LOCUS       NM_001290825            5515 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus collagen, type XVII, alpha 1 (Col17a1), transcript
            variant 1, mRNA.
ACCESSION   NM_001290825 XM_006526627
VERSION     NM_001290825.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5515)
  AUTHORS   Namba,T., Ichii,O., Natsuga,K., Nakamura,T., Otani,Y. and Kon,Y.
  TITLE     Collagen 17A1 in the Urothelium Regulates Epithelial Cell Integrity
            and Local Immunologic Responses in Obstructive Uropathy
  JOURNAL   Am J Pathol 194 (8), 1550-1570 (2024)
   PUBMED   38768778
  REMARK    GeneRIF: Collagen 17A1 in the Urothelium Regulates Epithelial Cell
            Integrity and Local Immunologic Responses in Obstructive Uropathy.
REFERENCE   2  (bases 1 to 5515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5515)
  AUTHORS   Cao,J.H., Cao,C.H., Lin,J.L., Li,S.Y., He,L.J., Han,K., Chen,J.W.,
            Li,S., Wang,X., Xie,D. and Wang,F.W.
  TITLE     NEIL1 drives the initiation of colorectal cancer through
            transcriptional regulation of COL17A1
  JOURNAL   Cell Rep 43 (1), 113654 (2024)
   PUBMED   38175757
  REMARK    GeneRIF: NEIL1 drives the initiation of colorectal cancer through
            transcriptional regulation of COL17A1.
REFERENCE   4  (bases 1 to 5515)
  AUTHORS   Raymundo,J.R., Zhang,H., Smaldone,G., Zhu,W., Daly,K.E.,
            Glennon,B.J., Pecoraro,G., Salvatore,M., Devine,W.A., Lo,C.W.,
            Vitagliano,L. and Marneros,A.G.
  TITLE     KCTD1/KCTD15 complexes control ectodermal and neural crest cell
            functions, and their impairment causes aplasia cutis
  JOURNAL   J Clin Invest 134 (4), e174138 (2023)
   PUBMED   38113115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5515)
  AUTHORS   Zhou,R., Wang,Q., Zeng,S., Liang,Y. and Wang,D.
  TITLE     METTL14-mediated N6-methyladenosine modification of
            Col17a1/Itgalpha6/Itgbeta4 governs epidermal homeostasis
  JOURNAL   J Dermatol Sci 112 (3), 138-147 (2023)
   PUBMED   37951776
REFERENCE   6  (bases 1 to 5515)
  AUTHORS   Tsuji,K., Copeland,N.G., Jenkins,N.A. and Obinata,M.
  TITLE     Mammalian antioxidant protein complements alkylhydroperoxide
            reductase (ahpC) mutation in Escherichia coli
  JOURNAL   Biochem J 307 (Pt 2) (Pt 2), 377-381 (1995)
   PUBMED   7733872
REFERENCE   7  (bases 1 to 5515)
  AUTHORS   Kratochwil,K., Ghaffari-Tabrizi,N., Holzinger,I. and Harbers,K.
  TITLE     Restricted expression of Mov13 mutant alpha 1(I) collagen gene in
            osteoblasts and its consequences for bone development
  JOURNAL   Dev Dyn 198 (4), 273-283 (1993)
   PUBMED   8130375
REFERENCE   8  (bases 1 to 5515)
  AUTHORS   Li,K., Tamai,K., Tan,E.M. and Uitto,J.
  TITLE     Cloning of type XVII collagen. Complementary and genomic DNA
            sequences of mouse 180-kilodalton bullous pemphigoid antigen
            (BPAG2) predict an interrupted collagenous domain, a transmembrane
            segment, and unusual features in the 5'-end of the gene and the
            3'-untranslated region of the mRNA
  JOURNAL   J Biol Chem 268 (12), 8825-8834 (1993)
   PUBMED   8473327
REFERENCE   9  (bases 1 to 5515)
  AUTHORS   Li,K., Guidice,G.J., Tamai,K., Do,H.C., Sawamura,D., Diaz,L.A. and
            Uitto,J.
  TITLE     Cloning of partial cDNA for mouse 180-kDa bullous pemphigoid
            antigen (BPAG2), a highly conserved collagenous protein of the
            cutaneous basement membrane zone
  JOURNAL   J Invest Dermatol 99 (3), 258-263 (1992)
   PUBMED   1512460
REFERENCE   10 (bases 1 to 5515)
  AUTHORS   Harbers,K., Kuehn,M., Delius,H. and Jaenisch,R.
  TITLE     Insertion of retrovirus into the first intron of alpha 1(I)
            collagen gene to embryonic lethal mutation in mice
  JOURNAL   Proc Natl Acad Sci U S A 81 (5), 1504-1508 (1984)
   PUBMED   6324198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131719.5 and AC125075.4.
            
            On Jan 3, 2023 this sequence version replaced NM_001290825.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125031.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC131719.5         73983-74191         c
            210-272             AC131719.5         67705-67767         c
            273-317             AC131719.5         65408-65452         c
            318-422             AC131719.5         64558-64662         c
            423-554             AC131719.5         63548-63679         c
            555-602             AC131719.5         62572-62619         c
            603-638             AC131719.5         61589-61624         c
            639-686             AC131719.5         60581-60628         c
            687-830             AC131719.5         58958-59101         c
            831-989             AC131719.5         57606-57764         c
            990-1061            AC131719.5         56919-56990         c
            1062-1133           AC131719.5         55504-55575         c
            1134-1202           AC131719.5         54591-54659         c
            1203-1364           AC131719.5         53538-53699         c
            1365-1445           AC131719.5         53084-53164         c
            1446-1490           AC131719.5         52569-52613         c
            1491-1712           AC131719.5         51408-51629         c
            1713-1928           AC131719.5         50665-50880         c
            1929-1958           AC131719.5         50254-50283         c
            1959-1985           AC131719.5         49864-49890         c
            1986-2012           AC131719.5         48816-48842         c
            2013-2075           AC131719.5         48651-48713         c
            2076-2180           AC131719.5         48027-48131         c
            2181-2243           AC131719.5         47133-47195         c
            2244-2279           AC131719.5         46557-46592         c
            2280-2333           AC131719.5         45973-46026         c
            2334-2369           AC131719.5         45702-45737         c
            2370-2405           AC131719.5         45191-45226         c
            2406-2468           AC131719.5         44506-44568         c
            2469-2504           AC131719.5         43267-43302         c
            2505-2576           AC131719.5         42953-43024         c
            2577-2603           AC131719.5         42161-42187         c
            2604-2639           AC131719.5         41395-41430         c
            2640-2675           AC125075.4         188296-188331       c
            2676-2756           AC125075.4         187918-187998       c
            2757-2792           AC125075.4         187016-187051       c
            2793-2870           AC125075.4         186024-186101       c
            2871-2924           AC125075.4         185002-185055       c
            2925-2966           AC125075.4         184846-184887       c
            2967-3020           AC125075.4         184614-184667       c
            3021-3080           AC125075.4         184182-184241       c
            3081-3131           AC125075.4         183423-183473       c
            3132-3254           AC125075.4         182957-183079       c
            3255-3392           AC125075.4         182586-182723       c
            3393-3458           AC125075.4         182044-182109       c
            3459-3599           AC125075.4         181559-181699       c
            3600-3689           AC125075.4         181090-181179       c
            3690-3800           AC125075.4         180881-180991       c
            3801-3947           AC125075.4         180159-180305       c
            3948-4307           AC125075.4         179564-179923       c
            4308-4436           AC125075.4         178932-179060       c
            4437-4499           AC125075.4         178627-178689       c
            4500-4580           AC125075.4         178433-178513       c
            4581-5515           AC125075.4         177177-178111       c
FEATURES             Location/Qualifiers
     source          1..5515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 40.07 cM"
     gene            1..5515
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /note="collagen, type XVII, alpha 1"
                     /db_xref="GeneID:12821"
                     /db_xref="MGI:MGI:88450"
     exon            1..209
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..272
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..4633
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     collagen alpha-1(XVII) chain; bullous pemphigoid antigen
                     2; 180 kDa bullous pemphigoid antigen 2; procollagen, type
                     XVII, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XVII) chain isoform 1"
                     /protein_id="NP_001277754.1"
                     /db_xref="CCDS:CCDS70959.1"
                     /db_xref="GeneID:12821"
                     /db_xref="MGI:MGI:88450"
                     /translation="MDVTKKSKRDGTEVTERIVTETVTTRLTSLPPKGSTSNGYAKTG
                     SLGGGSRLEKQSLTHGSSGYINSSGSIRGNASTSSYRRTHSPASTLPNSPGSTFERKA
                     HMTRHGTYEGSSSGNSSPEYPRKELASSSTRGRSQTRESEIRVRLQSASPSTRWTELD
                     EVKRLLKGSRSASASPTRNTSNTLPIPKKGTVETKTVTASSHSVSGTYDSAILDTNFP
                     PHMWSSTLPAGSSLGTYQNNITAQSTSLLNTNAYSTGSVFGVPNNMASCSPTLHPGLS
                     SCSSVFGMQNNLAPSSSVLSHGTTTASTAYGAKKNVPQPPTVTSTGVSTSATCTTSVQ
                     SDDLLHKDCKFLILEKDNTPAKKEMELLIMTKDSGKVFTASPATISSTSFSEDTLKKE
                     KQAAYAADTCLKADVNGDLNTVSTKSKMTSAENHGYDRGGGGGRGKGGGAGGGGGGGG
                     ASGGGGAWGAAPAWCPCGSCCSWWKWLLGLLLTWLLLLGLLFGLIALAEEVRKLKARV
                     EELEKTKVLYHDVQMDKSNRDRLQAEAPSLGPGLGKAELDGYSQEAIWLFVRNKLMTE
                     QENGNLRGSPGPKGDMGSQGPKGDRGLPGTPGIPGPLGHPGPEGPKGQKGSIGDPGME
                     GPIGQRGLAGPMGPRGEPGPPGSGEKGDRGIAGEQGPQGLPGVPGPPGLRGHSGSPGP
                     QGPPGAVGPQGLRGDVGLPGVKGDKGLMGPPGPKGDQGEKGPRGLTGEPGIRGLPGAV
                     GEPGAKGAMGPAGADGQQGSRGEQGLTGMPGTRGPPGPAGDPGKPGLTGPQGPQGLPG
                     SPGRPGTKGEPGAPGRVMTSEGSSTITVPGPPGPPGAMGPPGPPGTPGPAGPAGLPGQ
                     QGPRGEPGLAGDSFLSSGSSISEVLSAQGVDLRGPPGPPGPRGPPGPSIPGPPGPRGP
                     PGEGVPGPPGPPGSFLTDSETFFTGPPGPPGPPGPKGDQGDPGVPGTPGISGGLSHGA
                     SSSTLYMQGPPGPPGPPGPPGSLSSSGQDIQHYIAEYMQSDNIRTYLSGVQGPPGPPG
                     PPGPVITITGETFDYSQLASQVVSYLRSSGYGAGLSSASSSEDILAMLRRNDVWQYLR
                     QNLVGPPGPPGPPGVSGDGSLLSLDYGELSRHILNYMSSSGISFGHPGPPGPPGLPGT
                     SYEELLTMLRGSDYRNIIGPPGPPGPPGMPGNAWSSISVEDLSSYLHTAGLSSIPGPP
                     GPPGPPGPRGPPGVSAALSTYAAENSDNFRSELISYLTSPDVRSFIVGPPGPPGPQGP
                     PGDGHLRENYNWSSNSSARRGTSYSSSTGTGGTNGGSLGEGGAYGAGDGGPYGTDIGP
                     GGGYGAAAGGGIYGTNGDSFRDGFTGDLDYNKLAVRVSESMQRQGLLQGMAYTVQGPP
                     GPQGPPGISRVFSAYSNVTQDLMDFFQTYGTIPGPPGQKGDVGTPGPKGDRGPAGPRG
                     PPGPPGPRGNKGEKGDKGDQVYTGRRKRSIAIKP"
     exon            273..317
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..422
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..554
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..602
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..638
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..686
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            687..830
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..989
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1061
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1133
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1202
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1364
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1445
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1490
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1712
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1928
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..1958
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..1985
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2012
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2075
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2180
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2243
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2279
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2333
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2369
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2405
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2468
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2504
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2576
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2603
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2639
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2675
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2756
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2792
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2870
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2924
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..2966
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3020
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3080
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3131
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3254
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3392
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3458
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3599
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3689
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3800
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3947
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4307
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4436
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4499
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            4500..4580
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     exon            4581..5515
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5491..5496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /note="hexamer: ATTAAA"
     polyA_site      5515
                     /gene="Col17a1"
                     /gene_synonym="BP180; Bpag; Bpag2"
                     /note="major polyA site"
ORIGIN      
        1 gttttttgaa ggaaagcgct gaaggaaaca gaagggagag aagaagcgaa catttttgaa
       61 cgatcactca gctttaacac accttgactg ggtctgaatt taaaaaaaaa agtgccaggg
      121 caaacttcta gaagaaaagc atccgaggga ggaagagaga gagggtgtct gcctgaagtg
      181 gttcccagct cctccagacg cgaagccagg tggctatggg atggatgtga ccaagaaaag
      241 caagcgagat ggcactgaag tcaccgagag aattgtcacg gaaacagtaa cgacaagact
      301 tacatcccta ccgccaaaag ggagcaccag caatggatat gctaagacag gctctctggg
      361 tggaggaagt cggttggaga agcagagctt gacccatggc agcagcggct acatcaactc
      421 aagtggaagc atccgaggca acgcttccac ctccagttac aggagaacgc actcaccggc
      481 ctctaccctg cccaactctc ccggctccac ctttgaaagg aaagctcaca tgacccgcca
      541 tggaacttat gaagggagct ctagcggcaa ctcctcccct gagtacccac gaaaggaact
      601 cgcctcttct tcaaccagag gacgaagcca aacacgagag agcgaaattc gagttcggtt
      661 gcagagcgcg tcgccatcca ccagatggac agaactggat gaggtgaagc gtttgcttaa
      721 ggggagccgc tctgcaagtg caagtcccac caggaacacc tccaacacac tccccatccc
      781 caagaaaggc accgtagaga ccaaaacagt gacagcgagc tcccactcag tgtccggaac
      841 ctatgattca gcaatactgg acaccaactt tccgccccac atgtggtcct ccaccttgcc
      901 tgcagggtcc tccctgggga cctatcagaa caacataaca gcccagagca catccctcct
      961 caacaccaat gcctactcaa cgggatcagt ctttggagtg ccaaataaca tggcgtcctg
     1021 ctctcccacc ctgcaccccg gactcagcag ctgctcctca gtgtttggca tgcagaacaa
     1081 tctggccccc agctcttctg tcctctccca tggcacaacc accgcttcca cagcatacgg
     1141 agcgaagaaa aacgtgcccc agcctcccac tgtcaccagc accggcgtgt ccacctctgc
     1201 cacctgcacc accagtgtcc agagtgacga cctcttgcat aaagactgca agttcctgat
     1261 tctggagaaa gacaacacac cagctaagaa agagatggaa ctcttgatca tgaccaagga
     1321 cagtgggaag gtcttcactg cctcccctgc caccatctct tcaacttcct tttcagaaga
     1381 caccctgaaa aaggagaagc aggctgcata tgccgctgac acctgcctga aggcagatgt
     1441 gaatggagac ctaaataccg tgtccacaaa gagcaagatg acctcggcag aaaaccatgg
     1501 ctacgaccga ggtggcggtg gtggcagagg caaaggcgga ggtgctggtg gtggcggtgg
     1561 tggcggtggc gccagtggcg gtggaggagc atggggggct gcaccagcct ggtgcccctg
     1621 cggctcctgc tgcagctggt ggaagtggct gctgggcctg ctgctcacct ggctgctgct
     1681 gctgggtctg ctcttcggcc tcattgctct ggcggaggag gtaagaaagc tgaaggcccg
     1741 cgtggaggag ctggaaaaga ccaaggtgct atatcatgac gtccagatgg acaaaagcaa
     1801 cagggaccgc ctccaggccg aggcacccag cctgggacct ggattaggca aggctgagct
     1861 ggacggctac agccaggagg ccatctggct gtttgtaagg aacaagctga tgaccgagca
     1921 ggagaacggg aatctcagag gaagtcctgg tccaaaaggt gacatgggga gtcaaggacc
     1981 taaaggagac cgaggccttc ctgggacccc aggtatccct gggcccctgg gccaccctgg
     2041 cccggaagga ccaaagggac aaaaaggcag cattggagat cctggcatgg aaggacccat
     2101 aggccagaga ggactagcag gccccatggg acctcgtggt gaacccgggc ctcctgggtc
     2161 tggagagaaa ggagacagag ggattgctgg tgaacaaggt cctcagggcc ttcctggtgt
     2221 cccaggtcct ccgggtctca gaggtcacag cggctctcct ggtccccaag gccccccagg
     2281 tgctgtgggt ccccaagggc tccgaggtga cgtgggactt cctggtgtca aaggtgacaa
     2341 aggactcatg ggaccaccag gacccaaagg tgaccagggt gagaagggac ccagaggcct
     2401 cacaggggag cctggcattc gaggtttgcc tggagctgtg ggtgaacccg gagccaaagg
     2461 cgcaatgggt ccggctggcg ctgatggaca gcaaggttcc agaggtgaac aaggcttgac
     2521 agggatgcct ggaacccggg gccccccagg acccgctgga gacccaggaa agccaggtct
     2581 cacaggaccc cagggacctc agggacttcc tggtagccct ggccgaccag ggactaaagg
     2641 cgaacccggc gctcccggca gagtcatgac ttcagaggga tcatcaacaa tcactgtgcc
     2701 cggacctccc ggacctcctg gtgccatggg tcccccagga cctccaggga cgccaggtcc
     2761 agctggccct gctggtctcc caggacaaca aggcccacga ggggagccag gacttgctgg
     2821 tgactcattc ctaagcagtg gcagctccat ctctgaggtc ctctctgccc aaggtgttga
     2881 cttacgaggt ccccctggcc cacctggccc acgagggcca ccagggcctt ccatcccagg
     2941 cccgccagga cccagaggtc caccagggga aggcgtacca ggcccacccg ggccaccagg
     3001 atccttcctg actgactcag aaaccttctt cactggccct ccaggtccac ccggcccccc
     3061 aggtcccaag ggagaccaag gtgatcctgg tgtcccaggt actcctggca tctctggtgg
     3121 tctttctcat ggggcgtcat caagcactct gtacatgcag ggcccccctg gccctccagg
     3181 gccccctggg cctccgggct ccctcagcag ctccggccag gatatccagc actacatcgc
     3241 tgaatacatg caaagtgaca acatcaggac ttatctctca ggggttcagg gtcccccagg
     3301 cccaccaggt cccccagggc ctgtcatcac catcacagga gagactttcg actactccca
     3361 gctggcaagc caggtcgtaa gctacttgcg gtcatcaggc tacggtgctg gcttgtcctc
     3421 tgcctcctcc tcagaagata tcttggccat gctgcgacgg aacgatgtgt ggcagtactt
     3481 acgtcagaat ctggtgggtc ctcccggtcc cccagggcca ccaggcgtca gtggagatgg
     3541 gtccctcctg tctttggact atggagagct gagcagacac attctcaact atatgtcaag
     3601 ttctgggatc agctttgggc atcctggccc accgggaccc cctggcctgc caggaacatc
     3661 ctacgaggag ctactgacca tgctccgagg gtctgactac agaaacatca ttggacctcc
     3721 agggccccca gggccacccg ggatgccagg caatgcatgg tccagcatca gtgtggagga
     3781 cctctcatca tacttgcaca ccgctggttt gtcctccatc ccaggccctc caggcccacc
     3841 agggccccca ggtcctcgag ggcccccagg tgtctcagca gctctgtcca cctatgcagc
     3901 tgagaacagc gacaacttcc gcagcgagct gattagctac ctcacaagtc ctgatgttcg
     3961 cagcttcatc gttggccctc caggccctcc ggggccacag ggaccacctg gagatggtca
     4021 cttaagggag aactacaact ggagcagcaa ctcctcagcc agaaggggca cttcctacag
     4081 ctcttccacg ggcacagggg gaaccaacgg aggctccctg ggtgaaggtg gagcctatgg
     4141 tgcaggagat gggggcccct atggtaccga catcggccca ggcggaggct atggggcagc
     4201 tgcaggtggt ggtatatatg gcaccaatgg tgactcgttc cgggatggct tcactggaga
     4261 cctagattac aacaagctgg cagtgcgggt gtcggagagc atgcagcgtc agggtctgct
     4321 acaagggatg gcctacactg tccagggccc acctgggccc caaggccctc ctggcatcag
     4381 cagggtcttc tcagcctaca gcaacgtgac acaagacctc atggacttct tccaaaccta
     4441 cggcactatc ccgggaccac ctgggcagaa gggagatgtg ggaaccccag gccccaaagg
     4501 tgacaggggc cctgctggac cacgaggtcc tccagggcca cccggcccca gagggaacaa
     4561 aggagagaaa ggagacaaag gtgaccaagt ctatactggg agaaggaaga gaagtattgc
     4621 catcaagccg taagctgcac ttggcagagc caccaagtat ctgggaccgg ttcttgggcg
     4681 cctatgtcca agggtccccg tcctcctgag accaaatcac ccagcgacac ttgttttagt
     4741 ctgaaccaaa tatatacata cagaaaattc aaagacacac aatctgaaac agctccattg
     4801 gttgggtggg cctttcggaa tagctgcaat gtttaatatg agacttgacc tctctgctac
     4861 atagatctga gctccccggc ttctttagca tttagcccag cctctgccag gcctcggaag
     4921 ccagttacat aactgttggc tggggatctt ggagctttgc ctaaaaagtg agcccagaaa
     4981 atggaaaatg ggaatgggga cctttgtaga tgacgtgtga tgggttatgt tacgaaggct
     5041 gctgtcagct cctcctcctc tcttcactct gcattctcca gtcacagagg tgactcttgc
     5101 aactgaaaac actcaaagtt cacttcctca gaggaggtga catggttacc ttcagttacc
     5161 atggtgcaga tgccaatcac cttcccactg gcttacaaag cttgactggt cgtagctatg
     5221 gcctgtgtcc acaggtacag gccagaagta caactatgac accacactag acccagacag
     5281 gacaagaggg gcagtgggca aggaagggag aaaagagagg acacagaact cctgatgctg
     5341 aggaagcatg gcttccacac accatcctgc acttaggaaa tggcataaaa gactgggcac
     5401 agttggtttt tatttaagca ctttccactg tctaaaaaca tttgtatgta acctgtaaga
     5461 tgaaaaatca tttcaactgt aaaattttca attaaagttt ttttttcttt tttaa
//
