LOCUS       NM_001290308           11719 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus collagen, type XII, alpha 1 (Col12a1), mRNA.
ACCESSION   NM_001290308 XM_006510799
VERSION     NM_001290308.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11719)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11719)
  AUTHORS   Vallecillo-Garcia,P., Kuhnlein,M.N., Orgeur,M., Hansmeier,N.R.,
            Kotsaris,G., Meisen,Z.G., Timmermann,B., Giesecke-Thiel,C.,
            Hagerling,R. and Stricker,S.
  TITLE     Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel
            formation
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39221968
REFERENCE   3  (bases 1 to 11719)
  AUTHORS   Zhu,M., Metzen,F., Hopkinson,M., Betz,J., Heilig,J., Sodhi,J.,
            Imhof,T., Niehoff,A., Birk,D.E., Izu,Y., Kruger,M.,
            Pitsillides,A.A., Altmuller,J., van Osch,G.J.V.M., Straub,V.,
            Schreiber,G., Paulsson,M., Koch,M. and Brachvogel,B.
  TITLE     Ablation of collagen XII disturbs joint extracellular matrix
            organization and causes patellar subluxation
  JOURNAL   iScience 26 (7), 107225 (2023)
   PUBMED   37485359
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11719)
  AUTHORS   Vallecillo-Garcia,P., Orgeur,M., Comai,G., Poehle-Kronawitter,S.,
            Fischer,C., Gloger,M., Dumas,C.E., Giesecke-Thiel,C., Sauer,S.,
            Tajbakhsh,S., Hopken,U.E. and Stricker,S.
  TITLE     A local subset of mesenchymal cells expressing the transcription
            factor Osr1 orchestrates lymph node initiation
  JOURNAL   Immunity 56 (6), 1204-1219 (2023)
   PUBMED   37160119
REFERENCE   5  (bases 1 to 11719)
  AUTHORS   Donovan,C., Cogswell,D., Sun,M., Adams,S., Avila,M.Y., Margo,C.E.,
            Koch,M. and Espana,E.M.
  TITLE     Collagen XII regulates stromal wound closure
  JOURNAL   Exp Eye Res 230, 109456 (2023)
   PUBMED   36967080
REFERENCE   6  (bases 1 to 11719)
  AUTHORS   Gerecke,D.R., Olson,P.F., Koch,M., Knoll,J.H., Taylor,R.,
            Hudson,D.L., Champliaud,M.F., Olsen,B.R. and Burgeson,R.E.
  TITLE     Complete primary structure of two splice variants of collagen XII,
            and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX)
            collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human
            chromosome 6q12-q13
  JOURNAL   Genomics 41 (2), 236-242 (1997)
   PUBMED   9143499
REFERENCE   7  (bases 1 to 11719)
  AUTHORS   Rao,G., Alland,L., Guida,P., Schreiber-Agus,N., Chen,K., Chin,L.,
            Rochelle,J.M., Seldin,M.F., Skoultchi,A.I. and DePinho,R.A.
  TITLE     Mouse Sin3A interacts with and can functionally substitute for the
            amino-terminal repression of the Myc antagonist Mxi1
  JOURNAL   Oncogene 12 (5), 1165-1172 (1996)
   PUBMED   8649810
REFERENCE   8  (bases 1 to 11719)
  AUTHORS   Bohme,K., Li,Y., Oh,P.S. and Olsen,B.R.
  TITLE     Primary structure of the long and short splice variants of mouse
            collagen XII and their tissue-specific expression during embryonic
            development
  JOURNAL   Dev Dyn 204 (4), 432-445 (1995)
   PUBMED   8601036
REFERENCE   9  (bases 1 to 11719)
  AUTHORS   Oh,S.P., Griffith,C.M., Hay,E.D. and Olsen,B.R.
  TITLE     Tissue-specific expression of type XII collagen during mouse
            embryonic development
  JOURNAL   Dev Dyn 196 (1), 37-46 (1993)
   PUBMED   8334298
REFERENCE   10 (bases 1 to 11719)
  AUTHORS   Oh,S.P., Taylor,R.W., Gerecke,D.R., Rochelle,J.M., Seldin,M.F. and
            Olsen,B.R.
  TITLE     The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes
            are localized on mouse chromosome 9 and human chromosome 6
  JOURNAL   Genomics 14 (2), 225-231 (1992)
   PUBMED   1427837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028536.1, AC157477.2, AC166055.5, CN669497.1, CF535620.1,
            CF532120.1, CB722900.1, AK076278.1, CK624229.1 and CA315556.1.
            
            On Mar 12, 2014 this sequence version replaced XM_006510799.1.
            
            This RefSeq record was created from transcript and genomic sequence
            data because no single transcript was available for the full length
            of the gene. There are no full-length mouse transcripts supporting
            this exon combination; inferred from partial mouse transcripts, and
            alignment to human transcript U73778.1.
            
            CCDS Note: This CCDS representation has an inferred exon
            combination due to a lack of full-length transcript support for
            this gene. It is supported by a combination of RNA-seq data,
            partial mouse transcript alignments and orthologous transcript
            alignments (e.g., human U73778.1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1103              AK028536.1         2-1104
            1104-1105           AC157477.2         124863-124864       c
            1106-2628           AK028536.1         1105-2627
            2629-2776           AC157477.2         114872-115019       c
            2777-3049           AC157477.2         113668-113940       c
            3050-3322           AC157477.2         105702-105974       c
            3323-3589           AC166055.5         1742-2008
            3590-3782           AC166055.5         2449-2641
            3783-3904           AC166055.5         3616-3737
            3905-4054           AC166055.5         5420-5569
            4055-4174           AC166055.5         5652-5771
            4175-4339           AC166055.5         5872-6036
            4340-4486           AC166055.5         6726-6872
            4487-4626           AC166055.5         9210-9349
            4627-4756           AC166055.5         9844-9973
            4757-4899           AC166055.5         10531-10673
            4900-4921           AC166055.5         10997-11018
            4922-5423           CN669497.1         1-502
            5424-5995           CF535620.1         48-619
            5996-6385           CF532120.1         327-716
            6386-6412           AC166055.5         35343-35369
            6413-6555           AC166055.5         36309-36451
            6556-6584           AC166055.5         38239-38267
            6585-7197           CB722900.1         1-613
            7198-7991           AK076278.1         45-838
            7992-8812           AK076278.1         840-1660
            8813-9045           CK624229.1         382-614
            9046-9762           CA315556.1         7-723
            9763-9928           AK076278.1         2613-2778
            9929-11719          AC166055.5         83253-85043
FEATURES             Location/Qualifiers
     source          1..11719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.82 cM"
     gene            1..11719
                     /gene="Col12a1"
                     /note="collagen, type XII, alpha 1"
                     /db_xref="GeneID:12816"
                     /db_xref="MGI:MGI:88448"
     exon            1..304
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..412
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..9537
                     /gene="Col12a1"
                     /note="collagen alpha-1(XII) chain; procollagen, type XII,
                     alpha 1"
                     /codon_start=1
                     /product="collagen alpha-1(XII) chain precursor"
                     /protein_id="NP_001277237.1"
                     /db_xref="CCDS:CCDS72284.1"
                     /db_xref="GeneID:12816"
                     /db_xref="MGI:MGI:88448"
                     /translation="MQTRLPRALAALGVALLLSSIEAEVDPPSDLNFKIIDENTVHMS
                     WERPVDPIVGYRITVDPTTDGPTKEFTLAASTTETLLSDLIPETQYVVTITSYNEVEE
                     SVPVIGQLTIQTGGPTKPGEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYIL
                     DFIVALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYRREDLLAAVKKIPYKGGNTM
                     TGDAIDYLVKNTFTESAGSRAGFPKVAIIITDGKSQDEVEIPARELRNIGVEVFSLGI
                     KAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVI
                     EPPSNLVVTELSSKYIRLSWDPSPSAVTGYKILLTPMAAGSRHHALSVGPQTTTLNVR
                     DLTADTEYQISVFAMKGLTSSEPTSVMEKTQPMKVQVECSRGVDIKADIVFLVDGSYS
                     IGIANFVKVRAFLEVLAKSFEISPNRVQISLVQYSRDPHTEFTLKEFNRVEDIIKAIN
                     TFPYRGGSTNTGKAMTYVREKIFVPNKGSRSNVPKVMILITDGKSSDAFRDPAIKLRN
                     SDVEIFAVGVKDAVRSELEAIASPPAETHVFTVEDFDAFQRISFELTQSICLRIEQEL
                     AAIKKKAYVPPKDLRFTQVTANSFKAEWSPPGDNVFSYHVTYKDANGDDEVTVVEPAS
                     STSVVLNNLRPETLYLVNVTAEYEDGFSVPITGEETTAEVKGVPRNLKVTDETTDSFK
                     LTWSQAPGRVLRYRIRYRPVSGGESKEVSTPANQRRKTLENLTPDTKYEISVIAEYSS
                     GPGSPLTGNAATEEVRGNPRDLRVSDATTSTLKLSWSRAPGKVKQYLVTYTPAAGGET
                     QEVTVRGDTTTTMLRKLKEGTQYDLSVTALYASGAGEALSGKGSTLEERGSPQNLVTK
                     DITDTSIGAYWTSAPGMVRGYRVSWKSLYDDIEAGETTLPGDAIHTMIENLQPETKYK
                     ISVFATYSSGEGEPVTGDATTELSQDSKILRVDEETEHTMRVTWKAAPGKVVNYRVVY
                     RPQGGGRQMVAKVPPTVTSTVLKRLQPQTTYDITVLPMYKTGEGKLRQGSGTTASRFK
                     SPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVLGPYDNTVVLEE
                     LRAGTTYRVNVFGMFDGGESLPLVGQEMTTLSDTTVTPFLSSGMDCLTRAEADIVLLV
                     DGSWSIGRANFRTVRSFISRIVEVFEIGPKRVQIALAQYSGDPRTEWQLNAHRDKKSL
                     LQAVANLPYKGGNTLTGMALNFIRQQSFKTQAGMRPRARKIGVLITDGKSQDDVEAPS
                     KKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSKIVDDLTINLCNS
                     VKGPGDLEAPTNLVISERTHRSFRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRLD
                     TSTVLKDLKPETDYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDVGPTTMHVQW
                     QPVGGATGYTVSYQPTRSPEGTKPKEMRVGPTVNDVQLTGLLPNTEYEVTVQAVLYDL
                     TSEPAKAREVTLPLPRPQDVKLRDVTHSTMNVVWEPVLGKVRKYIVRYKTPDEEFKEV
                     EVDRSRASTILKDLSSQTQYTVSVSAVYDEGTSPPATAYDTTRRVPAPTNLQFTEVTP
                     ESFRGTWDHGASDVSLYRITWAPVGNPDKMETILNGDENTLVFENLNPNTPYEVSITA
                     IYPDESESEDLSGTERTLRLIPLTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQK
                     YRITYQPSTGEGNEQTITVGGRQNSVLLQKLKPDTPYTITVYSQYPDGEGGRMTGRGK
                     TKPLNTVRNLRVYDPSTSSLSVRWDHAEGNPRQYKLFYAPTSGGPEELVPIPGNTNYA
                     ILRNLQPDTPYTITVVPVYTEGDGGRTSDTGRTLVRGLARNIQVYNPTPNSLDVRWDP
                     APGPVQQYRIVYSPVAGTRPSESIVVPGNTRTVHLERLIPDTPYSVNIVALYSDGEGN
                     PSPSQGRTLPRSGPRNIRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPIDEYTT
                     VPGRRNNVILQPLQPDTPYKITVIAIYEDGDGGHLTGNGRTVGLLPPQNIHIFDEWYT
                     RFRVSWDPSPSPVLGYKIVYKPVGSNEPMEAFVGEVTSYTLHNLNPSTTYDVSVYAQY
                     DSGLSVPLTDQGTTLYLNVTDLKTYQVGWDTFCVKWSPHRAATSYRLKLSPADGTRGQ
                     EITVRGSETSHCFTGLSPEAEYGVTVFVQTPNLEGPGVPIKEQTTVKPTEAPTEPPTP
                     SPPPTIPPARDVCKGAKADIVFLTDASWSIGDDNFNKVVKFIFNTVGAFDEVNPAGIQ
                     VSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGNTRTGKALTFIKEKVLTWESG
                     MRKNVPKVLVVVTDGRSQDEVKKAAFVIQQSGFSVFVVGVADVDYNELANIASKPSER
                     HVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPGFKMLEAYNLTEKNFAS
                     VQGVSLESGSFPSYSAYRLQKNAFINQPTAELHPNGLPPSYTIILLFRLLPETPSDPF
                     AIWQITDRDYRPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTDEVKTLFYGSFHKVH
                     IVVTSKSVKIYIDCYEIIEKDIKEAGNITTDGYEILGKLLKGERKSATFQIQSFDIVC
                     SPVWTSRDRCCDIPSRRDEAKCPALPNACTCTQDSVGPPGPPGPAGGPGAKGPRGERG
                     INGAVGPPGPRGDTGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLPGRTGTP
                     GLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDHGRPG
                     QSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMSRFNQMLNQIPNDYHSSRNQPG
                     PPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPPGERGLPGEKGERGTGSQGPRGPP
                     GPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQG
                     YPGSG"
     exon            413..529
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..673
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..733
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..997
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1162
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1336
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1627
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..2230
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2503
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2776
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..3049
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3322
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3589
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3782
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3904
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..4054
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4174
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4339
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4486
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4626
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4627..4756
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4899
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            4900..5029
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..5166
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5167..5296
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5436
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5437..5569
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5570..5596
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5597..5739
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5740..5869
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            5870..6009
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6010..6139
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6140..6282
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6283..6412
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6413..6555
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6556..6685
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6686..6805
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6952
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            6953..7069
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7070..7216
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7217..7291
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7292..7431
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7432..7555
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7556..7699
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7700..7864
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7865..7903
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            7904..8042
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8043..8185
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8186..8295
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8296..8445
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8446..8523
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8524..8610
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8611..8664
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8665..8760
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8761..8814
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8815..8868
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8869..8922
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8923..8994
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            8995..9030
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            9031..9097
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            9098..9286
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            9287..9355
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            9356..9526
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     exon            9527..11719
                     /gene="Col12a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9906..9911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col12a1"
                     /note="hexamer: AATAAA"
     polyA_site      9932
                     /gene="Col12a1"
                     /note="major polyA site"
     regulatory      11694..11699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Col12a1"
                     /note="hexamer: AATAAA"
     polyA_site      11715
                     /gene="Col12a1"
                     /note="major polyA site"
ORIGIN      
        1 ccttctcagg cgtttcgtaa ccgagtaaac tgagagccgg gaacagccct ctattaagta
       61 gcccgcggcg cggagtctct tcccagtcgg caaaggcggc cgctgcagac gcgtccgccc
      121 gcagctgcat tcagtccccc tgcctccgct cactctgcgc actaggcgct gctgctgggt
      181 gctcccatcg ccttttccac accggcggcc gccaggtgct cccggagcgc agcgccctcc
      241 caggcccggg gggtcccacg cgcaggctgc tggacgcccg ctccctctgt cacctccggc
      301 tcagatccct tcatgaggct gtgagcttga ggcccaaaca tgcagaccag gcttccccga
      361 gcgctggccg ccctgggcgt ggccctactc ctgtcttcca ttgaggcaga agttgaccca
      421 ccttccgact tgaattttaa aattatagat gaaaatactg ttcatatgtc atgggagaga
      481 ccagttgatc caattgtggg ttacagaata acagtggacc ctacaacaga tgggcctact
      541 aaagaattta cccttgcagc tagtaccact gaaactctat tatcagatct tattcctgaa
      601 acacagtatg tggtgactat aacttcctat aatgaagtag aagaaagtgt gccagtaata
      661 ggtcaactaa caattcaaac aggtggtcct acaaagccag gggagaagaa acctggaaaa
      721 acagaaatac aaaagtgctc tgtcagtgcc tggaccgacc tagtgtttct tgtggacggc
      781 tcctggagtg tgggaagaaa taatttcaag tacattttag acttcattgt tgctctggtg
      841 tctgcatttg acattgggga ggagaagacg agggttggag ttgttcagta cagctcagat
      901 accaggactg aatttaactt aaatcagtat taccgaagag aagacctcct tgctgcagtt
      961 aaaaaaatac catacaaagg cggcaacaca atgacagggg atgccattga ttacttagtt
     1021 aaaaacactt ttactgaatc tgctggctca cgagctggct ttcctaaagt ggcaattatt
     1081 atcacggacg gcaagtctca ggacgaagtg gaaattccag cgcgggagct tcggaatatt
     1141 ggagttgagg ttttctctct gggcattaaa gctgcagatg caaaagaact caaacaaatt
     1201 gcatccacac cttccctgaa ccatgtgttc aatgtggcca attttgatgc aattgtggac
     1261 atccagaatg agataatctc gcaggtgtgt tcaggagttg atgagcagct tggtgagctg
     1321 gtcagtggag aagaagtcat cgagcctcct tcaaatctgg tagtcactga actctcatca
     1381 aaatacatta ggctgagctg ggatccgtct cccagcgctg tgaccggcta taagatcctc
     1441 ctcacaccaa tggcagcggg aagccggcat cacgctttga gtgtggggcc ccagacgacc
     1501 acgctcaatg ttcgtgacct tacagcggac acggagtacc agatcagcgt ttttgccatg
     1561 aagggcctga cgtccagtga acccacttcg gtcatggaga agacgcagcc aatgaaagtt
     1621 caagtggaat gttcacgtgg tgtggatata aaagctgaca tcgtgttttt ggttgatggt
     1681 tcctatagca tcgggattgc aaattttgtt aaagttcgag cctttttaga agttcttgca
     1741 aaaagttttg agatttctcc gaacagggtg cagataagcc ttgtacagta cagcagggac
     1801 cctcacaccg agttcacatt gaaggagttc aacagagttg aagatataat caaagcaata
     1861 aacaccttcc cgtacagggg aggatccaca aacacaggca aagccatgac ttatgtcaga
     1921 gagaaaatat ttgtgccaaa caaaggttcc agaagcaacg taccgaaggt gatgattctc
     1981 atcacagatg ggaagtcatc agatgctttc agggatcctg ctataaaact caggaactcc
     2041 gacgtggaga tcttcgcagt cggtgtaaag gacgctgtgc gctcagaact ggaagccatt
     2101 gcctctcctc ctgctgagac ccacgtgttc acagtggagg attttgatgc ctttcagagg
     2161 atatcatttg aactcacaca gtccatctgt cttagaattg agcaagagtt ggcagctata
     2221 aagaagaaag cttacgttcc accaaaggat ctgaggttta ctcaggtaac tgctaatagt
     2281 ttcaaagctg aatggtctcc tcctggagac aatgtctttt cgtatcacgt cacatacaag
     2341 gatgctaatg gtgatgatga ggtcacagtg gtggagccag cctccagcac tagtgttgtt
     2401 ctcaacaacc tgaggccaga aaccctgtac ttggtgaatg tgacagccga gtatgaggac
     2461 ggcttcagtg ttcctataac tggggaggag accactgcag aagtaaaagg agttccacga
     2521 aacctgaagg tgacagatga gactacggac agttttaaac ttacctggtc ccaagctcca
     2581 gggagagtct taaggtatcg gattagatac agaccagttt ctggtggaga aagcaaagaa
     2641 gtgagtaccc cagccaatca gaggaggaaa acactggaga atctgacgcc cgacacaaaa
     2701 tatgaaatat ctgtgattgc tgaatattcc tcgggacctg gatctccact gacaggaaat
     2761 gcagccactg aagaagttag agggaatcca agagacctaa gagtttctga tgctacgaca
     2821 tcaacgctga agttgtcttg gagtagggca ccaggaaagg tgaagcaata tcttgtcaca
     2881 tacaccccag cagcaggagg tgaaactcag gaggtcactg tgagaggaga tacaaccact
     2941 accatgttga ggaaattgaa ggaagggaca cagtatgact tatctgtgac agcactgtat
     3001 gcgtctgggg ctggcgaagc cctttctgga aaaggatcaa ctcttgaaga acgtggctca
     3061 cctcagaacc tagttaccaa agacatcaca gacacatcaa tcggagccta ttggacatct
     3121 gccccaggga tggttcgagg gtacagggtc tcatggaaat cgctttacga cgacattgag
     3181 gctggagaga caactcttcc tggagatgca attcatacta tgatagagaa cctgcagcca
     3241 gagaccaagt acaaaatttc agttttcgca acttacagca gtggagaagg agagcccgtg
     3301 accggagatg ccacaactga attatctcaa gattccaaaa tcttaagagt ggatgaagaa
     3361 acagaacaca cgatgagagt tacctggaaa gcagcaccgg ggaaagtcgt caactaccgt
     3421 gttgtgtatc gccctcaagg gggtgggagg cagatggttg ctaaggtgcc acccacggtc
     3481 acttcaacag tgctaaagag acttcaaccc cagaccacat atgacatcac agttctccca
     3541 atgtacaaga caggagaagg aaagctcagg caaggctcag gaacaacagc gtctcgattt
     3601 aaatcgccga gaaacctcaa aacttctgac ccaaccatgt caagtttcag agtgacttgg
     3661 gagcctgccc ctggggaagt gaaaggttac aaagtcacat tccaccctac aggcgatgac
     3721 agaagacttg gggagttggt ccttggacca tatgacaaca cagttgtctt ggaggagctt
     3781 agggcaggca ccacctatag agtcaatgtt tttgggatgt ttgatggagg agaaagttta
     3841 ccactcgttg ggcaagaaat gacaactctt tctgacacaa ctgtgacacc atttctatct
     3901 tctgggatgg attgtctcac cagagctgaa gcagacattg tgttgctggt ggatgggtca
     3961 tggagcatcg gccgtgcaaa ttttagaact gtgcgaagct tcatttctcg tattgtagaa
     4021 gtctttgaaa ttggccccaa aagagtacaa attgctctcg ctcagtacag tggagacccc
     4081 agaacagagt ggcagttaaa tgctcataga gacaagaaga gtttattaca ggctgtggcg
     4141 aacttaccat acaaaggagg aaataccctc acaggcatgg ctttgaattt cattcgccaa
     4201 cagagcttca agactcaagc tggcatgagg cctcgtgctc gcaaaattgg agttctcatt
     4261 accgatggaa aatcacaaga tgatgtggag gctccatcca agaaactcaa ggatgaaggc
     4321 gtggagctgt ttgctattgg tattaagaat gctgatgaag ttgagttaaa gatgattgcc
     4381 actgatccag atgacactca cgcatacaat gtggcagatt ttgagtcatt gtccaagatt
     4441 gtggatgacc tcaccatcaa cttgtgtaac agtgtcaagg gccctggtga cttggaagca
     4501 ccgactaact tagtaatttc agagagaact caccgttctt ttagagtgag ctggacaccc
     4561 ccttctgaca gtgtggacag atacaaggtg gaatactacc ctgtctctgg agggaaacgc
     4621 caggagtttt atgtgagtcg actagacact agcacagtgc tgaaggacct gaagcctgag
     4681 actgactatg tggtgaacgt gtactctgtg gttgaagatg agtacagtga gcctctgaag
     4741 ggcacagaga aaaccctgcc agtccctgta gttagcctga atatttatga tgttggcccc
     4801 accactatgc atgtgcaatg gcagcctgtg ggaggagcta ctggctacac cgtatcatac
     4861 caacctactc gatctccaga aggaacaaag cccaaagaga tgcgcgtggg gccaacagtg
     4921 aatgatgtgc agctgactgg cctccttcct aacacagagt atgaggtcac cgtccaggcc
     4981 gtcctgtatg acctcactag tgaacctgcc aaagctcggg aagtcacatt gcctttaccc
     5041 agacctcagg atgtgaaact cagagatgtg acccacagca ccatgaatgt cgtctgggaa
     5101 cctgtgcttg gaaaagttcg caagtacatt gttagataca aaactccaga tgaggagttc
     5161 aaagaggtgg aggtggacag atcaagggcc agcactatcc tcaaagacct ctcctctcaa
     5221 acccagtaca cagtgagcgt ttctgctgtg tacgatgagg gcacatctcc cccagcaact
     5281 gcatatgaca caacccggcg tgttccagcc ccaaccaacc tccagtttac tgaagtcaca
     5341 ccagagagtt tcagggggac ctgggatcat ggagcttcag atgtgtctct ctacaggata
     5401 acttgggcac ctgttgggaa cccagataag atggagacca ttttaaatgg agatgaaaat
     5461 actttggtgt ttgaaaatct gaaccccaat actccgtatg aagtctccat caccgccatc
     5521 tatcctgatg agtctgaaag cgaggacctg agtggcacag agcgcacact gcgtctgata
     5581 cccttaacaa cacaagctcc aaaaagtggt ccacggaacc ttcaggtgta caatgccaca
     5641 tctaacagct tgactgttaa gtgggatcct gctagtggtc gtgtgcagaa gtacagaatc
     5701 acctatcagc cttcaacagg agaaggcaat gaacaaacga tcacagtagg aggacggcag
     5761 aacagcgtgc tcctgcagaa actgaagcct gacactccat acaccatcac ggtgtattcc
     5821 cagtatcccg atggtgaagg tggccggatg accggaaggg gaaagaccaa acctctgaat
     5881 accgtgagga atttgagagt gtatgacccg tctaccagct ctttgagtgt ccgctgggac
     5941 catgcagaag gcaatcctcg tcagtacaaa ctcttttatg ccccaacatc aggtggccca
     6001 gaagaactgg tcccaatccc cgggaatacc aactatgcca ttcttaggaa cctgcagcca
     6061 gatactccat acaccatcac agtggttccg gtctatacag aaggtgatgg cgggcgcaca
     6121 tcagatactg gaaggacatt ggtgagagga ctggcaagaa acatccaagt gtataaccct
     6181 acgcccaaca gccttgatgt tcgctgggac cccgccccag ggccagtgca gcagtaccgc
     6241 attgtgtact cccctgttgc tggtacaaga ccctcagaat ctattgtggt gccagggaat
     6301 acccgaacgg tgcatctgga gaggttgatt cctgacacac cctactctgt gaatatcgtg
     6361 gctctctact cagatggaga ggggaatccc agccccagcc agggccgaac acttccaaga
     6421 agtggaccaa ggaacatacg ggtctttggg gagacgacca acagcctctc tgtagcctgg
     6481 gaccatgctg atgggccagt tcagcaatac aggatcatct actctcctac tgtcggcgat
     6541 ccaattgatg aatataccac agttccaggc agaagaaaca atgtaatact gcagcccttg
     6601 caacctgaca ctccatataa aattactgtc attgctattt atgaggatgg agatggtggt
     6661 cacctaactg gaaacgggag gactgtgggt ctgcttcctc ctcagaacat acacatcttc
     6721 gatgaatggt acacaaggtt ccgagtgtcc tgggaccctt caccctcacc agttcttgga
     6781 tataaaattg tgtacaagcc agtgggttcc aatgagccca tggaagcctt tgttggagaa
     6841 gtgacatcat acactttaca caacctcaat cccagcacta cctatgacgt cagtgtttat
     6901 gcacagtatg actctggact cagcgttccc ctcacagatc aaggcaccac attgtactta
     6961 aatgtgacag atctgaaaac ttaccaggtt ggatgggata cattctgtgt caagtggtca
     7021 cctcaccggg cagccacctc ctacaggcta aagctgagtc ctgcagatgg aaccagggga
     7081 caagaaataa ccgtgcgagg atcagagacc agtcattgct tcactggtct ctccccggag
     7141 gctgagtacg gcgttactgt ttttgtgcag acaccaaatc tcgaggggcc gggtgtcccc
     7201 atcaaagaac agaccactgt gaaaccaaca gaggctccta cagaaccacc cacgccttct
     7261 cctcctccca ctattccacc tgcccgtgat gtatgcaaag gggccaaggc agatattgtg
     7321 ttcttgacgg atgcctcttg gagtattgga gatgacaatt ttaacaaagt tgtaaaattt
     7381 atctttaata ctgtgggggc ctttgatgaa gtcaaccctg ctgggattca ggtttctttt
     7441 gtgcagtaca gtgatgaggt caagtctgaa ttcaagctga acacatacaa cgataaagct
     7501 ctagccctcg gagccctcca gaacattcgc tacagaggag gaaacacaag aacaggcaag
     7561 gccctcacat ttatcaagga gaaggtcttg acctgggaga gcggcatgag aaagaatgtc
     7621 ccgaaggtgc tggttgtggt cacagatggc cggtcgcagg atgaggtgaa gaaggcagcc
     7681 tttgtcatcc agcagtcagg gttcagtgta ttcgttgttg gtgtggctga tgtggactac
     7741 aacgagcttg ccaacattgc cagcaagccc agcgagaggc atgtattcat cgtggatgac
     7801 tttgaatctt ttgagaagat tgaggacaat ctgatcacat ttgtttgtga aactgccact
     7861 tcaagttgcc ctctcatcta tctggatggc tacacatcac caggctttaa gatgcttgaa
     7921 gcttacaacc tgacagaaaa gaattttgct tctgtccaag gagtctcttt ggaatccgga
     7981 tctttcccta gctattcagc ctacagactt cagaagaatg cctttatcaa tcagcccaca
     8041 gcagaactgc atccaaatgg actccctcct tcgtacacga ttatattatt atttagactt
     8101 ctcccagaaa ctcctagtga cccctttgca atttggcaaa ttacagacag agactacaga
     8161 ccacaagttg gagtgattgc agatccttcc agcaagacac tatctttctt taataaggat
     8221 acaagagggg aggtacaaac tgttacattt gacacagatg aagtgaagac attattttat
     8281 ggaagctttc ataaggtcca tattgtagtg acctcaaaga gtgttaagat ttatattgac
     8341 tgctatgaaa ttatagaaaa agacatcaaa gaagctggaa atataacaac tgatggctac
     8401 gaaattcttg gaaaacttct taaaggagag aggaagtcag ccacattcca aatccagagc
     8461 tttgacattg tctgcagccc agtgtggacc agtagagaca gatgctgtga tattccctct
     8521 aggagagatg aagcaaaatg ccctgccctt ccgaatgctt gcacgtgtac ccaggacagc
     8581 gttggacctc caggccctcc gggccctgca ggaggacctg gcgcaaaagg tcccagaggt
     8641 gaaagaggca tcaatggggc agttgggccc ccaggtcccc gtggagatac tggccctcca
     8701 ggccctcaag gtcctccagg cccccaggga cccaatggac tctccattcc gggcgaacag
     8761 ggtcgccagg gaatgaaagg tgatgcagga gagccaggcc ttccgggacg gacaggaacc
     8821 ccaggattac ctggcccacc aggaccaatg ggaccaccag gagacagagg tttcactgga
     8881 aaagatggtg caatggggcc cagaggtccc ccggggccac cgggaagccc aggctctcca
     8941 ggagtcacag ggccaagtgg gaaaccagga aaacctggag accatggcag acctggtcaa
     9001 tctggcttaa aaggagaaaa aggtgatagg ggagacatcg cttcccagaa catgatgcga
     9061 gcggttgcaa gacaagtctg cgaacaactg atcagtggcc agatgagcag attcaatcag
     9121 atgctgaatc agattccaaa tgattaccac tcaagtcgaa accagcctgg cccaccaggg
     9181 cctccagggc cccctggcag tgctggagcc agaggagaac cagggcctgg gggtcgacca
     9241 ggattccctg gcacacctgg gatgcaagga ccccctggtg aacgaggttt gcctggagag
     9301 aaaggtgaaa ggggtactgg gtctcaagga ccccgaggac cgcctgggcc cccaggtcca
     9361 caaggcgaat cccgaacggg tccaccaggg tctacaggtt caagaggccc tcctggtccc
     9421 cctggtcgtc caggaaactc aggtatccga ggccctccag gtcctcctgg atattgtgat
     9481 tcatcccagt gtgccagcat cccgtacaat gggcaaggct atccaggttc cggctaacaa
     9541 attttctaag tctccagtgc tgcttacagt ttgaaataca tgagaatcct gtttctgaga
     9601 tgtttgcgca cgtgcttatt agaaaatgag tctgtatgga aatctcgcgg cagatatggt
     9661 taacgaactg ggtcggcatc atacaggagg gtggagactc catactaact tgaatgacac
     9721 aagggcagtg gtgtccgcct gatgcttttc agcagtaacg tagaacacca tcttttaaaa
     9781 agttcaaaca tagccaggag gagccctggt tgtgaaggag gcgcctaata agctactaac
     9841 caacagagtc atgccatgtt gagacagaca attaacctgg ttgaagagaa atgtcctatg
     9901 taaataataa actaattgtc gcttgtacac gatctgaatg tgatcctgta tactaaaatt
     9961 tcgtaacaac tcaacaaccc gcttctgcac caaagcctgc tggctgcttg ctctctgcag
    10021 tgataacaga gaatggatct gatcccctct tgcttgttag cagtgtgtct gagttcaggg
    10081 catgtgactt ctcagtactc tctgtgtgta tttttatttg ggtttcttaa ctgcaatttt
    10141 tcaaaccaaa gtttaaaatc aacatccctt cctttttggc tatagtcaca ggtgttcctg
    10201 cccactggct gtaactctgc atgagacata gccatagggg acaccgtgga gtgtacaaaa
    10261 cctggcgaca tctcctttca ccccgagttc agtctctagg ctccaatact tttcatgacc
    10321 tcagctctcc aagttatctg ttgacctgat aagtttgaag tcatgaacag ttatttaggg
    10381 atttgccaaa aatcctacct aggtattgtg tttacaattc tttggcccaa tttctgatcc
    10441 ttcccaggtt ttgtgcaatg attgtgttta ctgctggatc tttgagtccc ccactcccct
    10501 gtccagcact ccttatttgg tcaccaaatt cactctgcac acgtgcacat ggaaataatt
    10561 ggaacaccgc aatgcaatgc atctatttat ggttgtgaga ttaagggtgg agtgccctca
    10621 cctccagtga tgagttaact tttgctgtgc gtgtatacct tccaagtcat gccataactg
    10681 taatgttgaa tcggacagag ccttatgtgc ccgagggtgg ggcctacctg cctgaacgag
    10741 agcccttcat cgtgcctgtg gagccagaga ggacagcaga atatgaggat gactacggtg
    10801 cagatgagcc tgaccagcag caccctgatc acatgcgttg gcggcgagcc ctgcgcccag
    10861 gccctgggca gtgaacctga aatcacgggt tcactgaggt gggaggtgct gggattctca
    10921 atcacaggtc agacagagca gcagtgtacg tcatttctgt gatgttttct ctgcgtcgct
    10981 tcacccacaa gtgctccgat ctgactgtag agaatcttgt ttctgcaggc agcctagctg
    11041 gcaacagtct gtagacatcc atgcctttgc agttcaaatg gttacaacac aagctcttca
    11101 cagaagctgc atggagagaa cgcgtccagg gtgggctgcg gcagccaagc ttctaggtta
    11161 cccagcaagc cctggaaacc agagcagctg tctattcaga aagggccttt atctttctta
    11221 gaacaaatgc agttcaattg catcccattt ccagtcattc cactcttaaa accaaaaagg
    11281 aggggaacac cagctcactg cagcagttct cccttctttc cttccttctg ttacgcttta
    11341 gggcacagaa tgctctttag tcttttaaca accacagacc ttaagcctcg tagccgaagt
    11401 tattgtatca actggatact gttccatatc gcttttagac gtctttgttt tgacacacta
    11461 acatttatgc caaattgcag attattctgc agaaatggaa ttgcatgttt gtgttgtata
    11521 tttagaatga actttttttt tttttttttg caaaacatgt ttcttagtta tcaaagcagt
    11581 tggaaatgtt tgcaagacta tgaacataga attgctgctt ttatatttta actgcagatt
    11641 gtgaatttca ctgccttata ttatttattt ctgaaacaaa agaggcattt ttcaataaaa
    11701 ctactgaaaa tttgacctg
//
