtgg ccttgggttc
     4741 cgtcctcagc cccgaaggaa agaaacaaac ttgctctgaa aggaagcaaa atcccagtgg
     4801 tcttggctga atgtcttttt actccctacc tgttcattgc ttggagaaac cttgggtggg
     4861 gaaaactgat ttgctagaat actgagcaca aggtacaagg gctttgctga tagttagctg
     4921 gtgggtacca ctgacgctga gagcatgcca ccagagccct tcagtcccat gcctctaaga
     4981 gctcaggatt agaggggatg attttggtct gttcattgaa aaaagacaat gggtatagaa
     5041 aagcaaccca ctgaaagtgg gaaaagctgt gaacagtgtt ttcctgagaa gcatgcctga
     5101 cataaggcag cgtttgttta aatgcaccca tgatttgaac tggttttcat tataaacaga
     5161 tgagctgctg gcccggtact gtcaacatgg ctgtgcataa aataaccttt taggtatttc
     5221 atattgagtt ttgctgtata tttcaatcca agtttattta ttttccaagt ctactttatt
     5281 tatttccact gttttgggct tgaaattgct tattcctttg ttttcttttg tattcaatac
     5341 ctacaatggt gctctgtttt aaacttgcac aattggagta tgcaaatgtt tgcttatgta
     5401 tcttcatagc caactgataa tctaccccct aaatgtatat aaggtgaaaa gttggtgcta
     5461 tgtgtatatt ttgagcttct aatttgttga attttctgaa aacatacact ttacctgaca
     5521 tattaattta cttgaatttg ctgtatagca aagacttttc tatgttttca aagattattt
     5581 ttcatattaa ttgacaggtt atttatcctt ttgcattttg gattattcaa aaatatttat
     5641 tttgtaattt taatattttc acggacattt ggctggtggt gggcgattag tgtatttggg
     5701 tgtttgggtt tttttgtttg tttttttgtt ttttggtttt tttttttttt tggttgatca
     5761 attgatatga tgcaactcat tttcttgttt tgcaaattat atttacttca gttccacaga
     5821 acagaattct ttcttacaaa ttggatggtt cttactcctc ctttttctaa tttttgtgac
     5881 tgtgtgactg gcttatccct gtttcaagga tttagatttg tccccatggc ttgaggagtc
     5941 tgtcacagtg attcaagctc atttttagag cttgggacat gtgactgaat ctgacataac
     6001 cagagagatg ggactgggtt atacagctca aaccatcaat ctactgttat taatcttcag
     6061 attttctttt cttctgcctt ggctctattt gtaacaaaag gctttaagga gcacttggtc
     6121 aggctaacac aacaaagaaa ttggcaggtt ctcagcccct tcgtaaaaac gaacaggata
     6181 atttggtccc caaagcagga taaggaatat cccactaact aaccatttgt tcctggtatt
     6241 gtttatagca aaggaaaaga attatcgatt ttctctcatt ttgtacttca gatatgcttt
     6301 aaatacaaaa taattacagg ccaaagtggc aatgttaaaa ctgttttttt tttttccata
     6361 aacaaggatg tctgaattca agtcctaaat tatgccagtt cagttagcaa tttttggtag
     6421 aattttctta tgtagagaag atctgtcctc cattaagatc tgctttgctt ttagaatcta
     6481 aagaaagaga atatatgtgt gcattgttcc tcccagctga aaacatcggc tattactcct
     6541 aaccacagtg gaagtcagtc ttaagttctt caacttctta ccttaaccag agctgtgcaa
     6601 tcacttcaac cttgtgtggt cccccccccc cacacacaca cacacacttt ggaaaattaa
     6661 acctttgcct acttatagag attaaggaat tattttatga tatactgcct aaattctagt
     6721 ttaatgctca gcttataaag taatttccat gactatgtct tagacattaa ttatagttta
     6781 gctcttctgc agcttctccc acttcagaga agcttatgat atacctccta ttgtccacaa
     6841 gatggtgtct gaggcaattt gttcagaact gaacacagat tcacagaagc ctagaacctg
     6901 gaaaagtctg gtgaacaatt cagtcacaca ttggcctttg cactttattt ttggaaatat
     6961 tctttgtaaa ttatatttca ttttactaat tagtattttt acaaattttc agtatctttg
     7021 taaagcaggc acaataactt ttggtttgtt gatttttttc acttgtattt attgactgtg
     7081 tgtataccca tacttgtatg aaaatctgct ataaggttgt cttatgctac tattgtattt
     7141 tagtgactaa tgatcacaca ccggcacaca actgcattca tcctcccatg cacacaaagc
     7201 agatactctt ttgacaaatg aaaacactta gcttaccaca agaagtagac aatgtatact
     7261 gcatgatgtc taaactctta actgcactag ataaatttgt acagggtcta ttttcctaga
     7321 aacatggcac tatttaacaa tggttttcag aattccatct ttttctttta atgccatctt
     7381 ttttccagtg ttggtaattc tatccaagac agaagtaagt ccagtgatgc tgaggctgtc
     7441 tgaatgacct ttgaatgacc tttgaatgac ctttgcatga cctttggaag agctgagcag
     7501 agttgacctt tgcccttgtt ctgagttact tttcctactt gttatctgca tctactttgt
     7561 aaagattcat ggtgttttct atcctggcta catagcaggg actacactcc ccaccctggc
     7621 ccttttactc ctcttctccc agagattgac cagacctcta tgaggagatt cctagcagaa
     7681 tttaattatt aaccctttaa gtcatgtgca tcaatgtcaa gtcgatcata ggcattcatt
     7741 cgtcagccag taggtatagt agcatttgtt gtgttcaatt tgttcaatga agaggactta
     7801 caggaatcag gaaaagaggt tatctgtgtt tctatttatt aatgtagttg gagctatcat
     7861 ggtaacattt cactgagcaa aatcatatag aaaatttcat cattttggtt gaattgacct
     7921 cagctccaag aggacacagg gaacactagg gcagataagt agacccagca agaaaaaaaa
     7981 ttatccaaaa gatgatacaa agctaggaac atctacatgg aaaaactttc aagattaatt
     8041 ccagtagtgc tttgtggtag aactcaagaa gtgaacttct tgcttcagca atgtaggcat
     8101 cactaaactc aggaataaca acttaaaatt taactcaagt ctggtgttgg cttgaccata
     8161 ataaacttac gagcatctta aactaaagat gcaattttac aactttttat tttgctgtgg
     8221 tacttaagga gttttgggag aataaatact ttgggtgaat ttaaattccg attgtgttac
     8281 agaataacta cttattttaa aaataatatt tggggggtgt atttttatcc attttgtttg
     8341 ttcactatct tacctcatca tctacttaag gtttaatttt attacactta tgttaagtgg
     8401 agtgctactc cgtttattaa aaaccctggt gaatctatgc ttgcaggcat tgcctcctct
     8461 agctttatta tgtgcagtga acatgtttcc tctctcagca ataaaggagt cgactataaa
     8521 tcagggaact ccaaggtgcg attcttagca ctgtgtctac actttagccc ttctcagcag
     8581 ccgaagcggg agaacaattc tattctgcta agtcttagcc acactgaaga aacttcataa
     8641 tcagtctcac gccaggagca aacccacagc atccagggaa cctgagactg ctctattcca
     8701 agtactcaca gtttgaactt ataacctacc tccctggcag ctcatgaaaa gaccagtata
     8761 ttgatttcag atgagaatta taaacaacac caacagccag agggagccca aaatgatgct
     8821 ctcttctagc agagactaaa atcaatttag actctttgct ggagagaact cgaagaaagc
     8881 taagaagcat cacaagtaat tgtccccttt taataagttt gtcagtgtgt caataagtat
     8941 ttaaatgcac actgtgtttt ctaacagaaa ttaattatga taaaataggc cagtggcttt
     9001 gtgtgtctct atggattagc taatgactta aacagttctt gactgttctt accttcatat
     9061 ttcctcatga taaattaagt aggtgctctc taaggaatat tattatcttc tcttatgcag
     9121 ctgtggactt ggagaacaaa taaaaacaca tcaaaacaga cttaaataag aagacacaga
     9181 tcccaaaaag tttcttagag tcaatttccc ccatttgttc tctttagaaa ttaatgtgga
     9241 atgaaaggca ttatacaaaa acatggtgaa aagaaagtta gtgttaatcg ccatttatta
     9301 agactacaaa tatttatcac acagaatcct tccaacaacc aaatctatca aatatgctac
     9361 agttcttcag atagcattct aaatacaatt tgagtacgta tattgcatat gcggtattac
     9421 aatcagccaa tttatctaat atattctgag ccaacatata tcacagttca gcatcacaag
     9481 tttatttttt aaaaaaaaaa cttaagtaca tacctggaat gtattttact acataaaatg
     9541 gcaatctaca agtcttaagc acaaatatta tcttgtagtt ttaagatggc ttaggaccat
     9601 tttcatttgt accagaataa ataaaggcaa ttcccttgac atttggaatt atttgtgtca
     9661 tgagtgattt tcaacctcta ctggttaatt ttaaacctga atttcatacc tcagaaacac
     9721 tatgatatct ccaaaattaa acagtacgaa agcagggact tatattaagc acactttggg
     9781 tcagatctaa taatgtttaa ggattgcaat attggtttaa ccagcatgaa atataaagta
     9841 ttctgactga cagacagaag acaatcaccc agtcgcatca gtgaatttgt atgctcagac
     9901 tgcaaaatga tttccacatt ccttaaccaa cctgttggct atttggagtg agaattaaat
     9961 cataccgcct tgggagcact gagcagaaat aagccagaaa tttgctcttg attaatacgt
    10021 tagtgtctaa gcaactttaa ttacctacac attcccctct tggcaagttc tcaggtggac
    10081 actatccaac ttttaaaact acataaaagc tgtggagatc tctgctttgc taggggtgta
    10141 tatgaggtct gcctgtattc agcagctgtc tttcgcagag agggttcact aggcaaaact
    10201 tgtttgctag tttttcgtca ggaattggtg catctgtaag ttgtttaatt taactgaaat
    10261 ttaccataga ttgttcttat catttggaat gtgcgagttt cgcataagct tctgtaagtg
    10321 gctgttccca acactactta ctgtctctgt ggagcttgtt atacagccta gatacgcatc
    10381 aggtttctgt aacaggtggg tgaactgata tttggatttt tttaatttct tacaaatatg
    10441 actttataga actgaagaac atgtttaatt acataatttt tctttttctg tatttgatta
    10501 tgtcactgca attaaaataa aagcactttg atgcaaagat ca
//
