LOCUS       NM_181277               6447 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus collagen, type XIV, alpha 1 (Col14a1), transcript
            variant 2, mRNA.
ACCESSION   NM_181277
VERSION     NM_181277.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6447)
  AUTHORS   Ushiki,A., Sheng,R.R., Zhang,Y., Zhao,J., Nobuhara,M., Murray,E.,
            Ruan,X., Rios,J.J., Wise,C.A. and Ahituv,N.
  TITLE     Deletion of Pax1 scoliosis-associated regulatory elements leads to
            a female-biased tail abnormality
  JOURNAL   Cell Rep 43 (3), 113907 (2024)
   PUBMED   38461417
REFERENCE   2  (bases 1 to 6447)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6447)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   4  (bases 1 to 6447)
  AUTHORS   Angelozzi,M., Pellegrino da Silva,R., Gonzalez,M.V. and Lefebvre,V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   5  (bases 1 to 6447)
  AUTHORS   Sun,M., Zafrullah,N., Adams,S., Devaux,F., Avila,M.Y., Ziebarth,N.,
            Margo,C.E., Koch,M. and Espana,E.M.
  TITLE     Collagen XIV Is an Intrinsic Regulator of Corneal Stromal Structure
            and Function
  JOURNAL   Am J Pathol 191 (12), 2184-2194 (2021)
   PUBMED   34560063
  REMARK    GeneRIF: Collagen XIV Is an Intrinsic Regulator of Corneal Stromal
            Structure and Function.
REFERENCE   6  (bases 1 to 6447)
  AUTHORS   Ruehl,M., Erben,U., Schuppan,D., Wagner,C., Zeller,A., Freise,C.,
            Al-Hasani,H., Loesekann,M., Notter,M., Wittig,B.M., Zeitz,M.,
            Dieterich,W. and Somasundaram,R.
  TITLE     The elongated first fibronectin type III domain of collagen XIV is
            an inducer of quiescence and differentiation in fibroblasts and
            preadipocytes
  JOURNAL   J Biol Chem 280 (46), 38537-38543 (2005)
   PUBMED   16129687
  REMARK    GeneRIF: the fibronectin type III domain of collagen XIV is an
            inducer of quiescence and differentiation in fibroblasts and
            preadipocytes
REFERENCE   7  (bases 1 to 6447)
  AUTHORS   Gerecke,D.R., Meng,X., Liu,B. and Birk,D.E.
  TITLE     Complete primary structure and genomic organization of the mouse
            Col14a1 gene
  JOURNAL   Matrix Biol 22 (7), 595-601 (2004)
   PUBMED   15065570
  REMARK    GeneRIF: The 6456 nucleotide (nt) cDNA contains 5391-nt open
            reading frame encoding 1797 amino acid residues. Amino terminus has
            a28-residue signal peptide followed by mature polypeptide of 1769
            amino acid residues with calculated molecular mass of 193.2 kDa.
REFERENCE   8  (bases 1 to 6447)
  AUTHORS   Gerecke,D.R., Meng,X., Liu,B. and Birk,D.E.
  TITLE     Complete primary structure and genomic organization of the mouse
            Col14a1 gene
  JOURNAL   Matrix Biol 22 (3), 209-216 (2003)
   PUBMED   12853031
  REMARK    GeneRIF: The entire mouse cDNA sequence for type XIV collagen was
            determined using overlapping PCR products. The 6456 nucleotide (nt)
            cDNA sequence contains a 5391-nt open reading frame encoding 1797
            amino acid residues.
REFERENCE   9  (bases 1 to 6447)
  AUTHORS   Imhof,M. and Trueb,B.
  TITLE     Comparative cytogenetic mapping of COL14A1, the gene for human and
            mouse collagen XIV
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 217-219 (1999)
   PUBMED   10393435
REFERENCE   10 (bases 1 to 6447)
  AUTHORS   Proetzel,G., Pawlowski,S.A., Wiles,M.V., Yin,M., Boivin,G.P.,
            Howles,P.N., Ding,J., Ferguson,M.W. and Doetschman,T.
  TITLE     Transforming growth factor-beta 3 is required for secondary palate
            fusion
  JOURNAL   Nat Genet 11 (4), 409-414 (1995)
   PUBMED   7493021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131337.16 and AC133156.7.
            
            On Feb 13, 2019 this sequence version replaced NM_181277.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138345.1, SRR10223970.17515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC131337.16        104491-104724
            235-359             AC131337.16        125896-126020
            360-476             AC131337.16        135146-135262
            477-620             AC131337.16        138421-138564
            621-710             AC131337.16        141610-141699
            711-866             AC131337.16        159122-159277
            867-986             AC131337.16        160191-160310
            987-1151            AC131337.16        162789-162953
            1152-1313           AC131337.16        169312-169473
            1314-1465           AC131337.16        176240-176391
            1466-1595           AC131337.16        177467-177596
            1596-1741           AC131337.16        179166-179311
            1742-1871           AC131337.16        182953-183082
            1872-2011           AC131337.16        185290-185429
            2012-2138           AC133156.7         26313-26439
            2139-2278           AC133156.7         27398-27537
            2279-2411           AC133156.7         28494-28626
            2412-2471           AC133156.7         29855-29914
            2472-2614           AC133156.7         31248-31390
            2615-2744           AC133156.7         38366-38495
            2745-2867           AC133156.7         40496-40618
            2868-3017           AC133156.7         43059-43208
            3018-3134           AC133156.7         47562-47678
            3135-3281           AC133156.7         56619-56765
            3282-3338           AC133156.7         60978-61034
            3339-3478           AC133156.7         64231-64370
            3479-3602           AC133156.7         65415-65538
            3603-3746           AC133156.7         65832-65975
            3747-3911           AC133156.7         67043-67207
            3912-3950           AC133156.7         67876-67914
            3951-4089           AC133156.7         68410-68548
            4090-4232           AC133156.7         69478-69620
            4233-4342           AC133156.7         71950-72059
            4343-4501           AC133156.7         74856-75014
            4502-4579           AC133156.7         83364-83441
            4580-4666           AC133156.7         86276-86362
            4667-4720           AC133156.7         87638-87691
            4721-4816           AC133156.7         91299-91394
            4817-4870           AC133156.7         92605-92658
            4871-4924           AC133156.7         92958-93011
            4925-4978           AC133156.7         107610-107663
            4979-5050           AC133156.7         108144-108215
            5051-5086           AC133156.7         117156-117191
            5087-5153           AC133156.7         118094-118160
            5154-5342           AC133156.7         121057-121245
            5343-5420           AC133156.7         135842-135919
            5421-5576           AC133156.7         137860-138015
            5577-6447           AC133156.7         139611-140481
FEATURES             Location/Qualifiers
     source          1..6447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.96 cM"
     gene            1..6447
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /note="collagen, type XIV, alpha 1"
                     /db_xref="GeneID:12818"
                     /db_xref="MGI:MGI:1341272"
     exon            1..234
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            235..359
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..5656
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; collagen alpha-1(XIV) chain; procollagen, type
                     XIV, alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XIV) chain isoform 2 precursor"
                     /protein_id="NP_851794.3"
                     /db_xref="CCDS:CCDS37076.1"
                     /db_xref="GeneID:12818"
                     /db_xref="MGI:MGI:1341272"
                     /translation="MMIWQCKMRDWLILAFLAAACFCTIVRGQVAPPTRLRYNVISHD
                     SIQISWKAPRGKFGGYKLLVAPASGGKTNQMNLQNTATKAIIQGLLPEQNYTVQLIAY
                     YKDKESKPAQGQFRIKDLEKRKDPTKPKVKVVDKGNGSKPTSPEEVKFFCETPAIADI
                     VILVDGSWSIGRFNFRLVRNFLENLVTAFNVGSEKTRIGLAQYSGDPRIEWHLNAFNT
                     KDEVIDAVRSLPYKGGNTLTGLALNFIFENSFKPEAGSRSGVSKIGILITDGKSQDDI
                     IPPSRNLRESGVELFAIGVKNADLSELQEIASEPDSTHVYNVAEFDLMHTVVESLTRT
                     VCSRVEEQDKEIKASALATIGPPTELITSEVTARSFMVNWTQSPGKVEKYRVVYYPTR
                     GGKPEEVVVDGSVSSTVLKNLMSSTEYQIAVFAVSAHTASEGLRGAETTLALPMASDL
                     ELYDVTENSMRVRWDAVPGATGYLILYAPLTEGLAGDEKEMKIGETHTDIELSGLFPN
                     TEYTVTVYAMFGEEASDPATGQETTLPLTPPRNLRISNVGSNSARLTWDPASGKISGY
                     RIVYTSADGTEINEVEVDPITTFPLKGLTPLTEYSIAIFSIYEEGQSLPLVGEFTTEE
                     VPAQQYLEIDEVKTDSFRVTWHPLSAEEGQHKLMWIPVYGGKTQEVDLKEEQDSYVIE
                     GLDPGTEYEVSLLAVLDDGSESEVVTAVGTTLDDFWTEAPTAIEPTSPVTSVLQTGIR
                     NLVVDDETATSLRVSWDISDSNVEQFRVTYLKAQGDPMEEVVMVPGVQNSLLLKALLP
                     DTEYKVTVTPVYTVGEGVSVSAPGKTLPSSGPQNLRVSEEWYNRVRITWDPPSGPVKG
                     YRIVYKPVSVPGQTLETFVGADINTIVMTNLLSGMDYNVKIFASQASGFSDALTGLVQ
                     TLFLGVTDLQANQVEMTSLCARWQIHRHATAYRIVLESLQDTQAQESTVGGGVNRHCF
                     YGLQPDSEYKISVYTKLQELEGPSVSIMQKTQSLPTEPPTFPPTIPPAKEVCKAAKAD
                     LVFMVDGSWSIGDDNFNKIINFLYSTVGALDKIGADGTQVAMVQFTDDPRTEFKLDSY
                     KTKETLLDAIRHISYKGGNTKTGKAIKHVRDTLFTSDSGTRRGIPKVIVVITDGRSQD
                     DVNKISREMQADGFNIFAIGVADADYSELVQIGSKPSSRHVFFVDDFDAFKKIEDELI
                     TFVCETASATCPMVHKDGVDLAGFKMMEMFGLVEKDFSAVEGVSMEPGTFNLFPCYQI
                     HKDALVSQPTKYLHPEGLPSDYTMSFLFRILPDTPQEPFALWEILNKNSEPLVGIILD
                     NGGKTLTYFNYDYTGDFQTVTFEGPDIRKMFYGSFHKLHVVVSKTLAKVVVDCKEVGQ
                     KAINASANITSDGVEVLGRMVRSRGPNGNSAPFQLQMFDIVCSTSWASKDRCCELPGL
                     RDEESCPDLPRSCSCSETNEVALGPAGPPGGPGLRGPKGQQGEQGPKGPEGPRGETGP
                     AGPQGPPGPQGPSGLSIQGMPGMPGDKGDKGDAGLPGPQGVPGGVGSPGRDGSPGQRG
                     FPGKDGSSGPPGPPGPIGIPGAPGVPGITGSMGPQGALGPPGVPGAKGERGERGDLQS
                     QAMVRAVARQVCEQLIQSHMARYTAILNQIPSQSSSIRTIQGPPGEPGRPGSPGTPGE
                     QGPPGTPGFPGNAGVPGTPGERGLTGVKGEKGNPGIGTQGPRGPPGPAGPSGESRPGS
                     PGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVGVSHPDQPEFTPVQDEQ
                     EAMDLWSAGI"
     exon            360..476
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            477..620
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..710
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            711..866
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            867..986
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1151
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1313
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1465
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1595
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1741
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1871
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2011
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2138
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2278
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2411
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2471
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2614
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2744
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2867
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3017
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3134
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3281
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3338
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3478
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3602
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3746
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3911
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..3950
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4089
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4232
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4233..4342
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4501
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4579
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4666
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4667..4720
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4816
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4870
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4871..4924
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..4978
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5050
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5051..5086
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5087..5153
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5154..5342
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5343..5420
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5421..5576
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5577..6447
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6428..6433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6447
                     /gene="Col14a1"
                     /gene_synonym="5730412L22Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctcttatct gatcctgggt gagaggcgag gggaaggaag ctctgtaggg caggaggcga
       61 cgggagaggg acaaggagag gacagagtga acgacaggaa agagaagtta attgagaaag
      121 ggtactctga gggaaggcga gccagggcag tggttcgcta agaaccagtc ggcggctaat
      181 cttccctagg cgccaagagg tccccaacct gggctggaac gttgccctgc acaggcagct
      241 gttgcacctg atgtaagagg cagaaaataa gatgatgatt tggcagtgca agatgcggga
      301 ctggctgatt ctagcttttt tggcggctgc ttgtttctgc accattgtca ggggacaagt
      361 ggctccaccc acaaggttaa gatataatgt gatttcccat gatagtatac agatttcatg
      421 gaaagcacca agagggaaat ttggtggcta caaactgctc gtggctccag cttcaggagg
      481 aaagaccaac cagatgaatc tccagaacac tgcaacaaaa gcgattattc aaggccttct
      541 gccagagcag aactacacag ttcaactcat tgcctactat aaagacaagg aaagcaagcc
      601 cgctcaaggc cagttcagaa ttaaagattt agagaaaaga aaggatccaa caaagcccaa
      661 agtcaaggtt gtggacaaag gaaatggaag taaaccaact tcaccagaag aggtaaaatt
      721 cttctgtgag actccagcca tcgctgacat cgtcatcctg gtggatgggt cgtggagtat
      781 tgggaggttc aacttcaggc ttgtgcgcaa tttcttggaa aacctggtca cagcgttcaa
      841 cgtgggctca gaaaagacaa gaatcggctt ggcacagtac agtggggacc ccagaataga
      901 gtggcacttg aatgccttta acacaaaaga tgaggtgatt gatgctgtcc gaagccttcc
      961 atacaaagga ggaaataccc taacaggtct tgctttgaac tttatttttg agaatagctt
     1021 taaaccagaa gcaggatcga ggagtggagt ttccaagatt ggcattttga tcacagatgg
     1081 aaaatcccag gatgatatta tcccaccatc tagaaacctc cgtgagtctg gtgtagagct
     1141 gtttgccata ggggttaaaa atgccgacct gagtgagctg caggagatcg cctctgagcc
     1201 agacagcacc catgtgtaca atgttgctga gttcgacctg atgcacacag tggtggagag
     1261 cctgacccgg actgtatgct ctagagtgga agagcaggac aaggagatta aagcctcagc
     1321 ccttgccacc atcgggccac ctacagagct gatcacttct gaagtcactg ccaggagctt
     1381 tatggttaac tggactcagt ccccaggaaa agtggaaaaa tacagagttg tgtattatcc
     1441 caccagaggc ggaaagccgg aggaggtggt ggtggatggg agtgtatctt ccacagtgtt
     1501 gaaaaacttg atgtcttcaa ctgagtacca gatagcagtg tttgcagtat ctgcccacac
     1561 agctagtgaa ggcctgcggg gagcagagac cacattggcc ttgcccatgg cttccgacct
     1621 cgagctgtac gacgtgactg agaacagcat gcgcgtcagg tgggatgcag tacctggagc
     1681 cacaggctat ctgatcctct atgctcctct cacagaaggt ctggctggag atgagaaaga
     1741 gatgaaaatt ggagagacac acacagacat tgaactgagt gggctattcc ccaatacaga
     1801 atatacagtc actgtgtatg ccatgtttgg agaagaggcc agcgatcctg ctacaggaca
     1861 agagacaacc ctacccttaa ccccaccaag aaatttgcgg atctccaatg ttggctctaa
     1921 cagcgctcgg ttaacctggg accccgcatc gggaaagatc agtggttaca gaattgtgta
     1981 taccagtgca gacgggacag aaatcaatga ggttgaagtc gatcctatca ctacattccc
     2041 tctgaaaggc ttgacccccc tcacggagta ctccattgca atcttctcca tctacgagga
     2101 ggggcagtcc ttgcccctgg ttggagagtt taccacagag gaagttcccg cccagcaata
     2161 cttggaaatt gatgaggtga agacagacag ttttcgagtg acttggcatc cgctctccgc
     2221 tgaggagggg cagcacaagc tgatgtggat tccggtctat ggcgggaaga cccaggaggt
     2281 tgacctcaaa gaagaacagg actcttatgt tattgaaggc ctggatcctg gaaccgagta
     2341 cgaagtctcc ctgttagctg tgcttgatga cggaagcgag agtgaggtgg tgaccgcagt
     2401 gggaaccaca cttgatgatt tttggactga agcacccaca gccatagaac ctaccagccc
     2461 tgtgacttca gttctccaga caggaatcag aaacctggtt gtagatgacg aaactgctac
     2521 tagcctgcgg gtatcgtggg acatttctga cagcaatgtg gagcagttta gggtgaccta
     2581 cctgaaagcc caaggggacc ctatggaaga agtggttatg gtgcctggag tgcaaaacag
     2641 tctccttctg aaggctctac ttccagacac tgagtataaa gtcacagtaa cccctgtcta
     2701 tactgttgga gaaggcgtca gcgtctccgc tccagggaag actttgccct cctctggtcc
     2761 tcaaaacctg agggtctcag aagaatggta caaccgggtg cgcattacat gggacccacc
     2821 ctctggcccc gtgaagggct ataggattgt ctacaaacct gtgagtgtcc ctggtcaaac
     2881 tctggagacc ttcgtgggtg ctgacatcaa caccattgtc atgacaaatc tcctcagtgg
     2941 aatggactac aatgtgaaga tctttgcttc ccaggcgtca ggcttcagtg atgctctgac
     3001 tggcctcgtg caaacactgt tcttaggggt gacagatctc caagccaatc aggttgaaat
     3061 gacaagcttg tgtgctcggt ggcaaataca tcgccatgcc acagcctaca ggatagttct
     3121 agaatccctt caggacacac aagcacagga atccacggtg ggaggaggcg taaacaggca
     3181 ttgcttctat ggacttcagc ctgattcaga gtataaaatc agtgtttaca caaagctcca
     3241 ggagctagag ggacccagtg tgagcatcat gcagaaaaca cagtcacttc ccacggaacc
     3301 accgactttt cctccaacca tcccaccagc aaaggaagta tgtaaagctg ccaaggcaga
     3361 cctggtattc atggtggatg gatcttggag cataggagat gacaatttca ataaaatcat
     3421 caattttcta tacagcactg tgggagccct ggacaagatt ggtgcagatg gaactcaggt
     3481 ggcaatggtt cagttcactg atgacccccg aacagaattc aaacttgatt cttacaaaac
     3541 caaagagacc cttcttgatg caattagaca catttcctac aaaggaggaa atactaaaac
     3601 aggaaaagct atcaagcatg ttcgggatac cttatttaca tcagactcag ggacaaggag
     3661 aggcatccca aaggtcatcg tggtgataac tgatggacgg tcacaagatg atgtcaacaa
     3721 aatctccagg gagatgcagg cagatggttt caacatcttt gccatcggtg tggctgacgc
     3781 tgactactcc gagttggttc agatcggcag caagcccagc tcacggcatg tcttctttgt
     3841 ggatgacttt gatgccttta agaaaattga agatgaattg attacttttg tctgtgaaac
     3901 tgcatcagca acctgcccaa tggtgcacaa ggatggagtt gatcttgcag ggtttaagat
     3961 gatggaaatg tttggtttgg ttgaaaagga cttttctgca gtggaaggag tatctatgga
     4021 acctggtacc ttcaatttgt tcccatgcta tcaaatccat aaggatgctc tggtttctca
     4081 gccaacaaag tatctgcacc cagaaggatt gccttctgac tatacaatga gtttcctgtt
     4141 ccggattctt cctgacacac cacaggagcc atttgctctt tgggagattt taaacaaaaa
     4201 ttctgagccg ctagttggga tcatattgga caatggtggg aaaactctaa cttatttcaa
     4261 ctatgactat actggagatt ttcaaactgt cacttttgaa ggacccgaca tcaggaaaat
     4321 gttctatgga agctttcaca agctccatgt tgttgtcagc aagactctgg ccaaagtggt
     4381 tgttgactgc aaggaagttg gtcagaaggc aataaatgca tcagcgaata tcacatcgga
     4441 tggtgtggaa gtactaggaa gaatggtcag atcaagagga ccaaatggaa actctgcacc
     4501 attccagtta caaatgtttg atatcgtttg ctctacatca tgggccagta aagacagatg
     4561 ctgcgaactt cctggtctgc gggatgaaga gtcctgccca gaccttccac ggtcctgctc
     4621 ttgctcggaa accaatgaag tggctctagg accagctggc cccccaggtg gtccaggact
     4681 ccgaggacca aaaggccaac aaggtgaaca gggtccgaag ggaccagagg gacctcgggg
     4741 agaaacaggt cctgcaggac cccagggccc ccctggaccc cagggaccta gtggtctgtc
     4801 cattcaaggc atgcctggaa tgccgggtga taaaggagat aaaggagatg ctggtcttcc
     4861 tggtccacag ggtgtccctg gaggtgttgg ttcaccaggc cgtgatggct caccaggcca
     4921 gaggggattt cccgggaagg acggttcctc tgggcctcca ggaccacctg ggccaattgg
     4981 cattcctgga gcccctggtg tcccagggat cacaggcagc atgggaccgc aaggagccct
     5041 ggggccacct ggtgtccctg gagcgaaggg agagcgaggt gaacggggag acctgcagtc
     5101 tcaagccatg gtgagggcgg tggcacgtca agtatgcgag cagctcattc agagtcacat
     5161 ggccaggtac acagccatcc tcaaccagat ccccagccag tcctcatcta tccggaccat
     5221 ccagggccct cctggggagc ccgggagacc aggttcacct ggaacccctg gagaacaagg
     5281 acccccaggt accccaggct tcccaggaaa tgcaggagtt ccggggaccc caggagaacg
     5341 aggtctaact ggtgtcaaag gagagaaagg aaatccaggc attggaactc aaggcccaag
     5401 aggtccccct gggccagcag gaccttcagg ggaaagtcgt cctggaagtc ctgggccacc
     5461 tggctctcct ggaccaaggg gtcccccggg ccacctggga gtacctggac ctcagggtcc
     5521 ttctggccag cctgggtatt gtgacccctc ctcgtgctct gcttatggcg ttggagtgtc
     5581 ccatcctgat cagcctgagt tcacaccggt ccaggacgag caggaggcca tggatctgtg
     5641 gagcgcaggc atctgatgac ctcaggagac atttgaagag caggggcagg ccctcttctg
     5701 gagcttcact taccaaatgc tgtcacgtgg tttgtcctct actttgcaga gggaggcagg
     5761 gctgatggta tggggtatat ttcctctgtg gataacgtca atattaccgt tttttaaaaa
     5821 ttgtgttttg aaaccgcccc tttctgtgac actgttttaa ctgtacacca gttactttgg
     5881 acttcttcca atgaagagtg ctgagaagga tacaccctgg agtgtcttct ctgttacatc
     5941 atttcaagtt gtaaaattaa taagagaagc gtggttatat cagagggaat ttggggccct
     6001 atcagcagaa gagcgaattc agagattccc agtttatacc actgtccctg tacccatgtc
     6061 agtgaccttg ctggtaattg aataacacca tcactgagga aactacctcc tacttgttta
     6121 acctgatctg tctaactcat agattactca gtaactggtt ttcacgggtg ttcagaaata
     6181 agagctagaa tatagccttt ctcgattctg taattaaaaa caaaaccata gagtctgttt
     6241 tccagtagtc ttgattcgta taaaataatg acttccttcc agttccgatg cagaaaagac
     6301 ccatcttttg gcagatcatt tgtccaggag tgtgtttcag ggcttgcctc tcctcgactt
     6361 acagggattg ctttgtaaat gcagatatgt ttttgaagac ttgtttttat cctttttttt
     6421 ataagcaaat aaaaacttaa aacacca
//
